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1. 发明授权

US08688230B2 System comprising a box for implanting in a body part 有权
标题翻译：系统包括用于植入身体部位的盒子
公开(公告)号：US08688230B2
公开(公告)日：2014-04-01
申请号：US13265408
申请日：2010-04-21
申请人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
发明人： Michel Gerardus Pardoel , Michel Marcel Jose Decre , Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jozef Elisabeth Franciscus Gootzen , Jeroen Jacob Arnold Tol
IPC分类号： A61N1/08
CPC分类号： A61N1/375 , A61N1/0529 , A61N1/0539 , A61N1/37229
摘要： A system (102) comprising a box (104) for implanting in a mammal body part (106), which box is provided with a first electrical contact (110, 121, 114, 116, 118, 120), and a module (108) for accommodating in the box, which module is provided with a second electrical contact (122, 124, 126) for cooperation with said first electrical contact. The first electrical contact and the second electrical contact are mutually movable, at least in a stationary accommodation of the module in the box, between a contact position in which said first and second electrical contacts are electrically connected, and a non-contact position in which said first and second electrical contacts are separated from each other.
摘要翻译：一种系统（102），包括用于植入哺乳动物体部分（106）中的盒（104），所述盒设置有第一电触头（110,121,114,116,118,120）和模块（108 ），用于容纳在盒中，该模块设置有用于与所述第一电触点配合的第二电触点（122,124,126）。所述第一电触点和所述第二电接触件至少在所述模块在所述模块的静态容纳部中，在所述第一和第二电触点电连接的触点位置和非接触位置之间，所述第一和第二电触点彼此分离。

2. 发明申请

US20110184492A1 SYSTEM AND METHOD FOR COMMUNICATING INFORMATION BETWEEN IMPLANTABLE DEVICES 有权
标题翻译：用于在可移植设备之间传递信息的系统和方法
公开(公告)号：US20110184492A1
公开(公告)日：2011-07-28
申请号：US13054857
申请日：2009-07-22
申请人： Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jeroen Jacob Arnold Tol
发明人： Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jeroen Jacob Arnold Tol
IPC分类号： A61N1/36
CPC分类号： A61N1/37288 , A61N1/362 , A61N1/37252
摘要： A system for communicating information between at least two medical devices implanted within the body of a subject using volume conduction of electrical signals as a means of communication and wherein one of the implanted medical devices is configured to provide electrical stimulation to the tissue is disclosed. The system comprises a first implant device having at least two transmit electrodes configured to transmit electrical stimulation pulses, wherein one of the electrodes may be a common return electrode, an encoding means configured to employ a channel as a transmitter transmission medium for stimulation pulses and encoding the information into the stimulation pulses, a second implant device having at least two receive electrodes configured to receive the transmitted stimulation pulses with encoded information, and a decoding means configured to decode the information encoded into the stimulation pulses. The disclosed system provides reliable and efficient communication between implantable receiver devices.
摘要翻译：公开了一种系统，用于在作为通信手段的电信号的体积传导之间在植入物体内的至少两个医疗设备之间传送信息，并且其中植入的医疗设备中的一个被配置为向组织提供电刺激。所述系统包括具有至少两个发射电极的第一注入装置，所述至少两个发射电极被配置为传输电刺激脉冲，其中所述电极中的一个可以是公共返回电极，编码装置被配置为使用通道作为用于刺激脉冲的发射器传输介质和编码将信息输入到刺激脉冲中，具有至少两个接收电极的第二植入装置，所述接收电极被配置为用编码信息接收所发送的刺激脉冲;以及解码装置，被配置为对编码为刺激脉冲的信息进行解码。所公开的系统在可植入接收器设备之间提供可靠和有效的通信。

