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1. 发明授权

US08163470B2 Simulated 5-part differential leukocyte granules, the method for preparing the same and control products and calibrators comprising the same 有权
标题翻译：模拟的5部分差异白细胞颗粒，其制备方法和对照品及包含其的校准品
公开(公告)号：US08163470B2
公开(公告)日：2012-04-24
申请号：US12274070
申请日：2008-11-19
申请人： Hui Zhang , Lu Wang , Zuyue Xu , Mulong Liu , Li Zhang
发明人： Hui Zhang , Lu Wang , Zuyue Xu , Mulong Liu , Li Zhang
IPC分类号： A01N1/02 , C12N5/00 , C12N5/02
CPC分类号： C12N5/0641 , C12N2500/60 , C12N2503/00
摘要： A method for preparing five-part differential leukocyte analogs from red blood cells includes selecting appropriate red blood cells; treating the red blood cells with a multi-functional reagent system for maintenance of a structural integrity of the membranes of the red blood cells and synchronous adjustment of cell volume, morphology and inclusions; subjecting the treated red blood cells to an intensified fixation; and washing the treated cells for preservation. The present disclosure also relates to leukocyte analogs prepared by the above method, a reagent system used for preparing the analogs, and a quality control and a calibrator including the analogs for use in a hematology analyzer.
摘要翻译：从红细胞制备五部分差异白细胞类似物的方法包括选择合适的红细胞; 用多功能试剂系统处理红细胞，维持红细胞膜的结构完整性，同时调节细胞体积，形态和内含物; 对经处理的红细胞进行强化固定; 并洗涤经处理的细胞进行保存。本公开还涉及通过上述方法制备的白细胞类似物，用于制备类似物的试剂系统，以及包括用于血液分析仪的类似物的质量控制和校准品。

2. 发明申请

US20060194191A1 Processing method for the long-term stabilization of biological red blood cell volume 有权
标题翻译：生物红细胞体积长期稳定的加工方法
公开(公告)号：US20060194191A1
公开(公告)日：2006-08-31
申请号：US11323702
申请日：2005-12-30
申请人： Hui Zhang , Zuyue Xu , Mulong Liu
发明人： Hui Zhang , Zuyue Xu , Mulong Liu
IPC分类号： A01N1/02 , C12N5/08
CPC分类号： A01N1/02 , A01N1/0226 , Y10T436/101666 , Y10T436/107497 , Y10T436/2525
摘要： The present invention relates to a processing method for long-term stabilization of biological red blood cell volume. The red blood cells can be further used in reference materials and calibrators of a hematology analyzer. The method of the present invention comprises contacting the sample with a solution comprising a membrane-fixation reagent and an aldehyde for a processing period to terminate or slow down the red blood cell metabolism. It is provided by experiments that such process enables the volume of the red blood cells to be stable in a period over 120 days.
摘要翻译：本发明涉及生物红细胞体积长期稳定化的处理方法。红细胞可以进一步用于血液分析仪的参考物质和校准品。本发明的方法包括使样品与包含膜固定剂和醛的溶液接触，以处理或终止红细胞代谢。通过实验提供这种方法使得红细胞的体积在120天的时间内是稳定的。

3. 发明授权

US08029978B2 Processing method for the long-term stabilization of biological red blood cell volume 有权
标题翻译：生物红细胞体积长期稳定的加工方法
公开(公告)号：US08029978B2
公开(公告)日：2011-10-04
申请号：US11323702
申请日：2005-12-30
申请人： Hui Zhang , Zuyue Xu , Mulong Liu
发明人： Hui Zhang , Zuyue Xu , Mulong Liu
IPC分类号： A01N1/02 , C01N5/08
CPC分类号： A01N1/02 , A01N1/0226 , Y10T436/101666 , Y10T436/107497 , Y10T436/2525
摘要： The present invention relates to a processing method for long-term stabilization of biological red blood cell volume. The red blood cells can be further used in reference materials and calibrators of a hematology analyzer. The method of the present invention comprises contacting the sample with a solution comprising a membrane-fixation reagent and an aldehyde for a processing period to terminate or slow down the red blood cell metabolism. It is provided by experiments that such process enables the volume of the red blood cells to be stable in a period over 120 days.
摘要翻译：本发明涉及生物红细胞体积长期稳定化的处理方法。红细胞可以进一步用于血液分析仪的参考物质和校准品。本发明的方法包括使样品与包含膜固定剂和醛的溶液接触，以处理或终止红细胞代谢。通过实验提供这种方法使得红细胞的体积在120天的时间内是稳定的。

