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1. 发明授权

US07745206B2 AFM for simultaneous recognition of multiple factors 有权
标题翻译： AFM同时识别多个因素
公开(公告)号：US07745206B2
公开(公告)日：2010-06-29
申请号：US12022072
申请日：2008-01-29
申请人： Hongda Wang , Stuart Lindsay
发明人： Hongda Wang , Stuart Lindsay
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01Q60/42 , G01Q30/04
摘要： An atomic force microscope and a method for detecting interactions between a probe and two or more sensed agents on a scanned surface and determining the relative location of two or more sensed agents is provided. The microscope has a scanning probe with a tip that is sensitive to two or more sensed agents on said scanned surface; two or more sensing agents tethered to the tip of the probe; and a device for recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the two or more sensed agents on said surface.
摘要翻译：提供了一种原子力显微镜和用于检测探针与扫描表面上的两个或更多个感测到的试剂之间的相互作用并确定两个或更多个感测到的试剂的相对位置的方法。显微镜具有扫描探针，其具有对所述扫描表面上的两个或更多个感测到的试剂敏感的尖端; 两个或更多个感测剂束缚于探针的尖端; 以及用于根据时间，地形图像以及所述探针与所述表面上的两个或更多个感测到的试剂之间的相互作用的空间位置记录所述探针尖端的位移的装置。

2. 发明申请

US20080209989A1 AFM FOR SIMULTANEOUS RECOGNITION OF MULTIPLE FACTORS 有权
标题翻译： AFM同时识别多因素
公开(公告)号：US20080209989A1
公开(公告)日：2008-09-04
申请号：US12022072
申请日：2008-01-29
申请人： Hongda Wang , Stuart Lindsay
发明人： Hongda Wang , Stuart Lindsay
IPC分类号： G01B5/28
CPC分类号： G01Q60/42 , G01Q30/04
摘要： An atomic force microscope and a method for detecting interactions between a probe and two or more sensed agents on a scanned surface and determining the relative location of two or more sensed agents is provided. The microscope has a scanning probe with a tip that is sensitive to two or more sensed agents on said scanned surface; two or more sensing agents tethered to the tip of the probe; and a device for recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the two or more sensed agents on said surface.
摘要翻译：提供了一种原子力显微镜和用于检测探针与扫描表面上的两个或更多个感测到的试剂之间的相互作用并确定两个或更多个感测到的试剂的相对位置的方法。显微镜具有扫描探针，其具有对所述扫描表面上的两个或更多个感测到的试剂敏感的尖端; 两个或更多个感测剂束缚于探针的尖端; 以及用于根据时间，地形图像以及所述探针与所述表面上的两个或更多个感测到的试剂之间的相互作用的空间位置记录所述探针尖端的位移的装置。

3. 发明授权

US08628649B2 Nanopore and carbon nanotube based DNA sequencer and a serial recognition sequencer 有权
标题翻译：纳米孔和基于碳纳米管的DNA测序仪和序列识别测序仪
公开(公告)号：US08628649B2
公开(公告)日：2014-01-14
申请号：US12920809
申请日：2009-03-18
申请人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/327
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/48721 , C12Q2565/631
摘要： The present invention is directed to systems, devices and methods for identifying biopolymers, such as strands of DNA, as they pass through a constriction such as a carbon nanotube nanopore. More particularly, the invention is directed to such systems, devices and methods in which a newly translocated portion of the biopolymer forms a temporary electrical circuit between the nanotube nanopore and a second electrode, which may also be a nanotube. Further, the invention is directed to such systems, devices and methods in which the constriction is provided with a functionalized unit which, together with a newly translocated portion of the biopolymer, forms a temporary electrical circuit that can be used to characterize that portion of the biopolymer.
摘要翻译：本发明涉及用于识别生物聚合物的系统，装置和方法，例如当DNA通过诸如碳纳米管纳米孔的收缩体时，DNA的链。更具体地，本发明涉及这样的系统，装置和方法，其中生物聚合物的新易位部分在纳米管纳米孔和也可以是纳米管的第二电极之间形成临时电路。此外，本发明涉及这样的系统，装置和方法，其中收缩部设置有功能化单元，其与生物聚合物的新易位部分一起形成临时电路，其可用于表征该部分的生物聚合物。

4. 发明申请

US20180299424A1 SYSTEM AND METHOD FOR NUCLEOTIDE SEQUENCING 审中-公开
公开(公告)号：US20180299424A1
公开(公告)日：2018-10-18
申请号：US15524147
申请日：2015-11-10
申请人： Bharath Takulapalli , Stuart Lindsay
发明人： Bharath Takulapalli , Stuart Lindsay
IPC分类号： G01N33/487 , G01N27/414
摘要： The present invention provides a system and method of sequencing complex molecules including DNA, RNA, proteins, and glycans. The method includes the steps of modifying a field effect nanopore transistor device with chemical recognition molecules, translocating the complex molecule into the field effect nanopore transistor device, applying bias potential to the silicon gate of the field effect nanopore transistor device, and measuring the resulting change in drain current across the source drain contacts.

