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1. 发明授权

US07259366B2 Apparatus for the detection of photons of a light beam having a three-dimensional array of detectors 有权
标题翻译：用于检测具有三维检测器阵列的光束的光子的装置
公开(公告)号：US07259366B2
公开(公告)日：2007-08-21
申请号：US10568002
申请日：2004-04-02
申请人： Holger Birk , Rafael Storz , Volker Seyfried
发明人： Holger Birk , Rafael Storz , Volker Seyfried
IPC分类号： H01L31/00
CPC分类号： G02B21/26
摘要： An apparatus for detecting photons of a light beam emanating from a spatially limited source includes a detection device having a plurality of detectors forming a three-dimensional array with semitranslucent EMCCDs disposed one behind another. A light splitting device is disposed in a path of rays of the light beam for splitting the light beam so as to distribute the photons over the detectors for detection.
摘要翻译：用于检测从空间有限的源发出的光束的光子的装置包括具有多个检测器的检测装置，所述检测器形成具有一个彼此设置的半透明EMCCD的三维阵列。光分离装置设置在光束的光线路径中，用于分离光束，以将光子分布在检测器上用于检测。

2. 发明授权

US07223961B2 Device for selectively detecting specific wavelength components of a light beam 有权
标题翻译：用于选择性地检测光束的特定波长分量的装置
公开(公告)号：US07223961B2
公开(公告)日：2007-05-29
申请号：US10923239
申请日：2004-08-20
申请人： Holger Birk , Volker Seyfried , Rafael Storz
发明人： Holger Birk , Volker Seyfried , Rafael Storz
IPC分类号： G01J3/50 , G01J3/28
CPC分类号： G01N21/6458 , G01J3/0229 , G01J3/14 , G01J3/2803 , G01J3/36 , G01J3/4406
摘要： A device for selectively detecting specific wavelength components of a light beam includes a spectral spreading element for spectrally spreading the light beam, and a detector array arranged downstream of the element. The detector array includes light-insensitive regions and light-sensitive regions. The element and the detector array are matched to each other so that selectable wavelength components of the light beam hit the light-insensitive regions and remaining wavelength components of the light beam hit the light-sensitive regions.
摘要翻译：用于选择性地检测光束的特定波长分量的装置包括用于光谱扩展光束的光谱扩展元件和布置在元件下游的检测器阵列。检测器阵列包括光不敏感区域和光敏区域。元件和检测器阵列彼此匹配，使得光束的可选择的波长分量撞击光不敏感区域，并且光束的剩余波长分量撞击光敏区域。

3. 发明申请

US20060215264A1 Apparatus for the detection of photons of a light beam 有权
标题翻译：用于检测光束的光子的装置
公开(公告)号：US20060215264A1
公开(公告)日：2006-09-28
申请号：US10568002
申请日：2004-04-02
申请人： Holger Birk , Rafael Storz , Volker Seyfried
发明人： Holger Birk , Rafael Storz , Volker Seyfried
IPC分类号： G02B27/28 , G02B5/30
CPC分类号： G02B21/26
摘要： An apparatus for detecting photons of a light beam emanating from a spatially limited source includes a detection device having a plurality of detectors forming a three-dimensional array with semitranslucent EMCCDs disposed one behind another. A light splitting device is disposed in a path of rays of the light beam for splitting the light beam so as to distribute the photons over the detectors for detection.
摘要翻译：用于检测从空间有限的源发出的光束的光子的装置包括具有多个检测器的检测装置，所述检测器形成具有一个彼此设置的半透明EMCCD的三维阵列。光分离装置设置在光束的光线路径中，用于分离光束，以将光子分布在检测器上用于检测。

4. 发明申请

US20050045812A1 Device for selectively detecting specific wavelength components of a light beam 有权
标题翻译：用于选择性地检测光束的特定波长分量的装置
公开(公告)号：US20050045812A1
公开(公告)日：2005-03-03
申请号：US10923239
申请日：2004-08-20
申请人： Holger Birk , Volker Seyfried , Rafael Storz
发明人： Holger Birk , Volker Seyfried , Rafael Storz
IPC分类号： G01J3/14 , G01J3/28 , G01J3/36 , G01J3/44 , G01N21/64 , G01J1/42
CPC分类号： G01N21/6458 , G01J3/0229 , G01J3/14 , G01J3/2803 , G01J3/36 , G01J3/4406
摘要： A device for selectively detecting specific wavelength components of a light beam includes a spectral spreading element for spectrally spreading the light beam, and a detector array arranged downstream of the element. The detector array includes light-insensitive regions and light-sensitive regions. The element and the detector array are matched to each other so that selectable wavelength components of the light beam hit the light-insensitive regions and remaining wavelength components of the light beam hit the light-sensitive regions.
摘要翻译：用于选择性地检测光束的特定波长分量的装置包括用于光谱扩展光束的光谱扩展元件和布置在元件下游的检测器阵列。检测器阵列包括光不敏感区域和光敏区域。元件和检测器阵列彼此匹配，使得光束的可选择的波长分量撞击光不敏感区域，并且光束的剩余波长分量撞击光敏区域。