3. 发明授权

US09248301B2 System and method for communicating information between implantable devices 有权
标题翻译：用于在可植入装置之间传递信息的系统和方法
公开(公告)号：US09248301B2
公开(公告)日：2016-02-02
申请号：US13054857
申请日：2009-07-22
申请人： Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jeroen Jacob Arnold Tol
发明人： Hubert Cécile François Martens , Franciscus Paulus Maria Budzelaar , Jeroen Jacob Arnold Tol
IPC分类号： A61N1/362 , A61N1/372
CPC分类号： A61N1/37288 , A61N1/362 , A61N1/37252
摘要： A system for communicating information between at least two medical devices implanted within the body of a subject using volume conduction of electrical signals as a means of communication and wherein one of the implanted medical devices is configured to provide electrical stimulation to the tissue is disclosed. The system comprises a first implant device having at least two transmit electrodes configured to transmit electrical stimulation pulses, wherein one of the electrodes may be a common return electrode, an encoding means configured to employ a channel as a transmitter transmission medium for stimulation pulses and encoding the information into the stimulation pulses, a second implant device having at least two receive electrodes configured to receive the transmitted stimulation pulses with encoded information, and a decoding means configured to decode the information encoded into the stimulation pulses. The disclosed system provides reliable and efficient communication between implantable devices.
摘要翻译：公开了一种系统，用于在作为通信手段的电信号的体积传导之间在植入物体内的至少两个医疗设备之间传送信息，并且其中植入的医疗设备中的一个被配置为向组织提供电刺激。所述系统包括具有至少两个发射电极的第一注入装置，所述至少两个发射电极被配置为传输电刺激脉冲，其中所述电极中的一个可以是公共返回电极，编码装置被配置为使用通道作为用于刺激脉冲的发射器传输介质和编码将信息输入到刺激脉冲中，具有至少两个接收电极的第二植入装置，所述接收电极被配置为用编码信息接收所发送的刺激脉冲;以及解码装置，被配置为对编码为刺激脉冲的信息进行解码。所公开的系统在可植入装置之间提供可靠和有效的通信。

4. 发明申请

US20130030500A1 Method and System for Determining Settings for Deep Brain Stimulation 有权
标题翻译：用于确定深脑刺激设置的方法和系统
公开(公告)号：US20130030500A1
公开(公告)日：2013-01-31
申请号：US13581484
申请日：2011-02-25
申请人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
发明人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (η)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译：提供一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与相应的V场之间的关系。脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。所述方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于在n个刺激之一的每个测试电流电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为2个与脑刺激探针（10）的刺激电极（11）的数量之间的数字，导出耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵刺激设置与相应V字段之间的关系。

5. 发明授权

US08929992B2 Method and system for determining settings for deep brain stimulation 有权
标题翻译：用于确定深部脑刺激设置的方法和系统
公开(公告)号：US08929992B2
公开(公告)日：2015-01-06
申请号：US13581484
申请日：2011-02-25
申请人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
发明人： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decre , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
IPC分类号： A61N1/36 , A61N1/05 , A61N1/00
CPC分类号： A61N1/36139 , A61N1/00 , A61N1/0534 , A61N1/36185
摘要： A method and a control system (20) are provided for determining a relation between stimulation settings for a brain stimulation probe (10) and a corresponding V-field. The brain stimulation probe (10) comprises multiple stimulation electrodes (11). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (11). The method comprises sequentially applying a test current to n stimulation electrodes (11), n being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), for each test current at one of the n stimulation electrodes (11), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes (11) of the brain stimulation probe (10), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (η)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (11), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
摘要翻译：提供一种方法和控制系统（20），用于确定脑刺激探针（10）的刺激设置与相应的V场之间的关系。脑刺激探针（10）包括多个刺激电极（11）。 V场是围绕刺激电极（11）的脑组织中的电场。所述方法包括对n个刺激电极（11）依次施加测试电流，n是在刺激探针（10）的刺激电极（11）的数量之间的数量，对于在n个刺激之一的每个测试电流电极（11），根据刺激设置和所测量的激发电压，测量m个刺激电极处的所得激励电压，m为2个与脑刺激探针（10）的刺激电极（11）的数量之间的数字，导出耦合矩阵中的元素（q，p），反映两个刺激电极（11）之间的电阻抗的量，并且使用用于确定的耦合矩阵刺激设置与相应V字段之间的关系。

6. 发明申请

US20110128841A1 MULTI-SPEED RECORDING FOR MULTI-LAYER DISC 失效
标题翻译：多层盘的多速记录
公开(公告)号：US20110128841A1
公开(公告)日：2011-06-02
申请号：US13017234
申请日：2011-01-31
申请人： Ronald Joseph Antonius Van Den Oetelaar , Hubert Cécile François Martens , Wilhelmus Robert Koppers , Pierre Hermanus Woerlee
发明人： Ronald Joseph Antonius Van Den Oetelaar , Hubert Cécile François Martens , Wilhelmus Robert Koppers , Pierre Hermanus Woerlee
IPC分类号： G11B7/24
CPC分类号： G11B7/0045 , G11B7/00456 , G11B7/00736 , G11B7/24038 , G11B2007/0013
摘要： The present invention relates to a recording apparatus, record carrier and method of recording data on at least two layers of a recording medium by using a radiation power, wherein individual recording speeds are determined for respective ones of the at least two layers at different values of the radiation power. A recording speed to be used for recording on an individual one of the at least two recording layers is selected based on a maximum radiation power specified for the recording operation, and the speed of the recording operation is controlled individually for each of the at least two layers based on the selected recording speed. The determination of the individual recording speeds at different radiation power values may be written or embossed on the record carrier. Furthermore, a recording sequence used for recording on the recording layers can be set based on the sensitivities and thus recording speeds. Thereby, total recording time can be minimized for multi-layer recording media.
摘要翻译：本发明涉及一种通过使用辐射功率在至少两层记录介质上记录数据的记录装置，记录载体和方法，其中针对所述至少两个层中的不同值确定各个记录速度辐射功率。基于为记录操作指定的最大辐射功率来选择用于记录在至少两个记录层中的单个记录层上的记录速度，并且对于至少两个记录层中的每一个单独地控制记录操作的速度基于所选记录速度的层。在不同辐射功率值下的单个记录速度的确定可以被写入或压印在记录载体上。此外，可以基于灵敏度和因此记录速度来设置用于记录层上的记录的记录顺序。因此，对于多层记录介质，总记录时间可以最小化。

