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1. 发明授权

US07390649B2 Sensor chips with multiple layers of polysiloxane 有权
标题翻译：具有多层聚硅氧烷的传感器芯片
公开(公告)号：US07390649B2
公开(公告)日：2008-06-24
申请号：US10343024
申请日：2001-07-24
申请人： Holger Klapproth , Jürgen Rühe , Sonia Mohry
发明人： Holger Klapproth , Jürgen Rühe , Sonia Mohry
IPC分类号： C12M1/34
CPC分类号： G01N33/54373 , Y10T428/31663
摘要： The invention relates to sensor chips with multiple layers of polysiloxane with improve homogeneity.
摘要翻译：本发明涉及具有提高均匀性的多层聚硅氧烷的传感器芯片。

2. 发明授权

US07250253B1 Immobilization of molecules on surfaces via polymer brushes 有权
标题翻译：通过聚合物刷固定表面上的分子
公开(公告)号：US07250253B1
公开(公告)日：2007-07-31
申请号：US09889935
申请日：2000-01-25
申请人： Holger Klapproth , Oswald Prucker , Jürgen Rühe
发明人： Holger Klapproth , Oswald Prucker , Jürgen Rühe
IPC分类号： C12Q1/68 , C12M1/36 , C12N11/16 , C07H21/04
CPC分类号： G01N33/54353 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722 , C12Q1/6834 , C40B40/06 , G01N33/545
摘要： The invention relates to polyfunctional polymer monolayers (polymer brushes) comprising a multitude of polymer chains attached to a surface, with each polymer chain comprising a multitude of units carrying at least on functional group which allows the interaction of the polymer chain with a sample molecule.
摘要翻译：本发明涉及包含多个连接到表面上的聚合物链的多官能聚合物单层（聚合物刷），其中每个聚合物链包含至少含有能够使聚合物链与样品分子相互作用的官能团的多个单元。

3. 发明授权

US08329104B2 Measurement device with at least one sensor 有权
标题翻译：至少有一个传感器的测量装置
公开(公告)号：US08329104B2
公开(公告)日：2012-12-11
申请号：US12146644
申请日：2008-06-26
申请人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
发明人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/00 , G01N33/53 , G01N33/566 , G01N33/543
CPC分类号： G01N33/54373 , G01D3/08 , G01N27/414 , G01N27/4163 , G01N33/0032
摘要： A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor.
摘要翻译：测量装置具有用于检测参数的至少一个传感器，用于所述传感器和数据存储单元的数据存储单元和电源。除了第一传感器之外，测量装置具有连接到电源和数据存储单元的至少一个第二传感器。提供第二传感器用于检测作用在第一传感器上的物理量，并且能够永久地改变第一传感器的测量特性。评估器与第二传感器和数据存储单元共同作用，使得可以根据第二传感器的测量信号来记录第一传感器的测量特性的永久变化。

4. 发明申请

US20090175764A1 Measurement Device with At Least One Sensor 有权
标题翻译：具有至少一个传感器的测量装置
公开(公告)号：US20090175764A1
公开(公告)日：2009-07-09
申请号：US12146644
申请日：2008-06-26
申请人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
发明人： Mirko Lehmann , Ingo Freund , Sonja Mohry , Holger Klapproth
IPC分类号： B01J19/00
CPC分类号： G01N33/54373 , G01D3/08 , G01N27/414 , G01N27/4163 , G01N33/0032
摘要： A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor.
摘要翻译：测量装置具有用于检测参数的至少一个传感器，用于所述传感器和数据存储单元的数据存储单元和电源。除了第一传感器之外，测量装置具有连接到电源和数据存储单元的至少一个第二传感器。提供第二传感器用于检测作用在第一传感器上的物理量，并且能够永久地改变第一传感器的测量特性。评估器与第二传感器和数据存储单元共同作用，使得可以根据第二传感器的测量信号来记录第一传感器的测量特性的永久变化。

