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1. 发明授权

US08697441B2 Method of inducing high activity of human adipose stem cell and medium therefor 有权
标题翻译：诱导人类脂肪干细胞及其培养基高活性的方法
公开(公告)号：US08697441B2
公开(公告)日：2014-04-15
申请号：US13510528
申请日：2010-10-08
申请人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee
发明人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee
IPC分类号： C12N5/071
CPC分类号： C12N5/0667 , C12N2500/36 , C12N2502/1305
摘要： The present invention relates to a method of inducing high activity of human adipose stem cells, highly active stem cells induced by the method, cell therapeutic agents including the highly active stem cells, and a medium for inducing high activity of human adipose stem cells. The method of the present invention enables a long-term culture of human adipose stem cells while maintaining high activity, production yield and differentiation potency of the stem cells through in vitro culture, even in case culture conditions are not appropriate for mature human adipocytes, security of adipocytes is not guaranteed, or adipocytes are diseased.
摘要翻译：本发明涉及一种诱导人类脂肪干细胞高活性的方法，由该方法诱导的高活性干细胞，包括高活性干细胞的细胞治疗剂和诱导人类脂肪干细胞高活性的培养基。本发明的方法能够通过体外培养保持人体脂肪干细胞的长期培养，同时通过体外培养保持干细胞的高活性，产量和分化效能，即使培养条件不适合成熟的人类脂肪细胞，安全性的脂肪细胞不能保证，或脂肪细胞患病。

2. 发明授权

US09388384B2 Mesenchymal stem cells produced from human pluripotent stem cells 有权
标题翻译：由人多能干细胞产生的间充质干细胞
公开(公告)号：US09388384B2
公开(公告)日：2016-07-12
申请号：US13504881
申请日：2009-10-28
申请人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
发明人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
IPC分类号： C12N5/00 , C12N5/0775 , A61K35/48
CPC分类号： C12N5/0662 , A61K35/48 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/39 , C12N2506/02
摘要： Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human pluripotent stem cells; b) attaching the embryonic bodies to a culture dish to induce natural differentiation of the embryonic bodies into mesenchymal stem cells; and c) performing continuous proliferative culturing of the mesenchymal stem cells while still maintaining the identity of the mesenchymal stem cells. Also, provided is a standardized method for inducing differentiation of mesenchymal stem cells, which can be broadly applied to all human pluripotent stem cells regardless of a difference in the genetic background thereof. Ultimately, the present invention can continuously mass-produces the mesenchymal stem cells necessary for regenerative medicine and cell therapy by using human pluripotent stem cells, thereby realizing practical uses of cell therapy products, and further the present invention is expected to highly contribute to treatments of incurable diseases, such as cardiovascular diseases and neurological disorders.
摘要翻译：提供一种从人多能干细胞产生间充质干细胞的方法，所述方法包括：a）从人多能干细胞形成胚体; b）将胚胎体附着到培养皿中以诱导胚胎体自然分化成间充质干细胞; 和c）对间充质干细胞进行连续增殖培养，同时仍保持间充质干细胞的特性。此外，提供了诱导间充质干细胞分化的标准化方法，其可以广泛地应用于所有人多能干细胞，而与其遗传背景的差异无关。最终，本发明可以通过使用人多能干细胞连续批量生产再生医学和细胞治疗所需的间充质干细胞，从而实现细胞治疗产品的实际应用，并且进一步预期本发明对不治之症，如心血管疾病和神经系统疾病。

3. 发明申请

US20130023048A1 Method of Inducing High Activity of Human Adipose Stem Cell and Medium Therefor 有权
标题翻译：诱导人类脂肪干细胞及其介质的高活性的方法
公开(公告)号：US20130023048A1
公开(公告)日：2013-01-24
申请号：US13510528
申请日：2010-10-08
申请人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee
发明人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee
IPC分类号： C12N5/0775
CPC分类号： C12N5/0667 , C12N2500/36 , C12N2502/1305
摘要： The present invention relates to a method of inducing high activity of human adipose stem cells, highly active stem cells induced by the method, cell therapeutic agents including the highly active stem cells, and a medium for inducing high activity of human adipose stem cells.The method of the present invention enables a long-term culture of human adipose stem cells while maintaining high activity, production yield and differentiation potency of the stem cells through in vitro culture, even in case culture conditions are not appropriate for mature human adipocytes, security of adipocytes is not guaranteed, or adipocytes are diseased.
摘要翻译：本发明涉及一种诱导人类脂肪干细胞高活性的方法，由该方法诱导的高活性干细胞，包括高活性干细胞的细胞治疗剂和诱导人类脂肪干细胞高活性的培养基。本发明的方法能够通过体外培养保持人体脂肪干细胞的长期培养，同时通过体外培养保持干细胞的高活性，产量和分化效能，即使培养条件不适合成熟的人类脂肪细胞，安全性的脂肪细胞不能保证，或脂肪细胞患病。

