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1. 发明授权

US5659036A Process for the production of 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester, and process for the production of quinacridone from said ester as intermediate 失效
标题翻译：制备2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯的方法，以及由所述酯制备喹吖啶酮的方法，为中间体
公开(公告)号：US5659036A
公开(公告)日：1997-08-19
申请号：US409931
申请日：1995-03-23
申请人： Hitoshi Maki , Shigeki Kato , Yoshimi Kikuchi
发明人： Hitoshi Maki , Shigeki Kato , Yoshimi Kikuchi
IPC分类号： C07B61/00 , C07C227/08 , C07C227/22 , C07C229/32 , C07C229/62 , C07D471/04 , C09B48/00
CPC分类号： C09B48/00 , C07C227/22 , C07C2101/16
摘要： A process for producing 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester having a high purity from 1,4-cyclohexanedione-2,5-di(carboxylic acid alkyl ester) at high yields for a short period of time; a process for producing quinacridone of which the byproduct content is small, from the above 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester; and a process for producing quinacridone of which the particle diameter is adjusted as desired, from the above 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester without adding a step of forming a pigment.
摘要翻译：一种从1,4-环己二酮-2,5-二（羧酸烷基酯）以高产率生产具有高纯度的2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯的方法，的时间由上述2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯制备副产物含量小的喹吖啶酮的方法; 以及根据需要从上述2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯制备其粒径的喹吖啶酮的方法，而不添加形成颜料的步骤。

2. 发明授权

US5817817A Process for the production of 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester, and process for the production of quinacridone from said ester as intermediate 失效
标题翻译：制备2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯的方法，以及由所述酯制备喹吖啶酮的方法，为中间体
公开(公告)号：US5817817A
公开(公告)日：1998-10-06
申请号：US848179
申请日：1997-04-29
申请人： Hitoshi Maki , Shigeki Kato , Yoshimi Kikuchi
发明人： Hitoshi Maki , Shigeki Kato , Yoshimi Kikuchi
IPC分类号： C07B61/00 , C07C227/08 , C07C227/22 , C07C229/32 , C07C229/62 , C07D471/04 , C09B48/00
CPC分类号： C09B48/00 , C07C227/22 , C07C2101/16
摘要： A process for producing 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester having a high purity from 1,4-cyclohexanedione-2,5-di(carboxylic acid alkyl ester) at high yields for a short period of time; a process for producing quinacridone of which the byproduct content is small, from the above 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester; and a process for producing quinacridone of which the particle diameter is adjusted as desired, from the above 2,5-di(arylamino)-3,6-dihydroterephthalic acid dialkyl ester without adding a step of forming a pigment.
摘要翻译：一种从1,4-环己二酮-2,5-二（羧酸烷基酯）以高产率生产具有高纯度的2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯的方法，的时间由上述2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯制备副产物含量小的喹吖啶酮的方法; 以及根据需要从上述2,5-二（芳基氨基）-3,6-二氢对苯二甲酸二烷基酯制备其粒径的喹吖啶酮的方法，而不添加形成颜料的步骤。

