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1. 发明申请

US20130096303A1 PROCESS FOR THE PREPARATION OF HMG-COA REDUCTASE INHIBITORS AND INTERMEDIATES THEREOF 有权
标题翻译：制备HMG-COA还原酶抑制剂及其中间体的方法
公开(公告)号：US20130096303A1
公开(公告)日：2013-04-18
申请号：US13806626
申请日：2011-06-30
申请人： Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
发明人： Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
IPC分类号： C07D239/69 , C07D215/14 , C07D405/06 , C07D209/18
CPC分类号： C07D239/69 , A61K31/443 , C07D209/18 , C07D209/24 , C07D215/14 , C07D239/42 , C07D405/06 , C07D405/12
摘要： The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
摘要翻译：本发明提供使用具有R2-NO-R1部分作为关键中间体的新型含酰胺键的化合物，在温和条件下制备HMG-CoA还原酶抑制剂如瑞舒伐他汀钙，氟伐他汀钠和匹伐他汀钙的改进方法。而且，本发明还提供了新型化合物，可用于其制备的中间体及其制备方法。

2. 发明授权

US08476432B2 Process for the preparation of HMG-COA reductase inhibitors and intermediates thereof 有权
标题翻译：制备HMG-COA还原酶抑制剂的方法及其中间体
公开(公告)号：US08476432B2
公开(公告)日：2013-07-02
申请号：US13806626
申请日：2011-06-30
申请人： Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
发明人： Hyun Ju , Sang-Sun Joung , Hyun-Jik Yi , Ja-Heouk Khoo , Jong-Chul Lim , Jae-Gyu Kim
IPC分类号： C07D239/42 , C07D215/12 , C07D405/06 , C07D209/10 , C07D257/04
CPC分类号： C07D239/69 , A61K31/443 , C07D209/18 , C07D209/24 , C07D215/14 , C07D239/42 , C07D405/06 , C07D405/12
摘要： The present invention provides an improved process for preparing HMG-CoA reductase inhibitors such as rosuvastatin calcium, fluvastatin sodium, and pitavastatin calcium under a mild condition, using a novel amide-bond-containing compound having R2—N—O—R1 moiety as a key intermediate. And also, the present invention provides the novel compound, an intermediate useful for the preparation thereof, and a process for the preparation thereof.
摘要翻译：本发明提供使用具有R2-NO-R1部分作为关键中间体的新型含酰胺键的化合物，在温和条件下制备HMG-CoA还原酶抑制剂如瑞舒伐他汀钙，氟伐他汀钠和匹伐他汀钙的改进方法。而且，本发明还提供了新型化合物，可用于其制备的中间体及其制备方法。

3. 发明授权

US5965666A Thermoplastic resin composition with high impact strength at low temperatures 失效
标题翻译：低温冲击强度高的热塑性树脂组合物
公开(公告)号：US5965666A
公开(公告)日：1999-10-12
申请号：US26744
申请日：1998-02-20
申请人： Jung-Kee Koo , Hee-Gu Yeo , Jong-Chul Lim
发明人： Jung-Kee Koo , Hee-Gu Yeo , Jong-Chul Lim
IPC分类号： C08L55/02 , C08L77/00 , C08G63/48
CPC分类号： C08L55/02 , C08L77/00
摘要： This invention relates to a resin composition having high impact strength at low temperatures, comprising a polyamide, a graft copolymer obtained by graft polymerizing a monomer mixture of an aromatic vinyl monomer and a vinyl cyanide monomer to a conjugated diene rubber, a copolymer comprising an aromatic vinyl monomer, a vinyl cyanide monomer and other vinyl monomer copolymerizable with the aromatic vinyl monomer and the vinyl cyanide monomer, a modified hydrogenated block copolymer comprising a conjugated diene rubber and styrene or its derivatives to which has been grafted an unsaturated carboxylic acid or an unsaturated carboxylic anhydride, a copolymer comprising an aromatic vinyl monomer, a maleimide monomer, an unsaturated carboxylic acid or an unsaturated carboxylic anhydride, and other vinyl monomer copolymerizable with the aromatic vinyl monomer, and a graft copolymer obtained by graft polymerizing a maleic anhydride to an ethylene-propylene rubber.
摘要翻译：本发明涉及一种在低温下具有高冲击强度的树脂组合物，其包含聚酰胺，通过将芳族乙烯基单体和乙烯基氰单体的单体混合物接枝聚合到共轭二烯橡胶上得到的接枝共聚物，包含芳香族乙烯基单体，乙烯基氰单体和可与芳族乙烯基单体和乙烯基氰单体共聚的其它乙烯基单体，包含共轭二烯橡胶和苯乙烯或其衍生物的改性氢化嵌段共聚物，其已经接枝不饱和羧酸或不饱和羧酸羧酸酐，包含芳族乙烯基单体，马来酰亚胺单体，不饱和羧酸或不饱和羧酸酐的共聚物和可与芳族乙烯基单体共聚的其它乙烯基单体的共聚物，以及通过将马来酸酐接枝聚合到乙烯丙烯橡胶。

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