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1. 发明授权

US5081246A Compound having vessel smooth muscle relaxation activity 失效
标题翻译：具有血管平滑肌肉松弛活性的化合物
公开(公告)号：US5081246A
公开(公告)日：1992-01-14
申请号：US453623
申请日：1989-12-20
申请人： Horoyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
发明人： Horoyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
CPC分类号： C07D401/12 , C07C311/16 , C07D217/02 , C07D217/10 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.
摘要翻译：具有血管平滑肌松弛活性的新型喹啉磺氨基衍生物以及血小板凝集抑制活性和对蛋白激酶A，肌球蛋白轻链激酶，蛋白激酶C和钙调蛋白依赖性蛋白激酶II的抑制活性，但几乎没有作用或心脏功能; 制备衍生物的方法和含有该衍生物的药物组合物。

2. 发明授权

US5216150A Derivatives of isoquinoline (and naphthalene) sulfonamides 失效
标题翻译：异喹啉（和萘）磺酰胺的衍生物
公开(公告)号：US5216150A
公开(公告)日：1993-06-01
申请号：US758808
申请日：1991-09-12
申请人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
发明人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
CPC分类号： C07D401/12 , C07C311/16 , C07D217/02 , C07D217/10 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.
摘要翻译：具有血管平滑肌松弛活性的新型喹啉磺氨基衍生物以及血小板凝集抑制活性和对蛋白激酶A，肌球蛋白轻链激酶，蛋白激酶C和钙调蛋白依赖性蛋白激酶II的抑制活性，但几乎没有作用或心脏功能; 制备衍生物的方法和含有该衍生物的药物组合物。

3. 发明授权

US5245034A Compound having vessel smooth muscle relaxation activity 失效
标题翻译：具有血管平滑肌松弛活性的化合物
公开(公告)号：US5245034A
公开(公告)日：1993-09-14
申请号：US856178
申请日：1992-03-23
申请人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
发明人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Masatoshi Hagiwara , Tsutomu Inoue , Kenji Naitoh , Osamu Sakuma , Masayuki Yuasa , Tadashi Morita , Tadashi Toshioka , Isao Umezawa , Takashi Inaba
IPC分类号： C07C311/16 , C07D217/02 , C07D217/10 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
CPC分类号： C07D401/12 , C07C311/16 , C07D217/02 , C07D217/10 , C07D401/14 , C07D405/12 , C07D409/12 , C07D491/10
摘要： Novel quinoline sulfonamino derivatives having a vessel smooth muscle relaxation activity as well as a platelet agglutination inhibitory activity and inhibitory activity to protein kinase A, myosin light chain kinase, proteinkinase C, and calmodulindependent proteinkinase II, but having little action or cardio function; a process for the production of the derivatives, and a pharmaceutical composition containing the derivative.
摘要翻译：具有血管平滑肌松弛活性的新型喹啉磺氨基衍生物以及血小板凝集抑制活性和对蛋白激酶A，肌球蛋白轻链激酶，蛋白激酶C和钙调蛋白依赖性蛋白激酶II的抑制活性，但几乎没有作用或心脏功能; 制备衍生物的方法和含有该衍生物的药物组合物。

4. 发明授权

US5059692A Novel compounds exhibiting a vasodilating activity and inhibitory activity for platelet aggregation 失效
标题翻译：新型化合物展示血小板聚集的血管活性和抑制活性
公开(公告)号：US5059692A
公开(公告)日：1991-10-22
申请号：US574730
申请日：1990-08-30
申请人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Tsutomu Inoue , Masayuki Yuasa , Takashi Inaba , Kenji Naito , Osamu Sakuma , Tadashi Morita , Shinpei Kidokoro
发明人： Hiroyoshi Hidaka , Tomohiko Ishikawa , Tsutomu Inoue , Masayuki Yuasa , Takashi Inaba , Kenji Naito , Osamu Sakuma , Tadashi Morita , Shinpei Kidokoro
IPC分类号： C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D495/14
摘要： Novel compounds represented by the formula: ##STR1## wherein R.sub.1 represents an alkyl group having 1 to 3 carbon atoms, R.sub.2 represents an amino group or a group of formula ##STR2## in which R.sub.4 represents an alkyl group having 1 to 3 carbon atoms, R.sub.5 represents an alkyl group having 1 to 3 carbon atoms or may combine with R.sub.6 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.6 represents a hydrogen atom or may combine with R.sub.5 to form a five or six membered ring containing 4 to 5 carbon atoms, R.sub.3 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a halogen atom, X represents a carbonyl group or a methylene group, Y represents a sulfur atom or a vinylene group and pharmaceutically acceptable salts thereof which exhibit a vasodilating activity and inhibitory activity for platelet aggregation. Thus, they are useful as therapeutic agents for treatment of angina pectoris, hypertension, throbosis and the like.