3. 发明授权

US07972829B2 Process for producing transglutaminase 有权
标题翻译：转谷氨酰胺酶的制备方法
公开(公告)号：US07972829B2
公开(公告)日：2011-07-05
申请号：US12714151
申请日：2010-02-26
申请人： Yoshimi Kikuchi , Masayo Date , Yukiko Umezawa , Keiichi Yokoyama , Hiroshi Matsui
发明人： Yoshimi Kikuchi , Masayo Date , Yukiko Umezawa , Keiichi Yokoyama , Hiroshi Matsui
IPC分类号： C12N9/10 , C12N1/20 , C12N15/00 , C12P21/04 , A61K38/00 , C07H21/04 , C07H21/02 , C07K1/00 , C12Q1/68 , C12Q1/00
CPC分类号： C12N9/1044 , C07K2319/02 , C07K2319/036 , C12N9/52 , C12N15/625 , C12Y203/02013
摘要： The present invention relates to a process for secretory production of a foreign protein, in particular, transglutaminase by a coryneform bacterium.According to the present invention, a process is provided for the secretory production of a foreign protein, in particular, transglutaminase, by making a coryneform bacterium to produce an industrially useful foreign protein, in particular, transglutaminase and efficiently release the product extracellularly (i.e., secretory production).An intended foreign protein, in particular, transglutaminase, is produced by using an expression construct wherein the gene sequence of the intended foreign protein containing the pro-structure part, in particular, pro-transglutaminase gene sequence, is ligated to the downstream of a sequence encoding the signal peptide region from a coryneform bacterium, introducing this expressional genetic construct into a coryneform bacterium, culturing the thus transformed coryneform bacterium, and treating the extracellularly released protein with a protease, etc. to cleave and eliminate the pro-part.
摘要翻译：本发明涉及通过棒状细菌分泌外源蛋白质，特别是转谷氨酰胺酶的方法。根据本发明，提供了通过制备棒状细菌以产生工业上有用的外源蛋白质，特别是转谷氨酰胺酶并有效地将细胞外释放产物（即，通过转运谷氨酰胺酶）分泌外源蛋白质，特别是转谷氨酰胺酶的方法，分泌生产）。通过使用表达构建体产生预期的外源蛋白质，特别是转谷氨酰胺酶，其中含有前结构部分，特别是原转谷氨酰胺酶基因序列的预期外源蛋白的基因序列连接到序列的下游编码来自棒状细菌的信号肽区域，将该表达遗传构建体引入棒状杆菌型细菌，培养由此转化的棒状杆菌型细菌，用蛋白酶等处理细胞外释放的蛋白质以切割和消除前体部分。

4. 发明申请

US20110137007A1 METHOD FOR PRODUCING AN AMINOHYDROXYBENZOIC ACID-TYPE COMPOUND 有权
标题翻译：制备氨基羟基苯甲酸型化合物的方法
公开(公告)号：US20110137007A1
公开(公告)日：2011-06-09
申请号：US12983500
申请日：2011-01-03
申请人： Mototaka Suzuki , Keiichi Yokoyama , Yoshimi Kikuchi
发明人： Mototaka Suzuki , Keiichi Yokoyama , Yoshimi Kikuchi
IPC分类号： C08G73/22 , C12P13/00
CPC分类号： C12P13/008 , C08G73/22 , C12N9/16 , C12N9/88
摘要： Provided is a method for efficiently producing a 3-amino-4-hydroxybenzoic acid-type compound by culturing a coryneform bacterium that has a gene encoding a mutated aspartokinase not subject to feedback inhibition, and that is transformed with a recombinant vector containing a DNA encoding a protein having an activity to form 3-amino-4-hydroxybenzoic acid from dihydroxyacetone phosphate and aspartate semialdehyde.
摘要翻译：提供了通过培养具有编码不经反馈抑制的突变型天冬氨酸激酶的基因的棒状细菌，并且用含有编码的DNA的重组载体转化的有效产生3-氨基-4-羟基苯甲酸型化合物的方法具有从磷酸二羟丙酮和天冬氨酸半醛形成3-氨基-4-羟基苯甲酸的活性的蛋白质。

