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    • 8. 发明授权
    • Method and apparatus for manufacturing tablet capable of quick disintegration in oral cavity
    • 用于制造能够在口腔中快速分解的片剂的方法和装置
    • US06316026B1
    • 2001-11-13
    • US09227921
    • 1999-01-08
    • Mitsutoshi TataraKoji MatsunagaToshihito Shimizu
    • Mitsutoshi TataraKoji MatsunagaToshihito Shimizu
    • A61K920
    • B30B15/32A61J3/10A61K9/0056A61K9/2095B30B11/08
    • A method and an apparatus are adapted to manufacture a tablet capable of quick disintegration in the oral cavity that has a sufficiently large porosity and can be disintegrated in the oral cavity in a very short period of time, typically between 3 and 5 seconds. A tablet manufactured by means of such a method and such an apparatus also constitutes part of the present invention. The method for manufacturing a tablet capable of quickly disintegration in the oral cavity comprises steps of punching a tablet out of a pharmaceutical composition containing one or more than one medicinal agents and one or more than one water-soluble saccharides under pressure between 0.20 and 0.01 t/cm2 and shaping the tablet by moisturizing and drying it, while transferring it without causing it to drop, said tablet having a porosity between 20 and 40%.
    • 一种方法和装置适于制造能够在口腔中快速崩解的片剂,其具有足够大的孔隙率并且可以在非常短的时间段(通常为3至5秒)内在口腔中分解。 通过这种方法制造的片剂和这种装置也构成本发明的一部分。 用于制造能够在口腔中快速崩解的片剂的方法包括以下步骤:从含有一种或多于一种药物和一种或多于一种在0.20至0.01t之间的压力下的水溶性糖类的药物组合物冲压片剂 / cm2,并且通过保湿和干燥来成形片剂,同时转移它而不会使其下降,所述片剂具有20-40%的孔隙率。