5. 发明授权

US07312867B2 Method and device for the detection of at least one luminescent substance 有权
标题翻译：用于检测至少一种发光物质的方法和装置
公开(公告)号：US07312867B2
公开(公告)日：2007-12-25
申请号：US10529048
申请日：2003-09-12
申请人： Holger Klapproth , Mirko Lehmann
发明人： Holger Klapproth , Mirko Lehmann
IPC分类号： G01J3/30
CPC分类号： G01N21/6454 , G01N21/6428 , G01N21/648 , H01L2924/0002 , H01L2924/00
摘要： Disclosed is a device for detecting at least one luminescent substance, comprising a radiation source for emitting excitation radiation to the at least one luminescent substance. The excitation radiation is provided with at least one excitation wavelength at which the luminescent substance is excited so as to emit luminescent radiation. At least one radiation receiver is provided, which detects the luminescent radiation and is configured regarding the spectral sensitivity thereof in such a way that said radiation receiver is insensitive to the radiation emitted by the radiation source. The luminescent substance is located inside a measuring chamber that is essentially impermeable to the luminescent radiation and comprises at least one wall area which is transparent to the excitation radiation emitted by the radiation source. The radiation source is placed outside the measuring chamber such that the excitation radiation emitted by the radiation source is coupled into the inside of the measuring chamber by penetrating said wall area.
摘要翻译：公开了一种用于检测至少一种发光物质的装置，包括用于向至少一种发光物质发射激发辐射的辐射源。激发辐射具有至少一个激发波长，在该激发波长处激发发光物质以发射发光辐射。提供至少一个辐射接收器，其检测发光辐射，并且被配置为关于其光谱灵敏度，使得所述辐射接收器对由辐射源发射的辐射不敏感。发光物质位于测量室内，其基本上不透气于发光辐射，并且包括对由辐射源发射的激发辐射透明的至少一个壁区域。辐射源被放置在测量室的外部，使得由辐射源发射的激发辐射通过穿透所述壁区域而耦合到测量室的内部。

6. 发明申请

US20060141445A1 Method for manufacturing a sensor chip and sensor chip blank 审中-公开
标题翻译：制造传感器芯片和传感器芯片空白的方法
公开(公告)号：US20060141445A1
公开(公告)日：2006-06-29
申请号：US11316674
申请日：2005-12-22
申请人： Holger Klapproth
发明人： Holger Klapproth
IPC分类号： C12Q1/00
CPC分类号： G01N33/54353 , G01N33/54393
摘要： In a process for manufacturing a sensor chip a support is prepared having at least one surface region in which at least one reactive group is arranged. A buffer solution is applied to the surface region for coating at least one surface region. Then, at least one receptor having binding specificity for a ligand to be detected is brought into contact with the surface coating so obtained in such a manner that said receptor binds covalently to at least one reactive group.
摘要翻译：在制造传感器芯片的方法中，制备具有至少一个表面区域的载体，其中布置有至少一个反应性基团。将缓冲溶液施加到表面区域以涂覆至少一个表面区域。然后，使具有对待检测配体具有结合特异性的至少一种受体与如此获得的表面涂层接触，使得所述受体共价结合至至少一个反应性基团。

7. 发明申请

US20060115906A1 Sensor surface comprising an improved signal-noise ratio 审中-公开
标题翻译：传感器表面包括改善的信噪比
公开(公告)号：US20060115906A1
公开(公告)日：2006-06-01
申请号：US10521817
申请日：2003-07-21
申请人： Holger Klapproth
发明人： Holger Klapproth
IPC分类号： G01N33/543
CPC分类号： G01N33/54353 , G01N33/54373 , G01N33/54393
摘要： The present invention concerns a sensor surface with an improved signal/noise ratio that is based on a blocking reagent covalently immobilized on the sensor surface, as well as apparatuses comprising such surfaces and methods for the use of same.
摘要翻译：本发明涉及一种基于共价固定在传感器表面上的封闭剂，具有改进的信噪比的传感器表面以及包括这些表面的设备及其使用方法。