5. 发明申请

US20100297729A1 PROCESS FOR PRODUCING TRANSGLUTAMINASE 有权
标题翻译：生产转氨酶的方法
公开(公告)号：US20100297729A1
公开(公告)日：2010-11-25
申请号：US12714151
申请日：2010-02-26
申请人： Yoshimi Kikuchi , Masayo Date , Yukiko Umezawa , Keiichi Yokoyama , Hiroshi Matsui
发明人： Yoshimi Kikuchi , Masayo Date , Yukiko Umezawa , Keiichi Yokoyama , Hiroshi Matsui
IPC分类号： C12N9/48 , C07H21/04
CPC分类号： C12N9/1044 , C07K2319/02 , C07K2319/036 , C12N9/52 , C12N15/625 , C12Y203/02013
摘要： The present invention relates to a process for secretory production of a foreign protein, in particular, transglutaminase by a coryneform bacterium.According to the present invention, a process is provided for the secretory production of a foreign protein, in particular, transglutaminase, by making a coryneform bacterium to produce an industrially useful foreign protein, in particular, transglutaminase and efficiently release the product extracellularly (i.e., secretory production).An intended foreign protein, in particular, transglutaminase, is produced by using an expression construct wherein the gene sequence of the intended foreign protein containing the pro-structure part, in particular, pro-transglutaminase gene sequence, is ligated to the downstream of a sequence encoding the signal peptide region from a coryneform bacterium, introducing this expressional genetic construct into a coryneform bacterium, culturing the thus transformed coryneform bacterium, and treating the extracellularly released protein with a protease, etc. to cleave and eliminate the pro-part.
摘要翻译：本发明涉及通过棒状细菌分泌外源蛋白质，特别是转谷氨酰胺酶的方法。根据本发明，提供了通过制备棒状细菌以产生工业上有用的外源蛋白质，特别是转谷氨酰胺酶并有效地释放产物的方法（即，通过使细胞外有效释放外源蛋白质，特别是转谷氨酰胺酶）分泌生产）。通过使用表达构建体产生预期的外源蛋白质，特别是转谷氨酰胺酶，其中含有前结构部分，特别是原转谷氨酰胺酶基因序列的预期外源蛋白的基因序列连接到序列的下游编码来自棒状细菌的信号肽区域，将该表达遗传构建体引入棒状杆菌型细菌，培养由此转化的棒状杆菌型细菌，用蛋白酶等处理细胞外释放的蛋白质以切割和消除前体部分。

6. 发明授权

US07723081B1 Bacteria containing aspartate-semialdehyde dehydrogenase, phosphoenolpyruvate carboxylase, and transhydrogenase to produce L-lysine in escherichia, and methods of using same 有权
标题翻译：含有天冬氨酸 - 半醛脱氢酶，磷酸烯醇丙酮酸羧化酶和转氢酶在埃希氏菌中产生L-赖氨酸的细菌及其使用方法
公开(公告)号：US07723081B1
公开(公告)日：2010-05-25
申请号：US10149450
申请日：2000-01-21
申请人： Kazuo Nakanishi , Yoshimi Kikuchi , Junichiro Kojima , Tomoko Suzuki , Yasushi Nishimura , Hiroyuki Kojima
发明人： Kazuo Nakanishi , Yoshimi Kikuchi , Junichiro Kojima , Tomoko Suzuki , Yasushi Nishimura , Hiroyuki Kojima
IPC分类号： C12P13/08
CPC分类号： C12P13/08 , C12N15/52
摘要： An Escherichia bacterium (1) which harbors dihydrodipicolinate synthase of which feedback inhibition by L-lysine is desensitized and aspartokinase of which feedback inhibition by L-lysine is desensitized, (2) in which intracellular activity of dihydrodipicolinate reductase is enhanced, and (3) in which a diaminopimelate dehydrogenase gene is introduced or intracellular activities of tetrahydrodipicolinate succinylase and succinyl diaminopimelate deacylase are enhanced, wherein intracellular activity of aspartate-semialdehyde dehydrogenase or phosphoenolpyruvate carboxylase is enhanced, is cultured in a suitable medium to produce and accumulate L-lysine in culture, and the L-lysine is collected from the culture.
摘要翻译：具有L-赖氨酸的反馈抑制脱敏的二氢吡啶并吡啶合酶的大肠杆菌细菌（1），L-赖氨酸的反馈抑制的天冬氨酸脱敏，（2）二氢吡啶二羧酸还原酶的细胞内活性增强，（3）其中引入二氨基庚二酸脱氢酶基因或增加四氢二吡啶甲酰基琥珀酰基酶和琥珀酰二氨基庚二酸脱酰基酶的细胞内活性，其中天冬氨酸半醛脱氢酶或磷酸烯醇丙酮酸羧化酶的细胞内活性增强，在合适的培养基中培养以在培养物中产生和积累L-赖氨酸，并从培养物中收集L-赖氨酸。