5. 发明申请

US20140162247A1 MOLECULAR TRANSISTOR 审中-公开
标题翻译：分子晶体管
公开(公告)号：US20140162247A1
公开(公告)日：2014-06-12
申请号：US14003851
申请日：2012-03-09
申请人： Stuart Lindsay , Pei Pang , Jin He
发明人： Stuart Lindsay , Pei Pang , Jin He
IPC分类号： G01N27/414
CPC分类号： G01N27/4146 , G01N33/48721
摘要： Fluidic nanotube devices and methods for their use are provided wherein the flow of charged molecules through a channel is controlled by the voltage potential of a gate electrode. In at least some embodiments, a molecular transistor is provided that includes a channel having a diameter such that only one target molecule at a time may traverse the channel. The channel may be a carbon nanotube that is electrically isolated from, and in communication with, a gate electrode. Methods are provided for controlling the flow of an individual molecule through the channel and for detecting a single chemical reaction.
摘要翻译：提供了流动的纳米管装置及其使用方法，其中通过通道的带电分子的流动由栅电极的电压电位来控制。在至少一些实施例中，提供了一种分子晶体管，其包括具有使得一次只能有一个靶分子可以穿过该通道的直径的通道。通道可以是与栅电极电隔离并与栅电极连通的碳纳米管。提供了用于通过通道控制单个分子的流动并用于检测单个化学反应的方法。

6. 发明申请

US20130302901A1 Electrodes for Sensing Chemical Composition 审中-公开
标题翻译：用于感应化学成分的电极
公开(公告)号：US20130302901A1
公开(公告)日：2013-11-14
申请号：US13838727
申请日：2013-03-15
申请人： Stuart Lindsay , Peiming Zhang , Brett Gyarfas , Suman Sen , Shuai Chang , Steven Lefkowitz , Hongbo Peng
发明人： Stuart Lindsay , Peiming Zhang , Brett Gyarfas , Suman Sen , Shuai Chang , Steven Lefkowitz , Hongbo Peng
IPC分类号： G01N27/327
CPC分类号： G01N27/3275 , G01N33/48721 , Y10T156/10 , Y10T436/143333
摘要： Some embodiments of the present disclosure provide methods, devices, and systems for sequencing nucleic acid polymers that utilize palladium (Pd), for example, at least in part, as an electrode material that is (i) functionalized with one or more adaptor molecules and (ii) capable for use to sense one or more chemical compositions.
摘要翻译：本公开的一些实施方案提供了用于测序核酸聚合物的方法，装置和系统，其利用钯（Pd），例如至少部分地作为（i）用一个或多个衔接子分子官能化的电极材料，以及（ii）能够用于感测一种或多种化学成分。

7. 发明申请

US20120288948A1 CONTROLLED TUNNEL GAP DEVICE FOR SEQUENCING POLYMERS 有权
标题翻译：用于测序聚合物的控制隧道缝隙装置
公开(公告)号：US20120288948A1
公开(公告)日：2012-11-15
申请号：US13395956
申请日：2011-01-31
申请人： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
发明人： Stuart Lindsay , Shuai Chang , Jin He , Peiming Zhang , Shuo Huang
IPC分类号： G01N27/00 , C25B7/00 , B82Y5/00
CPC分类号： G01N33/48721 , C12Q1/6869 , G01N27/3275 , Y10T436/143333
摘要： The invention includes compositions, devices, and methods for analyzing a polymer and/or polymer unit. The polymer may be a homo- or hetero-polymer such as DNA, RNA, a polysaccharide, or a peptide. The device includes electrodes that form a tunnel gap through which the polymer can pass. The electrodes are functionalized with a reagent attached thereto, and the reagent is capable of forming a transient bond to a polymer unit. When the transient bond forms between the reagent and the unit, a detectable signal is generated and used to analyze the polymer.
摘要翻译：本发明包括用于分析聚合物和/或聚合物单元的组合物，装置和方法。聚合物可以是均聚物或异质聚合物，例如DNA，RNA，多糖或肽。该装置包括形成隧道间隙的电极，聚合物可通过该间隙通过。电极用附着于其上的试剂进行功能化，并且试剂能够形成与聚合物单元的暂时结合。当试剂和单元之间形成瞬态键时，产生可检测的信号并用于分析聚合物。

