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1. 发明申请

US20060035373A1 Stem cell libraries 审中-公开
标题翻译：干细胞库
公开(公告)号：US20060035373A1
公开(公告)日：2006-02-16
申请号：US11003840
申请日：2004-12-06
申请人： Hongbing Zhang , Lewis Williams , Keting Chu , Fred Cohen
发明人： Hongbing Zhang , Lewis Williams , Keting Chu , Fred Cohen
IPC分类号： C12N5/08 , C12N15/87 , C40B40/02
CPC分类号： C12N5/0606
摘要： A stem cell library is created by genetically modifying stem cells with nucleic acids encoding polypeptides which can promote stem cell differentiation into specific cell types. Alternatively, the stem cell library is exposed to an externally added factor that promotes stem cell differentiation into a desired cell line, e.g., neuronal or muscle. The library is used to determine the effect of the encoded protein on the differentiation process. The library is also used to produce nucleic acids for insertion into embryonic stem cells to produce transfected embryonic stem cells. The nucleic acids are inserted into a locus that permits widespread expression of the encoded polypeptide in animals produced from blastocysts that incorporate the transfected cells. Non-human chimeric animals produced by combining blastocysts derived from animal models of human disease and embryonic stem cells transfected with molecules from the library provide an in vivo system for therapeutic design.
摘要翻译：通过用能够促进干细胞分化成特定细胞类型的多肽的核酸对遗传修饰干细胞产生干细胞文库。或者，干细胞文库暴露于促进干细胞分化成所需细胞系（例如神经元或肌肉）的外部添加因子。该文库用于确定编码的蛋白质对分化过程的影响。该文库还用于生产用于插入胚胎干细胞以产生转染的胚胎干细胞的核酸。将核酸插入到允许编码的多肽在掺入转染细胞的囊胚产生的动物中广泛表达的基因座。通过将源自人类疾病的动物模型的胚泡和来自文库的分子转染的胚胎干细胞组合产生的非人类嵌合动物提供用于治疗设计的体内系统。

2. 外观设计

USD706917S1 Combined ceiling fan and light kit 有权
公开(公告)号：USD706917S1
公开(公告)日：2014-06-10
申请号：US29431999
申请日：2012-09-12
申请人： Fred Cohen
设计人： Fred Cohen

3. 发明申请

US20050182121A1 Thio semicarbazone and semicarbozone inhibitors of cysteine proteases and methods of their use 失效
标题翻译：硫脲缩氨基脲和半胱氨酸蛋白酶的半胱氨酸抑制剂及其使用方法
公开(公告)号：US20050182121A1
公开(公告)日：2005-08-18
申请号：US11084626
申请日：2005-03-18
申请人： Fred Cohen , Xiaohui Du , Chun Guo , James McKerrow
发明人： Fred Cohen , Xiaohui Du , Chun Guo , James McKerrow
IPC分类号： C07C281/14 , C07C337/08 , C07D207/48 , C07D209/14 , C07D231/06 , C07D307/52 , C07D333/22 , C07D333/28 , C07D409/04 , A61K31/415 , A61K31/175 , C07C281/06 , C07C337/06 , C07D43/02
CPC分类号： C07D231/06 , C07C281/14 , C07C337/08 , C07D207/48 , C07D209/14 , C07D307/52 , C07D333/22 , C07D333/28 , C07D409/04
摘要： The present invention relates to thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of using such compounds to prevent and treat protozoan infections such as trypanosomiasis, malaria and leishmaniasis. The compounds also find use in inhibiting cysteine proteases associated with carcinogenesis, including cathepsins B and L.
摘要翻译：本发明涉及半胱氨酸蛋白酶的硫代缩氨基脲和缩氨基脲抑制剂以及使用这些化合物来预防和治疗原生动物感染如锥虫病，疟疾和利什曼病的方法。该化合物还可用于抑制与癌发生相关的半胱氨酸蛋白酶，包括组织蛋白酶B和L.

4. 发明授权

US4696029A Telephone traffic load control system 失效
标题翻译：电话流量负载控制系统
公开(公告)号：US4696029A
公开(公告)日：1987-09-22
申请号：US808249
申请日：1985-12-12
申请人： Fred Cohen
发明人： Fred Cohen
IPC分类号： H04H1/00 , H04H60/33 , H04M3/36 , H04M3/46 , H04M11/00
CPC分类号： H04H60/33 , H04M3/36 , H04M3/46 , H04M3/465 , H04M2203/1041
摘要： A system for controlling the initiation of voting telephone calls by controlling character generators at a group of affiliated television broadcast stations through a control center which receives real-time feedback of telephone voting traffic data from polling terminals at telephone central offices and utilizes this information to regulate visual stimuli broadcast by the television station. The control center initiates polling traffic by causing associated character generators at the affiliate transmitter to produce the desired message displays across the TV screen. The control center monitors the polling call traffic at each central office until it determines that the traffic being generated has reached a level which is not within the traffic-handling capabilities of that particular central office switching machines. It then sends messages which cause the character generators at the local affiliate to reduce the frequency and/or duration of the message until the traffic generated has dropped to a level which is within the traffic handling capabilities of the central office, whereupon the frequency and/or duration is again increased.
摘要翻译：一种通过控制中心控制一组附属电视广播台的角色发生器来控制投票电话呼叫的系统，该控制中心从电话中心局的投票终端接收电话投票业务数据的实时反馈并利用该信息进行调节电视台播放的视觉刺激。控制中心通过在联盟发射机处引起相关联的字符发生器来产生在电视屏幕上产生期望的消息显示来发起轮询业务。控制中心监控每个中央局的轮询呼叫流量，直到它确定正在生成的流量已达到不在该特定中心局交换机的流量处理能力内的水平。然后，它发送导致本地分支机构的字符发生器的消息，以减少消息的频率和/或持续时间，直到产生的流量已经下降到在中心局的业务处理能力内的水平，于是频率和/ 或持续时间再次增加。