4. 发明申请

US20120276625A1 METHOD FOR PRODUCING MESENCHYMAL STEM CELLS FROM HUMAN PLURIPOTENT STEM CELLS, AND MESENCHYMAL STEM CELLS PRODUCED BY SAME 有权
标题翻译：用于从人源性干细胞生产间充质干细胞的方法和由其生产的骨髓干细胞
公开(公告)号：US20120276625A1
公开(公告)日：2012-11-01
申请号：US13504881
申请日：2009-10-28
申请人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
发明人： Hyo Soo Kim , Hyun Jae Kang , Eun Ju Lee , Young Bae Park
IPC分类号： C12N5/0775
CPC分类号： C12N5/0662 , A61K35/48 , C12N2500/38 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/165 , C12N2501/39 , C12N2506/02
摘要： Provided is a method for producing mesenchymal stem cells from human pluripotent stem cells, the method including: a) forming embryonic bodies from human pluripotent stem cells; b) attaching the embryonic bodies to a culture dish to induce natural differentiation of the embryonic bodies into mesenchymal stem cells; and c) performing continuous proliferative culturing of the mesenchymal stem cells while still maintaining the identity of the mesenchymal stem cells. Also, provided is a standardized method for inducing differentiation of mesenchymal stem cells, which can be broadly applied to all human pluripotent stem cells regardless of a difference in the genetic background thereof. Ultimately, the present invention can continuously mass-produces the mesenchymal stem cells necessary for regenerative medicine and cell therapy by using human pluripotent stem cells, thereby realizing practical uses of cell therapy products, and further the present invention is expected to highly contribute to treatments of incurable diseases, such as cardiovascular diseases and neurological disorders.
摘要翻译：提供一种从人多能干细胞产生间充质干细胞的方法，所述方法包括：a）从人多能干细胞形成胚体; b）将胚胎体附着到培养皿中以诱导胚胎体自然分化成间充质干细胞; 和c）对间充质干细胞进行连续增殖培养，同时仍保持间充质干细胞的特性。此外，提供了诱导间充质干细胞分化的标准化方法，其可以广泛地应用于所有人多能干细胞，而与其遗传背景的差异无关。最终，本发明可以通过使用人多能干细胞连续批量生产再生医学和细胞治疗所需的间充质干细胞，从而实现细胞治疗产品的实际应用，并且进一步预期本发明对不治之症，如心血管疾病和神经系统疾病。

5. 发明授权

US09139811B2 Composition for suspension culturing of stem cells 有权
标题翻译：用于干细胞悬浮培养的组合物
公开(公告)号：US09139811B2
公开(公告)日：2015-09-22
申请号：US13981508
申请日：2011-12-27
申请人： Eun Ju Lee , Hyo Soo Kim
发明人： Eun Ju Lee , Hyo Soo Kim
IPC分类号： C12N5/071 , C12N5/00 , C12N5/0775 , A61K31/4409
CPC分类号： C12N5/0018 , A61K31/4409 , C12N5/0663 , C12N2501/727
摘要： The present invention relates to a composition for suppressing the death of stem cells during suspension culturing, a composition for mass culturing of stem cells, and a method for suppressing cell death of stem cells during suspension culturing. The composition of the present invention can be usefully used for effective single suspension culturing of stem cells, particularly, mesenchymal stem cells, or used for mass suspension culturing under the circumstances in which cell aggregation does not occur.
摘要翻译：本发明涉及一种用于抑制悬浮培养期间干细胞死亡的组合物，用于干细胞的大规模培养的组合物，以及用于在悬浮培养期间抑制干细胞的细胞死亡的方法。本发明的组合物可有效地用于干细胞，特别是间充质干细胞的有效单悬液培养，或用于在不发生细胞聚集的情况下进行大规模悬浮培养。