5. 发明授权

US5093370A Quaternary ammonium compounds having muscle relaxation activity 失效
标题翻译：具有肌肉松弛活性的季铵化合物
公开(公告)号：US5093370A
公开(公告)日：1992-03-03
申请号：US506862
申请日：1990-04-09
申请人： Masayasu Kimura , Kenji Naito , Osamu Sakuma , Tadashi Morita
发明人： Masayasu Kimura , Kenji Naito , Osamu Sakuma , Tadashi Morita
IPC分类号： A61K31/14 , A61K31/215 , A61P21/02 , C07C43/174 , C07C45/41 , C07C57/34 , C07C57/40 , C07C69/612 , C07C69/618 , C07C205/11 , C07C209/12 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/30 , C07C211/49 , C07C211/63 , C07C215/18 , C07C215/30 , C07C215/40 , C07C217/10 , C07C217/20 , C07C219/22 , C07C225/06 , C07C225/16 , C07C227/18 , C07C229/34 , C07C229/38 , C07C231/12 , C07C233/43 , C07C317/28 , C07C323/25 , C07C323/62 , C07D213/06 , C07D213/16 , C07D295/02 , C07D295/135 , C07D309/12 , C07D339/08
CPC分类号： C07D213/06 , C07C205/11 , C07C211/27 , C07C211/28 , C07C211/29 , C07C211/30 , C07C211/49 , C07C211/63 , C07C215/18 , C07C215/30 , C07C215/40 , C07C217/10 , C07C217/20 , C07C219/22 , C07C225/06 , C07C229/34 , C07C229/38 , C07C233/43 , C07C317/28 , C07C323/25 , C07C323/62 , C07C43/174 , C07C45/41 , C07C69/612 , C07C69/618 , C07D295/135 , C07D309/12 , C07D339/08
摘要： A quaternary ammonium having a muscle relaxation activity compound represented by the formula (I): ##STR1## wherein R.sub.1 represents a methylene, a lower alkylenoxy, a lower alkenylene, a lower alkynylene, --CO--, --COO--, a lower alkylene carbonyloxy, --CH(OR.sub.5)--, a lower alkylenecarbonyl, a hydroxy lower alkylene, --O--, --S--, --SO--, or --SO.sub.2 --; R.sub.2 represents a hydrogen atom, a hydroxy lower alkyl, an aldehyde, a lower alkyl carbonyl, --NO.sub.2, or --NHR.sub.6 ; R.sub.3 represents a hydrogen atom of a group --R.sub.1 --(CH.sub.2).sub.a --[CH(CH.sub.2 A)--CH.sub.2 ].sub.b --A; R.sub.4 represents an anion; R.sub.5 and R.sub.6 represent a hydrogen atom or a acetyl; A represents a quaternary ammonium group; a represents an integer of 1 to 8; b represents 0 or 1; m represents an integer of 1 to 4; and (Z) represents a trivalent benzene ring, a trivalent naphthalene ring, a trivalent diphenyl or a trivalent ethane radical.
摘要翻译：具有式（I）表示的肌肉松弛活性化合物的季铵：其中R1表示亚甲基，低级亚烷基氧基，低级亚烯基，低级亚烷基，-CO-，-COO-，低级亚烷基羰氧基，-CH（OR 5） - ，低级亚烷基羰基，羟基低级亚烷基，-O - ， - S - ， - SO-或-SO 2 - ; R2表示氢原子，羟基低级烷基，醛，低级烷基羰基，-NO2或-NHR6; R3表示-R1-（CH2）a- [CH（CH2A）-CH2] b-A基团的氢原子; R4表示阴离子; R5和R6代表氢原子或乙酰基; A代表季铵基团; a表示1〜8的整数， b表示0或1; m表示1〜4的整数，和（Z）表示三价苯环，三价萘环，三价二苯基或三价乙烷基。

6. 外观设计

USD597864S1 Digital indicating controller 有权
标题翻译：数字指示控制器
公开(公告)号：USD597864S1
公开(公告)日：2009-08-11
申请号：US29312360
申请日：2008-10-16
申请人： Osamu Sakuma , Noriaki Semba
设计人： Osamu Sakuma , Noriaki Semba