4. 发明授权

US08383403B2 Reticulocyte mimetics and method of preparation of the same 有权
标题翻译：网织红细胞模拟物及其制备方法
公开(公告)号：US08383403B2
公开(公告)日：2013-02-26
申请号：US12774442
申请日：2010-05-05
申请人： Lu Wang , Zuyue Xu , Tao Xia
发明人： Lu Wang , Zuyue Xu , Tao Xia
IPC分类号： C12N5/071
CPC分类号： G01N33/96 , G01N33/80
摘要： In one aspect of the present disclosure there is provided a method for preparing reticulocyte mimetics. In another aspect of the present disclosure there are provided reticulocyte mimetics obtained using the method. In yet another aspect of the present disclosure there is provided a whole blood reference control including the reticulocyte mimetics as provided. In still another aspect of the present disclosure there is provided a composition useful for preparing reticulocyte mimetics.
摘要翻译：在本公开的一个方面，提供了一种制备网织红细胞模拟物的方法。在本公开的另一方面，提供了使用该方法获得的网织红细胞模拟物。在本公开的另一方面，提供了包括如所提供的网织红细胞模拟物的全血参照对照。在本公开的另一方面，提供了可用于制备网织红细胞模拟物的组合物。

5. 发明授权

US08647877B2 Preparation and use of nucleated red blood cell simulating particles and hematology control mixtures 有权
标题翻译：有核红细胞模拟颗粒和血液控制混合物的制备和使用
公开(公告)号：US08647877B2
公开(公告)日：2014-02-11
申请号：US12975053
申请日：2010-12-21
申请人： Cheng Deng , Zuyue Xu , He Liu
发明人： Cheng Deng , Zuyue Xu , He Liu
IPC分类号： G01N31/00 , A01N1/02
CPC分类号： G01N33/5094 , G01N21/6428 , G01N33/80 , G01N33/96 , G01N2800/22 , Y10T436/101666
摘要： The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product. The present disclosure also provides a hematology control mixture containing the nucleated red blood cell simulating particles. In addition, the present disclosure describes the use of the nucleated red blood cell simulating particles and the hematology control mixtures comprising the same, for the quality control of a blood cell analyzer.
摘要翻译：本公开提供了模拟粒子的有核红细胞，其可以是与能够稳定地结合细胞核的荧光染色抑制剂或细胞中的核酸结合的白细胞，以降低颗粒与荧光的结合能力染料在检测期间。本发明还提供了一种制备有模红细胞模拟颗粒的方法，包括以下步骤：（a）获得纯化的白细胞; （b）将白细胞悬浮于含有稳定结合细胞核的荧光染色抑制剂的细胞处理溶液或细胞中的核酸上，（c）洗涤所得产物。本公开还提供了含有模拟红细胞模拟颗粒的血液控制混合物。此外，本公开内容描述了用于血细胞分析仪的质量控制的模拟有核红细胞模拟颗粒的使用和包含其的血液控制混合物的用途。

6. 发明申请

US20110159535A1 PREPARATION AND USE OF NUCLEATED RED BLOOD CELL SIMULATING PARTICLES AND HEMATOLOGY CONTROL MIXTURES 有权
标题翻译：核红细胞模拟颗粒和血液学控制混合物的制备和使用
公开(公告)号：US20110159535A1
公开(公告)日：2011-06-30
申请号：US12975053
申请日：2010-12-21
申请人： Cheng Deng , Zuyue Xu , He Liu
发明人： Cheng Deng , Zuyue Xu , He Liu
IPC分类号： C12Q1/04 , C12N5/078 , C12N5/0787 , G01N1/28
CPC分类号： G01N33/5094 , G01N21/6428 , G01N33/80 , G01N33/96 , G01N2800/22 , Y10T436/101666
摘要： The present disclosure provides a nucleated red blood cell simulating particle, which may be leukocytes bound to a fluorescent-staining inhibitor capable of stably binding to the nucleus or a nucleic acid in a cell so as to reduce the binding capacity of the particles to a fluorescent dye during their detection. The present disclosure also provides a method for preparing nucleated red blood cell simulating particles, including the following steps: (a) obtaining purified leukocytes; (b) suspending the leukocytes in a cell treatment solution containing a fluorescent-staining inhibitor which stably binds to the nucleus or a nucleic acid in a cell, and (c) washing the obtained product. The present disclosure also provides a hematology control mixture containing the nucleated red blood cell simulating particles. In addition, the present disclosure describes the use of the nucleated red blood cell simulating particles and the hematology control mixtures comprising the same, for the quality control of a blood cell analyzer.
摘要翻译：本公开提供了模拟粒子的有核红细胞，其可以是与能够稳定地结合细胞核的荧光染色抑制剂或细胞中的核酸结合的白细胞，以降低颗粒与荧光的结合能力染料在检测期间。本发明还提供了一种制备有模红细胞模拟颗粒的方法，包括以下步骤：（a）获得纯化的白细胞; （b）将白细胞悬浮于含有稳定结合细胞核的荧光染色抑制剂的细胞处理溶液或细胞中的核酸上，（c）洗涤所得产物。本公开还提供了含有模拟红细胞模拟颗粒的血液控制混合物。此外，本公开内容描述了用于血细胞分析仪的质量控制的模拟有核红细胞模拟颗粒的使用和包含其的血液控制混合物的用途。

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