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1. 发明授权

US08574614B2 Surgical grafts for repairing chondral defects 有权
标题翻译：手术移植修复软骨缺损
公开(公告)号：US08574614B2
公开(公告)日：2013-11-05
申请号：US12700469
申请日：2010-02-04
申请人： Hwa-Chang Liu , Feng-Huei Lin , Shing-Mou Lee , Chun-Che Yen
发明人： Hwa-Chang Liu , Feng-Huei Lin , Shing-Mou Lee , Chun-Che Yen
IPC分类号： A61F2/00 , A01N63/00 , A01N65/00
CPC分类号： A61L27/3817 , A61L27/24 , A61L27/3852
摘要： An implant containing a collagen matrix embedded with chondrocyte-like cells, its use in repairing a chondral defect, and a method of preparing the implant.
摘要翻译：包含嵌入软骨细胞样细胞的胶原基质的植入物，其用于修复软骨缺损的方法以及制备植入物的方法。

2. 发明申请

US20110189254A1 SURGICAL GRAFTS FOR REPAIRING CHONDRAL DEFECTS 有权
标题翻译：修复手术缺损的外科手术
公开(公告)号：US20110189254A1
公开(公告)日：2011-08-04
申请号：US12700469
申请日：2010-02-04
申请人： Hwa-Chang Liu , Feng-Huei Lin , Shing-Mou Lee , Chun-Che Yen
发明人： Hwa-Chang Liu , Feng-Huei Lin , Shing-Mou Lee , Chun-Che Yen
IPC分类号： A61F2/00 , A61K35/32
CPC分类号： A61L27/3817 , A61L27/24 , A61L27/3852
摘要： An implant containing a collagen matrix embedded with chondrocyte-like cells, its use in repairing a chondral defect, and a method of preparing the implant.
摘要翻译：包含嵌入软骨细胞样细胞的胶原基质的植入物，其用于修复软骨缺损的方法以及制备植入物的方法。

3. 发明申请

US20130337434A1 Method of Preparing Magnetic Bead Type Nasopharyngeal Enzyme Immunoassay Reagents by Polymerase Chain Reaction 审中-公开
标题翻译：通过聚合酶链反应制备磁珠型鼻咽癌免疫测定试剂的方法
公开(公告)号：US20130337434A1
公开(公告)日：2013-12-19
申请号：US13527212
申请日：2012-06-19
申请人： Ching-Yan Tsai , Kuan-Yin Chen , Ping-Hung Yu , Chia-Chieh Chen , Chia-Ching Liu , Feng-Huei Lin
发明人： Ching-Yan Tsai , Kuan-Yin Chen , Ping-Hung Yu , Chia-Chieh Chen , Chia-Ching Liu , Feng-Huei Lin
IPC分类号： C12Q1/70 , G01N27/26
CPC分类号： C12Q1/70 , C12Q1/6804 , C12Q2521/301 , C12Q2531/113 , C12Q2563/143 , C12Q2563/155 , C12Q2563/179
摘要： A method of preparing magnetic bead type nasopharyngeal enzyme immunoassay reagents by polymerase chain reaction according to this invention offers in-vitro diagnostic reagents by means of utilizing nanotechnology. This method uses magnetic beads to coat EBV nuclear antigen (Epstein-Barr virus nuclear antigen, EBNA1) or early antigen (Early Antigen, EA). The use of polymerase chain reaction (polymerase Chain Reaction PCR) is for amplified detection. It is found that positive controls of different concentrations, after amplified by PCR, change in their brightness and concentration. That reveals the EBV antigens on the magnetic beads can specifically detect IgA antigens in the serum.
摘要翻译：根据本发明通过聚合酶链反应制备磁珠型鼻咽酶免疫测定试剂的方法通过利用纳米技术提供体外诊断试剂。该方法使用磁珠涂覆EBV核抗原（爱泼斯坦 - 巴尔病毒核抗原，EBNA1）或早期抗原（早期抗原，EA）。聚合酶链反应（polymerase chain reaction，聚合酶链式反应PCR）用于扩增检测。发现通过PCR扩增后，不同浓度的阳性对照改变其亮度和浓度。这表明磁珠上的EBV抗原可以特异性检测血清中的IgA抗原。