7. 发明授权

US07704707B2 Method of producing microbial transglutaminase 有权
标题翻译：微生物转谷氨酰胺酶的生产方法
公开(公告)号：US07704707B2
公开(公告)日：2010-04-27
申请号：US11218780
申请日：2005-09-06
申请人： Yukiko Umezawa , Keiichi Yokoyama , Yoshimi Kikuchi , Masayo Date , Norimasa Onishi
发明人： Yukiko Umezawa , Keiichi Yokoyama , Yoshimi Kikuchi , Masayo Date , Norimasa Onishi
IPC分类号： C12P21/06 , C12N9/48
CPC分类号： C12N9/1044 , C12N9/6489
摘要： The present invention provides a neutral metalloprotease from actinomycetes which selectively cleaves a pro-structure part of a microbial protransglutaminase and a gene encoding said neutral metalloprotease. An active microbial transglutaminase having the pro-structure part cleaved can be obtained by culturing a microorganism into which a gene encoding the neutral metalloprotease from actinomycetes according to the present invention has been introduced, where by producing the neutral metalloprotease from actinomycetes, and reacting it on a microbial protransglutaminase.
摘要翻译：本发明提供来自放线菌的中性金属蛋白酶，其选择性地切割微生物转谷氨酰胺酶的前体结构部分和编码所述中性金属蛋白酶的基因。具有前体结构部分切割的活性微生物转谷氨酰胺酶可以通过培养从引入放线菌中产生中性金属蛋白酶的本发明的编码中性金属蛋白酶的基因的微生物获得，其中通过从放线菌产生中性金属蛋白酶，微生物抗转谷氨酰胺酶。

8. 发明申请

US20070184525A1 METHOD OF PRODUCING PROTEINS 有权
标题翻译：生产蛋白质的方法
公开(公告)号：US20070184525A1
公开(公告)日：2007-08-09
申请号：US11550972
申请日：2006-10-19
申请人： Masayo Date , Yoshimi Kikuchi , Hiroshi Itaya , Nami Nakamura
发明人： Masayo Date , Yoshimi Kikuchi , Hiroshi Itaya , Nami Nakamura
IPC分类号： C12P21/06 , C12N9/06 , C07H21/04 , C12N15/74 , C12N1/21
CPC分类号： C12P21/02 , C12N15/77
摘要： The present invention provides a method for efficiently producing an industrially useful protein in coryneform bacteria, and more particularly, a method for efficiently producing a protein for which secretion was difficult using conventional protein secretion pathways. In particular, the present invention provides a method for efficiently producing heterologous proteins comprising culturing coryneform bacteria containing an genetic construction containing a promoter sequence which functions in coryneform bacteria, a nucleic acid sequence encoding a Tat system-dependent signal peptide region, and a nucleic acid sequence encoding a heterologous protein, in the direction from 5′-end to 3′-end, and secretory producing the heterologous protein by coryneform bacteria.
摘要翻译：本发明提供了一种在棒状细菌中有效生产工业上有用的蛋白质的方法，更具体地，涉及使用常规的蛋白质分泌途径有效制备难以分泌的蛋白质的方法。特别地，本发明提供了一种有效生产异源蛋白的方法，包括培养含有在棒状细菌中起作用的启动子序列的遗传构建的棒状细菌，编码Tat系统依赖性信号肽区的核酸序列和核酸从5'端到3'端的方向编码异源蛋白的序列，以及通过棒状细菌产生异源蛋白的分泌。

