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1. 发明授权

US09354234B2 Multi-fluorescent substance including novel coumarin derivative, and LED light source-based microfluorescent quantitative biosensor for diagnosis using same 有权
标题翻译：多种荧光物质，包括新型香豆素衍生物，以及基于LED光源的微量荧光定量生物传感器，用于诊断
公开(公告)号：US09354234B2
公开(公告)日：2016-05-31
申请号：US14350035
申请日：2012-03-05
申请人： Hyun Park , Hak Sung Kim , Hyun Ok Song , Chom Kyu Chong , Sung Yeon Kim
发明人： Hyun Park , Hak Sung Kim , Hyun Ok Song , Chom Kyu Chong , Sung Yeon Kim
IPC分类号： G01N33/58 , C07D417/04 , C07D417/14 , G01N33/558 , G01N33/569 , C07D277/66
CPC分类号： G01N33/582 , C07D277/66 , C07D417/04 , C07D417/14 , G01N33/558 , G01N33/56905 , G01N2333/445 , G01N2458/00 , Y02A50/58
摘要： The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is able to emit light using an LED light source. A novel coumarin derivative multi-fluorescent substance according to the present invention has an optimal emission wavelength band of 512 nm to 590 nm and thereby is effective in improving a signal intensity and stability since light emission using an LED light source is possible.In addition, higher fluorescence reactivity is exhibited compared to coumarin fluorescent substances known in the related arts since one molecule has a plurality of fluorescent substances, and the problem of the coumarin fluorescent substance possibly binding to a binding site of the antigen of the antibody is solved since fluorescence detection is possible even when a minimum number of fluorescent substance molecules bind to an antibody.Moreover, the novel coumarin derivative multi-fluorescent substance according to the present invention is suitably used in a fluorescent-linked immunosorbent assay (FLISA) and a rapid fluorescent immunochromatographic test (FICT) as an LED-based microfluorescent quantitative biosensor for diagnosis, therefore, diseases such as malaria may be rapidly and quantitatively analyzed.
摘要翻译：本发明涉及一种新型香豆素衍生物及其制备方法，以及包含多种香豆素衍生物并且能够使用LED光源发光的多荧光物质。根据本发明的新型香豆素衍生物多荧光物质具有512nm至590nm的最佳发射波长带，因此可以有效地改善信号强度和稳定性，因为使用LED光源的发光是可能的。此外，与现有技术中已知的香豆素荧光物质相比，由于一个分子具有多个荧光物质，所以可以发现更高的荧光反应性，并且解决了可能与抗体的抗原的结合位点结合的香豆素荧光物质的问题因为即使当荧光物质分子的最小数目与抗体结合时，荧光检测也是可能的。此外，根据本发明的新型香豆素衍生物多荧光物质适合用于荧光联免疫吸附测定（FLISA）和快速荧光免疫色谱测试（FICT），作为用于诊断的基于LED的微荧光定量生物传感器，疾病如疟疾可能会被迅速和定量分析。

2. 发明申请

US20140350227A1 MULTI-FLUORESCENT SUBSTANCE INCLUDING NOVEL COUMARIN DERIVATIVE, AND LED LIGHT SOURCE-BASED MICROFLUORESCENT QUANTITATIVE BIOSENSOR FOR DIAGNOSIS USING SAME 有权
标题翻译：多种荧光物质，包括新型香豆素衍生物和基于LED光源的微量元素定量生物传感器，用于诊断使用
公开(公告)号：US20140350227A1
公开(公告)日：2014-11-27
申请号：US14350035
申请日：2012-03-05
申请人： Hyun Park , Hak Sung Kim , Hyun Ok Song , Chom Kyu Chong , Sung Yeon Kim
发明人： Hyun Park , Hak Sung Kim , Hyun Ok Song , Chom Kyu Chong , Sung Yeon Kim
IPC分类号： G01N33/58 , C07D277/66
CPC分类号： G01N33/582 , C07D277/66 , C07D417/04 , C07D417/14 , G01N33/558 , G01N33/56905 , G01N2333/445 , G01N2458/00 , Y02A50/58
摘要： The present invention relates to a novel coumarin derivative, to a method for preparing the same, and a multi-fluorescent substance that includes a plurality of the coumarin derivatives and is able to emit light using an LED light source. A novel coumarin derivative multi-fluorescent substance according to the present invention has an optimal emission wavelength band of 512 nm to 590 nm and thereby is effective in improving a signal intensity and stability since light emission using an LED light source is possible.In addition, higher fluorescence reactivity is exhibited compared to coumarin fluorescent substances known in the related arts since one molecule has a plurality of fluorescent substances, and the problem of the coumarin fluorescent substance possibly binding to a binding site of the antigen of the antibody is solved since fluorescence detection is possible even when a minimum number of fluorescent substance molecules bind to an antibody.Moreover, the novel coumarin derivative multi-fluorescent substance according to the present invention is suitably used in a fluorescent-linked immunosorbent assay (FLISA) and a rapid fluorescent immunochromatographic test (FICT) as an LED-based microfluorescent quantitative biosensor for diagnosis, therefore, diseases such as malaria may be rapidly and quantitatively analyzed.
摘要翻译：本发明涉及一种新型香豆素衍生物及其制备方法，以及包含多种香豆素衍生物并且能够使用LED光源发光的多荧光物质。根据本发明的新型香豆素衍生物多荧光物质具有512nm至590nm的最佳发射波长带，因此可以有效地改善信号强度和稳定性，因为使用LED光源的发光是可能的。此外，与现有技术中已知的香豆素荧光物质相比，由于一个分子具有多个荧光物质，所以可以发现更高的荧光反应性，并且解决了可能与抗体的抗原的结合位点结合的香豆素荧光物质的问题因为即使当荧光物质分子的最小数目与抗体结合时，荧光检测也是可能的。此外，根据本发明的新型香豆素衍生物多荧光物质适合用于荧光联免疫吸附测定（FLISA）和快速荧光免疫色谱测试（FICT），作为用于诊断的基于LED的微荧光定量生物传感器，疾病如疟疾可能会被迅速和定量分析。

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