专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050254062A1 Fiber-optic assay apparatus based on phase-shift interferometry 有权
标题翻译：基于相移干涉测量的光纤测定装置
公开(公告)号：US20050254062A1
公开(公告)日：2005-11-17
申请号：US10981901
申请日：2004-11-04
申请人： Hong Tan , Duan Chen , Yushan Tan , Krista Witte
发明人： Hong Tan , Duan Chen , Yushan Tan , Krista Witte
IPC分类号： G01N21/77 , G01N33/543 , G01B9/02
CPC分类号： G01N33/54373 , G01N21/7703
摘要： Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.
摘要翻译：公开了用于检测样品溶液中分析物结合的存在或量或速率的装置和方法。该装置包括一个光学组件，该光学组件的第一和第二反射表面间隔大于50nm的距离“d”，其中第一表面由分析物结合分子层形成，以及用于将光束引导到所述第一和第二反射面。该装置中的检测器用于检测由分析物与分析物结合分子结合而产生的第一反射层的厚度的变化，当通过检测光波相位偏移将组件放置在分析物的溶液中时从第一和第二表面反射。

2. 发明申请

US20070070356A1 Fiber-Optic Assay Apparatus Based on Phase-Shift Interferometry 有权
标题翻译：基于相移干涉测量的光纤测定装置
公开(公告)号：US20070070356A1
公开(公告)日：2007-03-29
申请号：US11423671
申请日：2006-06-12
申请人： Hong Tan , Yushan Tan , Krista Witte , Robert Zuk , Greg Carricato , Scott Lockard
发明人： Hong Tan , Yushan Tan , Krista Witte , Robert Zuk , Greg Carricato , Scott Lockard
IPC分类号： G01B9/02 , G01N21/00 , G01N21/03 , B32B27/04
CPC分类号： G01N33/54373 , G01N21/45 , G01N21/7703 , G01N21/8507 , G01N2021/772 , G01N2021/7723 , G01N2021/7779
摘要： Apparatus and method for detecting an analyte in a sample based on optical interference. The apparatus includes a light source, detector unit and one or more disposable detector tips. The apparatus also includes an optical coupling assembly that couples light from the source to the detector tips, and from the detector tips to the detector unit.
摘要翻译：基于光学干涉检测样品中分析物的装置和方法。该装置包括光源，检测器单元和一个或多个一次性检测器尖端。该装置还包括将来自源的光与检测器尖端以及从检测器尖端耦合到检测器单元的光耦合组件。

3. 发明授权

US08309369B2 Detection system and method for high sensitivity fluorescent assays 有权
标题翻译：用于高灵敏度荧光测定的检测系统和方法
公开(公告)号：US08309369B2
公开(公告)日：2012-11-13
申请号：US13224174
申请日：2011-09-01
申请人： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
发明人： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , C08B37/006 , G01N21/6428 , G01N21/645 , G01N33/54373 , G01N2021/6439 , G01N2201/06113
摘要： This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked Ficoll molecule having a plurality of binding molecules and a plurality of fluorescent labels.
摘要翻译：本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。本发明还涉及一种使用具有小表面积（＆NlE; 5mm）的探针尖端和具有多个结合分子和多个荧光标记的高分子量聚合物（≥1MD）来检测液体样品中的分析物的方法。通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。本发明还涉及包含具有多个结合分子和多个荧光标记的交联Ficoll分子的荧光标记组合物。

4. 发明授权

US07728982B2 Fiber-optic assay apparatus based on phase-shift interferometry 有权
标题翻译：基于相移干涉测量的光纤测定装置
公开(公告)号：US07728982B2
公开(公告)日：2010-06-01
申请号：US12099751
申请日：2008-04-08
申请人： Hong Tan , Yushan Tan , Duan Jun Chen , Krista Leah Witte
发明人： Hong Tan , Yushan Tan , Duan Jun Chen , Krista Leah Witte
IPC分类号： G01B9/02
CPC分类号： G01N33/54373 , G01N21/7703
摘要： Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.
摘要翻译：公开了用于检测样品溶液中分析物结合的存在或量或速率的装置和方法。该装置包括一个光学组件，该光学组件的第一和第二反射表面间隔大于50nm的距离“d”，其中第一表面由分析物结合分子层形成，以及用于将光束引导到所述第一和第二反射面。该装置中的检测器用于检测由分析物与分析物结合分子结合而产生的第一反射层厚度的变化，当通过检测光波相位偏移将组件放置在分析物溶液中时从第一和第二表面反射。

