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1. 发明申请

WO1991017159A1 1,3-OXATHIOLANE NUCLEOSIDE ANALOGUES 审中-公开
标题翻译： 1,3-氧化亚烷基核苷类似物
公开(公告)号：WO1991017159A1
公开(公告)日：1991-11-14
申请号：PCT/GB1991000706
申请日：1991-05-02
申请人： IAF BIOCHEM INTERNATIONAL INC. , COATES, Jonathan, Alan, Victor , MUTTON, Ian, Martin , PENN, Charles, Richard , STORER, Richard , WILLIAMSON, Christopher
发明人： IAF BIOCHEM INTERNATIONAL INC.
IPC分类号： C07D411/04
CPC分类号： A61K31/7068 , A61K31/505 , A61K31/506 , A61K31/70 , A61K45/06 , C07D411/04 , A61K2300/00
摘要： (-)-4-Amino-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one, its pharmaceutically acceptable derivatives, pharmaceutical formulations thereof, methods for its preparation and its use as an antiviral agent are described.
摘要翻译：（ - ） - 4-氨基-1-（2-羟甲基-1,3-氧硫杂环戊烷-5-基） - （1H） - 嘧啶-2-酮，其药学上可接受的衍生物，其药物制剂，其制备方法和描述其作为抗病毒剂的用途。

2. 发明申请

WO1991002748A1 RUBELLA E1 PEPTIDES 审中-公开
公开(公告)号：WO1991002748A1
公开(公告)日：1991-03-07
申请号：PCT/CA1990000263
申请日：1990-08-17
申请人： IAF BIOCHEM INTERNATIONAL INC.
发明人： IAF BIOCHEM INTERNATIONAL INC. , LACROIX, Martial , ZREIN, Maan , DIONNE, Gervais
IPC分类号： C07K07/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/10 , C12N2770/36222
摘要： Linear and cyclic peptides of the E1 and C protein of the rubella virus. These peptides and analogues, mixtures and combinations of them are useful in detecting and quantifying antibodies raised against the rubella virus. They are also useful in raising antibodies to the rubella virus for use in the diagnosis of and protection against rubella viral infections.

3. 发明申请

WO1992008717A1 SUBSTITUTED 1,3-OXATHIOLANES AND SUBSTITUTED 1,3-DITHIOLANES WITH ANTIVIRAL PROPERTIES 审中-公开
标题翻译：取代的1,3-二氧杂环己烷和取代的具有抗病性的1,3-二脱水
公开(公告)号：WO1992008717A1
公开(公告)日：1992-05-29
申请号：PCT/CA1991000407
申请日：1991-11-12
申请人： IAF BIOCHEM INTERNATIONAL INC.
发明人： IAF BIOCHEM INTERNATIONAL INC. , BELLEAU, Bernard +di , BRASILI, Livio , NGUYEN-BA, Nghe , LAVAL, Chan, Chun, Kong
IPC分类号： C07D409/04
CPC分类号： C07D473/00 , C07D409/04 , C07D411/04 , C07F7/1804 , C07H21/00
摘要： This invention relates to novel substituted 1,3-oxathiolanes and substituted 1,3-dithiolanes of formula (1) wherein X is S, S=O, or SO2; Y is O, S, S=O, or SO2; R1 is hydrogen, trisubstituted silyl, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted C1-16 acyl; and R2 is a purine or pyrimidine base or an analogue or derivative thereof; and pharmaceutically acceptable derivatives thereof. This invention also relates to processes for preparing these compounds, intermediates useful in their preparation, to pharmaceutical compositions containing them and to the use of these compounds as antiviral agents.
摘要翻译：本发明涉及式（1）的新的取代的1,3-氧硫杂环戊烷和取代的1,3-二硫戊环，其中X是S，S = O或SO 2; Y是O，S，S = O或SO 2; R 1是氢，三取代甲硅烷基，取代或未取代的C 1-6烷基，取代或未取代的芳烷基或取代或未取代的C 1-16酰基; R2是嘌呤或嘧啶碱基或其类似物或衍生物; 及其药学上可接受的衍生物。本发明还涉及制备这些化合物的方法，可用于其制备的中间体，含有它们的药物组合物以及这些化合物作为抗病毒剂的用途。

4. 发明申请

WO1992001713A1 PEPTIDES AND ANALOGUES AND MIXTURES THEREOF FOR DETECTING ANTIBODIES TO HTLV-I AND HTLV-II VIRUSES 审中-公开
标题翻译：用于检测HTLV-I和HTLV-II病毒的抗体的肽和类似物及其混合物
公开(公告)号：WO1992001713A1
公开(公告)日：1992-02-06
申请号：PCT/CA1991000238
申请日：1991-07-10
申请人： IAF BIOCHEM INTERNATIONAL INC.
发明人： IAF BIOCHEM INTERNATIONAL INC. , LACROIX, Martial , ZREIN, Maan
IPC分类号： C07K13/00
CPC分类号： C07K14/005 , A61K39/00 , C12N2740/14022
摘要： This invention relates to novel linear peptides and mixtures and chemical combinations thereof useful for detecting and quantifying HTLV-I and HTLV-II infections. These peptides are also useful in vaccines against HTLV-I and HTLV-II viral infections.
摘要翻译：本发明涉及用于检测和定量HTLV-1和HTLV-II感染的新型线性肽及其混合物及其化学组合。这些肽也可用于抗HTLV-1和HTLV-II病毒感染的疫苗中。