5. 发明授权

US10101203B2 Device and method for detecting light 有权
公开(公告)号：US10101203B2
公开(公告)日：2018-10-16
申请号：US13545999
申请日：2012-07-11
申请人： Holger Birk , Volker Seyfried
发明人： Holger Birk , Volker Seyfried
IPC分类号： G01J3/02 , G01J1/02 , G01J1/18 , G01J1/44 , G01J3/28 , G01J3/36
摘要： A device for detecting light includes at least one silicon photomultiplier (SiPM) having an array of a plurality of single-photon avalanche diodes (SPADs), the array being larger in area than an incident light. The device is configured so as to at least one of activate and analyze only the SPADs upon which a specific minimum intensity of light impinges.

6. 发明授权

US09042010B2 Scanning microscope and method for optically scanning one or more samples 有权
标题翻译：扫描显微镜和光学扫描一个或多个样品的方法
公开(公告)号：US09042010B2
公开(公告)日：2015-05-26
申请号：US13578607
申请日：2011-02-11
申请人： Bernd Widzgowski , Holger Birk , Volker Seyfried
发明人： Bernd Widzgowski , Holger Birk , Volker Seyfried
IPC分类号： G02B21/08 , G02B21/00
CPC分类号： G02B21/0036
摘要： A device in the form of a scanning microscope, a device in the form of a structural unit for a microscope and a method and a device for optically scanning one or more samples. A device in the form of a scanning microscope has a light source (42), which emits an illuminating light beam (32). A focusing lens system (34) focuses the illuminating light beam (32) on a region to be examined of a sample (36). An actuator arrangement moves the focusing lens system (34) according to a prescribed scanning pattern transversely in relation to a center axis of the illuminating light beam (32) and/or in relation to a housing of a structural unit (20) that encloses the focusing lens system (34).
摘要翻译：呈扫描显微镜形式的装置，用于显微镜的结构单元形式的装置以及用于光学扫描一个或多个样品的方法和装置。扫描显微镜形式的装置具有发射照明光束（32）的光源（42）。聚焦透镜系统（34）将照明光束（32）聚焦在被检样品（36）的区域上。致动器装置根据规定的扫描图案相对于照明光束（32）的中心轴线横向移动聚焦透镜系统（34）和/或相对于包围该照明光束的结构单元（20）的壳体移动聚焦透镜系统聚焦透镜系统（34）。

7. 发明申请

US20130044370A1 DEVICE AND METHOD FOR SCANNING AN OBJECT AND A MICROSCOPE 审中-公开
标题翻译：用于扫描对象和显微镜的装置和方法
公开(公告)号：US20130044370A1
公开(公告)日：2013-02-21
申请号：US13578608
申请日：2011-02-11
申请人： Volker Seyfried , Bernd Widzgowski , Holger Birk
发明人： Volker Seyfried , Bernd Widzgowski , Holger Birk
IPC分类号： G02B21/33
CPC分类号： G02B21/33 , G02B21/0036
摘要： The invention relates to a device for scanning an object comprising a focusing lens system (30) which focuses an illuminating light beam (24) onto a region of the object to be analyzed. An actuator assembly is coupled to the focusing lens system (30) and moves the focusing lens system (30) in accordance with a predefined scanning pattern transversely to the cecenternter axis of the illumination light beam (24) in a reference position of the illumination light beam (24). A front glass (38) is disposed downstream of the focusing lens system (30) viewed in the direction of the illuminating light beam (24). An internal immersion medium (40) is disposed between the focusing lens system (30) and the front glass (38). An external immersion medium (48) can be introduced between the front glass (38) and the object.
摘要翻译：本发明涉及一种用于扫描物体的装置，包括聚焦透镜系统（30），其将照明光束（24）聚焦在被分析物体的区域上。致动器组件联接到聚焦透镜系统（30）并且在照明光的参考位置中根据预定的扫描图案横向于照明光束（24）的入射角轴线移动聚焦透镜系统（30）梁（24）。从照明光束（24）的方向观察，配置在聚焦透镜系统（30）的下游的前玻璃（38）。在聚焦透镜系统（30）和前玻璃（38）之间设置内部浸没介质（40）。可以在前玻璃（38）和物体之间引入外部浸没介质（48）。

