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1. 发明申请

WO2006017295A3 TETRAPEPTIDE ANALOGS 审中-公开
标题翻译：四肽类似物
公开(公告)号：WO2006017295A3
公开(公告)日：2007-07-12
申请号：PCT/US2005024700
申请日：2005-07-12
申请人： IDUN PHARMACEUTICALS INC , CHAO BIN , DECKWERTH THOMAS L , FURTH PAUL S , LINTON STEVEN D , SPADA ALFRED P , ULLMAN BRETT R , WEINHOUSE MICHAEL I
发明人： CHAO BIN , DECKWERTH THOMAS L , FURTH PAUL S , LINTON STEVEN D , SPADA ALFRED P , ULLMAN BRETT R , WEINHOUSE MICHAEL I
IPC分类号： C07D207/00 , A01N43/64 , A61K38/00
CPC分类号： C07D207/16 , A61K38/00 , C07D207/22 , C07D207/24 , C07D207/273 , C07D209/42 , C07D209/44 , C07D211/76 , C07D213/64 , C07D233/10 , C07D263/06 , C07D277/06 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/1008
摘要： Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.
摘要翻译：提供了用于治疗过度增殖性疾病如癌症的化合物，组合物和方法。

2. 发明专利

JP2011102312A Tetrapeptide analog 审中-公开
标题翻译： TETRAPEPTIDE ANALOG
公开(公告)号：JP2011102312A
公开(公告)日：2011-05-26
申请号：JP2011000916
申请日：2011-01-06
申请人： Idun Pharmaceuticals Inc , アイディーユーエヌ・ファーマスーティカルズ・インコーポレーテッド
发明人： CHAO BIN , DECKWERTH THOMAS L , FURTH PAUL S , LINTON STEVEN D , SPADA ALFRED P , ULLMAN BRETT R , WEINHOUSE MICHAEL I
IPC分类号： C07K5/103 , A61K38/00 , A61K45/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： C07D207/16 , A61K38/00 , C07D207/22 , C07D207/24 , C07D207/273 , C07D209/42 , C07D209/44 , C07D211/76 , C07D213/64 , C07D233/10 , C07D263/06 , C07D277/06 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/1008
摘要： PROBLEM TO BE SOLVED: To provide a compound, a composition and a method for treatment of hyperproliferative diseases such as cancers. SOLUTION: A composition and a method for treatment of cell proliferative diseases are provided. A compound provided therefor is a peptide analog of an N-terminal tetrapeptide in Smac which is mitochondrial protein. The Smac is considered to promote apoptosis in cells via pathways in relation to an inhibitor of apoptosis protein (IAP). These peptides are combined to the IAP. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：待解决的问题：提供用于治疗过度增殖性疾病如癌症的化合物，组合物和方法。解决方案：提供了一种治疗细胞增殖性疾病的组合物和方法。为此提供的化合物是Smac中N末端四肽的肽类似物，其是线粒体蛋白。认为Smac可通过与凋亡蛋白（IAP）抑制剂相关的途径促进细胞凋亡。这些肽与IAP组合。版权所有（C）2011，JPO＆INPIT

