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1. 发明授权

US06592897B1 Slow release tablet prepared from linear water-insoluble polysacchrides 失效
标题翻译：由线性水不溶性多糖制备的缓释片剂
公开(公告)号：US06592897B1
公开(公告)日：2003-07-15
申请号：US09673072
申请日：2001-01-25
申请人： Holger Bengs , Silke Schuth , Jürgen Grande , Gitte Böhm , Arnold Schneller
发明人： Holger Bengs , Silke Schuth , Jürgen Grande , Gitte Böhm , Arnold Schneller
IPC分类号： A61K922
CPC分类号： A61K9/2081 , A61K9/1652
摘要： The invention relates to a controlled release tablet which in part or as a whole contains water-insoluble linear polysaccharides, preferably the polysaccharide poly(1,4-&agr;-D-glucan), in the form of microparticles, as retardation material. The tablet is also capable of controllably releasing an active agent.
摘要翻译：本发明涉及一种控释片，其部分或全部含有水不溶性线性多糖，优选为微粒形式的多糖聚（1,4-α-D-葡聚糖）作为延迟材料。片剂还能够可控地释放活性剂。

2. 发明授权

US06723429B2 Method for preparing smooth-surface spherical microparticles completely or partially made of at least one water-insoluble linear polysaccharide and microparticles produced according to this method 失效
标题翻译：完全或部分由至少一种不溶于水的线性多糖制成的光滑表面球形微粒和根据该方法生产的微粒的方法
公开(公告)号：US06723429B2
公开(公告)日：2004-04-20
申请号：US09795562
申请日：2001-02-28
申请人： Holger Bengs , Jürgen Grande , Silke Schuth , Gitte Böhm , Arnold Schneller , Anette Brunner
发明人： Holger Bengs , Jürgen Grande , Silke Schuth , Gitte Böhm , Arnold Schneller , Anette Brunner
IPC分类号： B32B516
CPC分类号： C08J3/14 , C08J2305/00 , C08L3/12 , C08L5/00 , Y10T428/2982 , C08L2666/02
摘要： The present invention relates to a method for preparing smooth-surface spherical microparticles which are completely or partially made of at least one water-insoluble linear polysaccharide. This method involves dissolving the at least one water-insoluble linear polysaccharide in a solvent or a mixture of solvents, introducing the solution into a precipitation agent or a mixture of precipitation agents, optionally cooling the mixture thus obtained, and separating the microparticles thus formed. The precipitation agent used consists of at least one water-soluble cellulose derivative. This invention also relates to microparticles obtained according to this method.
摘要翻译：本发明涉及一种完全或部分由至少一种不溶于水的线性多糖制成的光滑球形微粒的方法。该方法包括将至少一种水不溶性线性多糖溶解在溶剂或溶剂混合物中，将溶液引入沉淀剂或沉淀剂混合物中，任选地冷却由此获得的混合物，并分离由此形成的微粒。所用的沉淀剂由至少一种水溶性纤维素衍生物组成。本发明还涉及根据该方法获得的微粒。

3. 发明授权

US06313105B1 Thermoplastic mixtures containing dialdehyde starch and natural polymers 失效
标题翻译：含有二醛淀粉和天然聚合物的热塑性混合物
公开(公告)号：US06313105B1
公开(公告)日：2001-11-06
申请号：US09462525
申请日：2000-03-13
申请人： Holger Bengs , Arnold Schneller , Gitte Böhm , Silke Schuth , Jürgen Grande
发明人： Holger Bengs , Arnold Schneller , Gitte Böhm , Silke Schuth , Jürgen Grande
IPC分类号： A61K3170
CPC分类号： C08K5/0016 , C08L3/00 , C08L3/08 , C08L3/10 , C08L2201/06 , C08L2666/02
摘要： Homogeneous mixtures are described and can be processed to give shaped biodegradable and physiologically nonhazardous articles, such as packagings for food or drink or pharmaceutical products, sausage casings and the like. The mixtures comprise dialdehyde starch with a degree of oxidation of greater than 30%, starch which does not exhibit any iodine-starch reaction, and/or modified starch, water and other plasticizers, and also, if desired, other biopolymers and additives.
摘要翻译：描述均匀的混合物并且可以加工以形成成形的可生物降解和生理学上非危险的制品，例如用于食品或饮料或药品的包装，香肠肠衣等。混合物包括氧化度大于30％的二醛淀粉，不显示任何碘淀粉反应的淀粉和/或改性淀粉，水和其它增塑剂，以及如果需要的话，其它生物聚合物和添加剂。

