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1. 发明申请

US20050081750A1 Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates 有权
$Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates$
公开(公告)号：US20050081750A1
公开(公告)日：2005-04-21
申请号：US10975190
申请日：2004-10-28
申请人： Huakun Xu , Laurence Chow , Shozo Takagi , Frederick Eichmiller
发明人： Huakun Xu , Laurence Chow , Shozo Takagi , Frederick Eichmiller
IPC分类号： A61F2/00 , A61F2/02 , A61F2/28 , A61F2/30 , A61L27/42 , C04B12/02 , C04B28/34
CPC分类号： A61L27/425 , A61F2/28 , A61F2/30965 , A61F2002/2835 , A61F2002/30032 , A61F2002/30062 , A61F2002/30069 , A61F2002/30971 , A61F2210/0004 , A61F2250/003 , A61F2310/00293 , A61L2430/02
摘要： A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.

2. 发明申请

US20060270752A1 Dental releasing materials 审中-公开
公开(公告)号：US20060270752A1
公开(公告)日：2006-11-30
申请号：US11439850
申请日：2006-05-24
申请人： Huakun Xu , Limin Sun , Shozo Takagi , Laurence Chow
发明人： Huakun Xu , Limin Sun , Shozo Takagi , Laurence Chow
IPC分类号： A61K6/08
CPC分类号： A61L27/54 , A61L27/44 , A61L2300/112 , A61L2300/624 , A61L2400/12
摘要： Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

3. 发明申请

US20070123604A1 Dental releasing materials 审中-公开
标题翻译：牙齿释放材料
公开(公告)号：US20070123604A1
公开(公告)日：2007-05-31
申请号：US11138182
申请日：2005-05-26
申请人： Huakun Xu , Limin Sun , Shozo Takagi , Laurence Chow
发明人： Huakun Xu , Limin Sun , Shozo Takagi , Laurence Chow
IPC分类号： A61K6/08
CPC分类号： A61K6/033 , A61K6/0017 , A61K6/0023 , A61K6/083 , C08L33/00
摘要： The present invention relates to methods and compositions of dental materials containing nano-sized calcium phosphate and other fillers that release calcium, phosphate and fluoride. This invention further relates to dental compositions for restorations, stress-bearing applications, artificial crowns, anterior and posterior tooth fillings, adhesives, cavity liners, cements, bases, orthodontic devices, prostheses, and sealants utilizing high stress-bearing materials that release materials for the remineralization of decayed tooth structures.
摘要翻译：本发明涉及含有纳米级磷酸钙和其他释放钙，磷酸盐和氟化物的填料的牙科材料的方法和组合物。本发明还涉及用于修复的牙科用组合物，应力承载应用，人造冠，前后牙填充物，粘合剂，腔衬，水泥，基底，矫正装置，假体和使用高应力承载材料的密封剂，衰变的牙结构的再矿化。

4. 发明申请

US20060171904A1 Enhanced anti-carious dentifrices, rinses, lozenges, candies and chewing gums and methods of using same 有权
公开(公告)号：US20060171904A1
公开(公告)日：2006-08-03
申请号：US11048445
申请日：2005-02-01
申请人： Gerald Vogel , Laurence Chow , Shozo Takagi
发明人： Gerald Vogel , Laurence Chow , Shozo Takagi
IPC分类号： A61K8/21 , A61K8/30
CPC分类号： A61K8/19 , A61K8/21 , A61K8/30 , A61K2800/5922 , A61Q11/00
摘要： Mouth rinses, dentifrices, lozenges, confections, chewing gums, and similar delivery vehicles containing non-toxic soluble calcium are used prior to administration of a fluoride-containing composition to increase the effectiveness of the fluoride therapy. An effective amount of calcium is released into the oral cavity and allowed to penetrate into the oral tissue. Calcium-bound fluoride deposits form in the oral tissue upon subsequent administration of the fluoride-containing composition to provide increased salivary, plaque and oral tissue fluoride concentrations.