3. 发明申请

WO2007061741A2 MODULATORS OF THE H3 RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO 审中-公开
标题翻译： H3受体调节剂可用于治疗与其有关的疾病
公开(公告)号：WO2007061741A2
公开(公告)日：2007-05-31
申请号：PCT/US2006044479
申请日：2006-11-16
申请人： ARENA PHARM INC , SANTORA VINCENT J , COVEL JONATHAN A , HAYASHI RENA , WEBB ROBERT R , REN ALBERT S , CHEN WEICHAO G , DUFFIELD JONATHAN J , IBARRA JASON B , PULLEY MICHELLE , SEMPLE GRAEME , WEINHOUSE MICHAEL I
发明人： SANTORA VINCENT J , COVEL JONATHAN A , HAYASHI RENA , WEBB ROBERT R , REN ALBERT S , CHEN WEICHAO G , DUFFIELD JONATHAN J , IBARRA JASON B , PULLEY MICHELLE , SEMPLE GRAEME , WEINHOUSE MICHAEL I
CPC分类号： C07D209/52 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D405/10 , C07D405/14 , C07D409/06 , C07D413/06 , C07D417/04
摘要： The present invention relates to certain fused heterobicyclic derivatives of Formula (Ia) and pharmaceutical compositions thereof that modulate the activity of the H3 receptor. Compounds and pharmaceutical compositions thereof are directed to methods useful in the treatment of H3-associated disorders, such as, cognitive disorders, epilepsy, brain trauma, depression, obesity, motion sickness and vertigo, disorders of sleep and wakefulness such as narcolepsy, shift-work syndrome, drowsiness as a side effect from a medication, maintenance of vigilance to aid in completion of tasks and the like, cataplexy, hypersomnia, somnolence syndrome, jet lag, sleep apnea and the like, attention deficit hyperactivity disorder (ADHD), schizophrenia, allergies, allergic responses in the upper airway, allergic rhinitis, nasal congestion, dementia, Alzheimer's disease and the like.
摘要翻译：本发明涉及调节H3受体活性的式（Ia）的某些稠合杂双环衍生物及其药物组合物。其化合物和药物组合物涉及用于治疗H3相关病症例如认知障碍，癫痫症，脑创伤，抑郁症，肥胖症，晕动病和眩晕，睡眠和觉醒失调例如发作性睡病，偏头痛，工作综合症，作为药物副作用的困倦，保持警惕以帮助完成任务等，猝倒，睡眠过度，嗜睡综合征，时差，睡眠呼吸暂停等，注意力缺陷多动障碍（ADHD），精神分裂症，过敏，上呼吸道过敏反应，过敏性鼻炎，鼻充血，痴呆，阿尔茨海默病等。

4. 发明申请

WO0214349A3 NON-COVALENT INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION 审中-公开
标题翻译：尿素和血管形成的非共价抑制剂
公开(公告)号：WO0214349A3
公开(公告)日：2002-10-03
申请号：PCT/US0125337
申请日：2001-08-10
申请人： CORVAS INT INC , LEVY ODILE ESTHER , MADISON EDWIN L , SEMPLE JOSEPH EDWARD , TAMIZ AMIR P , WEINHOUSE MICHAEL I
发明人： LEVY ODILE ESTHER , MADISON EDWIN L , SEMPLE JOSEPH EDWARD , TAMIZ AMIR P , WEINHOUSE MICHAEL I
IPC分类号： C12N9/99 , A61K38/00 , A61P1/04 , A61P7/06 , A61P9/00 , A61P9/10 , A61P17/02 , A61P17/06 , A61P19/02 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/10 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P43/00 , C07K5/06 , C07K5/062 , C07K5/078 , A61K38/05
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06026 , C07K5/06069
摘要： Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have P1 a group having an amidino or guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.
摘要翻译：提供了具有作为尿激酶非共价抑制剂的活性并具有减少或抑制血管形成活性的新型化合物。这些化合物具有P1 a具有脒基或胍基部分或其衍生物的基团。这些化合物在体外可用于监测纤溶酶原激活物水平和体内治疗通过抑制或降低尿激酶活性和改善血管形成与病理状况相关的病理状况而改善的病症。