4. 发明授权

US06548075B1 Cosmetic or medical preparation for topical use 有权
标题翻译：用于局部使用的化妆品或医疗制剂
公开(公告)号：US06548075B1
公开(公告)日：2003-04-15
申请号：US09869399
申请日：2001-11-14
申请人： Holger Bengs , Arnold Schneller , Jürgen Grande , Silke Schuth , Gitte Böhm , Alfred Braunagel
发明人： Holger Bengs , Arnold Schneller , Jürgen Grande , Silke Schuth , Gitte Böhm , Alfred Braunagel
IPC分类号： A61K600
CPC分类号： A61K8/0241 , A61K8/73 , A61K2800/412 , A61K2800/654 , A61Q1/02 , A61Q19/00
摘要： The present invention relates to a topical preparation containing spherical microparticles as the essential component, wherein the microparticles comprise water-insoluble linear polyglucan.
摘要翻译：本发明涉及含有球状微粒作为必需成分的局部制剂，其中微粒包含水不溶性线性聚葡聚糖。

5. 发明授权

US06703048B1 Spherical microparticles containing linear polysaccharides 失效
公开(公告)号：US06703048B1
公开(公告)日：2004-03-09
申请号：US09486357
申请日：2000-04-14
申请人： Holger Bengs , Jürgen Grande , Arnold Schneller , Gitte Böhm
发明人： Holger Bengs , Jürgen Grande , Arnold Schneller , Gitte Böhm
IPC分类号： A61K914
CPC分类号： C08J3/14 , A61K9/1652 , C08J2305/00
摘要： Microparticles with a uniform spherical shape and a very narrow size distribution are described. They consist wholly or partly of a linear water-insoluble polysaccharide, preferably of 1,4-&agr;-D-polyglucan, and may contain other, in particular biodegradable, polymers and/or active substances. They are suitable inter alia for the controlled delivery of active substances. They are prepared by dissolving 1,4-&agr;-D-polyglucan or the polysaccharide in a solvent, introducing the solution into a precipitant, cooling the mixture and removing the particles formed.

6. 发明授权

US06323265B1 Thermoplastic mixture containing 1,4-&agr;-D-polyglucane, method for making the same and use thereof 有权
标题翻译：含有1,4-α-D-聚葡糖的热塑性混合物，其制备方法及其应用
公开(公告)号：US06323265B1
公开(公告)日：2001-11-27
申请号：US09462231
申请日：2000-03-13
申请人： Holger Bengs , Jürgen Grande , Gitte Böhm
发明人： Holger Bengs , Jürgen Grande , Gitte Böhm
IPC分类号： C08K515
CPC分类号： C08J5/18 , A22C13/0013 , A22C2013/0059 , B32B9/00 , B32B23/04 , B32B23/14 , C08J2303/12 , C08J2305/00 , C08L3/02 , C08L3/12 , C08L5/00 , C08L5/12 , C08L29/04 , C08L67/04 , C08L89/06 , C08L2666/02
摘要： 1,4-&agr;-D-Polyglucan-based thermoplastic mixture, process for the preparation and use thereof The present invention relates to a thermoplastic mixture based on biopolymers obtainable by preparing and mixing (A) 100 parts by weight of a biocatalytically produced 1,4-&agr;-D-polyglucans, (B) up to 400 parts by weight of a melt-processable polymeric material different from (A), (C) water in an amount sufficient for plastification of the mixture, (D) at least one plasticizer in an amount of 10 parts by weight up to half the total of the parts by weight of (A) and (B), and (E) where appropriate up to ((A)+(B)) parts by weight of other conventional additives, where the water content of components (A) and (B) has been corrected to zero by calculation where the plastification takes place with introduction of thermal and mechanical energy, to the use of the mixture for producing essentially biodegradable moldings and sheets, and to a process for preparing the mixture.
摘要翻译：基于生物聚合物的热塑性混合物技术领域本发明涉及一种基于生物聚合物的热塑性混合物，其通过制备和混合（A）100重量份的生物催化生产的1,4 -β-D-聚葡聚糖，（B）至多400重量份不同于（A），（C）的可熔融加工的聚合物材料，其量足以使混合物塑化，（D）至少一种增塑剂（A）和（B）的重量份的总量的10重量份，以及（E）适当的至（A）+（B））重量份的其它常规添加剂，其中通过计算将组分（A）和（B）的水含量校正为零，其中通过引入热和机械能量进行塑化，使用混合物来生产基本上可生物降解的模制品和片材，以及一种制备该混合物的方法。