7. 发明授权

US4535384A Heat sink for a semiconductor device 失效
标题翻译：散热器用于半导体器件
公开(公告)号：US4535384A
公开(公告)日：1985-08-13
申请号：US620522
申请日：1984-06-12
申请人： Tetsushi Wakabayashi , Norio Honda , Osamu Sakuma
发明人： Tetsushi Wakabayashi , Norio Honda , Osamu Sakuma
IPC分类号： H01L23/36 , H01L23/367 , H05K7/20
CPC分类号： H01L23/367 , H01L2924/0002
摘要： A semiconductor device comprising at least one heat sink joined to a plurality of IC packages mounted on a mother board. Plural individual heat sinks are joined to respectively corresponding IC packages each comprising a central shaft joined to and extending in substantially perpendicular relationship from a respective said package and plural, parallel spaced fins extending outwardly from and in perpendicular relationship to the shaft. A common heat sink for plural IC packages comprises a base board portion, a heat conducting shaft portion arranged perpendicular to the base board portion and a plurality of heat dissipating fins arranged perpendicular to said heat conducting shaft portion and in parallel, spaced relationship to each other, the common heat sink having one or more slits which are formed parallel to and extending through the heat conducting shaft from the base board portion to midway of the height of the heat conducting shaft and defining a plurality of sections of the base board portion, respectively, joined to the plurality of IC packages.
摘要翻译：一种半导体器件，包括连接到安装在母板上的多个IC封装的至少一个散热器。多个独立的散热器连接到分别对应的IC封装，每个封装包括一个中心轴，该中心轴与相应的所述封装相接合并基本垂直地延伸，并且与从轴垂直的方向向外延伸多个平行隔开的翅片。用于多个IC封装的公共散热器包括基板部分，垂直于基板部分布置的导热轴部分和垂直于所述导热轴部分布置并且彼此间隔开的多个散热片所述共用散热器具有一个或多个狭缝，所述狭缝与所述导热轴平行并且从所述基板部分延伸到所述导热轴的高度的中间并且分别限定所述基板部分的多个部分，连接到多个IC封装。

8. 发明申请

US20100152261A1 NOVEL NITROGEN-CONTAINING HETEROCYCLIC COMPOUND 审中-公开
标题翻译：含有氮的杂环化合物
公开(公告)号：US20100152261A1
公开(公告)日：2010-06-17
申请号：US11996922
申请日：2006-07-25
申请人： Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
发明人： Hideyuki Aizawa , Makoto Seki , Jun-ichi Endoh , Minoru Tanaka , Naoto Fujie , Osamu Sakuma , Takao Kamahori
IPC分类号： A61K31/4196 , A61K31/4164 , C07D249/08 , C07D233/66 , C07D233/56 , A61P9/00 , A61P1/00 , A61P11/00 , A61P13/00 , A61P25/00
CPC分类号： C07D233/56 , C07D233/18 , C07D233/60 , C07D233/61 , C07D249/08 , C07D407/06
摘要： A nitrogen-containing heterocyclic derivative represented by the following general formula (I), or a hydrate or solvate thereof, which has a selective antagonistic action on the muscarinic M3 receptor and causes reduced cardiac side effect and thus is safe, and has superior pharmacological efficacy and prolonged action even by inhalation administration, and a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
摘要翻译：由以下通式（I）表示的含氮杂环衍生物或其水合物或溶剂化物，其对毒蕈碱性M3受体具有选择性拮抗作用并引起心脏副作用降低，因此是安全的，并且具有优异的药理功效以及甚至通过吸入给药延长的作用，以及包含该化合物和药学上可接受的载体的药物组合物。

9. 发明授权

US4435772A Interactive graphic system 失效
标题翻译：互动图形系统
公开(公告)号：US4435772A
公开(公告)日：1984-03-06
申请号：US273424
申请日：1981-06-15
申请人： Yoshihiro Suzuki , Shuichi Nakagawa , Nobuhisa Kawamura , Shuichi Kurihara , Osamu Sakuma , Masahiro Ito
发明人： Yoshihiro Suzuki , Shuichi Nakagawa , Nobuhisa Kawamura , Shuichi Kurihara , Osamu Sakuma , Masahiro Ito
IPC分类号： G06F3/13 , G06F3/153 , G06K15/22 , G06T11/20
CPC分类号： G06F3/13
摘要： An interactive graphic system is provided which introduces drawing data step by step in the form of interaction to describe figures, characters, numerical figures or the like with the aid of a microcomputer. The interactive graphic system consists of a keyboard for introducing drawing data, a plotter for recording the figures, a microcomputer, and a memory unit that are constructed as a unitary structure which features small size, reduced cost and enhanced operational performance. Further, the interactive graphic system is so constructed that application software packages can be freely exchanged to diversify the functions.
摘要翻译：提供了一种交互式图形系统，其以相互作用的形式逐步介绍绘图数据，借助于微型计算机来描述图形，字符，数字等。交互式图形系统包括用于引入绘图数据的键盘，用于记录图形的绘图仪，微型计算机和存储单元，其被构造为具有小尺寸，降低成本和增强的操作性能的整体结构。此外，交互式图形系统的构造使得应用软件包可以自由交换以使功能多样化。

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