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1. 发明专利

SG11201911580QA FLUID CACHING 未知
公开(公告)号：SG11201911580QA
公开(公告)日：2020-01-30
申请号：SG11201911580Q
申请日：2019-01-10
申请人： ILLUMINA INC , ILLUMINA CAMBRIDGE LTD
发明人： COX-MURANAMI WESLEY , SEGALE DARREN , MILLER OLIVER , FOLEY JENNIFER , KHURANA TARUN KUMAR , CRIVELLI PAUL , WATTS GARY
IPC分类号： G01N35/08 , G01N35/02 , G01N37/00
摘要： An apparatus for directing fluid into and out of a fluidic device includes two or more fluid prime channels connected to a fluid inlet of the fluidic device, a flow control valve for each fluid prime channel to control flow between the fluid prime channel and the fluid inlet, one or more outlet channels connected to a fluid outlet of the fluidic device, and a flow control valve for each outlet channel to control flow between the fluid outlet and the associated outlet channel. An apparatus for delivering fluids to a fluid inlet includes a plate that is rotatable about an axis of rotation and a plurality of fluid compartments disposed on the plate, each compartment having a fluid exit port disposed at a common radial distance from the axis of rotation and positioned to align with the fluid inlet as the plate rotates about the axis of rotation.

2. 发明专利

DK3628025T3 STRØMNINGSCELLE MED FLEKSIBEL TILSLUTNING 未知
公开(公告)号：DK3628025T3
公开(公告)日：2021-11-15
申请号：DK19802686
申请日：2019-05-01
申请人： ILLUMINA INC
发明人： DELATTRE CYRIL , RHEE MINSOUNG , LIU JEFFREY , COX-MURANAMI WESLEY , CRIVELLI PAUL , FOLEY JENNIFER , SEGALE DARREN , TAYLOR JAY , HAGE MATTHEW , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ-SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
IPC分类号： B01L3/00 , F16L1/00 , F16L11/22

3. 发明专利

IL271267D0 Flow cell with flexible connection 未知
公开(公告)号：IL271267D0
公开(公告)日：2020-01-30
申请号：IL27126719
申请日：2019-12-08
申请人： ILLUMINA INC , HAGE MATTHEW WILLIAM , SEGALE DARREN , CRIVELLI PAUL , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX MURANAMI WESLEY , DELATTRE CYRIL , LIU JEFFREY , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
发明人： HAGE MATTHEW WILLIAM , SEGALE DARREN , CRIVELLI PAUL , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX-MURANAMI WESLEY , DELATTRE CYRIL , LIU JEFFREY , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ-SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
IPC分类号： B01L20060101
摘要： An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

4. 发明专利

CA3067426A1 FLOW CELL WITH INTEGRATED MANIFOLD 未知
公开(公告)号：CA3067426A1
公开(公告)日：2019-11-07
申请号：CA3067426
申请日：2019-04-30
申请人： ILLUMINA INC
发明人： LIN SZ-CHIN , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX-MURANAMI WESLEY , DELATTRE CYRIL , KHURANA TARUN , CRIVELLI PAUL
IPC分类号： G01N35/08 , G01N37/00
摘要： In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

5. 发明专利

CA3067426C FLOW CELL WITH INTEGRATED MANIFOLD 未知
公开(公告)号：CA3067426C
公开(公告)日：2022-07-19
申请号：CA3067426
申请日：2019-04-30
申请人： ILLUMINA INC
发明人： LIN SZ-CHIN , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX-MURANAMI WESLEY , DELATTRE CYRIL , KHURANA TARUN , CRIVELLI PAUL
IPC分类号： G01N35/08 , G01N37/00
摘要： In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

6. 发明专利

ES2896697T3 Celda de flujo con conexión flexible 未知
公开(公告)号：ES2896697T3
公开(公告)日：2022-02-25
申请号：ES19802686
申请日：2019-05-01
申请人： ILLUMINA INC
发明人： DELATTRE CYRIL , RHEE MINSOUNG , LIU JEFFREY , COX-MURANAMI WESLEY , CRIVELLI PAUL , FOLEY JENNIFER , SEGALE DARREN , TAYLOR JAY , HAGE MATTHEW , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ-SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
IPC分类号： B01L3/00 , F16L1/00 , F16L11/22
摘要： Un instrumento (100) que comprende: un sistema (104) de gestión de reactivos, comprendiendo el sistema (104) de gestión de reactivos una pluralidad de pocillos (132) de reactivos, pudiendo utilizarse cada pocillo (132) de reactivos de modo que contenga un reactivo de una pluralidad de reactivos colocados en él, pudiendo utilizarse el sistema (104) de gestión de reactivos para seleccionar un flujo de reactivo de uno de la pluralidad de pocillos (132) de reactivos; una conexión flexible (106) que comprende una pila de estratificados, comprendiendo la conexión flexible (106) un primer canal flexible (136) en comunicación fluida con el sistema (104) de gestión de reactivos, pudiendo utilizarse el primer canal flexible (136) para dirigir el flujo de reactivo a través de este; y una celda (102) de flujo, que se puede utilizar para colocarla en el instrumento (100), comprendiendo la celda (102) de flujo un canal (124) de flujo en comunicación fluida con el primer canal flexible (136), pudiéndose utilizar el canal (124) de flujo para dirigir el flujo del reactivo sobre analitos colocados en el canal (124) de flujo; y un módulo (126) de detección; en donde la celda (102) de flujo puede ser movida por el instrumento (100) con relación a un punto (128) de referencia fijo en el instrumento (100), en donde la conexión flexible (106) comprende: una capa superior (210) que define una parte superior del primer canal flexible (136); una capa inferior (212) que define una parte inferior del primer canal flexible (136); y una capa intermedia (214) que define un ancho de pared y un ancho de canal del primer canal flexible (136); en donde una relación del ancho de pared al ancho de canal es superior a aproximadamente 2,5.

