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1. 发明申请

US20110014610A1 COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING NEUROPSYCHIATRIC DISORDERS 审中-公开
标题翻译：用于诊断和治疗神经缺血性疾病的组合物和方法
公开(公告)号：US20110014610A1
公开(公告)日：2011-01-20
申请号：US12701177
申请日：2010-02-05
申请人： Huda Akil , Mary Atz , William E. Bunney, JR. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
发明人： Huda Akil , Mary Atz , William E. Bunney, JR. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/573 , G01N33/6896 , G01N2500/00 , G01N2500/04 , G01N2800/28 , G01N2800/30 , G01N2800/302 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译：本发明提供了用于诊断精神障碍（例如精神病性障碍如精神分裂症和情绪障碍如重性抑郁障碍和双相情感障碍）的方法。本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。

2. 发明授权

US07687235B2 Compositions and methods for diagnosing and treating neuropsychiatric disorders 有权
标题翻译：用于诊断和治疗神经精神障碍的组合物和方法
公开(公告)号：US07687235B2
公开(公告)日：2010-03-30
申请号：US11396050
申请日：2006-03-31
申请人： Huda Akil , Mary Atz , William E. Bunney, Jr. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
发明人： Huda Akil , Mary Atz , William E. Bunney, Jr. , William Byerley , Kathleen Casey , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , Richard M. Myers , Brandi Rollins , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/573 , G01N33/6896 , G01N2500/00 , G01N2500/04 , G01N2800/28 , G01N2800/30 , G01N2800/302 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders (e.g., psychotic disorders such as schizophrenia and mood disorders such as major depression disorder and bipolar disorder). The invention also provides methods of identifying modulators of such mental disorders as well as methods of using these modulators to treat patients suffering from such mental disorders.
摘要翻译：本发明提供了用于诊断精神障碍（例如精神病性障碍如精神分裂症和情绪障碍如重性抑郁障碍和双相情感障碍）的方法。本发明还提供鉴定这种精神障碍的调节剂的方法以及使用这些调节剂来治疗患有这种精神障碍的患者的方法。

3. 发明授权

US08415298B2 Administration of FGF2 for treamtent of anxiety 有权
标题翻译：管理FGF2治疗焦虑症
公开(公告)号：US08415298B2
公开(公告)日：2013-04-09
申请号：US11158530
申请日：2005-06-21
申请人： Huda Akil , William E. Bunney, Jr. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , David M. Lyons , Margherita Molnar , Richard M. Myers , Alan F. Schatzberg , Richard Stein , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
发明人： Huda Akil , William E. Bunney, Jr. , Prabhakara V. Choudary , Simon J. Evans , Edward G. Jones , Jun Li , Juan F. Lopez , David M. Lyons , Margherita Molnar , Richard M. Myers , Alan F. Schatzberg , Richard Stein , Robert C. Thompson , Hiroaki Tomita , Marquis P. Vawter , Stanley J. Watson
IPC分类号： A61K38/18
CPC分类号： C12Q1/6883 , A61K31/713 , A61K38/1825 , C07K16/22 , C12N15/1136 , C12N2310/14 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N33/6896 , G01N33/74 , G01N2333/726 , G01N2800/304
摘要： The present invention provides methods for diagnosing mental disorders. The invention also provides methods of identifying modulators of mental disorders as well as methods of using these modulators to treat patients suffering from mental disorders.
摘要翻译：本发明提供了诊断精神障碍的方法。本发明还提供识别精神障碍调节剂的方法以及使用这些调节剂治疗患有精神障碍的患者的方法。

4. 发明申请

US20090233842A1 FGF2-RELATED METHODS FOR DIAGNOSING AND TREATING DEPRESSION 审中-公开
标题翻译： FGF2相关方法诊断和治疗抑郁症
公开(公告)号：US20090233842A1
公开(公告)日：2009-09-17
申请号：US12093437
申请日：2006-11-13
申请人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert C. Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William E. Bunney, JR. , Marquis P. Vawter , Edward G. Jones , Prabhakara V. Choudary , Richard M. Myers , Alan F. Schatzberg , Jun Li , Devin Absher , Hiroaki Tomita
发明人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert C. Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William E. Bunney, JR. , Marquis P. Vawter , Edward G. Jones , Prabhakara V. Choudary , Richard M. Myers , Alan F. Schatzberg , Jun Li , Devin Absher , Hiroaki Tomita
IPC分类号： A61K38/00 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/03 , A61K38/10 , A61K38/1774 , A61K38/1825 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N2800/304
摘要： The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.
摘要翻译：本申请涉及心理障碍的治疗和诊断，包括双相情感障碍，重症抑郁障碍和精神分裂症。本发明提供了新的诊断标记和测定，以及用于开发和发现可用于治疗患有精神疾病的患者的药剂和化合物的研究工具。

