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1. 发明专利

AU2020231007A1 Multiplexed fluorescent detection of analytes 未知
公开(公告)号：AU2020231007A1
公开(公告)日：2021-04-29
申请号：AU2020231007
申请日：2020-03-02
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： ROMANOV NIKOLAI , HONG STANLEY S , MCCAULEY PATRICK , LIU XIAOHAI , CONDELLO DANILO , SIU MEREK
IPC分类号： C12Q1/6869
摘要： In a first aspect, a method includes:providing a sample, the sample including a first nucleotide and a second nucleotide;contacting the sample with a first fluorescent dye and a second fluorescent dye, the first fluorescent dye emitting first emitted light within a first wavelength band responsive to a first excitation illumination light, the second fluorescent dye emitting second emitted light within a second wavelength band responsive to a second excitation illumination light; simultaneously collecting, using one or more image detectors, multiplexed fluorescent light comprising the first emitted light and the second emitted light, the first emitted light being a first color channel corresponding to the first wavelength band and the second emitted light being a second color channel corresponding to the second wavelength band; and identifying the first nucleotide based on the first wavelength band of the first color channel and the second nucleotide based on the second wavelength band of the second color channel.

2. 发明专利

CA3114733A1 MULTIPLEXED FLUORESCENT DETECTION OF ANALYTES 未知
公开(公告)号：CA3114733A1
公开(公告)日：2020-09-10
申请号：CA3114733
申请日：2020-03-02
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： ROMANOV NIKOLAI , HONG STANLEY S , MCCAULEY PATRICK , LIU XIAOHAI , CONDELLO DANILO , SIU MEREK
IPC分类号： C12Q1/6869
摘要： In a first aspect, a method includes:providing a sample, the sample including a first nucleotide and a second nucleotide;contacting the sample with a first fluorescent dye and a second fluorescent dye, the first fluorescent dye emitting first emitted light within a first wavelength band responsive to a first excitation illumination light, the second fluorescent dye emitting second emitted light within a second wavelength band responsive to a second excitation illumination light; simultaneously collecting, using one or more image detectors, multiplexed fluorescent light comprising the first emitted light and the second emitted light, the first emitted light being a first color channel corresponding to the first wavelength band and the second emitted light being a second color channel corresponding to the second wavelength band; and identifying the first nucleotide based on the first wavelength band of the first color channel and the second nucleotide based on the second wavelength band of the second color channel.

3. 发明专利

SG11202103214TA MULTIPLEXED FLUORESCENT DETECTION OF ANALYTES 未知
公开(公告)号：SG11202103214TA
公开(公告)日：2021-09-29
申请号：SG11202103214T
申请日：2020-03-02
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： ROMANOV NIKOLAI , HONG STANLEY S , MCCAULEY PATRICK , LIU XIAOHAI , CONDELLO DANILO , SIU MEREK
IPC分类号： C12Q1/6869
摘要： In a first aspect, a method includes: providing a sample, the sample including a first nucleotide and a second nucleotide; contacting the sample with a first fluorescent dye and a second fluorescent dye, the first fluorescent dye emitting first emitted light within a first wavelength band responsive to a first excitation illumination light, the second fluorescent dye emitting second emitted light within a second wavelength band responsive to a second excitation illumination light; simultaneously collecting, using one or more image detectors, multiplexed fluorescent light comprising the first emitted light and the second emitted light, the first emitted light being a first color channel corresponding to the first wavelength band and the second emitted light being a second color channel corresponding to the second wavelength band; and identifying the first nucleotide based on the first wavelength band of the first color channel and the second nucleotide based on the second wavelength band of the second color channel.

4. 发明专利

IL281861D0 Multiplexed fluorescent detection of analytes 未知
公开(公告)号：IL281861D0
公开(公告)日：2021-05-31
申请号：IL28186121
申请日：2021-03-26
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD , ROMANOV NIKOLAI , HONG STANLEY S , MCCAULEY PATRICK , LIU XIAOHAI , CONDELLO DANILO , SIU MEREK
发明人： ROMANOV NIKOLAI , HONG STANLEY S , MCCAULEY PATRICK , LIU XIAOHAI , CONDELLO DANILO , SIU MEREK
摘要： In a first aspect, a method includes: providing a sample, the sample including a first nucleotide and a second nucleotide; contacting the sample with a first fluorescent dye and a second fluorescent dye, the first fluorescent dye emitting first emitted light within a first wavelength band responsive to a first excitation illumination light, the second fluorescent dye emitting second emitted light within a second wavelength band responsive to a second excitation illumination light; simultaneously collecting, using one or more image detectors, multiplexed fluorescent light comprising the first emitted light and the second emitted light, the first emitted light being a first color channel corresponding to the first wavelength band and the second emitted light being a second color channel corresponding to the second wavelength band; and identifying the first nucleotide based on the first wavelength band of the first color channel and the second nucleotide based on the second wavelength band of the second color channel.