5. 发明授权

US07516227B2 Method and apparatus for network deception/emulation 失效
标题翻译：网络欺骗/仿真的方法和装置
公开(公告)号：US07516227B2
公开(公告)日：2009-04-07
申请号：US11463301
申请日：2006-08-08
申请人： Fred Cohen
发明人： Fred Cohen
IPC分类号： H04L9/32
CPC分类号： H04L63/1441 , H04L29/12009 , H04L29/1233 , H04L61/25 , H04L63/0218 , H04L63/1491
摘要： A number of innovations in the field of networking are disclosed. These techniques use multiple address translation to achieve effective deceptions, emulations, extended private networks and related goals. A further embodiment using a deception network having a number of different actual computer systems each performing emulation where deceived datagrams are routed to an actual machine that is particularly able to perform the desired emulation. The invention allows the emulation to receive a datagram just at it would appear at an external access point, operate on that datagram and return a datagram which is then passed through a deception wall using multiple address translations.
摘要翻译：披露了网络领域的一些创新。这些技术使用多个地址转换来实现有效的欺骗，仿真，扩展的专用网络和相关目标。使用具有多个不同实际计算机系统的欺骗网络的另一实施例，每个欺骗网络执行仿真，其中欺骗的数据报被路由到特别能够执行期望仿真的实际机器。本发明允许仿真接收一个数据报，它将出现在外部接入点，对该数据报进行操作，并返回一个数据报，然后通过多个地址转换通过欺骗墙。

6. 发明授权

US07107347B1 Method and apparatus for network deception/emulation 有权
公开(公告)号：US07107347B1
公开(公告)日：2006-09-12
申请号：US09696893
申请日：2000-10-26
申请人： Fred Cohen
发明人： Fred Cohen
IPC分类号： H04L9/32
CPC分类号： H04L63/1441 , H04L29/12009 , H04L29/1233 , H04L61/25 , H04L63/0218 , H04L63/1491
摘要： A number of innovations in the field of networking are disclosed. These techniques use multiple address translation to achieve effective deceptions, emulations, extended private networks and related goals. A further embodiment using a deception network having a number of different actual computer systems each performing emulation where deceived datagrams are routed to an actual machine that is particularly able to perform the desired emulation. The invention allows the emulation to receive a datagram just at it would appear at an external access point, operate on that datagram and return a datagram which is then passed through a deception wall using multiple address translations.

7. 外观设计

USD447264S1 Lamp housing 失效
公开(公告)号：USD447264S1
公开(公告)日：2001-08-28
申请号：US29115931
申请日：1999-12-22
申请人： Fred Cohen
设计人： Fred Cohen

8. 外观设计

USD429016S Lamp housing 失效
公开(公告)号：USD429016S
公开(公告)日：2000-08-01
申请号：US105551
申请日：1999-05-24
申请人： Fred Cohen
设计人： Fred Cohen

9. 外观设计

USD706921S1 Fan blade iron 有权
标题翻译：风扇叶片铁
公开(公告)号：USD706921S1
公开(公告)日：2014-06-10
申请号：US29431996
申请日：2012-09-12
申请人： Fred Cohen
设计人： Fred Cohen

10. 发明申请

US20110012435A1 CENTER-TAPPED BATTERY AND POWER DISTRIBUTION SYSTEM FOR SAME 审中-公开
标题翻译：中心电池和功率分配系统
公开(公告)号：US20110012435A1
公开(公告)日：2011-01-20
申请号：US12504181
申请日：2009-07-16
申请人： Fred Cohen , Cheng-Yi Lu , Kenneth John Metcalf
发明人： Fred Cohen , Cheng-Yi Lu , Kenneth John Metcalf
IPC分类号： H01H9/54 , H01M2/02
CPC分类号： H01M2/1016 , H01M2/30 , H01M2/34 , H01M2/345 , H01M10/425 , H01M2200/103 , Y10T307/937
摘要： A battery for a power distribution system includes a cell assembly having a positive terminal and a negative terminal that together provide a relative battery DC voltage. A neutral tap is electrically connected to the cell assembly between the positive and negative terminals, splitting the voltage into positive and negative voltages. The positive terminal is at a positive DC voltage greater than the neutral tap. The negative voltage is at a negative DC voltage less than the neutral tap. The relative battery DC voltage is greater than each of the relative voltages between the neutral tap and each of the positive and negative DC voltages.
摘要翻译：用于配电系统的电池包括具有一起提供相对电池DC电压的正极端子和负极端子的电池组件。中性抽头电连接到正极和负极端子之间的电池组件，将电压分为正和负电压。正极端子处于大于中性抽头的正直流电压。负电压处于小于中性抽头的负直流电压。相对电池的直流电压大于中性抽头与每个正和负的直流电压之间的每个相对电压。

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