5. 发明申请

US20080199866A1 SNP DETECTION AND OTHER METHODS FOR CHARACTERIZING AND TREATING BIPOLAR DISORDER AND OTHER AILMENTS 审中-公开
标题翻译：表征和处理双极性疾病及其他物质的SNP检测及其他方法
公开(公告)号：US20080199866A1
公开(公告)日：2008-08-21
申请号：US11868456
申请日：2007-10-05
申请人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara V. Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher
发明人： Huda Akil , Stanley J. Watson , Simon J. Evans , Cortney Turner , Rene Bernard , Ilan Kerman , Robert Thompson , Margit Burmeister , Laura J. Scott , Fan Meng , Michael Boehnke , William Bunney , Marquis Vawter , Edward Jones , Prabhakara V. Choudary , Richard Myers , Alan Schatzberg , Jun Li , Devin Absher
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present application relates to the use of SNPs and differential exon expression to characterize, diagnose or treat bipolar disorder and other mental illnesses, such as major depressive disorder and schizophrenia.
摘要翻译：本申请涉及使用SNP和差异外显子表达来表征，诊断或治疗双相情感障碍和其他精神疾病，如重度抑郁障碍和精神分裂症。

6. 发明授权

US09234242B2 Methods for treating depression using NCAM peptide mimetics 有权
标题翻译：使用NCAM肽模拟物治疗抑郁症的方法
公开(公告)号：US09234242B2
公开(公告)日：2016-01-12
申请号：US13431893
申请日：2012-03-27
申请人： Huda Akil , Stanley J. Watson , Cortney Turner , William E. Bunny , Edward G. Jones , Richard M. Myers , Alan F. Schatzberg
发明人： Huda Akil , Stanley J. Watson , Cortney Turner , William E. Bunny , Edward G. Jones , Richard M. Myers , Alan F. Schatzberg
IPC分类号： A61K38/10 , A61K38/18 , C12Q1/68 , A61K38/17 , G01N33/50 , A61K38/03
CPC分类号： C12Q1/6883 , A61K38/03 , A61K38/10 , A61K38/1774 , A61K38/1825 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5023 , G01N2800/304
摘要： The present application relates to the treatment and diagnosis of mood disorders, including bipolar disorder, major depression disorder and schizophrenia. The invention provides novel diagnostic markers and assays, as well as research tools for the development and discovery of agents and compounds which are useful for treating patients who suffer from mental illness.
摘要翻译：本申请涉及心理障碍的治疗和诊断，包括双相情感障碍，重症抑郁障碍和精神分裂症。本发明提供了新的诊断标记和测定，以及用于开发和发现可用于治疗患有精神疾病的患者的药剂和化合物的研究工具。

7. 发明授权

US4432079A Synchronous/asynchronous independent single sideband acoustic telemetry 失效
标题翻译：同步/异步独立单边带声学遥测
公开(公告)号：US4432079A
公开(公告)日：1984-02-14
申请号：US317357
申请日：1981-11-02
申请人： Gerald R. Mackelburg , Stanley J. Watson , Alan Gordon
发明人： Gerald R. Mackelburg , Stanley J. Watson , Alan Gordon
IPC分类号： H04B1/68 , H04B11/00 , H04J1/04
CPC分类号： H04B1/68 , H04B11/00 , H04J1/04
摘要： An undersea communications system provides for improved data transmission pabilities. Two separate sources of information respectively modulate the upper and the lower sidebands of an acoustic carrier. The discretely modulated sidebands are simultaneously transmitted without the acoustic carrier or the acoustic carrier can be added to allow asynchronous or synchronous demodulation and use of the two modulating informations. Separation of the information in the two discretely modulated sidebands is assured by shifting the modulating information to ultrasonic regions and filtering out upper and lower sidebands of modulating information. Next, the shifted sidebands are modulated by an acoustic carrier which, optionally, is transmitted along with the discretely modulated upper and lower sidebands. A phase locked loop in the receiver portion assures synchronous demodulation or a crystal oscillator allows asynchronous demodulation of the discretely modulated upper and lower sidebands.
摘要翻译：海底通信系统提供改进的数据传输能力。两个独立的信息源分别调制声载波的上边带和下边带。离散调制的边带在没有声载波或声载波的情况下被同时传输，以允许异步或同步解调和使用两个调制信息。通过将调制信息移动到超声波区域并滤除调制信息的上边和下边带来确保两个离散调制边带中信息的分离。接下来，移动的边带由声载波调制，声载波可选地与离散调制的上边带和下边带一起传输。接收器部分中的锁相环确保同步解调，或者晶体振荡器允许离散调制的上边带和下边带的异步解调。