4. 发明申请

US20120108536A1 PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING INFLAMMATION 有权
标题翻译：药物组合物和抑制炎症的方法
公开(公告)号：US20120108536A1
公开(公告)日：2012-05-03
申请号：US13024764
申请日：2011-02-10
申请人： Feng-Huei Lin , Teng-Le Huang , Horng-Chaung Hsu
发明人： Feng-Huei Lin , Teng-Le Huang , Horng-Chaung Hsu
IPC分类号： A61K31/715 , A61P19/02
CPC分类号： A61K31/366 , A61K31/728 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical composition for inhibiting inflammation, comprising (a) hyaluronic acid, (b) a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, and (c) a pharmaceutically acceptable carrier, is provided. Also provided is a method for inhibiting inflammation in a mammal, comprising administrating to the mammal an effective amount of a composition comprising (a) hyaluronic acid and (b) an HMG-CoA reductase inhibitor.
摘要翻译：一种用于抑制炎症的药物组合物，其包含（a）透明质酸，（b）3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂和（c）药学上可接受的载体。还提供了抑制哺乳动物炎症的方法，其包括向哺乳动物施用有效量的组合物，其包含（a）透明质酸和（b）HMG-CoA还原酶抑制剂。

5. 发明授权

US08889106B2 Non-alcohol mouthwash composition without chemical antibacterial medicament 有权
标题翻译：非酒精漱口水组成无化学抗菌药物
公开(公告)号：US08889106B2
公开(公告)日：2014-11-18
申请号：US13931153
申请日：2013-06-28
申请人： Feng-Huei Lin , Chun-Pin Lin , Hsuan-Yu Chen , Tzu-Piao Tang , Hsu-Wei Fang , Chung-King Hsu , Chia-Ming Chang
发明人： Feng-Huei Lin , Chun-Pin Lin , Hsuan-Yu Chen , Tzu-Piao Tang , Hsu-Wei Fang , Chung-King Hsu , Chia-Ming Chang
IPC分类号： A61K8/66 , A61K8/96 , A61K38/00 , A61K51/00 , A61Q11/00 , A61K8/92
CPC分类号： A61Q11/00 , A61K8/64
摘要： A non-alcohol mouthwash composition without chemical antibacterial medicament is disclosed. The non-alcohol mouthwash composition includes from 0.03% to 1.5% of γ-polyglutamic acid (γ-PGA) and from 0.5% to 4% of surfactant, all percentages based on the total weight of the mouthwash composition. The non-alcohol mouthwash composition preferably includes from 0.4% to 1.5% by weight, or more preferably from 0.8% to 1.3% by weight, of γ-PGA. Containing no chemical antibacterial medicament, the non-alcohol mouthwash composition can effectively inhibit bacterial growth in the oral cavity without irritating the oral mucosa.
摘要翻译：公开了一种不含化学抗菌药物的非酒精漱口剂组合物。非酒精漱口剂组合物含有0.03％〜1.5％的γ-聚谷氨酸（γ-PGA）和0.5％〜4％的表面活性剂，所有百分比均基于漱口水组合物的总重量。非醇漱口剂组合物优选含有0.4〜1.5重量％，更优选0.8〜1.3重量％的γ-PGA。不含任何化学抗菌药物，非酒精漱口水组合物可有效抑制口腔细菌生长而不刺激口腔黏膜。