6. 发明申请

US20140011275A1 COMPOSITION FOR SUSPENSION CULTURING OF STEM CELLS 有权
标题翻译：用于悬挂培养干细胞的组合物
公开(公告)号：US20140011275A1
公开(公告)日：2014-01-09
申请号：US13981508
申请日：2011-12-27
申请人： Eun Ju Lee , Hyo Soo Kim
发明人： Eun Ju Lee , Hyo Soo Kim
IPC分类号： C12N5/00
CPC分类号： C12N5/0018 , A61K31/4409 , C12N5/0663 , C12N2501/727
摘要： The present invention relates to a composition for suppressing the death of stem cells during suspension culturing, a composition for mass culturing of stem cells, and a method for suppressing cell death of stem cells during suspension culturing. The composition of the present invention can be usefully used for effective single suspension culturing of stem cells, particularly, mesenchymal stem cells, or used for mass suspension culturing under the circumstances in which cell aggregation does not occur.
摘要翻译：本发明涉及一种用于抑制悬浮培养期间干细胞死亡的组合物，用于干细胞的大规模培养的组合物，以及用于在悬浮培养期间抑制干细胞的细胞死亡的方法。本发明的组合物可有效地用于干细胞，特别是间充质干细胞的有效单悬液培养，或用于在不发生细胞聚集的情况下进行大规模悬浮培养。

7. 发明授权

US09323427B2 Method and apparatus for displaying lists 有权
标题翻译：用于显示列表的方法和装置
公开(公告)号：US09323427B2
公开(公告)日：2016-04-26
申请号：US13270337
申请日：2011-10-11
申请人： Seock Hyun Yu , Giang Yoon Kwon , Chang Mo Yang , Jae Myung Lee , Yu Sic Kim , Bo Young Lee , Eun Ju Lee
发明人： Seock Hyun Yu , Giang Yoon Kwon , Chang Mo Yang , Jae Myung Lee , Yu Sic Kim , Bo Young Lee , Eun Ju Lee
IPC分类号： G06F3/0483 , G06F3/0482
CPC分类号： G06F3/0483 , G06F3/0482 , G06F3/0485 , G06F2203/04803
摘要： A list display method and apparatus are disclosed. The list display method, for a terminal having a display unit, includes detecting a necessity for displaying a list, classifying list items into viewable items and aggregated items, displaying the viewable items in the list view region and displaying information regarding the aggregated items in the list aggregate region. Responsive to inputs aggregate items may be classified as viewable items and corresponding ones of the viewable items are classified as aggregate items.
摘要翻译：公开了列表显示方法和装置。列表显示方法，对于具有显示单元的终端，包括检测列表的显示必要性，将列表项分类为可查看项目和聚合项目，将可查看项目显示在列表视图区域中，并且显示有关聚合项目的信息列表聚合区域。响应输入的总项可以分类为可查看项目，相应的可查看项目被分类为总项目。

8. 发明授权

US08916380B2 Embryonic stem cell-like cells 有权
标题翻译：胚胎干细胞样细胞
公开(公告)号：US08916380B2
公开(公告)日：2014-12-23
申请号：US12377493
申请日：2006-12-20
申请人： Jeong Mook Lim , Jae Yong Han , Hee Bal Kim , Seoung Tae Lee , Eun Ju Lee , Seung Pyo Gong
发明人： Jeong Mook Lim , Jae Yong Han , Hee Bal Kim , Seoung Tae Lee , Eun Ju Lee , Seung Pyo Gong
IPC分类号： C12N5/07 , C12N5/02 , C12N5/10 , C12N5/074
CPC分类号： C12N5/0696 , C12N2501/235 , C12N2502/03 , C12N2502/04 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394
摘要： Disclosed is a method for preparing an embryonic stem cell (ESC)-like cell, which includes the steps of: (a) obtaining a first cell population from a mammalian tissue or body fluid, wherein the first cell population comprises adult stem cells; (b) obtaining a second somatic cell population from a mammalian tissue, wherein the mammalian tissue is different from the mammalian tissue in step (a) and the second cell population is different from the first cell population; (c) coculturing the first cell population and the second cell population in a medium for a period of time sufficient to form a colony from either the first cell population or the second cell population; and (d) subculturing a cell from the colony in a medium for a period time sufficient to prepare the ESC-like cell.
摘要翻译：公开了一种制备胚胎干细胞（ESC）样细胞的方法，其包括以下步骤：（a）从哺乳动物组织或体液获得第一细胞群，其中第一细胞群包含成体干细胞; （b）从哺乳动物组织获得第二体细胞群，其中所述哺乳动物组织在步骤（a）中不同于哺乳动物组织，而第二细胞群与第一细胞群不同; （c）在培养基中共培养第一细胞群体和第二细胞群体足以从第一细胞群体或第二细胞群体形成菌落的时间; 和（d）在培养基中将细胞从菌落中传代培养足以制备ESC样细胞的时间。