5. 发明授权

US07394547B2 Fiber-optic assay apparatus based on phase-shift interferometry 有权
标题翻译：基于相移干涉测量的光纤测定装置
公开(公告)号：US07394547B2
公开(公告)日：2008-07-01
申请号：US10981901
申请日：2004-11-04
申请人： Hong Tan , Duan Jun Chen , Yushan Tan , Krista Leah Witte
发明人： Hong Tan , Duan Jun Chen , Yushan Tan , Krista Leah Witte
IPC分类号： G01B9/02
CPC分类号： G01N33/54373 , G01N21/7703
摘要： Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.
摘要翻译：公开了用于检测样品溶液中分析物结合的存在或量或速率的装置和方法。该装置包括一个光学组件，该光学组件的第一和第二反射表面间隔大于50nm的距离“d”，其中第一表面由分析物结合分子层形成，以及用于将光束引导到所述第一和第二反射面。该装置中的检测器用于检测由分析物与分析物结合分子结合而产生的第一反射层的厚度的变化，当通过检测光波相位偏移将组件放置在分析物的溶液中时从第一和第二表面反射。

6. 发明授权

US08597578B2 Optical sensor of bio-molecules using thin-film interferometer 有权
公开(公告)号：US08597578B2
公开(公告)日：2013-12-03
申请号：US13213525
申请日：2011-08-19
申请人： Hong Tan , Yushan Tan , Erhua Cao , Min Xia , Robert F. Zuk
发明人： Hong Tan , Yushan Tan , Erhua Cao , Min Xia , Robert F. Zuk
IPC分类号： G01N21/00 , G01B9/02 , G02B6/26 , G02B6/36 , G02B6/00 , G01N21/63
CPC分类号： G01N21/7703 , G01J3/45 , G01N21/45 , G01N21/648 , G01N21/8507 , G01N2021/7779 , G01N2201/062 , G01N2201/08 , G02B6/262 , G02B6/30
摘要： The present invention is directed to an assembly for use in detecting an analyte in a sample based on thin-film spectral interference. The assembly comprises a waveguide, a monolithic substrate optically coupled to the waveguide, and a thin-film layer directly bonded to the sensing side of the monolithic substrate. The refractive index of the monolithic substrate is higher than the refractive index of the transparent material of the thin-film layer. A spectral interference between the light reflected into the waveguide from a first reflecting surface and a second reflecting surface varies as analyte molecules in a sample bind to the analyte binding molecules coated on the thin-film layer.

7. 发明授权

US08305585B2 Fiber-optic assay apparatus based on phase-shift interferometry 有权
标题翻译：基于相移干涉测量的光纤测定装置
公开(公告)号：US08305585B2
公开(公告)日：2012-11-06
申请号：US12790736
申请日：2010-05-28
申请人： Hong Tan , Yushan Tan , Duan Jun Chen , Krista Leah Witte
发明人： Hong Tan , Yushan Tan , Duan Jun Chen , Krista Leah Witte
IPC分类号： G01B9/02
CPC分类号： G01N33/54373 , G01N21/7703
摘要： Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance “d” greater than 50 nm, where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces.
摘要翻译：公开了用于检测样品溶液中分析物结合的存在或量或速率的装置和方法。该装置包括光学组件，该光学组件具有分开距离d大于50nm的第一和第二反射表面，其中第一表面由分析物结合分子层形成;以及光源，用于将光束引导到所述第一和第二反射面。该装置中的检测器用于检测由分析物与分析物结合分子结合而产生的第一反射层的厚度的变化，当通过检测光波相位偏移将组件放置在分析物的溶液中时从第一和第二表面反射。

