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1. 发明申请

US20060205927A1 Templated native silk smectic gels 有权
公开(公告)号：US20060205927A1
公开(公告)日：2006-09-14
申请号：US10533611
申请日：2003-10-31
申请人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
发明人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
IPC分类号： C07K14/78 , C07K14/435
CPC分类号： A61K47/42 , C07K14/43586 , Y10T436/25375
摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.

2. 发明申请

US20100294716A1 Templated Native Silk Smectic Gels 有权
标题翻译：模板本地丝绸水晶凝胶
公开(公告)号：US20100294716A1
公开(公告)日：2010-11-25
申请号：US12536793
申请日：2009-08-06
申请人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
发明人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
IPC分类号： B01D15/08 , B01D59/26 , C07K14/435 , B32B9/02 , C12N9/00 , C09K3/00 , B01J31/02
CPC分类号： A61K47/42 , C07K14/43586 , Y10T436/25375
摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.
摘要翻译：本发明的一个方面涉及一种通过溶剂模板法制备纤维蛋白质近晶水凝胶的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 并收集所得到的纤维蛋白质近晶凝胶并使其干燥。本发明的另一方面涉及从外消旋混合物主要获得一种对映异构体的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 允许外消旋混合物的对映体选择性地扩散到溶液中的近晶水凝胶中; 从溶液中除去近晶凝胶; 从近晶水凝胶的表面主要漂洗一种对映异构体; 并从近晶水凝胶的内部主要提取一种对映异构体。本发明还涉及根据上述方法制备的近晶型水凝胶。

3. 发明授权

US08580924B2 Templated native silk smectic gels 有权
公开(公告)号：US08580924B2
公开(公告)日：2013-11-12
申请号：US12536793
申请日：2009-08-06
申请人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
发明人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
IPC分类号： A61K38/17
CPC分类号： A61K47/42 , C07K14/43586 , Y10T436/25375
摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.

4. 发明授权

US07572894B2 Templated native silk smectic gels 有权
标题翻译：模板的天然丝状近晶凝胶
公开(公告)号：US07572894B2
公开(公告)日：2009-08-11
申请号：US10533611
申请日：2003-10-31
申请人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
发明人： Hyoung-Joon Jin , Jae-Hyung Park , Regina Valluzzi
IPC分类号： C07K14/00 , G01N33/50
CPC分类号： A61K47/42 , C07K14/43586 , Y10T436/25375
摘要： One aspect of the present invention relates to a method of preparing a fibrous protein smectic hydrogel by way of a solvent templating process, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; and collecting the resulting fibrous protein smectic hydrogel and allowing it to dry. Another aspect of the present invention relates to a method of obtaining predominantly one enantiomer from a racemic mixture, comprising the steps of pouring an aqueous fibrous protein solution into a container comprising a solvent that is not miscible with water; sealing the container and allowing it to age at about room temperature; allowing the enantiomers of racemic mixture to diffuse selectively into the smectic hydrogel in solution; removing the smectic hydrogel from the solution; rinsing predominantly one enantiomer from the surface of the smectic hydrogel; and extracting predominantly one enantiomer from the interior of the smectic hydrogel. The present invention also relates to a smectic hydrogel prepared according to an aforementioned method.
摘要翻译：本发明的一个方面涉及一种通过溶剂模板法制备纤维蛋白质近晶水凝胶的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 并收集所得到的纤维蛋白质近晶凝胶并使其干燥。本发明的另一方面涉及从外消旋混合物主要获得一种对映异构体的方法，包括以下步骤：将水性纤维蛋白溶液倒入包含不与水混溶的溶剂的容器中; 密封容器并使其在约室温下老化; 允许外消旋混合物的对映体选择性扩散到溶液中的近晶水凝胶中; 从溶液中除去近晶凝胶; 从近晶水凝胶的表面主要漂洗一种对映异构体; 并从近晶水凝胶的内部主要提取一种对映异构体。本发明还涉及根据上述方法制备的近晶型水凝胶。

5. 发明授权

US08871160B2 Biomaterial detecting device 有权
标题翻译：生物材料检测装置
公开(公告)号：US08871160B2
公开(公告)日：2014-10-28
申请号：US13554504
申请日：2012-07-20
申请人： Sung-Min Seo , Jae-Hyung Park , Oleksandrov Sergiy , Joong Hwan Lee , Mun-Cheol Paek , Su-Jin Ku
发明人： Sung-Min Seo , Jae-Hyung Park , Oleksandrov Sergiy , Joong Hwan Lee , Mun-Cheol Paek , Su-Jin Ku
IPC分类号： C40B60/12 , B01L3/00
CPC分类号： B01L3/50853 , B01L3/50825 , B01L2200/025 , B01L2300/046 , B01L2300/0609 , B01L2300/0636
摘要： Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
摘要翻译：提供一种用于确认或检测生物材料反应的生物材料检测装置，更具体地说，涉及一种生物材料检测装置，其以棒状形式形成，从而浸入含有待测试的生物材料溶液的管中; 具有帽结构的上部，从而诱导与生物材料的反应，从而促进生物材料的确认和检测; 并且形成为帽结构，从而防止样品的蒸发和管中的生物材料反应时的外部材料的渗透，从而提高分析的可靠性。