6. 发明授权

US08835405B2 Inhibiting arthritis via injection of synergistic combination of hyaluronic acid and vitamin C and/or vitamin E 有权
标题翻译：通过注射透明质酸和维生素C和/或维生素E的协同组合来抑制关节炎
公开(公告)号：US08835405B2
公开(公告)日：2014-09-16
申请号：US13336178
申请日：2011-12-23
申请人： Feng-Huei Lin , Teng-Le Huang , Horng-Chaung Hsu , Chun-Hsu Yao , Yueh-Sheng Chen , Wen-Yu Su
发明人： Feng-Huei Lin , Teng-Le Huang , Horng-Chaung Hsu , Chun-Hsu Yao , Yueh-Sheng Chen , Wen-Yu Su
IPC分类号： A61K31/728 , A61K31/355 , A61K31/375 , A61K31/59 , A61K9/00
CPC分类号： A61K31/728 , A61K9/0019 , A61K31/355 , A61K31/375 , A61K31/59 , A61K47/02 , A61K2300/00
摘要： A pharmaceutical composition for inhibiting inflammation is provided. The pharmaceutical composition comprises (a) hyaluronic acid, (b) a vitamin and (c) a pharmaceutically acceptable carrier.
摘要翻译：提供了用于抑制炎症的药物组合物。药物组合物包含（a）透明质酸，（b）维生素和（c）药学上可接受的载体。

7. 发明申请

US20130164335A1 METHODS AND COMPOSITIONS FOR CELLULAR DRUG RELEASE 审中-公开
标题翻译：细胞毒素释放的方法和组合物
公开(公告)号：US20130164335A1
公开(公告)日：2013-06-27
申请号：US13338073
申请日：2011-12-27
申请人： Cheng CHEN , Feng-Huei Lin
发明人： Cheng CHEN , Feng-Huei Lin
IPC分类号： A61K9/14 , C12N5/071 , C12N5/0787 , C12N5/0786 , A61K47/02 , A61P25/24 , A61K47/40 , A61K47/44 , A61K47/24 , C12N5/0784 , B82Y5/00
CPC分类号： A61K31/5513 , A61K9/0019 , A61K9/5115 , A61K9/5123 , A61K9/5138
摘要： Methods and compositions for producing a cellular drug release are disclosed. The method comprises: a) providing a composition comprising a therapeutically effective amount of a pharmacological agent adsorbed onto mesoporous hydroxyapatite (HAP) with hydrophobic surfaces; b) exposing the composition to a cell; c) causing entry of the mesoporous HAP into the cell and degradation of the HAP in the lysosomes of the cell and desorption of the agent from the mesoporous HAP; d) causing release of the desorbed agent from the lysosomes into the cytoplasm of the cell; and e) causing release of the desorbed agent to outside the cell. The composition comprises a) mesoporous HAP with hydrophobic surfaces; and b) a therapeutically effective amount of a pharmacological agent, adsorbed onto the hydrophobic surfaces of the mesoporous. HAP. The composition is characterized in that it constantly releases the agent in vivo for a period of at least 4 weeks.
摘要翻译：公开了用于产生细胞药物释放物的方法和组合物。该方法包括：a）提供包含治疗有效量的吸附在具有疏水表面的介孔羟基磷灰石（HAP）上的药理学试剂的组合物; b）将组合物暴露于细胞; c）导致介孔HAP进入细胞并且细胞溶酶体中HAP的降解和药物从介孔HAP中的解吸; d）使解吸剂从溶酶体释放到细胞的细胞质中; 和e）引起解吸剂释放到细胞外。该组合物包含a）具有疏水表面的中孔HAP; 和b）吸附在介孔的疏水表面上的治疗有效量的药理学试剂。 HAP。该组合物的特征在于其在体内不断释放至少4周的时间。