9. 发明申请

US20130072466A1 COMPOSITION CONTAINING PLACENTA EXTRACTS 审中-公开
标题翻译：含有特殊提取物的组合物
公开(公告)号：US20130072466A1
公开(公告)日：2013-03-21
申请号：US13580242
申请日：2011-02-21
申请人： In Ho Choi , Dong Mok Lee , Eun Ju Lee , Ki-Ho Lee , Yong-Pil Cheon , Tae-Hoon Chun
发明人： In Ho Choi , Dong Mok Lee , Eun Ju Lee , Ki-Ho Lee , Yong-Pil Cheon , Tae-Hoon Chun
IPC分类号： A61K31/5685 , A61K31/565 , A61K31/568
CPC分类号： A61K31/5685 , A61K31/565 , A61K31/568 , A61K35/50 , C12N5/0605
摘要： Provided is a composition containing placenta extracts as active ingredients. Placenta extracts are natural substances extracted from placentas of livestock and show effects that can replace steroids and reduce adverse effects of steroids, so that placenta extracts have a wide range of applications including contraceptives, anti-osteoporosis drugs, anti-anemic drugs, therapeutic agents for wasting diseases of muscular atrophy, agents for treating sexual dysfunction, therapeutic agents for wounds, and adipocyte differentiation stimulating agents for improving meat quality of livestock, etc.
摘要翻译：提供含有胎盘提取物作为活性成分的组合物。胎盘提取物是从家畜胎盘中提取的天然物质，显示可替代类固醇并减少类固醇的不良反应的作用，因此胎盘提取物具有广泛的应用，包括避孕药，抗骨质疏松症药物，抗贫血药物，治疗药物消耗肌肉萎缩症，用于治疗性功能障碍的药物，用于伤口的治疗剂，以及用于改善家畜肉质的脂肪细胞分化刺激剂等。

10. 发明申请

US20120034235A1 Marker for Liver-Cancer Diagnosis and Recurrence and Survival Prediction, a Kit Comprising the Same, and Prognosis Prediction in Liver-Cancer Patients Using the Marker 审中-公开
标题翻译：用于肝癌诊断和复发和生存预测的标记物，包含其的试剂盒和使用标记物的肝癌患者的预后预测
公开(公告)号：US20120034235A1
公开(公告)日：2012-02-09
申请号：US13145773
申请日：2010-01-22
申请人： Kee Ho Lee , Eun Ran Park , Pu Hyeon Cha , Sang Bum Kim , Sun Hoo Park , Dong Hyoung Lee , Seon Rang Woo , Chul Ju Han , Yong Ho Ham , Eun Ju Lee , Myoung Jin Park , Sang Gu Hwang , Hyun Jin Shin
发明人： Kee Ho Lee , Eun Ran Park , Pu Hyeon Cha , Sang Bum Kim , Sun Hoo Park , Dong Hyoung Lee , Seon Rang Woo , Chul Ju Han , Yong Ho Ham , Eun Ju Lee , Myoung Jin Park , Sang Gu Hwang , Hyun Jin Shin
IPC分类号： A61K39/395 , C12Q1/26 , A61P35/00 , C40B40/10 , C40B30/04 , C12Q1/68 , G01N33/573
CPC分类号： G01N33/57438 , C12N15/113 , C12N2310/11 , C12N2310/14
摘要： A composition for detecting a marker for the diagnosis or prognosis of liver cancer is disclosed. The composition includes an agent capable of assessing the expression level of UQCRH (ubiquinol-cytochrome c reductase hinge protein). In addition, a kit having the composition, a microarray for the diagnosis of liver cancer using the marker, and a method for detecting the marker, and predicting recurrence following surgery in liver cancer patients are disclosed. The marker is able to contribute to the early diagnosis of liver cancer and prediction of recurrence following surgery and survival of liver cancer patients who have undergone hepatic resection, and also is significant for being a promising therapeutic target for liver cancer.
摘要翻译：公开了一种用于检测肝癌诊断或预后的标志物的组合物。该组合物包括能够评估UQCRH（ubiquinol-cytochrome c还原酶铰链蛋白）的表达水平的试剂。此外，公开了具有该组成的试剂盒，使用该标记物诊断肝癌的微阵列，以及用于检测标志物的方法，以及预测肝癌患者手术后的复发。该标记能够有助于肝癌的早期诊断和手术后的复发预测以及经过肝切除术的肝癌患者的生存，并且对于成为有希望的肝癌治疗靶标也是重要的。

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