6. 发明申请

US20130225453A1 BIOMATERIAL DETECTING DEVICE 有权
标题翻译：生物体检测装置
公开(公告)号：US20130225453A1
公开(公告)日：2013-08-29
申请号：US13554504
申请日：2012-07-20
申请人： Sung-Min SEO , Jae-Hyung Park , Oleksandrov Sergiy , Joong Hwan Lee , Mun-Cheol Paek , Su-Jin Ku
发明人： Sung-Min SEO , Jae-Hyung Park , Oleksandrov Sergiy , Joong Hwan Lee , Mun-Cheol Paek , Su-Jin Ku
IPC分类号： C40B60/12 , G01N31/00 , G01N21/01
CPC分类号： B01L3/50853 , B01L3/50825 , B01L2200/025 , B01L2300/046 , B01L2300/0609 , B01L2300/0636
摘要： Provided is a biomaterial detecting device for confirming or detecting a biomaterial reaction, and more particularly to a biomaterial detecting device, which is formed in a stick type to thereby be immersed in a tube containing a biomaterial solution to be tested; has an upper portion with a cap structure to thereby induce reaction with a biomaterial, and thus facilitate confirmation and detection of the biomaterial; and is formed in a cap structure to thereby prevent evaporation of a sample and infiltration of an external material at the time of a biomaterial reaction in the tube, and thus improve reliability in analysis.
摘要翻译：提供一种用于确认或检测生物材料反应的生物材料检测装置，更具体地说，涉及一种生物材料检测装置，其以棒状形式形成，从而浸入含有待测试的生物材料溶液的管中; 具有帽结构的上部，从而诱导与生物材料的反应，从而促进生物材料的确认和检测; 并且形成为帽结构，从而防止样品的蒸发和管中的生物材料反应时的外部材料的渗透，从而提高分析的可靠性。

7. 发明授权

US06974472B2 Flexible self-expandable stent using shape memory alloy and method and apparatus for fabricating the same 有权
标题翻译：使用形状记忆合金的柔性自扩张支架及其制造方法和装置
公开(公告)号：US06974472B2
公开(公告)日：2005-12-13
申请号：US10098431
申请日：2002-03-18
申请人： Soon-Hyung Hong , Woong-Hee Son , Jae-Hyung Park , Jong-Taek Lee , Jin-Wook Jung , Kyoung-Min Shin
发明人： Soon-Hyung Hong , Woong-Hee Son , Jae-Hyung Park , Jong-Taek Lee , Jin-Wook Jung , Kyoung-Min Shin
IPC分类号： A61F2/84 , A61F2/06 , A61F2/82 , A61F2/90 , A61M29/02
CPC分类号： A61F2/90 , Y10S623/901
摘要： Disclosed herein is a flexible self-expandable stent using shape memory alloy for expanding stenosal portions and method and apparatus for fabricating the same. The self-expandable stent using shape memory allow, comprises a first cylindrical stent member comprised of a first wire formed of super elastic shape memory alloy, the first wire being bent a large number of times while being extended upwardly and downwardly a large number of times, so the first wire forms a plurality of variable rhombic spaces by forming a plurality of intersections for causing the first wire to be intersected with itself to resist longitudinal constriction of the first cylindrical stent member and a plurality of interlocked points for causing the first wire to be interlocked with itself at spaced positions to allow longitudinal constriction of the first cylindrical stent member; and a second cylindrical stent member comprised of a second wire formed of super elastic shape memory alloy, the second wire being diagonally extended in parallel with the previously positioned first wire and passed alternately under and over the first wire so as to divide each of a plurality of rhombic spaces formed in the first cylindrical stent member into four equal parts, thereby preventing the first and second cylindrical stent members from being separated from each other.
摘要翻译：本文公开了使用形状记忆合金用于扩张狭缝部分的柔性自扩张支架及其制造方法和装置。使用形状记忆的自扩张支架允许包括由超弹性形状记忆合金形成的第一线构成的第一圆柱形支架构件，第一线弯曲多次，同时向上和向下延伸多次因此第一线通过形成多个交叉点形成多个可变菱形空间，以使第一线与其自身相交，以抵抗第一圆柱形支架构件的纵向收缩和多个互锁点，以使第一线在间隔位置处与其自身互锁以允许第一圆柱形支架构件的纵向收缩; 以及由超弹性形状记忆合金形成的第二线构成的第二圆柱形支架构件，所述第二线与先前定位的第一线平行地对角地延伸，并且交替地在所述第一线上下交叉，以将多个在第一圆柱形支架构件中形成的菱形空间形成四个相等的部分，从而防止第一和第二圆柱形支架构件彼此分离。