7. 发明专利

SG11201911979RA FLOW CELL WITH FLEXIBLE CONNECTION 未知
公开(公告)号：SG11201911979RA
公开(公告)日：2020-01-30
申请号：SG11201911979R
申请日：2019-05-01
申请人： ILLUMINA INC
发明人： DELATTRE CYRIL , RHEE MINSOUNG , LIU JEFFREY , COX-MURANAMI WESLEY , CRIVELLI PAUL , FOLEY JENNIFER , SEGALE DARREN , TAYLOR JAY , HAGE MATTHEW , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ-SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
IPC分类号： G01N35/02 , B81B3/00
摘要： An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

8. 发明专利

CA2920390A1 MANIPULATION OF DROPLETS ON HYDROPHILIC OR VARIEGATED-HYDROPHILIC SURFACES 未知
公开(公告)号：CA2920390A1
公开(公告)日：2015-03-05
申请号：CA2920390
申请日：2014-08-29
申请人： ILLUMINA INC , ADVANCED LIQUID LOGIC FRANCE SAS
发明人： JAMSHIDI ARASH , LIN YAN-YOU , ARAVANIS ALEX , DELATTRE CYRIL , RIVAL ARNAUD , FOLEY JENNIFER , SABOUNCHI POORYA , KHURANA TARUN , BABAZADEH MAJID , AMINI HAMED , VENKATESAN BALA MURALI , BOWEN M SHANE , BARNARD STEVEN M , ROGERT BACIGALUPO MARIA CANDELARIA , DEHLINGER DIETRICH
IPC分类号： B41J2/04
摘要： Provided herein is a droplet actuator including (a) first and second substrates separated by a droplet- operations gap, the first and second substrates including respective hydrophobic surfaces that face the droplet-operations gap; (b) a plurality of electrodes coupled to at least one of the first substrate and the second substrate, the electrodes arranged along the droplet-operations gap to control movement of a droplet along the hydrophobic surfaces within the droplet-operations gap; and (c) a hydrophilic or variegated-hydrophilic surface exposed to the droplet-operations gap, the hydrophilic or variegated- hydrophilic surface being positioned to contact the droplet when the droplet is at a select position within the droplet-operations gap.

9. 发明专利

AU2019270818B2 Flow cell with flexible connection 未知
公开(公告)号：AU2019270818B2
公开(公告)日：2021-07-08
申请号：AU2019270818
申请日：2019-05-01
申请人： ILLUMINA INC
发明人： CRIVELLI PAUL , FOLEY JENNIFER , SEGALE DARREN , TAYLOR JAY , HAGE MATTHEW , DELATTRE CYRIL , RHEE MINSOUNG , LIU JEFFREY , COX-MURANAMI WESLEY , PAIK PHILIP , ALLEGOREN ERIK , HERTZOG DAVID , MOROZ-SMIETANA ALEX , MA XIAOXIAO , TAKAHASHI TSUKASA , WESTERBERG BRANDON
IPC分类号： G01N35/02 , B81B3/00
摘要： An instrument includes a reagent management system. The reagent management system includes a plurality of reagent wells, each reagent well operable to contain a reagent of a plurality of reagents positioned therein. The reagent management system is operable to select a flow of reagent from one of the plurality of reagents. A flexible connection includes a laminate stack and includes a first flexible channel in fluid communication with the reagent management system. The first flexible channel is operable to route the flow of reagent therethrough. A flow cell includes a flow channel in fluid communication with the first flexible channel. The flow channel is operable to route the flow of reagent over analytes positioned in the flow channel. The flexible connection enables the flow cell to be moved by the instrument relative to a fixed reference point in the instrument.

10. 发明专利

AU2019261940B2 Flow cell with integrated manifold 未知
公开(公告)号：AU2019261940B2
公开(公告)日：2021-07-08
申请号：AU2019261940
申请日：2019-04-30
申请人： ILLUMINA INC
发明人： LIN SZ-CHIN , TAYLOR JAY , RHEE MINSOUNG , FOLEY JENNIFER , COX-MURANAMI WESLEY , DELATTRE CYRIL , KHURANA TARUN , CRIVELLI PAUL
IPC分类号： G01N35/08 , G01N37/00
摘要： In one example, a flow cell includes a plurality of inlet ports sized to receive a flow of reagent from one of a plurality of reagents into the flow cell. An outlet port of the flow cell is sized to pass each flow of reagent out of the flow cell. A flow channel of the flow cell is positioned between, and in fluid communication with, each inlet port and the outlet port. The flow channel includes a manifold section and a detection section. The manifold section has a plurality of manifold branches in fluid communication with a common line, wherein each branch is connected to one of each inlet port. The detection section is in fluid communication with the common line and the outlet port. The detection section is operable to perform a plurality of different chemical reactions between the plurality of reagents and analytes positioned in the detection section.

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