5. 发明申请

WO0248097A9 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS 审中-公开
标题翻译：用于治疗寄生虫感染的化合物，组合物和方法
公开(公告)号：WO0248097A9
公开(公告)日：2003-05-08
申请号：PCT/US0148032
申请日：2001-12-11
申请人： CORVAS INT INC , LIM-WILBY MARGUERITA , SEMPLE JOSEPH EDWARD , ARALDI GIAN L , GOLDMAN ERICK A , WEINHOUSE MICHAEL I
发明人： LIM-WILBY MARGUERITA , SEMPLE JOSEPH EDWARD , ARALDI GIAN L , GOLDMAN ERICK A , WEINHOUSE MICHAEL I
IPC分类号： A61P33/02 , A61P33/06 , C07C271/22 , C07C311/19 , C07D209/08 , C07D295/215 , C07C237/22 , C07D295/20
CPC分类号： C07D295/215 , C07B2200/07 , C07C271/22 , C07C311/19 , C07D209/08
摘要： Compounds and pharmaceutical compositions useful as anti-parasitic agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.
摘要翻译：提供了用作抗寄生虫剂的化合物和药物组合物，特别是用于治疗，预防或改善疟疾或恰加斯病的一种或多种症状。具体而言，提供了用化合物和组合物调节falcipain或cruzain的活性，优选抑制falcipain或cruzain的方法。

6. 发明申请

WO0248097B1 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT OF PARASITIC INFECTIONS 审中-公开
标题翻译：化合物，组合物和治疗寄生虫感染的方法
公开(公告)号：WO0248097B1
公开(公告)日：2003-02-20
申请号：PCT/US0148032
申请日：2001-12-11
申请人： CORVAS INT INC , LIM-WILBY MARGUERITA , SEMPLE JOSEPH EDWARD , ARALDI GIAN L , GOLDMAN ERICK A , WEINHOUSE MICHAEL I
发明人： LIM-WILBY MARGUERITA , SEMPLE JOSEPH EDWARD , ARALDI GIAN L , GOLDMAN ERICK A , WEINHOUSE MICHAEL I
IPC分类号： A61P33/02 , A61P33/06 , C07C271/22 , C07C311/19 , C07D209/08 , C07D295/215 , C07C237/22 , C07D295/20
CPC分类号： C07D295/215 , C07B2200/07 , C07C271/22 , C07C311/19 , C07D209/08
摘要： Compounds and pharmaceutical compositions useful as anti-parasitic agents, particularly in the treatment, prevention or amelioration of one or more symptoms of malaria or Chagas' disease, are provided. In particular, methods of modulating the activity of falcipain or cruzain, preferably inhibiting falcipain or cruzain, with the compounds and compositions are provided.
摘要翻译：提供了用作抗寄生虫剂的化合物和药物组合物，特别是用于治疗，预防或改善一种或多种疟疾或恰加斯氏症的症状。特别地，提供了通过化合物和组合物调节镰刀菌或克鲁津的活性，优选抑制镰刀菌或克鲁津的活性的方法。

7. 发明专利

CA2573644A1 TETRAPEPTIDE ANALOGS 未知
公开(公告)号：CA2573644A1
公开(公告)日：2006-02-16
申请号：CA2573644
申请日：2005-07-12
申请人： IDUN PHARMACEUTICALS INC
发明人： DECKWERTH THOMAS L , CHAO BIN , SPADA ALFRED P , ULLMAN BRETT R , LINTON STEVEN D , FURTH PAUL S , WEINHOUSE MICHAEL I
IPC分类号： A61K31/5513
摘要： Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided. or a pharmaceutically acceptable derivative thereof, where: M is CO, SO or SO 2 ; R 1s and R 2s are selected as follows: (i) R 1s is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyI; and R 2s is selected from hydrogen, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, OR 11 and NR 15 R 16 , or (ii) R 1s and R 2s together with the nitrogen atom on which they are substituted form a heterocyclic or heteroaryl ring; R 3s , R 4s and R 5s are each independently selected from (i) or (ii) as follows: (i) R 3s is hydrogen or alkyl; R 4s is alkyl; and R 5s is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroarylium, cycloalkyl, heterocyclyl and NR 15 R 16 ; (ii )R 5s and R 3s or R 5s and R 4s together with the atoms on which they are substituted form heterocyclic or heteroaryl ring and the other of R 3s or R 4s is selected as (ii); R 6s is hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R 7s is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyl. The other variables are as defined in the claims.