8. 发明申请

US20090186408A1 Biocompatible bilayer porous matrix and preparation thereof 审中-公开
标题翻译：生物相容双层多孔基质及其制备
公开(公告)号：US20090186408A1
公开(公告)日：2009-07-23
申请号：US12010014
申请日：2008-01-18
申请人： Tzu-Wei Wang , Yi-Chau Huang , Feng-Huei Lin
发明人： Tzu-Wei Wang , Yi-Chau Huang , Feng-Huei Lin
IPC分类号： C12N5/02
CPC分类号： C12N5/0068 , C12N2533/54 , C12N2533/70 , C12N2533/80
摘要： The present invention provides a biocompatible bilayer porous matrix and preparation thereof. The bilayer porous matrix is composed of gelatin, chondroitin 6 sulfate, and hyaluronic acid, also, prepared through freeze-drying technique at different temperature and time duration to form varied pore sizes on each layer. The present invention also provides a method of cell culture using the bilayer porous matrix.
摘要翻译：本发明提供生物相容性双层多孔基质及其制备方法。双层多孔基质由明胶，硫酸软骨素6和透明质酸组成，也通过不同温度和时间的冷冻干燥技术制备，以在每层上形成不同的孔径。本发明还提供了使用双层多孔基质的细胞培养方法。

9. 发明申请

US20050179172A1 Method for preparing porous bioceramic bone substitute materials 审中-公开
标题翻译：多孔生物陶瓷骨替代材料的制备方法
公开(公告)号：US20050179172A1
公开(公告)日：2005-08-18
申请号：US11101574
申请日：2005-04-08
申请人： Feng-Huei Lin , Chun-Jen Liao
发明人： Feng-Huei Lin , Chun-Jen Liao
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/46 , A61L27/00 , A61L27/12 , A61L27/36 , A61L27/56 , C04B33/32
CPC分类号： A61L27/12 , A61F2/28 , A61F2/4644 , A61F2002/30968 , A61F2310/00293 , A61F2310/00359 , A61L27/3608 , A61L27/365 , A61L27/3691 , A61L27/56
摘要： A method for preparing porous bioceramic bone substitute materials is disclosed, which includes the following steps: (a) providing a cancellous bone of animals, (b) removing organic substances in the cancellous bone by thermal processing to obtain de-organic cancellous bone, (c) soaking the de-organic cancellous bone in a solution of phosphate salts, and (d) obtaining the porous bioceramic materials by sintering between 600 to 900° C. The porous bioceramic bone substitute materials of the present invention are suitable for use as filling materials of bone defect.
摘要翻译：公开了一种制备多孔生物陶瓷骨替代材料的方法，其包括以下步骤：（a）提供动物的松质骨，（b）通过热加工除去松质骨中的有机物质以获得去有机松质骨（ c）将去有机松质骨浸泡在磷酸盐溶液中，（d）通过在600-900℃之间烧结获得多孔生物陶瓷材料。本发明的多孔生物陶瓷骨替代材料适用于填充骨缺损的材料。

10. 发明授权

US06338752B1 &agr;-TCP/HAP biphasic cement and its preparing process 有权
标题翻译： α-TCP / HAP双相水泥及其制备方法
公开(公告)号：US06338752B1
公开(公告)日：2002-01-15
申请号：US09553176
申请日：2000-04-20
申请人： Feng-Huei Lin , Chun-Jen Liao
发明人： Feng-Huei Lin , Chun-Jen Liao
IPC分类号： C04B1202
CPC分类号： C04B12/025 , A61L24/0063 , A61L27/12 , C04B2111/00836
摘要： A biphasic cement of &agr;-TCP/HAP is primarily composed of 30-60 wt % &agr;-tricalcium phosphate (Ca3(PO4)2, &agr;-TCP) and 40-70 wt % of hydroxyapatite (Ca10(PO4)6(OH)2, HAP). The biphasic cement of &agr;-TCP/HAP of the present invention is superior since it can set rapidly while soaking in a water solution. The present invention also provides a process for preparing the biphasic cement of &agr;-TCP/HAP, in which the composition of the biphasic cement of &agr;-TCP/HAP can be controlled.
摘要翻译： α-TCP / HAP的双相水泥主要由30-60重量％的磷酸三钙（Ca3（PO4）2，α-TCP）和40-70重量％的羟基磷灰石（Ca10（PO4）6（OH） 2，HAP）。本发明的α-TCP / HAP的双相水泥优异，因为它可以在浸泡在水溶液中时快速固化。本发明还提供了一种制备α-TCP / HAP的双相水泥的方法，其中可以控制α-TCP / HAP的双相水泥的组成。

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