5. 发明申请

US20070098652A1 Fluoride-Calcium Compositions, Dental Products, and Methods for Providing Dental Fluoride 有权
标题翻译：氟化钙组合物，牙科产品和提供牙科氟化物的方法
公开(公告)号：US20070098652A1
公开(公告)日：2007-05-03
申请号：US11552414
申请日：2006-10-24
申请人： Laurence Chow , Shozo Takagi
发明人： Laurence Chow , Shozo Takagi
IPC分类号： A61K8/30 , A61K8/21
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/24
摘要： Disclosed are dental compositions and methods. In accordance with one embodiment, a dental composition includes calcium, fluorine, which is generally present in the form of fluoride, and phosphate or another stabilizing anion. The composition is stable as against precipitation of calcium fluoride during transport and storage, but is unstable against the precipitation of calcium fluoride in the oral cavity of a human. In many embodiments, the amount of fluoride may be less than the amount of fluoride used in a comparable composition intended for a similar purpose. A dental method comprises applying the composition to the oral cavity of a patient, whereupon calcium fluoride precipitates from the composition.
摘要翻译：公开了牙科用组合物和方法。根据一个实施方案，牙科用组合物包括通常以氟化物形式存在的钙，氟，磷酸盐或其它稳定阴离子。该组合物在运输和储存期间对于氟化钙的沉淀是稳定的，但是对于人体口腔中氟化钙的沉淀是不稳定的。在许多实施方案中，氟化物的量可以小于用于类似目的的类似组合物中使用的氟化物的量。牙科方法包括将组合物施用于患者的口腔，由此氟化钙从组合物中沉淀出来。

6. 发明申请

US20070092856A1 Dental and Endodontic Filling Materials and Methods 有权
标题翻译：牙科和牙髓填充材料和方法
公开(公告)号：US20070092856A1
公开(公告)日：2007-04-26
申请号：US11550543
申请日：2006-10-18
申请人： Laurence Chow , Shozo Takagi
发明人： Laurence Chow , Shozo Takagi
IPC分类号： A61C5/00
CPC分类号： A61C5/50 , A61K6/0038
摘要： Disclosed are endodontic filling materials and methods. A method for filling a dental root canal may include providing a hydrosetting filling material and inserting the hydrosetting filling material into the dental root canal, the material setting in the root canal to form a biocompatible filling. The hydrosetting filling material comprises a hydrogel former and a filler. The hydrogel former is at least one of a reactive organic hydrogel formers, an inorganic hydrogel formers, and a non-reactive organic hydrogel formers, and the filler is at least one of a self-hardening and a non-hardening filler. Plural filling material precursor compositions that collectively contain hydrogel formers and fillers may be provided.
摘要翻译：公示的是根管填充材料和方法。用于填充牙根管的方法可以包括提供水合物填充材料，并将水合物填充材料插入牙根管，根管中设置的材料以形成生物相容的填充物。水凝胶填充材料包括水凝胶形成剂和填料。水凝胶形成剂是反应性有机水凝胶形成剂，无机水凝胶形成剂和非反应性有机水凝胶形成剂中的至少一种，填料是自硬化和非硬化填料中的至少一种。可以提供集体含有水凝胶形成剂和填料的多种填充材料前体组合物。

7. 发明申请

US20070092580A1 Dual-Phase Cement Precursor Systems for Bone Repair 有权
标题翻译：用于骨修复的双相水泥前体系统
公开(公告)号：US20070092580A1
公开(公告)日：2007-04-26
申请号：US11550586
申请日：2006-10-18
申请人： Laurence Chow , Shozo Takagi
发明人： Laurence Chow , Shozo Takagi
IPC分类号： A61K33/42
CPC分类号： A61K33/42 , A61L27/12 , A61L27/425 , A61L27/427 , A61L27/46 , A61L27/54 , A61L2300/252 , A61L2300/60
摘要： Disclosed are dual-phase cement precursor systems and related methods and kits. The cement precursor systems are composed of a first and second discrete phases, at least one of which is aqueous. When combined, the cement precursor phases form a cement that is suitable as a bone graft material for bone repair procedures. In preferred embodiments, the materials are highly biocompatible, osteoinductive, and bioresorbable. A number of different but not mutually exclusive cement chemistries may be employed in the cement precursor systems. For instance, hydrogel-forming polymer cements, carboxyl/calcium cements, or calcium phosphate cements may be employed.
摘要翻译：公开了双相水泥前体体系及相关方法和试剂盒。水泥前体体系由第一和第二离散相组成，其中至少一个是水性的。当组合时，水泥前体相形成适合作为骨修复程序的骨移植材料的水泥。在优选的实施方案中，所述材料是高生物相容性的，骨诱导性的和生物可再吸收的。在水泥前体体系中可以使用许多不同但不相互排斥的水泥化学物质。例如，可以使用水凝胶形成聚合物水泥，羧基/钙水泥或磷酸钙水泥。