5. 发明专利

SG11201911647RA DUAL OPTICAL GRATING SLIDE STRUCTURED ILLUMINATION IMAGING 未知
公开(公告)号：SG11201911647RA
公开(公告)日：2020-01-30
申请号：SG11201911647R
申请日：2019-01-14
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： NEWMAN PETER , CONDELLO DANILO , LU SHAOPING , PRINCE SIMON , SIU MEREK , HONG STANLEY , LIU AARON , SKINNER GARY , EVANS GERAINT
IPC分类号： G02B21/14
摘要： The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

6. 发明专利

ES2861350T3 Micromatrices de planos múltiples 未知
公开(公告)号：ES2861350T3
公开(公告)日：2021-10-06
申请号：ES17776477
申请日：2017-03-28
申请人： ILLUMINA INC
发明人： BOWEN M SHANE , GRAIGE MICHAEL , HONG STANLEY S , MOON JOHN A , SIU MEREK
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/6837 , C12Q1/6844 , C12Q1/6874
摘要： Un sistema que comprende: una matriz que comprende un soporte sólido que tiene una superficie exterior que comprende un primer conjunto de pocillos intercalados con un segundo conjunto de pocillos, el primer conjunto de pocillos comprende un patrón de repetición de pocillos y el segundo conjunto de pocillos comprende un patrón de repetición de pocillos; en donde el primer conjunto de pocillos se yuxtapone al segundo conjunto de pocillos, teniendo cada pocillo del primer conjunto un primer fondo a una primera elevación, z1, con respecto al soporte sólido, teniendo cada pocillo del segundo conjunto un segundo fondo a una segunda elevación, z2, con respecto al soporte sólido; en donde la altura de la primera elevación, z1, y la segunda elevación, z2, a lo largo del eje z es diferente; y en donde cada pocillo del primer conjunto de pocillos y el segundo conjunto de pocillos comprende puntos de anclaje para anclar analitos mediante unión directa o indirecta al soporte sólido, por medio de lo cual los primeros pocillos están configurados para anclar analitos a una elevación diferente con respecto a los analitos anclados al segundo conjunto de pocillos; el sistema está caracterizado porque un paso entre un pocillo del primer conjunto de pocillos y cada pocillo vecino del segundo conjunto de pocillos en la matriz es menor de 500 nm y porque el sistema comprende adicionalmente una guía de ondas acoplada ópticamente de forma selectiva al primer conjunto de pocillos y no acoplada ópticamente al segundo conjunto de pocillos.

7. 发明专利

SG11202012810TA SYSTEM AND METHOD FOR STORAGE 未知
公开(公告)号：SG11202012810TA
公开(公告)日：2021-01-28
申请号：SG11202012810T
申请日：2020-05-26
申请人： ILLUMINA INC
发明人： SIU MEREK , AGAH ALI , HONG STANLEY , KHURANA TARUN , KARUNAKARAN AATHAVAN , CIESLA CRAIG , KIA AMIRALI
IPC分类号： G11C29/04 , G11C13/04
摘要： Devices, systems, and methods for non-volatile storage include a well activation device operable to modify one or more wells from a plurality of wells of a flow cell to provide a set of readable wells. Readable wells are configured to allow exposure of a well to substances from nucleotide sequencing fluids, and prevent exposure to other substances and fluids, such as nucleotide synthesizing fluids. The well activation device may also modify wells to provide a set of writeable wells. This set of wells is configured to allow exposure to the nucleotide synthesizing fluids and substances; and prevent exposure to the nucleotide sequencing fluids and substances. There may also be provisions made for risk mitigation for data errors such as generating commands to write specified data to a nucleotide sequence associated with a particular location in a storage device, reading the nucleotide sequence and performing a comparison.

8. 发明专利

SG11202012811RA FLOW CELL WITH ONE OR MORE BARRIER FEATURES 未知
公开(公告)号：SG11202012811RA
公开(公告)日：2021-01-28
申请号：SG11202012811R
申请日：2020-05-26
申请人： ILLUMINA INC
发明人： KHURANA TARUN , AGAH ALI , KARUNAKARAN AATHAVAN , HONG STANLEY , SIU MEREK , EMADI ARVIN , CIESLA CRAIG
IPC分类号： C12Q1/6869 , C12M1/00 , C12Q1/6874
摘要： An apparatus includes a flow cell body, a plurality of electrodes, an imaging assembly, and one or more barrier features. The flow cell body defines one or more flow channels and a plurality of wells defined as recesses in the floor of each flow channel. Each well is fluidically coupled with the corresponding flow channel. The flow cell body further defines interstitial surfaces between adjacent wells. Each well defines a corresponding depth. Each electrode is positioned in a corresponding well of the plurality of wells. The electrodes are to effect writing of polynucleotides in the wells. The imaging assembly is to capture images of polynucleotides written in the wells. The one or more barrier features are positioned in the wells, between the wells, or above the wells. The one or more barrier features contain reactions in each well, reduce diffusion between the wells, or reduce optical cross-talk between the wells.

9. 发明专利

DK3377226T3 Mikrorækker i flere niveauer 未知
公开(公告)号：DK3377226T3
公开(公告)日：2021-04-26
申请号：DK17776477
申请日：2017-03-28
申请人： ILLUMINA INC
发明人： BOWEN M SHANE , GRAIGE MICHAEL , HONG STANLEY S , MOON JOHN A , SIU MEREK
IPC分类号： B01L3/00 , B01J19/00 , C12Q1/6837 , C12Q1/6844 , C12Q1/6874

10. 发明专利

SG11201805665UA MULTI-PLANE MICROARRAYS 未知
公开(公告)号：SG11201805665UA
公开(公告)日：2018-10-30
申请号：SG11201805665U
申请日：2017-03-28
申请人： ILLUMINA INC
发明人： GRAIGE MICHAEL , HONG STANLEY S , BOWEN M SHANE , MOON JOHN A , SIU MEREK
IPC分类号： B01L3/00 , C12Q1/68 , G01N33/53 , G01N33/543
摘要： An array including a solid support having a plurality of contours along its exterior surface. A first subset of contours is positioned along the exterior surface of the solid support to form a first pattern of features and a second subset of contours is positioned along the exterior surface to form a second pattern of features. The contours of the first subset are juxtaposed with the second subset along the exterior surface, whereby the first and second patterns form an interleaved pattern. The features of the first pattern occur at a first elevation z 1 and the features of the second pattern occur at a second elevation z 2 . The features of the first pattern are configured to attach analytes at a different elevation relative to analytes attached to the features of the second pattern.

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