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1. 发明专利

NZ748879A Sensors having integrated protection circuitry 未知
公开(公告)号：NZ748879A
公开(公告)日：2021-02-26
申请号：NZ74887918
申请日：2018-04-19
申请人： ILLUMINA INC
发明人： SAMIEE KEVAN , FUNG TRACY HELEN , CAI XIUYU , KWOK LISA , TRAN HAI , QIANG LIANGLIANG , BOYANOV BOYAN
IPC分类号： G01N21/78 , G01N21/77 , G01N35/00
摘要： An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

2. 发明专利

PH12019501507A1 FLOW CELL PACKAGE AND METHOD FOR MAKING THE SAME 未知
公开(公告)号：PH12019501507A1
公开(公告)日：2020-06-29
申请号：PH12019501507
申请日：2019-06-26
申请人： ILLUMINA CAMBRIDGE LTD , ILLUMINA INC
发明人： TSAY JAMES , PRABHU ANMIV , HEINER DAVID , LI EDWIN , RICHEZ ALEXANDRE , BEIERLE JOHN M , SAMIEE KEVAN , MUNOZ KRISTINA , MALEVANCHIK LEONID , VINCENT LUDOVIC , ZHAN NAIQIAN , SHIEH PEYTON , YANG ROBERT , SCHMITT SAMANTHA , PARK SANG , BAILEY SCOTT , RAMIREZ SEAN M , AHN SUNMIN , UZZELL VALERIE , WEI WEI , HUANG YUXIANG , DILL TYLER JAMISON
IPC分类号： C12Q1/68 , C07C247/12 , H01L21/3105 , H01L21/3213 , H01L21/56
摘要： A flow cell package includes first and second surface-modified patterned wafers and a spacer layer. The first surface-modified patterned wafer includes first depressions separated by first interstitial regions, a first functionalized molecule bound to a first silane or silane derivative in at least some of the first depressions, and a first primer grafted to the first functionalized molecule in the at least some of the first depressions. The second surface-modified patterned wafer includes second depressions separated by second interstitial regions, a second functionalized molecule bound to a second silane or silane derivative in at least some of the second depressions, and a second primer grafted to the second functionalized molecule in the at least some of the second depressions. The spacer layer bonds at least some first interstitial regions to at least some second interstitial regions, and at least partially defines respective fluidic chambers of the flow cell package.

3. 发明专利

NZ747836A Wafer alignment method and system 未知
公开(公告)号：NZ747836A
公开(公告)日：2020-02-28
申请号：NZ74783617
申请日：2017-12-20
申请人： ILLUMINA INC
发明人： MAINS PETER , PRABHU ANMIV S , CAPELLA RICHARD , SAMIEE KEVAN
IPC分类号： H01L21/02 , H01L21/68
摘要： Wafers are aligned with one another by reference to features formed on or in each wafer. Notches are formed in each wafer, including a pivot-notch that allows for two-point contact, and a stop-notch that provides for single-point contact. A bias-notch is formed for pressing the wafers into engagement with the two-contact element when it is in the pivot-notch and with the single-contact element when it is in the stop-notch. The wafers may be bonded to one another to maintain the alignment of the referenced features.