8. 发明申请

US20110312105A1 DETECTION SYSTEM AND METHOD FOR HIGH SENSITIVITY FLUORESCENT ASSAYS 有权
标题翻译：检测系统和高灵敏度荧光测定方法
公开(公告)号：US20110312105A1
公开(公告)日：2011-12-22
申请号：US13224174
申请日：2011-09-01
申请人： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
发明人： Hong Tan , Robert F. Zuk , Yushan Tan , Erhua Cao , Min Xia , Jun Chen
IPC分类号： G01N21/64 , C07K14/36 , C07K16/00
CPC分类号： G01N33/54366 , C08B37/006 , G01N21/6428 , G01N21/645 , G01N33/54373 , G01N2021/6439 , G01N2201/06113
摘要： This invention relates to a detection system for measuring a fluorescent signal in a fluorescent assay. The system comprises a probe having a small sensing surface bound with a fluorescent label, and a light source and a detector both mounted at the proximal side of the sensing surface of the substrate. The invention also relates to a method for detecting an analyte in a liquid sample using a probe tip having a small surface area (≦5 mm) and a high molecular weight polymer (≧1 MD) having multiple binding molecules and multiple fluorescent labels. The binding reaction is accelerated by flowing the reaction solutions laterally and moving the probe tip up and down in the reaction vessels. The invention furthers relates to a fluorescent labeling composition comprising a cross-linked Ficoll molecule having a plurality of binding molecules and a plurality of fluorescent labels.
摘要翻译：本发明涉及一种用于在荧光测定中测量荧光信号的检测系统。该系统包括具有与荧光标签结合的小感测表面的探针，以及安装在基底的感测表面的近侧的光源和检测器。本发明还涉及一种使用具有小表面积（＆NlE; 5mm）的探针尖端和具有多个结合分子和多个荧光标记的高分子量聚合物（≥1MD）来检测液体样品中的分析物的方法。通过横向流动反应溶液并在反应容器中上下移动探针尖端来加速结合反应。本发明还涉及包含具有多个结合分子和多个荧光标记的交联Ficoll分子的荧光标记组合物。

9. 发明授权

US07319525B2 Fiber-optic assay apparatus based on phase-shift interferometry 有权
标题翻译：基于相移干涉测量的光纤测定装置
公开(公告)号：US07319525B2
公开(公告)日：2008-01-15
申请号：US11423671
申请日：2006-06-12
申请人： Hong Tan , Yushan Tan , Krista Leah Witte , Robert Zuk , Greg L. Carricato , Scott Lockard
发明人： Hong Tan , Yushan Tan , Krista Leah Witte , Robert Zuk , Greg L. Carricato , Scott Lockard
IPC分类号： G01B9/02
CPC分类号： G01N33/54373 , G01N21/45 , G01N21/7703 , G01N21/8507 , G01N2021/772 , G01N2021/7723 , G01N2021/7779
摘要： Apparatus and method for detecting an analyte in a sample based on optical interference. The apparatus includes a light source, detector unit and one or more disposable detector tips. The apparatus also includes an optical coupling assembly that couples light from the source to the detector tips, and from the detector tips to the detector unit.
摘要翻译：基于光学干涉检测样品中分析物的装置和方法。该装置包括光源，检测器单元和一个或多个一次性检测器尖端。该装置还包括将来自源的光与检测器尖端以及从检测器尖端耦合到检测器单元的光学耦合组件。

10. 发明授权

US06845634B2 Method for fabricating thallium-doped GRIN lens 失效
标题翻译：制造铊掺杂GRIN透镜的方法
公开(公告)号：US06845634B2
公开(公告)日：2005-01-25
申请号：US10175945
申请日：2002-06-20
申请人： Hong Tan , Youmin Liu , Yushan Tan
发明人： Hong Tan , Youmin Liu , Yushan Tan
IPC分类号： C03B25/02 , C03C3/089 , C03C15/02 , C03C21/00 , C03B25/00
CPC分类号： C03C15/025 , C03B25/02 , C03C3/089 , C03C21/002
摘要： A fabrication method for a thallium-doped GRIN lens composed of a simplified glass composition is described. The composition is composed of silicon, oxygen, boron, zinc, potassium, sodium, and thallium. The method is comprised of preparing a cylindrical preform, annealing the cylindrical preform, removing contaminants from preform thereafter extruded to form a glass rod, exposing the glass rod to an alkali salt bath, and chemically milling the glass rod within an acid bath. Method and composition produce colorless lenses with a refractive index from 1.5900 to 1.7810, an insertion loss no greater than 0.05 dB, and a chromatic transmittance greater than 90 percent.
摘要翻译：描述了由简化的玻璃组合物构成的铊掺杂的GRIN透镜的制造方法。该组合物由硅，氧，硼，锌，钾，钠和铊组成。该方法包括制备圆柱形预成型件，退火圆柱形预成型件，从预成型件中除去污染物，然后挤出以形成玻璃棒，将玻璃棒暴露于碱性盐浴中，并在酸浴内化学研磨玻璃棒。方法和组合物产生无色透镜，折射率为1.5900至1.7810，插入损耗不大于0.05dB，色透度大于90％。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式