8. 发明申请

US20110168562A1 Nanopore and Carbon Nanotube Based DNA Sequencer 有权
标题翻译：纳米孔和碳纳米管的DNA测序仪
公开(公告)号：US20110168562A1
公开(公告)日：2011-07-14
申请号：US12920817
申请日：2009-03-18
申请人： Colin Nuckolls , Jinyao Tang , Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
发明人： Colin Nuckolls , Jinyao Tang , Stuart Lindsay , Jin He , Peiming Zhang , Kevin Reinhart
IPC分类号： G01N27/00 , B32B37/24 , C23F1/00 , B82Y99/00
CPC分类号： G01N33/48721 , C12Q1/6869 , C12Q2565/631
摘要： The present invention provides a device for analyzing the composition of a heteropolymer comprising a carbon nanotube through which the heteropolymer is driven by electrophoresis. The carbon nanotube also serves as one electrode in a reading circuit. One end of the carbon nanotube is held in close proximity to a second electrode, and each end of the carbon nanotube is functionalized with flexibly-tethered chemical-recognition moieties, such that one will bind one site on the emerging polymer, and the second will bind another site in close proximity, generating an electrical signal between the two electrodes when the circuit is completed by the process of chemical recognition.
摘要翻译：本发明提供一种用于分析包含碳纳米管的杂聚物的组成的装置，通过该电极驱动该杂聚物。碳纳米管也用作读取电路中的一个电极。碳纳米管的一端保持靠近第二电极，并且碳纳米管的每一端用柔性系带的化学识别部分功能化，使得将结合新出现的聚合物上的一个位点，而第二个在另一个位置紧密接合，当通过化学识别过程完成电路时，在两个电极之间产生电信号。

9. 发明申请

US20080223121A1 APTAMER PROBE FOR LOCATING MOLECULES AND METHOD OF USE 审中-公开
标题翻译：用于定位分子的APTAMER探针和使用方法
公开(公告)号：US20080223121A1
公开(公告)日：2008-09-18
申请号：US11948960
申请日：2007-11-30
申请人： Liyun Lin , Hao Yan , Yan Liu , Stuart Lindsay
发明人： Liyun Lin , Hao Yan , Yan Liu , Stuart Lindsay
IPC分类号： G01B5/28
CPC分类号： G01Q60/42
摘要： An atomic force microscope and a method for detecting interactions between a probe and at least one sensed agent on a scanned surface is provided. The microscope has a scanning probe with a tip that is sensitive to a property of said scanned surface; a nucleic acid aptamer tethered to the tip of the probe; and a device for simultaneously recording the displacement of said probe tip as a function of time, topographic images, and the spatial location of interactions between said probe and the at least one sensed agent on said surface.
摘要翻译：提供了一种原子力显微镜和用于检测探针与被扫描表面上的至少一个检测到的试剂之间的相互作用的方法。显微镜具有扫描探针，其具有对所述扫描表面的特性敏感的尖端; 连接到探针末端的核酸适配子; 以及用于根据时间，地形图像以及所述探针和所述表面上的所述至少一个感测到的感测剂之间的相互作用的空间位置同时记录所述探针尖端的位移的装置。

10. 发明授权

US5515719A Controlled force microscope for operation in liquids 失效
标题翻译：控制力显微镜在液体中操作
公开(公告)号：US5515719A
公开(公告)日：1996-05-14
申请号：US246035
申请日：1994-05-19
申请人： Stuart Lindsay
发明人： Stuart Lindsay
IPC分类号： B81B3/00 , G01B21/30 , G01Q10/06 , G01Q30/14 , G01Q60/24 , G01Q60/32 , G01B5/28
CPC分类号： G01Q30/14 , G01Q10/06 , G01Q60/38 , B82Y35/00 , Y10S977/863 , Y10S977/865
摘要： An atomic force microscope in which the deflection of the force sensing probe owing to surface forces is canceled by an opposing magnetic force applied to a small magnetic particle on a force sensing cantilever. A deflection of the force sensing cantilever is detected by reflecting a laser beam from the cantilever into a position sensitive detector. The voltage signal from the position sensitive detector is used to drive an integrating servo loop which drives a current in a solenoid placed close to the force sensing cantilever, and exerts a force opposing the atomic force of attraction between the force sensing cantilever and the sample surface via a small magnetic particle attached to the cantilever and having its magnetic moment aligned with the axis of the solenoid. In this way, deflection of the force sensing cantilever is prevented for any force within the range of the servo control system. The driving signal for the cantilever is a measure of the operating force of the microscope and can be used to drive a conventional atomic force microscope controller to generate topographical images of the surface. The system works submerged in water and other liquids and can be used for profiling soft surfaces while avoiding the problem of the force sensing cantilever being pulled into the sample surface by attractive interactions between the sample surface and the force sensing cantilever.
摘要翻译：原子力显微镜，其中由于表面力的力传感探针的偏转被施加到力感测悬臂上的小磁性颗粒的相反的磁力抵消。通过将来自悬臂的激光束反射到位置敏感检测器来检测力感测悬臂的偏转。来自位置敏感检测器的电压信号用于驱动积分伺服回路，其驱动靠近力感测悬臂的螺线管中的电流，并施加与力感测悬臂与样本表面之间的原子吸力相反的力通过附着在悬臂上的小磁性颗粒并使其磁矩与螺线管的轴线对齐。以这种方式，可以防止在伺服控制系统的范围内的力的力传感悬臂的偏转。悬臂的驱动信号是显微镜操作力的量度，可用于驱动常规的原子力显微镜控制器以产生表面的地形图像。该系统工作在淹没在水和其他液体中，可以用于表面软化表面，同时避免通过样品表面和力感测悬臂之间的有吸引力的相互作用将力感测悬臂拉入样品表面的问题。

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