8. 发明申请

US20050158848A1 Method for immobolizing molecules on surfaces 审中-公开
标题翻译：表面上固定分子的方法
公开(公告)号：US20050158848A1
公开(公告)日：2005-07-21
申请号：US10511192
申请日：2003-04-10
申请人： Ulrich Sieben , Ingo Freund , Holger Klapproth
发明人： Ulrich Sieben , Ingo Freund , Holger Klapproth
IPC分类号： B01J20/32 , C09D125/06 , C09D179/08 , C09D201/00 , G01N33/543 , G01N37/00 , C12M1/34 , B05D3/00
CPC分类号： B01J20/3204 , B01J20/103 , B01J20/28011 , B01J20/3257 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J20/3276 , B01J20/3289 , G01N33/54393
摘要： In a method for immobilizing molecules on a surface, a layer of a hydrophobic, e.g., a non-swelling polymer, may be applied to the surface and molecules are immobilized on a surface of the polymer layer. The hydrophobic polymers may be polyimide or polystyrene, and the surface to which the polymer layer is applied may be made of an inorganic material, e.g., a semiconductor material (silicon), a semiconducting oxide (silicon dioxide), glass, nitride, or ceramic. Hydrophobic polymers such as polyimide or polystyrene can be applied to the surface of an inorganic support with conventional methods. Further, they electrically insulate the support with respect to the molecules applied to the surface of the polymer layer or substances associated with these molecules. Thus, electrical sensors and processor circuits can be integrated into the support without any detrimental effect on their function due to molecules and substances applied to the surface of the polymer layer.
摘要翻译：在将分子固定在表面上的方法中，可以将一层疏水的，例如不溶胀的聚合物施加到表面上，并将分子固定在聚合物层的表面上。疏水聚合物可以是聚酰亚胺或聚苯乙烯，并且施加聚合物层的表面可以由无机材料制成，例如半导体材料（硅），半导体氧化物（二氧化硅），玻璃，氮化物或陶瓷。疏水性聚合物如聚酰亚胺或聚苯乙烯可以用常规方法施加到无机载体的表面上。此外，它们相对于施加到聚合物层的表面上的分子或与这些分子相关联的物质将载体电绝缘。因此，电传感器和处理器电路可以集成到支撑件中，而不会由于施加到聚合物层表面的分子和物质而对它们的功能产生不利影响。

9. 发明授权

US07563762B2 Composition and process for stabilizing of biomolecules 失效
标题翻译：用于稳定生物分子的组成和方法
公开(公告)号：US07563762B2
公开(公告)日：2009-07-21
申请号：US10520158
申请日：2003-07-04
申请人： Holger Klapproth
发明人： Holger Klapproth
IPC分类号： A61K38/00 , A61K9/16 , A61K31/715 , C12P19/12
CPC分类号： C07K17/00 , C07K14/00
摘要： The present invention relates in general to the field of biotechnology. The invention particularly relates to a composition and process for stabilizing or preserving biological molecules, as well as devices that comprise correspondingly stabilized or preserved biomolecules.
摘要翻译：本发明一般涉及生物技术领域。本发明特别涉及用于稳定或保存生物分子的组合物和方法，以及包含相应稳定或保留的生物分子的装置。

10. 发明申请

US20090093047A1 Kit and Device for Generating Chemiluminescence Radiation 审中-公开
标题翻译：用于生成化学发光辐射的试剂盒和装置
公开(公告)号：US20090093047A1
公开(公告)日：2009-04-09
申请号：US12182676
申请日：2008-07-30
申请人： Holger Klapproth , Sonja Bender Mohry
发明人： Holger Klapproth , Sonja Bender Mohry
IPC分类号： C12M1/34
CPC分类号： G01N21/76 , G01N21/05 , G01N33/54386 , G01N33/581 , G01N2333/902
摘要： A device for generating a chemiluminescence radiation depending on the binding of at least one ligand that is contained in a sample that is to be tested to at least one receptor that is binding-specific for the ligand has a flow cell having an internal cavity. The internal cavity has a separating wall on which the at least one receptor is immobilized. The internal cavity has at least two compartments. In a first compartment solid is deposited that contains at least one peroxidase-enzyme-possessing marker for marking the ligand in lyophilized form. A second compartment contains salt-stabilized luminol and a solid substance that releases hydrogen peroxide upon contact with water.
摘要翻译：根据待测样品中所含的至少一种配体与至少一种对配体结合特异性的受体的结合产生化学发光辐射的装置具有具有内腔的流动池。内腔具有分离壁，其上固定有至少一种受体。内腔具有至少两个隔室。在第一隔室中沉积含有至少一种含有冻干形式标记配体的过氧化物酶 - 酶标记物。第二个隔间含有盐稳定的鲁米诺和与水接触时释放过氧化氢的固体物质。

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