4. 发明专利

SG11201906499XA SYSTEM AND METHOD WITH FIDUCIALS HAVING OFFSET LAYOUTS 未知
公开(公告)号：SG11201906499XA
公开(公告)日：2019-08-27
申请号：SG11201906499X
申请日：2018-01-31
申请人： ILLUMINA INC
发明人： VIECELI JOHN S , NEMIROSKI ALEX , BELITZ PAUL , LANGLOIS ROBERT , BOWEN M SHANE , CHAN DANNY YUAN , VENKATESAN BALA MURALI K , HAN HUI , SAMIEE KEVAN , TANNER STEPHEN
IPC分类号： G01N21/64
摘要： IMAGINGSYSTEM DATA ANALYSIS SYSTEM W O 18/ 14457 4 Al FIG. 1 DEBLOCK STATION X14 DOWNSTREAM / 1R PROCESSING STORAGE SYSTEM 12 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT onion °nolo DID Mo IIH 100 m° im mom oimIE (10) International Publication Number WO 2018/144574 Al (51) International Patent Classification: GO1N 21/64 (2006.01) (21) International Application Number: PCT/US2018/016189 (22) International Filing Date: 31 January 2018 (31.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701686.6 01 February 2017 (01.02.2017) GB (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, California 92122 (US). (72) Inventors: VIECELI, John S.; 1498 Flair Encinitas Dri- ve, Encinitas, California 92024 (US). NEMIROSKI, Alex; 5205 Fiore Ten, Apt. B410, San Diego, California 92122 (US). BELITZ, Paul; 5200 Illumina Way, San Diego, Cal- ifornia 92122 (US). LANGLOIS, Robert; 5200 Illumi- na Way, San Diego, California 92122 (US). BOWEN, M. Shane; 5200 Illumina Way, San Diego, California 92122 (US). CHAN, Danny Yuan; 5200 Illumina Way, San Diego, California 92122 (US). VENKATESAN, Bala Mu- rali K.; 499 Illinois Street, Suite 210, San Francisco, Cal- ifornia 94158 (US). HAN, Hui; 5200 Illumina Way, San Diego, California 92122 (US). SAMIEE, Kevan; 5200 Il- lumina Way, San Diego, California 92122 (US). TANNER, Stephen; 5200 Illumina Way, San Diego, California 92122 (US). (74) Agent: DIERKER, Julia Church et al.; Dierker & Ka- vanaugh, P.C., 3331 W. Big Beaver Road, Suite 109, Troy, Michigan 48084 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, (54) Title: SYSTEM AND METHOD WITH FIDUCIALS HAVING OFFSET LAYOUTS (57) : Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that enhance their detection in image or detection data, that facilitate or im- - 12 prove processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include offset layouts that may be useful in detecting the fiducials in different types and approaches in imaging, and that may help to distinguish regions of the 24-1 FLUSH I array from one another in image data. STATION NUCLEOTIDE DELIVERY SYSTEM [Continued on next page] WO 2018/144574 Al MIDEDIMODOMMEN3010MOIVINEHMEMOIMIE EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(H)) Published: — with international search report (Art. 21(3))

5. 发明专利

SG11201811339SA SENSORS HAVING INTEGRATED PROTECTION CIRCUITRY 未知
公开(公告)号：SG11201811339SA
公开(公告)日：2019-01-30
申请号：SG11201811339S
申请日：2018-04-19
申请人： ILLUMINA INC
发明人： FUNG TRACY HELEN , CAI XIUYU , KWOK LISA , TRAN HAI , SAMIEE KEVAN , QIANG LIANGLIANG , BOYANOV BOYAN
IPC分类号： G01N21/77 , G01N21/78 , G01N35/00
摘要： An example sensor includes a flow cell, a detection device, and a controller. The flow cell includes a passivation layer having opposed surfaces and a reaction site at a first of the opposed surfaces. The flow cell also includes a lid operatively connected to the passivation layer to partially define a flow channel between the lid and the reaction site. The detection device is in contact with a second of the opposed surfaces of the passivation layer, and includes an embedded metal layer that is electrically isolated from other detection circuitry of the detection device. The controller is to ground the embedded metal layer.

6. 发明专利

CA3022958A1 WAFER ALIGNMENT METHOD AND SYSTEM 未知
公开(公告)号：CA3022958A1
公开(公告)日：2018-08-09
申请号：CA3022958
申请日：2017-12-20
申请人： ILLUMINA INC
发明人： MAINS PETER , PRABHU ANMIV S , CAPELLA RICHARD , SAMIEE KEVAN
IPC分类号： H01L21/02 , H01L21/68
摘要： Wafers are aligned with one another by reference to features formed on or in each wafer. Notches are formed in each wafer, including a pivot-notch that allows for two-point contact, and a stop-notch that provides for single-point contact. A bias-notch is formed for pressing the wafers into engagement with the two-contact element when it is in the pivot-notch and with the single-contact element when it is in the stop-notch. The wafers may be bonded to one another to maintain the alignment of the referenced features.

7. 发明专利

DK3615922T3 SENSORER MED INTEGRERET BESKYTTELSESKREDSLØB 未知
公开(公告)号：DK3615922T3
公开(公告)日：2022-09-05
申请号：DK18791184
申请日：2018-04-19
申请人： ILLUMINA INC
发明人： FUNG TRACY HELEN , CAI XIUYU , KWOK LISA , TRAN HAI , SAMIEE KEVAN , QIANG LIANGLIANG , BOYANOV BOYAN
IPC分类号： G01N33/543 , B01L3/00 , C12Q1/68 , G01N21/62 , G01N21/64 , G01N21/77

8. 发明专利

SG10202108440WA SYSTEM AND METHOD WITH FIDUCIALS HAVING OFFSET LAYOUTS 未知
公开(公告)号：SG10202108440WA
公开(公告)日：2021-09-29
申请号：SG10202108440W
申请日：2018-01-31
申请人： ILLUMINA INC
发明人： VIECELI JOHN S , NEMIROSKI ALEX , BELITZ PAUL , LANGLOIS ROBERT , BOWEN M SHANE , CHAN DANNY YUAN , VENKATESAN BALA MURALI K , HAN HUI , SAMIEE KEVAN , TANNER STEPHEN
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations and layouts that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include offset layouts that may be useful in detecting the fiducials in different types and approaches in imaging, and that may help to distinguish regions of the array from one another in image data.

