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1. 发明授权

US08580291B2 Fibrous composite for tissue engineering 有权
标题翻译：组织工程纤维复合材料
公开(公告)号：US08580291B2
公开(公告)日：2013-11-12
申请号：US10507059
申请日：2003-03-14
申请人： Hoon Choi , I. Wei Chen
发明人： Hoon Choi , I. Wei Chen
IPC分类号： A61K9/70 , A61F2/00
CPC分类号： A61L27/56 , A61L27/025 , A61L27/18 , A61L27/446 , A61L27/58 , C08L67/04
摘要： Provided are fibrous composites prepared by methods of the present invention, comprising oxides and biodegradable polymers, in which the fibers are made of aerogel-like oxide materials having nanometer-sized pores. The fibrous composition advantageously has, at least, the following characteristics: (i) a very high nanoporous surface area, which also permits nucleation of crystallites; (ii) mesoporous/macroporous interspacial networks between the fibers, providing high bioactivity and a high transport rate; (iii) macropores for natural bone-like tissue growth; (iv) good mechanical properties for handling and for implant support; and (v) biodegradability for implant dissolution and time-variable mechanical properties. Further provided are methods for using the bioactive biodegradable fibrous composites as osteogenic composite materials for tissue engineering, tissue re-growth, bone implants, and bone repair, and/or for the delivery of drugs or therapeutic compounds.
摘要翻译：提供了通过本发明的方法制备的纤维复合材料，其包括氧化物和可生物降解的聚合物，其中纤维由具有纳米尺寸孔的气凝胶状氧化物材料制成。纤维组合物有利地至少具有以下特征：（i）非常高的纳米孔表面积，其也允许微晶成核; （ii）纤维间的介孔/大孔间隙网络，提供高生物活性和高传输速率; （iii）天然骨样组织生长的大孔; （iv）用于处理和植入支持的良好的机械性能; 和（v）植入物溶解和时变机械性能的生物降解性。还提供了使用生物活性生物可降解纤维复合材料作为用于组织工程，组织再生长，骨植入物和骨修复，和/或递送药物或治疗化合物的成骨复合材料的方法。

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