5. 发明申请

WO1992000997A1 SYNTHETIC PEPTIDES AND MIXTURES THEREOF FOR DETECTING HIV ANTIBODIES 审中-公开
标题翻译：用于检测艾滋病毒抗体的合成肽及其混合物
公开(公告)号：WO1992000997A1
公开(公告)日：1992-01-23
申请号：PCT/CA1991000233
申请日：1991-07-08
申请人： IAF BIOCHEM INTERNATIONAL INC.
发明人： IAF BIOCHEM INTERNATIONAL INC. , LACROIX, Martial
IPC分类号： C07K13/00
CPC分类号： C07K14/005 , A61K39/00 , C07K16/10 , C12N2740/16122 , G01N33/56988
摘要： There is provided cyclic peptides of general formulae (I) and (III), wherein x represents an amino acid sequence from position 585 to 604 (gp41-HIV-1) such amino acid sequences being characterized by at least one of a lysine at position 586 or a lysine at both positions 585 and 586; x represents an amino acid sequence from position 585 to 604 (gp41-HIV-1); y represents an amino acid sequence from position 612 to 629 (gp41-HIV-1); e and f represent one or more epitopes included in the amino acid sequence extending from 586 to 629 (gp41-HIV-1) or from 578 to 613 (gp36-HIV-2); and a and b represent the amino and carboxy terminals, respectively, as well as substituents which are effective to make the peptide more useful as an immunodiagnostic reagent. Peptides of formula III have one or both of e and f present. There is also provided peptides of general formulae (II) and (IV), wherein x represents an amino acid sequence from position 577 to 596 (gp36-HIV-2) such amino acid sequences being characterized by at least one of a lysine at position 578 or a lysine at both positions 577 and 578; x represents an amino acid sequence from postion 577 to 596 (gp36-HIV-2); y represents an amino acid sequence from position 604 to 613 (gp36-HIV-2); e and f represents one or more epitopes included in the amino acid sequence from 578 to 613 (gp36-HIV-2) or 586 to 629 (gp41-HIV-1); and a and b are as defined above. Peptides of formula (IV) have one or both of e and f present. These cyclic peptides alone or in admixture with other peptides are particularly useful in detecting HIV-1 and HIV-2 antibodies in analytes and sera.
摘要翻译：提供通式（I）和（III）的环肽，其中x表示585至604位的氨基酸序列（gp41-HIV-1），该氨基酸序列的特征在于位置上的至少一个赖氨酸 586位或585和586位的赖氨酸; x 2表示从585至604（gp41-HIV-1）的氨基酸序列; y表示从612位到629位的氨基酸序列（gp41-HIV-1）; e和f代表从586至629（gp41-HIV-1）或578至613（gp36-HIV-2）延伸的氨基酸序列中包含的一个或多个表位。和a和b分别表示氨基和羧基末端，以及有效使肽更有用的免疫诊断试剂的取代基。式III的肽具有e和f中的一个或两个。还提供了通式（II）和（IV）的肽，其中x 1表示577至596位氨基酸序列（gp36-HIV-2），该氨基酸序列的特征在于以下的至少一种： 578位的赖氨酸或577和578位的赖氨酸; x 3表示从位点577至596（gp36-HIV-2）的氨基酸序列; y <1>表示从604位至613位氨基酸序列（gp36-HIV-2）; e和f代表包括在578至613（gp36-HIV-2）或586至629（gp41-HIV-1）的氨基酸序列中的一个或多个表位; 和a和b如上所定义。式（IV）的肽具有e和f中的一个或两个。单独或与其他肽混合的这些环肽特别可用于检测分析物和血清中的HIV-1和HIV-2抗体。

6. 发明申请

WO1991001976A1 THIOACYLATING REAGENTS AND INTERMEDIATES, THIOPEPTIDES, AND METHODS FOR PREPARING AND USING SAME 审中-公开
标题翻译：硫化试剂和中间体，硫酸酯和其制备和使用方法
公开(公告)号：WO1991001976A1
公开(公告)日：1991-02-21
申请号：PCT/CA1990000248
申请日：1990-08-03
申请人： IAF BIOCHEM INTERNATIONAL INC.
发明人： IAF BIOCHEM INTERNATIONAL INC. , BRILLON, Denis , SAUVE, Gilles , BOULOS, Zacharie , BELLEAU, Bernard +di
IPC分类号： C07D235/26
CPC分类号： C07D403/12 , A61K38/00 , C07D235/26 , C07K5/02 , C07K5/0815 , C07K5/0819 , C07K5/1013 , C07K14/66
摘要： Thioacylating reagents are provided for the introduction of thioamide bonds into growing peptides represented by structure (I), where the substituents are disclosed herein. Intermediate precursors for preparing these thioacylating reagents are also provided. A process for preparing the thioacylating reagents and the intermediate precursors is further provided. Thiopeptides, and salts thereof, that exhibit pharmacological utility are provided and are represented by formula (II), wherein R?1, R3, R4¿, X and n are as defined herein. Methods for preparing these thiopeptides from solution and solid phase syntheses, utilizing the thioacylating reagents disclosed herein, are also provided.

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