9. 发明专利

SG10202108437SA SYSTEM AND METHOD WITH FIDUCIALS OF NON-CLOSED SHAPES 未知
公开(公告)号：SG10202108437SA
公开(公告)日：2021-09-29
申请号：SG10202108437S
申请日：2018-01-31
申请人： ILLUMINA INC
发明人： VIECELI JOHN S , NEMIROSKI ALEX , BELITZ PAUL , LANGLOIS ROBERT , BOWEN M SHANE , CHAN DANNY YUAN , VENKATESAN BALA MURALI K , HAN HUI , SAMIEE KEVAN , TANNER STEPHEN
摘要： Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations that enhance their detection in image or detection data, that facilitate or improve processing, that provide encoding of useful information, and so forth. Examples of the fiducials may include a non-closed shape that may encode information, allow for bubbles to escape during manufacture, and provide additional advantages over closed shape fiducials.

10. 发明专利

SG11201906497YA SYSTEM AND METHOD WITH FIDUCIALS OF NON-CLOSED SHAPES 未知
公开(公告)号：SG11201906497YA
公开(公告)日：2019-08-27
申请号：SG11201906497Y
申请日：2018-01-31
申请人： ILLUMINA INC
发明人： VIECELI JOHN S , NEMIROSKI ALEX , BELITZ PAUL , LANGLOIS ROBERT , BOWEN M SHANE , CHAN DANNY YUAN , VENKATESAN BALA MURALI K , HAN HUI , SAMIEE KEVAN , TANNER STEPHEN
IPC分类号： G01N21/64
摘要： WO 18/ 1445 63 Al NUCLEOTIDE DELIVERY SYSTEM 4 ! 28 12 IMAGING SYSTEM DATA ANALYSIS SYSTEM / 16 p DOW Ror N E S ss T l i t N EA t M r / 18 STORAGE SYSTEM (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 09 August 2018 (09.08.2018) WIP0 I PCT omit VIII °nolo 010 Ho min loll mom ow (10) International Publication Number WO 2018/144563 Al (51) International Patent Classification: GO1N 21/64 (2006.01) (21) International Application Number: PCT/US2018/016175 (22) International Filing Date: 31 January 2018 (31.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1701689.0 01 February 2017 (01.02.2017) GB (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, California 92122 (US). (72) Inventors: VIECELI, John S.; 1498 Flair Encinitas Dri- ve, Encinitas, California 92024 (US). NEMIROSKI, Alex; 5205 Fiore Ten, Apt. B410, San Diego, California 92122 (US). BELITZ, Paul; 5200 Illumina Way, San Diego, Cal- ifornia 92122 (US). LANGLOIS, Robert; 5200 Illumi- na Way, San Diego, California 92122 (US). BOWEN, M. Shane; 5200 Illumina Way, San Diego, California 92122 (US). CHAN, Danny Yuan; 5200 Illumina Way, San Diego, California 92122 (US). VENKATESAN, Bala Mu- rali K.; 499 Illinois Street, Suite 210, San Francisco, Cal- ifornia 94158 (US). HAN, Hui; 5200 Illumina Way, San Diego, California 92122 (US). SAMIEE, Kevan; 5200 Il- lumina Way, San Diego, California 92122 (US). TANNER, Stephen; 5200 Illumina Way, San Diego, California 92122 (US). (74) Agent: DIERKER, Julia Church et al.; Dierker & Ka- vanaugh, P.C., 3331 W. Big Beaver Road, Suite 109, Troy, Michigan 48084 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = (54) Title: SYSTEM AND METHOD WITH FIDUCIALS OF NON-CLOSED SHAPES (57) : Fiducial markers are provided on patterned arrays of the type that may be used for molecular analysis, such as sequencing. The fiducials may have configurations s Y 32 that enhance their detection in image or detection data, that facilitate or improve process- 2o. ing, that provide encoding of useful information, and so forth. Examples of the fiducials 22 12 may include a non-closed shape that may encode information, allow for bubbles to es- cape during manufacture, and provide additional advantages over closed shape fiducials. X26 i FLUSH STATION ( 3° DEBLOCK STATION 10 FIG. 1 [Continued on next page] WO 2018/144563 Al MIDEDIMOMMIDIRE1013010MOHMITHEIS EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))

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