8. 发明授权

US3944967A Updated diver navigation device 失效
标题翻译：更新了潜水员导航设备
公开(公告)号：US3944967A
公开(公告)日：1976-03-16
申请号：US535542
申请日：1974-12-23
申请人： Robert S. Acks , Stanley J. Watson , Howard B. McCracken
发明人： Robert S. Acks , Stanley J. Watson , Howard B. McCracken
IPC分类号： G01S3/808 , G01S3/80
CPC分类号： G01S3/8083 , Y10S367/91
摘要： In a diver's navigation system employing a receiver having three equal, alarly disposed hydrophone locations, a digital signal processing circuit is employed which receives frequency shift keyed digital data from remote beacons. Circuitry is provided to process this data to derive a bearing indication to the beacon.
摘要翻译：在潜水员的导航系统中，采用具有三个相等的，角度设置的水听器位置的接收器，采用数字信号处理电路，其从远程信标接收频移键控的数字数据。提供电路以处理该数据以导出信标的方位指示。

9. 发明授权

US4905211A Precision doppler effect compensator 失效
标题翻译：精密多普勒效应补偿器
公开(公告)号：US4905211A
公开(公告)日：1990-02-27
申请号：US326951
申请日：1989-03-22
申请人： Gerald R. Mackelburg , Stanley J. Watson , Jayson T. Durham , Alan Gordon
发明人： Gerald R. Mackelburg , Stanley J. Watson , Jayson T. Durham , Alan Gordon
IPC分类号： H04B11/00
CPC分类号： H04B11/00 , Y10S367/904
摘要： A precision Doppler effect compensator provides Doppler compensation in astic transmission by simultaneously sending a known reference signal with an information signal. The information signal and reference signal undergo identical Doppler effects. The compensator uses the Doppler shifted reference signal to sample the analog Doppler affected information signal. The analog information signals are digitally converted and stored in a first in first out shift register. The samples are read out of the FIFO at a rate corresponding to the frequency of a non-Doppler shifted reference signal so as to precisely reconstruct the information signal as transmitted. The samples read from the FIFO are reconverted from digital to analog form to be presented to a receiving modem for further information processing.
摘要翻译：精密多普勒效应补偿器通过同时发送具有信息信号的已知参考信号来提供声传播中的多普勒补偿。信息信号和参考信号经历相同的多普勒效应。补偿器使用多普勒偏移参考信号对模拟多普勒影响的信息信号进行采样。模拟信息信号被数字转换并存储在先进先出移位寄存器中。样本以与非多普勒偏移的参考信号的频率相对应的速率从FIFO读出，以便精确地重构所发送的信息信号。从FIFO读取的样本从数字模式转换为模拟形式，以呈现给接收调制解调器以进一步进行信息处理。

10. 发明授权

US5029143A Shaft rub simulator 失效
标题翻译：轴摩擦模拟器
公开(公告)号：US5029143A
公开(公告)日：1991-07-02
申请号：US654307
申请日：1976-02-02
申请人： Howard B. McCracken , Robert S. Acks , Stanley J. Watson
发明人： Howard B. McCracken , Robert S. Acks , Stanley J. Watson
IPC分类号： G10K15/02
CPC分类号： G10K15/02 , B63G13/02 , B63G7/08 , B63G9/00
摘要： A synthesizer for complex acoustic signatures includes a generator for an ectrical analog of a complex acoustic waveform corresponding the the "shaft rub" noise produced by the interaction of a marine propeller shaft and a stern tube or other through-the-hull marine fitting. This circuitry employs digital random generators to produce a nonrecurring characteristic signal synthesizing this acoustic noise. An arrangement to process this signal with other simulation circuitry is also disclosed.
摘要翻译：用于复合声学特征的合成器包括一个复合声波波形的电子模拟的发生器，该复合声波对应于由船用螺旋桨轴与船尾管或其他船体海上配件的相互作用产生的“轴摩擦”噪声。该电路使用数字随机发生器来产生合成这种声学噪声的非复现特征信号。还公开了用其他仿真电路处理该信号的装置。

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