7. 发明授权

US06406530B1 Biopolymer-based thermoplastic mixture for producing biodegradable shaped bodies 失效
标题翻译：用于生产可生物降解成形体的生物聚合物基热塑性混合物
公开(公告)号：US06406530B1
公开(公告)日：2002-06-18
申请号：US09462524
申请日：2000-03-13
申请人： Holger Bengs , Gitte Böhm
发明人： Holger Bengs , Gitte Böhm
IPC分类号： C08L302
CPC分类号： C08J5/18 , B65D65/466 , C08J2303/00 , C08K5/0016 , C08L3/00 , C08L89/005 , C08L97/005 , C08L97/007 , Y02A40/961 , Y02W90/11 , Y02W90/13 , C08L2666/02
摘要： Thermoplastic mixture based on biopolymers for producing shaped biodegradable articles with improved properties, preparation of the mixture, and also its use. A novel thermoplastic mixture based on biopolymers, in particular on starch, features the presence of lignin and is used for producing shaped biodegradable articles with improved properties, preferably with improved mechanical properties. The mixture is preferably obtained by preparing, and mixing with one another, A) 100 parts by weight of one or more physiologically nonhazardous, biodegradable, thermoplastically processable polymeric materials selected from the group consisting of polysaccharides and proteins, preferably at least one starch of any type which is native, chemically modified, fermentative, recombinant and/or prepared by biotransformation, and/or derivatives of the starches mentioned; B) from 10 to 100 parts by weight of water; C) from 1 to 100 parts by weight of lignin; D) if desired, up to 50 parts by weight of at least one plasticizer; and E) if desired, up to 200 parts by weight, preferably not more than 100 parts by weight, of other conventional additives; where the components are thermoplastified with introduction of thermal and mechanical energy into the mixture, preferably at an elevated temperature and with simultaneous exertion of shear forces onto the mixture. Surprisingly, the use of lignin with thermoplastic materials based on biopolymers, in particular based on starch, leads to improved thermoplastic materials which have advantages in particular in terms of their mechanical properties or other performance characteristics.
摘要翻译：基于用于生产具有改进性能的成型可生物降解制品的生物聚合物的热塑性混合物，混合物的制备及其用途。基于生物聚合物，特别是淀粉的新型热塑性混合物特征在于木质素的存在，并且用于生产具有改进性能的成型可生物降解制品，优选具有改善的机械性能。该混合物优选通过制备和彼此混合获得，A）100重量份的选自多糖和蛋白质的一种或多种生理学上非危险的，可生物降解的，热塑性可加工的聚合材料，优选至少一种任何天然，化学修饰，发酵，重组和/或通过生物转化制备的类型和/或所述淀粉衍生物; B）10至100重量份的水; C）1至100重量份的木质素 ; D）如果需要，最多50重量份的至少一种增塑剂; 和E），如果需要，最多200重量份，优选不超过100重量份的其它常规添加剂;其中组分通过将热和机械能引入混合物中，优选在升高的温度下并同时进行热塑化在混合物上施加剪切力。令人惊奇的是，使用基于生物聚合物，特别是基于淀粉的热塑性材料的木质素导致改进的热塑性材料，其特别是在它们的机械性能或其它性能特征方面具有优点。

8. 发明授权

US06565640B1 Compositions containing starch and/or modified starch and plasticisers 失效
标题翻译：含有淀粉和/或改性淀粉和增塑剂的组合物
公开(公告)号：US06565640B1
公开(公告)日：2003-05-20
申请号：US09462548
申请日：2000-03-20
申请人： Holger Bengs , Jürgen Grande
发明人： Holger Bengs , Jürgen Grande
IPC分类号： C09D10302
CPC分类号： C08J5/18 , C08J2303/02 , C08K5/1545 , C08L3/02 , C08L2201/06 , C08L2205/06
摘要： Compositions are described, based on starch and/or on modified starch and comprising, as plasticizers, polyhydroxycarboxylic acids derived from aldoses and/or from ketoses, in particular from pentoses and hexoses, or comprising lactones of these acids such as &dgr;-caprolactone. The materials can be processed thermoplastically to give shaped articles which are biodegradable and physiologically nonhazardous. They may be used as packaging or casing for food or drink or pharmaceutical products, or also for the controlled release of active substances, or else for producing temporary protective coatings.
摘要翻译：描述了基于淀粉和/或改性淀粉的组合物，其包含衍生自醛糖和/或衍生自酮糖，特别是戊糖和己糖的多羟基羧酸或包含这些酸的内酯如δ-己内酯的多羟基羧酸。这些材料可以热塑性加工，以得到可生物降解和生理上非危险的成型制品。它们可以用作食品或饮料或药品的包装或外壳，也可用作活性物质的控制释放，或用于生产临时保护涂层。