7. 发明授权

US07397734B2 Apparatus and method for recording an information on a recordable optical record carrier using oval spot profile 失效
标题翻译：使用椭圆形光斑轮廓在可记录光学记录载体上记录信息的装置和方法
公开(公告)号：US07397734B2
公开(公告)日：2008-07-08
申请号：US10537065
申请日：2003-11-06
申请人： Hubert Cécile François Martens , Erwin Rinaldo Meinders
发明人： Hubert Cécile François Martens , Erwin Rinaldo Meinders
IPC分类号： G11B7/00
CPC分类号： B82Y10/00 , G11B7/1369 , G11B7/139 , G11B7/1398
摘要： A method and a corresponding apparatus for recording an information on a recordable optical record carrier (2) by irradiation of a light beam through an optical system (3-7) onto said record carrier (2) for forming marks and lands representing said information along an information recording direction (t), obtains a higher recording density, and thus higher data capacity, by using astigmatism for influencing the light beam from the light source (8) to the record carrier (2) during recording of information so as to obtain a light beam having a substantially oval spot profile having a shorter axis in the information recording direction (t), i.e., the tangential direction for an optical disc, compared to the direction (r) orthogonal thereto, i.e., the radial direction.
摘要翻译：一种用于通过将光束通过光学系统（3-7）照射到所述记录载体（2）上来记录可记录光学记录载体（2）上的信息的方法和相应装置，用于形成表示所述信息的标记和平台信息记录方向（t）通过在记录信息期间通过使用用于影响从光源（8）到记录载体（2）的光束的散光来获得更高的记录密度，从而获得更高的数据容量，从而获得与沿其正交的方向（r）相比，具有在信息记录方向（t）上具有较短轴线的基本上椭圆形的光斑轮廓，即光盘的切线方向。

8. 发明申请

US20120303089A1 Method and System for Determining Settings for Deep Brain Stimulation 有权
标题翻译：用于确定深脑刺激设置的方法和系统
公开(公告)号：US20120303089A1
公开(公告)日：2012-11-29
申请号：US13575965
申请日：2011-02-02
申请人： Hubert Cécile François Martens , Michel Marcel Jose Decré , Kevin Thomas Dolan
发明人： Hubert Cécile François Martens , Michel Marcel Jose Decré , Kevin Thomas Dolan
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61N1/36082 , A61N1/36185
摘要： A method and control system for determining and applying stimulation settings for a brain stimulation probe (10, 12) is provided. The brain stimulation probe (10, 12) comprises a plurality of stimulation electrodes (11). The method comprises for multiple stimulation electrodes (11) of the plurality of stimulation electrodes (11): applying a test current and determining a corresponding patient response, determining a volume of influence based (32, 52, 71, 91) on the test current and a position of the stimulation electrode (11), combining the volume of influence (32, 52, 71, 91) and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence (32, 52, 71, 91) to an anatomic structure (33, 43, 53), and determining an intersection (41, 51) of the volume of influence (32, 52, 71, 91) and the associated anatomic structure (33, 43, 53). Then, based on the determined intersections (41, 51) an optimal stimulation volume and corresponding stimulation settings for the brain stimulation probe (10, 12) are determined.
摘要翻译：提供了一种用于确定和应用脑刺激探针（10,12）的刺激设置的方法和控制系统。脑刺激探针（10,12）包括多个刺激电极（11）。该方法包括多个刺激电极（11）的多个刺激电极（11）：施加测试电流并确定相应的患者反应，确定基于（32,52,71,91）的测试电流的影响体积以及刺激电极（11）的位置，将影响体积（32,52,71,91）和相应的患者反应与刺激诱导行为的广义解剖学知识相结合，影响体积（32,52,71），91）到解剖结构（33,43,53），并且确定影响体积（32,52,71,91）和相关联的解剖结构（33,43,53）的交叉点（41,51）。然后，基于确定的交叉点（41,51），确定用于脑刺激探针（10,12）的最佳刺激体积和相应的刺激设置。

