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1. 发明授权

US07268120B1 Methods for treating cancer using cytokine-expressing polynucleotides 失效
标题翻译：使用表达细胞因子的多核苷酸治疗癌症的方法
公开(公告)号：US07268120B1
公开(公告)日：2007-09-11
申请号：US09557907
申请日：2000-04-21
申请人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip L. Felgner , Jukka Hartikka
发明人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip L. Felgner , Jukka Hartikka
IPC分类号： A61K35/00
CPC分类号： A61K48/005 , A61K31/7052 , A61K38/00 , A61K38/2013 , A61K48/00 , A61K48/0075 , A61K48/0091 , C07K14/555 , C07K14/56
摘要： The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or more cationic compounds. The present invention also provides methods of treating cancer in a mammal, comprising administering into a muscle of the mammal a non-infectious, non-integrating DNA polynucleotide construct comprising a polynucleotide encoding a cytokine. In addition, the present invention also relates to the methodology for selective transfection of malignant cells with polynucleotides expressing therapeutic or prophylactic molecules in intra-cavity tumor bearing mammals. More specifically, the present invention provides a methodology for the suppression of an intra-cavity dissemination of malignant cells, such as intraperitoneal dissemination. Furthermore, the invention relates to compositions and methods to deliver polynucleotides encoding polypeptides to vertebrate cells in vivo, where the composition comprises an aqueous solution of sodium phosphate.
摘要翻译：本发明提供一种药物组合物，其包含非传染性非整合多核苷酸构建体，其包含编码干扰素ω和一种或多种阳离子化合物的多核苷酸。本发明还提供了治疗哺乳动物癌症的方法，包括向哺乳动物的肌肉中施用包含编码细胞因子的多核苷酸的非感染性非整合型DNA多核苷酸构建体。此外，本发明还涉及用于在具有腔内肿瘤的哺乳动物中表达治疗或预防分子的多核苷酸选择性转染恶性细胞的方法。更具体地，本发明提供了抑制恶性细胞的腔内传播的方法，例如腹膜内传播。此外，本发明涉及将体内编码多肽的多核苷酸递送至脊椎动物细胞的组合物和方法，其中组合物包含磷酸钠水溶液。

2. 发明授权

US07470675B2 Methods for treating cancer using interferon-ω-expressing polynucleotides 失效
标题翻译：使用干扰素-ω-表达多核苷酸治疗癌症的方法
公开(公告)号：US07470675B2
公开(公告)日：2008-12-30
申请号：US11709868
申请日：2007-02-23
申请人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip L. Felgner , Jukka Hartikka
发明人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip L. Felgner , Jukka Hartikka
IPC分类号： A01K54/04 , A61K37/715
CPC分类号： A61K48/005 , A61K31/7052 , A61K38/00 , A61K38/2013 , A61K48/00 , A61K48/0075 , A61K48/0091 , C07K14/555 , C07K14/56
摘要： The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or more cationic compounds. The present invention also provides methods of treating cancer in a mammal, comprising administering into a tissue of the mammal a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding a cytokine. In addition, the present invention also relates to the methodology for selective transfection of malignant cells with polynucleotides expressing therapeutic or prophylactic molecules in intra-cavity tumor bearing mammals. More specifically, the present invention provides a methodology for the suppression of an intra-cavity dissemination of malignant cells, such as intraperitoneal dissemination. Furthermore, the invention relates to compositions and methods to deliver polynucleotides encoding polypeptides to vertebrate cells in vivo, where the composition comprises an aqueous solution of sodium phosphate.
摘要翻译：本发明提供一种药物组合物，其包含非传染性非整合多核苷酸构建体，其包含编码干扰素ω和一种或多种阳离子化合物的多核苷酸。本发明还提供了治疗哺乳动物癌症的方法，包括向哺乳动物的组织施用包含编码细胞因子的多核苷酸的非感染性非整合多核苷酸构建体。此外，本发明还涉及用于在具有腔内肿瘤的哺乳动物中表达治疗或预防分子的多核苷酸选择性转染恶性细胞的方法。更具体地，本发明提供了抑制恶性细胞的腔内传播的方法，例如腹膜内传播。此外，本发明涉及将体内编码多肽的多核苷酸递送至脊椎动物细胞的组合物和方法，其中组合物包含磷酸钠水溶液。

3. 发明申请

US20070225243A1 Treatment of cancer using cytokine-expressing polynucleotides and compositions therefor 失效
标题翻译：使用表达细胞因子的多核苷酸及其组合物治疗癌症
公开(公告)号：US20070225243A1
公开(公告)日：2007-09-27
申请号：US11709868
申请日：2007-02-23
申请人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip Felgner , Jukka Hartikka
发明人： Holly Horton , Suezanne Parker , Marston Manthorpe , Philip Felgner , Jukka Hartikka
IPC分类号： A61K31/7052
CPC分类号： A61K48/005 , A61K31/7052 , A61K38/00 , A61K38/2013 , A61K48/00 , A61K48/0075 , A61K48/0091 , C07K14/555 , C07K14/56
摘要： The present invention provides a pharmaceutical composition, comprising a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding an interferon ω and one or more cationic compounds. The present invention also provides methods of treating cancer in a mammal, comprising administering into a tissue of the mammal a non-infectious, non-integrating polynucleotide construct comprising a polynucleotide encoding a cytokine. In addition, the present invention also relates to the methodology for selective transfection of malignant cells with polynucleotides expressing therapeutic or prophylactic molecules in intra-cavity tumor bearing mammals. More specifically, the present invention provides a methodology for the suppression of an intra-cavity dissemination of malignant cells, such as intraperitoneal dissemination. Furthermore, the invention relates to compositions and methods to deliver polynucleotides encoding polypeptides to vertebrate cells in vivo, where the composition comprises an aqueous solution of sodium phosphate.
摘要翻译：本发明提供一种药物组合物，其包含非传染性非整合多核苷酸构建体，其包含编码干扰素ω和一种或多种阳离子化合物的多核苷酸。本发明还提供了治疗哺乳动物癌症的方法，包括向哺乳动物的组织施用包含编码细胞因子的多核苷酸的非感染性非整合多核苷酸构建体。此外，本发明还涉及用于在具有腔内肿瘤的哺乳动物中表达治疗或预防分子的多核苷酸选择性转染恶性细胞的方法。更具体地，本发明提供了抑制恶性细胞的腔内传播的方法，例如腹膜内传播。此外，本发明涉及将体内编码多肽的多核苷酸递送至脊椎动物细胞的组合物和方法，其中组合物包含磷酸钠水溶液。

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