9. 发明授权

US06562459B1 Method for the production of spherical microparticles consisting totally or partly of at least one water insoluble polyglucan containing branches and microparticles produced according to said method 失效
标题翻译：制备全部或部分由根据所述方法生产的至少一种含水分子的分支和微粒的水不溶性聚葡聚糖的球形微粒的制备方法
公开(公告)号：US06562459B1
公开(公告)日：2003-05-13
申请号：US09786142
申请日：2001-06-07
申请人： Holger Bengs , Jürgen Grande
发明人： Holger Bengs , Jürgen Grande
IPC分类号： B32B516
CPC分类号： A61K9/5161 , A61K9/1652 , A61K9/5192 , C08J3/14 , C08J2305/00 , C08L3/12 , C08L5/00 , Y10T428/2982
摘要： The invention relates to a method for the production of spherical microparticles consisting totally or partly of at least one water-insoluble polysaccharide, wherein the at least one water-insoluble polysaccharide is dissolved in a solvent or solvent mixture, the solution thus formed is introduced into a precipitating agent or precipitating agent mixture, the mixture obtained is optionally cooled and the formed microparticles are separated. The invention is characterized in that the water-insoluble polysaccharide is selected from a polyglucan containing branches with a degree of branching higher than zero and no higher than 8% and a mixture of a polyglucan containing branches and a linear polysaccharide, wherein the proportion of polyglucan containing branches in the mixture is at the most 30% by weight in relation to the overall weight of the polysaccharide and the polyglucan.
摘要翻译：本发明涉及一种全部或部分由至少一种不溶于水的多糖组成的球形微粒的制造方法，其中将至少一种水不溶性多糖溶解在溶剂或溶剂混合物中，将形成的溶液引入沉淀剂或沉淀剂混合物，任选地将获得的混合物冷却并分离形成的微粒。本发明的特征在于，水不溶性多糖选自具有分支度高于零且不高于8％的支链的聚葡聚糖和含有支链的多聚葡聚糖和线性多糖的混合物，其中聚葡聚糖的比例混合物中含有的支链相对于多糖和聚葡聚糖的总重量为至多30重量％。

10. 发明授权

US06736889B2 Compositions comprising starch and/or modified starch and plasticizers 失效
标题翻译：包含淀粉和/或改性淀粉和增塑剂的组合物
公开(公告)号：US06736889B2
公开(公告)日：2004-05-18
申请号：US10402062
申请日：2003-03-28
申请人： Holger Bengs , Jürgen Grande
发明人： Holger Bengs , Jürgen Grande
IPC分类号： C09D10302
CPC分类号： C08J5/18 , C08J2303/02 , C08K5/1545 , C08L3/02 , C08L2201/06 , C08L2205/06
摘要： Compositions are described, based on starch and/or on modified starch and comprising, as plasticizers, polyhydroxycarboxylic acids derived from aldoses and/or from ketoses, in particular from pentoses and hexoses, or comprising lactones of these acids. The materials can be processed thermoplastically to give shaped articles which are biodegradable and physiologically nonhazardous. They may be used as packaging or casing for food or drink or pharmaceutical products, or also for the controlled release of active substances, or else for producing temporary protective coatings.
摘要翻译：描述了基于淀粉和/或改性淀粉的组合物，其包含衍生自醛糖和/或酮糖，特别是戊糖和己糖，或包含这些酸的内酯的多羟基羧酸作为增塑剂。这些材料可以热塑性加工，以得到可生物降解和生理上非危险的成型制品。它们可以用作食品或饮料或药品的包装或外壳，也可用作活性物质的控制释放，或用于生产临时保护涂层。

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