8. 发明申请

US20060263443A1 Premixed self-hardening bone graft pastes 有权
标题翻译：预混自硬骨移植膏
公开(公告)号：US20060263443A1
公开(公告)日：2006-11-23
申请号：US10552337
申请日：2004-03-11
申请人： Laurence Chow , Shozo Takagi
发明人： Laurence Chow , Shozo Takagi
IPC分类号： A61K33/42
CPC分类号： C04B28/344 , A61K31/19 , A61K33/06 , A61K33/42 , A61L27/12 , A61L27/46 , A61L2400/06 , C04B2111/00836 , C04B24/02 , C04B24/045 , C04B24/06 , C04B24/14 , C04B24/32 , C04B24/38 , C04B24/383 , C04B40/065 , A61K2300/00
摘要： A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders, liquid glycerol, organic acid and gelling agent. The paste is stable, resistant to washout and will harden upon exposure to water. Physical characteristics of the paste, including consistency, porosity, and hardening time, are controlled by the choice and ratio of constituents.
摘要翻译：糊状形式的骨或牙植入材料包括磷酸钙和/或含钙粉末，液体甘油，有机酸和胶凝剂的混合物。糊状物是稳定的，耐冲洗，并在暴露于水中时硬化。浆料的物理特性，包括稠度，孔隙率和硬化时间，均由组分的选择和比例控制。

9. 发明申请

US20050074415A1 Rapid-hardening calcium phosphate cement compositions 有权
标题翻译：快速硬化磷酸钙水泥组合物
公开(公告)号：US20050074415A1
公开(公告)日：2005-04-07
申请号：US10941443
申请日：2004-09-15
申请人： Laurence Chow , Shozo Takagi
发明人： Laurence Chow , Shozo Takagi
IPC分类号： A61K6/00 , A61K6/097 , A61L24/02 , A61L27/12 , C04B28/34 , C01B25/32 , A61K7/16 , A61K33/42
CPC分类号： A61L24/02 , A61K6/0038 , A61K6/0067 , A61K6/033 , A61K6/0625 , A61K6/0643 , A61K6/0668 , A61K6/0675 , A61K6/097 , A61L27/12 , C04B28/34 , C04B28/344 , C04B28/346 , C04B2103/10 , C04B2111/00836 , C04B14/28 , C04B20/008 , C04B22/064 , C04B22/143 , C04B24/003 , C04B24/06 , C04B38/02 , C04B40/0028 , C04B40/0082 , C04B40/0259 , C04B2103/42 , C04B2103/445 , C04B24/38 , C04B24/383 , C04B22/085 , C04B22/122 , C04B24/04 , C08L5/08 , C08L5/04 , C08L1/286 , C08L1/284
摘要： A bone or dental implant material in the form of a paste includes a mixture of calcium phosphate and/or calcium-containing powders and a solution that is (1) an acidic calcium phosphate solution saturated with respect to one or more calcium phosphate compounds, (2) a concentrated acid solution, or (3) salt solutions with a cationic component other than calcium. The paste is stable, resistant to washout and will form hydroxyapatite and harden relatively rapidly to a cement.
摘要翻译：糊状形式的骨或牙科植入材料包括磷酸钙和/或含钙粉末的混合物和（1）相对于一种或多种磷酸钙化合物饱和的酸性磷酸钙溶液的溶液（ 2）浓酸溶液，或（3）除钙以外的阳离子成分的盐溶液。糊状物稳定，耐冲洗，并形成羟基磷灰石，并相对于水泥硬化。

10. 发明申请

US20050249654A1 Nanostructured bioactive mateials prepared by spray drying techniques 有权
标题翻译：通过喷雾干燥技术制备的纳米结构生物活性物质
公开(公告)号：US20050249654A1
公开(公告)日：2005-11-10
申请号：US11100218
申请日：2005-04-06
申请人： Laurence Chow
发明人： Laurence Chow
IPC分类号： A61K6/06 , A61L27/12 , C01B25/26 , C01B25/32 , C01B25/455
CPC分类号： C01B25/32 , A61K6/0008 , A61K6/0017 , A61K6/0038 , A61K6/0073 , A61K6/033 , A61K6/0643 , A61L27/12 , C01B25/455 , Y10S977/776
摘要： Nano-particles of calcium and phosphorous compounds are made in a highly pure generally amorphous state by spray drying a weak acid solution of said compound and evaporating the liquid from the atomized spray in a heated column followed by collection of the precipitated particles. Hydroxy apetite (HA) particles formed by such apparatus and methods are examples of particle manufacture useful in bone and dental therapies.
摘要翻译：钙和磷化合物的纳米颗粒通过喷雾干燥所述化合物的弱酸溶液并在加热的柱子中蒸发来自雾化喷雾的液体然后收集沉淀的颗粒而以高纯度的通常非晶态制备。通过这种装置和方法形成的羟基磷灰石（HA）颗粒是用于骨和牙科治疗的颗粒制造的实例。

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