8. 发明公开

EP1773348A4 TETRAPEPTIDE ANALOGS 审中-公开
标题翻译： TETRAPEPTID-ANALOGA
公开(公告)号：EP1773348A4
公开(公告)日：2009-05-20
申请号：EP05771672
申请日：2005-07-12
申请人： IDUN PHARMACEUTICALS INC
发明人： CHAO BIN , DECKWERTH THOMAS L , FURTH PAUL S , LINTON STEVEN D , SPADA ALFRED P , ULLMAN BRETT R , WEINHOUSE MICHAEL I
IPC分类号： C07D207/00 , A01N43/64 , A61K31/4015 , A61K31/429 , A61K31/5517 , A61K38/00 , A61P35/00 , C07D207/16 , C07D207/22 , C07D207/24 , C07D207/273 , C07D209/42 , C07D209/44 , C07D211/76 , C07D213/64 , C07D233/10 , C07D263/06 , C07D277/06 , C07D487/04 , C07D487/06 , C07D513/04
CPC分类号： C07D207/16 , A61K38/00 , C07D207/22 , C07D207/24 , C07D207/273 , C07D209/42 , C07D209/44 , C07D211/76 , C07D213/64 , C07D233/10 , C07D263/06 , C07D277/06 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/1008
摘要： Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided. or a pharmaceutically acceptable derivative thereof, where: M is CO, SO or SO 2 ; R 1s and R 2s are selected as follows: (i) R 1s is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyI; and R 2s is selected from hydrogen, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, OR 11 and NR 15 R 16 , or (ii) R 1s and R 2s together with the nitrogen atom on which they are substituted form a heterocyclic or heteroaryl ring; R 3s , R 4s and R 5s are each independently selected from (i) or (ii) as follows: (i) R 3s is hydrogen or alkyl; R 4s is alkyl; and R 5s is selected from hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, heteroarylium, cycloalkyl, heterocyclyl and NR 15 R 16 ; (ii )R 5s and R 3s or R 5s and R 4s together with the atoms on which they are substituted form heterocyclic or heteroaryl ring and the other of R 3s or R 4s is selected as (ii); R 6s is hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R 7s is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl or heterocyclyl. The other variables are as defined in the claims.

9. 发明专利

MX2007000490A ANALOGOS DE TETRAPEPTIDO. 未知
公开(公告)号：MX2007000490A
公开(公告)日：2007-06-11
申请号：MX2007000490
申请日：2005-07-12
申请人： IDUN PHARMACEUTICALS INC
发明人： CHAO BIN , DECKWERTH THOMAS L , FURTH PAUL S , LINTON STEVEN D , SPADA ALFRED P , ULLMAN BRETT R , WEINHOUSE MICHAEL I
IPC分类号： A61K31/5513
摘要： Se proveen compuestos, composiciones y metodos para el tratamiento de enfermedades hiperproliferativas, tales como cancer.

10. 发明专利

GB2430935A Tetrapeptide analogs 未知
公开(公告)号：GB2430935A
公开(公告)日：2007-04-11
申请号：GB0700629
申请日：2007-01-12
申请人： IDUN PHARMACEUTICALS INC
发明人： CHAO BIN , DECKWERTH THOMAS L , FURTH PAUL S , LINTON STEVEN D , SPADA ALFRED P , ULLMAN BRETT R , WEINHOUSE MICHAEL I
IPC分类号： C07K5/083 , A61K38/06 , A61K38/07 , A61P1/00 , A61P1/16 , A61P3/10 , A61P3/14 , A61P5/00 , A61P5/18 , A61P5/50 , A61P7/00 , A61P7/06 , A61P9/00 , A61P13/12 , A61P15/08 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/18 , A61P33/06 , A61P35/00 , A61P35/02 , A61P37/02 , C07K5/103 , C09B57/00 , C09B57/14
摘要： Compounds, compositions and methods for treatment of hyperproliferative diseases, such as cancer are provided.

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