9. 发明授权

US5958128A Method of manufacturing a disazo pigment and disazo pigment manufactured thereby 失效
标题翻译：由此制造双偶氮颜料和双偶氮颜料的方法
公开(公告)号：US5958128A
公开(公告)日：1999-09-28
申请号：US945266
申请日：1997-10-24
申请人： Yoshimi Kikuchi , Hitoshi Sugamo
发明人： Yoshimi Kikuchi , Hitoshi Sugamo
IPC分类号： C09B35/10 , C09B41/00 , C09B27/00
CPC分类号： C09B35/105 , C09B41/006
摘要： In the method of manufacturing a disazo pigment according to the present invention, a superior coupling reaction rate during the coupling reaction process makes it possible to manufacture a disazo pigment having superior transparency, brightness, color strength and gloss for the case in which a color strength agent is used. In this method, a coupling reaction is carried out while continuously feeding a coupler aqueous solution comprising a coupler component having the general formula (I) shown below and a tetrazo aqueous solution comprising a benzidine derivative tetrazo component at a molar ratio of 2:0.8.about.0.99 into an acidic aqueous solution held in a batch type mixing vessel. ##STR1## (where each of X, Y, Z independently represents H, CH.sub.3, OCH.sub.3, Cl)
摘要翻译： PCT No.PCT / JP97 / 00547 Sec。 371 1997年10月24日第 102（e）1997年10月24日PCT PCT 1997年2月26日提交PCT公布。公开号WO97 / 31067 日本公开日1997年8月28日在本发明的双偶氮颜料的制造方法中，在偶联反应工序中优异的偶联反应速度使得可以制造具有优异透明性，亮度，着色强度和光泽度的双偶氮颜料其中使用着色剂。在该方法中，连续进料包含下述通式（I）所示的成色剂组分的偶合剂水溶液和包含联苯胺衍生物双偶氮组分的双偶氮水溶液，摩尔比为2:0.8。 0.99进入分批式混合容器中的酸性水溶液中。（其中X，Y，Z各自独立地表示H，CH 3，OCH 3，Cl）

10. 发明授权

US08669760B2 Angle detection system and method of manufacturing the same 失效
标题翻译：角度检测系统及其制造方法
公开(公告)号：US08669760B2
公开(公告)日：2014-03-11
申请号：US12992676
申请日：2009-05-09
申请人： Yoshimi Kikuchi , Kanji Kitazawa , Hisashi Mimura , Minow Okada
发明人： Yoshimi Kikuchi , Masahito Okada , Kanji Kitazawa , Hisashi Mimura
IPC分类号： H02K15/02
CPC分类号： G01D5/2013
摘要： An angle detection system of the present invention includes: a stator 200 which includes a plurality of salient pole portions which are formed on a flat sheet made of a magnetic material and are raised by bending, each salient pole portion constituting a winding magnetic core on which a winding member for excitation and a winding member for detection are mounted; and a rotor 300 which is made of a magnetic material and is configured to be rotatable relative to the stator such that gap permeance between the rotor and each salient pole portion is changed due to the rotation thereof about a rotational axis thereof. According to the angle detection device of the present invention, it is possible to provide the angle detection device which can largely reduce the number of parts and can realize the reduction of cost and the enhancement of reliability.
摘要翻译：本发明的角度检测系统包括：定子200，其包括形成在由磁性材料制成的平板上并通过弯曲而升高的多个凸极部，每个凸极部分构成卷绕磁心，安装用于激励的卷绕构件和用于检测的卷绕构件; 以及转子300，其由磁性材料制成并且被构造成能够相对于定子旋转，使得转子和每个凸极部分之间的间隙磁导由于其围绕其旋转轴的旋转而改变。根据本发明的角度检测装置，可以提供能够大幅度减少部件数量的角度检测装置，能够实现成本的降低和可靠性的提高。

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