8. 发明授权

US06645239B1 Flexible and self-expandable stent and inserting device for such stents 有权
标题翻译：用于这种支架的柔性和自扩张支架和插入装置
公开(公告)号：US06645239B1
公开(公告)日：2003-11-11
申请号：US10069156
申请日：2002-06-05
申请人： Jae-Hyung Park , Jin-Wook Jung , Kyoung-Min Shin
发明人： Jae-Hyung Park , Jin-Wook Jung , Kyoung-Min Shin
IPC分类号： A61F206
CPC分类号： A61F2/95 , A61F2/90 , A61F2002/9511 , A61F2002/9517
摘要： A stent (5), made of a shape-memory alloy and inserted into a stenosed vessel (50), and a stent foundation device for inserting such a stent (5) into a desired part (52) of the stenosed vessel (50) are disclosed. The stent (5) consists of a net-structural hollow cylindrical body (3) made by knitting one longitudinal superelastic shape-memory alloy wire while repeatedly crossing the wire at various points so as to form a plurality of diamond-shape meshes (2). The stent foundation device consists of an actuation steel core (12), a moveable tube (15) and an insert tube (20), which are received within an outside hollow tube (13) while being axially movable within the outside tube. (13). In the above device, an insert tip (23) is connected to the front end of the insert tube (20). The insert tip (23) has a step (22) forming a fitting end, at which the insert tip (23) is partially fitted into the front end of the outside tube (13) and is connected to the front end of the insert tube (20). A thread (21) is fixed at one end thereof to the insert tube (20) at a position spaced apart from the step (22) of the insert tip (23) by a distance. The above thread (21) holds the stent (5) on the insert tube (20) within the outside tube (13).
摘要翻译：由形状记忆合金制成并插入狭窄的容器（50）中的支架（5）和用于将这种支架（5）插入狭窄血管（50）的期望部分（52）中的支架基础装置被披露。支架（5）由通过编织一个纵向超弹性形状记忆合金线制成的网状中空圆柱体（3）组成，同时在各个点处重复地穿过线以形成多个菱形网格（2）。支架基础装置由致动钢芯（12），可移动管（15）和插入管（20）组成，它们被容纳在外部中空管（13）内，同时在外管内可轴向移动。（13）。在上述装置中，插入尖端（23）连接到插入管（20）的前端。插入尖端（23）具有形成嵌合端的台阶（22），嵌入端部（23）部分地配合到外管（13）的前端并连接到插管的前端（20）。螺纹（21）的一端在与刀片（23）的台阶（22）间隔一定距离的位置处固定在插入管（20）上。上述螺纹（21）将支架（5）保持在外管（13）内的插入管（20）上。

9. 外观设计

USD666628S1 Digital television with graphical user interface 有权
公开(公告)号：USD666628S1
公开(公告)日：2012-09-04
申请号：US29371286
申请日：2010-12-20
申请人： Jeong-Yeon Lee , Heui-Jin Kwon , Jae-Hyung Park
设计人： Jeong-Yeon Lee , Heui-Jin Kwon , Jae-Hyung Park

10. 发明申请

US20060104999A1 Composition for solubilization of paclitaxel and preparation method thereof 有权
标题翻译：紫杉醇溶解组合物及其制备方法
公开(公告)号：US20060104999A1
公开(公告)日：2006-05-18
申请号：US10521669
申请日：2003-07-18
申请人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee , Soon-Hong Yuk , Young-Wook Choi , Jae-Hyung Park , Jin-Wook Chung
发明人： Hesson Chung , Seo-Young Jeong , Ick-Chan Kwon , Yeong-Taek Park , In-Hyun Lee , Soon-Hong Yuk , Young-Wook Choi , Jae-Hyung Park , Jin-Wook Chung
IPC分类号： A61K9/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/0095 , A61K9/107 , A61K45/06 , A61K47/10 , A61K47/14 , A61K47/44 , A61K2300/00
摘要： The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil and 0.01˜20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4˜90% by weight of at least one selected from the monoglycerides, 0.01˜90% by weight of at least one oil, 0.01˜90% by weight of at least one emulsifier and 0.01˜20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.
摘要翻译：本发明涉及紫杉醇组合物及其制备方法，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油和0.01〜20重量％的至少一种紫杉醇的重量％。本发明还涉及包含乳化剂的紫杉醇组合物及其制备方法来溶解紫杉醇，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油， 0.01〜90重量％的至少一种乳化剂和0.01〜20重量％的紫杉醇。本发明的组合物是有效的紫杉醇递送系统，因为组合物溶解紫杉醇，在分散于水中后不形成聚集体，在肠壁上吸附良好，因此具有高的生物利用度。

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