8. 发明申请

US20080316469A1 Device and method for beam adjustment in an optical beam path 有权
标题翻译：光束路径中光束调整的装置和方法
公开(公告)号：US20080316469A1
公开(公告)日：2008-12-25
申请号：US12073360
申请日：2008-03-04
申请人： Holger Birk , Marcus Dyba , Hilmar Gugel , Volker Seyfried
发明人： Holger Birk , Marcus Dyba , Hilmar Gugel , Volker Seyfried
IPC分类号： G02B26/08 , G01N21/00
CPC分类号： G02B21/06
摘要： A device for beam adjustment in an optical beam path, having at least two mutually independent light sources (1, 2), in particular in a beam path (8, 9) of a preferably high or extremely high resolution microscope, the beams of the light sources (1, 2) requiring to be superposed in a common illumination beam path (10), is characterized in that a calibration sample (22) with the aid of which the pupil position and/or focal position of the beams can be checked can be brought into and taken out of the illumination beam path (10).
摘要翻译：一种用于光束路径中的光束调节的装置，具有至少两个相互独立的光源（1,2），特别是在优选高或极高分辨率显微镜的光束路径（8,9）中，所述光束需要叠加在公共照明光束路径（10）中的光源（1,2）的特征在于，借助于校准样品（22）可以检查光束的瞳孔位置和/或焦点位置可以被引入并从照明光束路径（10）中取出。

9. 发明授权

US09599804B2 System and method for computer-controlled execution of at least one test in a scanning microscope 有权
公开(公告)号：US09599804B2
公开(公告)日：2017-03-21
申请号：US13302025
申请日：2011-11-22
申请人： Holger Birk , Volker Seyfried , Roland Moschel , Derek Webster , Harald Brueggemann , Mario Belzer
发明人： Holger Birk , Volker Seyfried , Roland Moschel , Derek Webster , Harald Brueggemann , Mario Belzer
IPC分类号： G02B21/00 , G02B21/36
CPC分类号： G02B21/008 , G02B21/365
摘要： The invention relates to a method and a system for central computer controlled execution of at least one test run in a scanning microscope, particularly a confocal microscope, wherein at least one first software module of an application software is tested. The invention achieves the aim by a network made of individual scanning microscope clients and a central server. The clients can be contacted via a network interface and are administered in a central directory in the server. The application software for the individual components of a scanning microscope is made of individual software modules, each associated with a potential test. In order to be able to perform the various tests, the scanning microscope clients have been equipped on the hardware side with additional sensors and components that allow various operating parameters to be determined.

10. 发明授权

US08503084B2 Optical arrangement and method for controlling and influencing a light ray 有权
标题翻译：用于控制和影响光线的光学布置和方法
公开(公告)号：US08503084B2
公开(公告)日：2013-08-06
申请号：US12513495
申请日：2007-08-28
申请人： Holger Birk , Volker Seyfried
发明人： Holger Birk , Volker Seyfried
IPC分类号： G02B27/14 , G02B26/00
CPC分类号： G02B27/143 , G01J3/02 , G01J3/021 , G01J3/0229 , G01J3/16 , G01J2003/1282 , G01J2003/1286 , G02B21/06 , G02B26/0833 , G02B27/126
摘要： An optical arrangement and a related method for operating this optical arrangement are suggested, particularly in microscopes, for use as at least one of a main beam splitter and a beam combiner. One or more light beams can be coupled into the arrangement and at least one of the light beams that were coupled in can be coupled out again after having passed through the optical arrangement. In the path of the coupled in light beams at least one controllable microstructured element is provided, allowing to switch beam paths within the optical arrangement. This allows controlling or influencing the one or more light beams that are coupled out.
摘要翻译：建议用于操作该光学布置的光学布置和相关方法，特别是在显微镜中，用作主分束器和光束组合器中的至少一个。一个或多个光束可以耦合到该装置中，并且耦合的光束中的至少一个可以在穿过光学装置之后再次耦合出来。在光束耦合的路径中，提供至少一个可控微结构元件，允许在光学布置内切换光束路径。这允许控制或影响耦合出来的一个或多个光束。

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