9. 发明申请

US20120303088A1 System and A Method for Determination of an Orientation of a Biomedical Stimulation Device 审中-公开
标题翻译：系统和一种确定生物医学刺激装置取向的方法
公开(公告)号：US20120303088A1
公开(公告)日：2012-11-29
申请号：US13574719
申请日：2011-01-19
申请人： Patrick Wilhelmus Van Kaam , Johan Gerard Kleibeuker , Hubert Cécile François Martens , Emil-Codrut Toader
发明人： Patrick Wilhelmus Van Kaam , Johan Gerard Kleibeuker , Hubert Cécile François Martens , Emil-Codrut Toader
IPC分类号： A61N1/36
CPC分类号： A61B5/062 , A61N1/0534 , A61N1/36135 , A61N1/36182
摘要： The application relates to a system (1) for determination of an orientation (14) of a biomedical stimulation device (2) in respect to an object (20). The system comprises the first biomedical stimulation device (2) comprising at least two stimulator for elements (4A;4C) and a generator (22) arranged for feeding the stimulator elements (4A;4C) with time-varying electric signals (6A;6C), wherein the time-varying electric signals (6A;6C) differ by a predetermined phase. The system further comprises a sensor device (10) with a known relative position (X;α) with respect to the first biomedical stimulation device (2), arranged for sensing a sensing signal (8) from the stimulator elements (4A;4C), wherein the sensing signal (8) is originated from the time-varying electric signals (6A;6C) from the stimulator elements (4A;4C) and a processor device (12) arranged for determining the orientation (14) of the first biomedical stimulation device (2) based on a sensed phase of the sensing signal (8), phases of the time-varying signals (6A;6C) and the known relative position (X;α). Said system accurately determines the orientation, i.e. angular position, of the biomedical stimulation device in respect to the object. The orientation is also accurately determined when the biomedical stimulation device is implanted in the object. Such a system is relatively cheap. The application also relates to a method for determination of an orientation (14) of a first biomedical stimulation device (2) in respect to an object (20).
摘要翻译：本申请涉及一种用于确定生物医学刺激装置（2）相对于物体（20）的取向（14）的系统（1）。该系统包括第一生物医学刺激装置（2），其包括用于元件（4A; 4C）的至少两个刺激器和布置成用于将刺激元件（4A; 4C）馈送到时变电信号（6A; 6C）的发生器），其中所述时变电信号（6A; 6C）相差预定相位。所述系统还包括相对于所述第一生物医学刺激装置（2）具有已知相对位置（X;α）的传感器装置（10），所述相对位置被设置用于从所述刺激器元件（4A; 4C）感测感测信号（8），其中所述感测信号（8）源自所述刺激器元件（4A; 4C）的时变电信号（6A; 6C）和布置成用于确定所述第一生物医学的方向（14）的处理器装置（12）基于感测信号（8）的感测相位，时变信号（6A; 6C）的相位和已知的相对位置（X;α）的刺激装置（2）。所述系统精确地确定生物医学刺激装置相对于物体的取向，即角位置。当将生物医学刺激装置植入物体时也准确地确定取向。这样的系统相对便宜。本申请还涉及用于确定第一生物医学刺激装置（2）相对于物体（20）的取向（14）的方法。

10. 发明申请

US20120277821A1 High Resolution Electrical Stimulation Leads 有权
标题翻译：高分辨率电刺激引线
公开(公告)号：US20120277821A1
公开(公告)日：2012-11-01
申请号：US13517473
申请日：2010-12-21
申请人： Hubert Cécile François Martens , Michel Marcel Jose Decré , Emil-Codrut Toader
发明人： Hubert Cécile François Martens , Michel Marcel Jose Decré , Emil-Codrut Toader
IPC分类号： A61N1/36
CPC分类号： A61N1/0534 , A61N1/36082 , A61N1/36182 , A61N1/36185
摘要： System for providing a stimulus comprising a probe with multiple electrodes each capable of providing a particular current to surrounding tissue a generator for providing to each of the electrodes the particular current a controller for controlling the generator to provide current to the electrodes to achieve a desired electrical field around the probe.
摘要翻译：用于提供刺激的系统，其包括具有多个电极的探针，每个电极能够向周围组织提供特定的电流，用于向每个电极提供特定电流，用于控制发电机以向电极提供电流以实现期望的电探头周围的场。

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