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1. 发明申请

US20110034466A1 NOVEL FIVE-MEMBERED RING COMPOUND 审中-公开
标题翻译：新五元环化合物
公开(公告)号：US20110034466A1
公开(公告)日：2011-02-10
申请号：US12989516
申请日：2009-04-23
申请人： Hitoshi Fujita , Toshio Kanai , Satoki Imai
发明人： Hitoshi Fujita , Toshio Kanai , Satoki Imai
IPC分类号： A61K31/5377 , C07D413/10 , A61P29/00
CPC分类号： C07D277/20 , C07D277/42 , C07D417/10
摘要： Disclosed is a five-membered ring compound represented by formula (1) or a pharmaceutically acceptable salt thereof. The compound inhibits infiltration of leukocytes including eosinophils and lymphocytes, and is effective as a drug for treating various inflammations. The compound is highly safe and can be administered for a long period. A pharmaceutical product containing the five-membered ring compound or a pharmaceutically acceptable salt thereof is also disclosed. (In the formula, R1 represents a halogen atom or a phenyl group which may be substituted by a C1-C3 alkyl group or a C1-C3 alkoxy group; R2 represents a C1-C3 alkylene group which may be substituted by a C1-C3 alkyl group or a carbonyl group; R3 represents a C1-C3 alkyl group; R4 and R5 independently represent a hydrogen atom or a C1-C3 alkyl group, or —N(R4)R5 may represent a morpholino group which may be substituted by a C1-C3 alkyl group; Y2 represents a C2-C4 alkylene group; and R6 represents a hydrogen atom, a halogen atom, a C1-C3 alkyl group or a C1-C3 alkoxy group.)
摘要翻译：公开了由式（1）表示的五元环化合物或其药学上可接受的盐。该化合物抑制嗜酸性粒细胞和淋巴细胞等白细胞的浸润，作为治疗各种炎症的药物是有效的。该化合物是高度安全的，可以长期施用。还公开了含有五元环化合物或其药学上可接受的盐的药物。（式中，R1表示卤原子或可被C1-C3烷基或C1-C3烷氧基取代的苯基; R2表示可被C1-C3取代的C1-C3亚烷基烷基或羰基; R3表示C1-C3烷基; R4和R5独立地表示氢原子或C1-C3烷基，或-N（R4）R5可以表示可以被 C1-C3烷基; Y2表示C2-C4亚烷基; R6表示氢原子，卤素原子，C1-C3烷基或C1-C3烷氧基）。

2. 发明授权

US08012971B2 Therapeutic agent for chronic obstructive pulmonary disease 失效
标题翻译：慢性阻塞性肺疾病治疗剂
公开(公告)号：US08012971B2
公开(公告)日：2011-09-06
申请号：US11919135
申请日：2006-04-28
申请人： Toshinari Sugasawa , Takashi Nakajima , Hitoshi Fujita , Toshio Kanai
发明人： Toshinari Sugasawa , Takashi Nakajima , Hitoshi Fujita , Toshio Kanai
IPC分类号： A61K31/426 , A61K31/5377 , C07D417/10 , C07D277/38
CPC分类号： A61K31/56 , A61K9/10 , A61K31/5377 , C07D277/42
摘要： Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below: or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; R1 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Y1 represents single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; R3 represents a hydrogen atom, a substituted or unsubstituted aryl or the like; Y2 represents a substituted or unsubstituted alkylene or an alkenylene; R4 represents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and R5 represents a hydrogen atom or a substituted or unsubstituted alkyl.
摘要翻译：本发明公开了一种预防和/或治疗慢性阻塞性肺疾病的方法，该方法是通过给予由下式表示的5元环状化合物：或化合物的药学上可接受的盐或其化合物或盐的前体药物：其中X 表示氧或硫原子; R1表示氢原子，取代或未取代的烷基等; R 2表示氢原子，取代或未取代的烷基等; Y1表示单键，取代或未取代的亚烷基等; 波浪线表示（E）或（Z）配位; R3表示氢原子，取代或未取代的芳基等; Y2表示取代或未取代的亚烷基或亚烯基; R4表示氢原子，取代或未取代的烷酰基等; 并且R 5表示氢原子或取代或未取代的烷基。

3. 发明申请

US20090131439A1 Therapeutic agent for chronic obstructive pulmonary disease 失效
标题翻译：慢性阻塞性肺疾病治疗剂
公开(公告)号：US20090131439A1
公开(公告)日：2009-05-21
申请号：US11919135
申请日：2006-04-28
申请人： Toshinari Sugasawa , Takashi Nakajima , Hitoshi Fujita , Toshio Kanai
发明人： Toshinari Sugasawa , Takashi Nakajima , Hitoshi Fujita , Toshio Kanai
IPC分类号： A61K31/426 , A61K31/5377 , A61P11/00 , C07D417/10 , C07D277/38
CPC分类号： A61K31/56 , A61K9/10 , A61K31/5377 , C07D277/42
摘要： Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below: or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; R1 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Y1 represents single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; R3 represents a hydrogen atom, a substituted or unsubstituted aryl or the like; Y2 represents a substituted or unsubstituted alkylene or an alkenylene; R4 represents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and R5 represents a hydrogen atom or a substituted or unsubstituted alkyl.
摘要翻译：本发明公开了一种预防和/或治疗慢性阻塞性肺疾病的方法，该方法是通过给予由下式表示的5元环状化合物：或化合物的药学上可接受的盐或其化合物或盐的前体药物：其中X 表示氧或硫原子; R1表示氢原子，取代或未取代的烷基等; R 2表示氢原子，取代或未取代的烷基等; Y1表示单键，取代或未取代的亚烷基等; 波浪线表示（E）或（Z）配位; R3表示氢原子，取代或未取代的芳基等; Y2表示取代或未取代的亚烷基或亚烯基; R4表示氢原子，取代或未取代的烷酰基等; 并且R 5表示氢原子或取代或未取代的烷基。

4. 发明申请

US20110263550A1 THERAPEUTIC AGENT FOR CHRONIC OBSTRUCTIVE PULMONARY DISEASE 审中-公开
标题翻译：慢性阻塞性肺疾病治疗药物
公开(公告)号：US20110263550A1
公开(公告)日：2011-10-27
申请号：US13084503
申请日：2011-04-11
申请人： Toshinari Sugasawa , Takashi Nakajima , Hitoshi Fujita , Toshio Kanai
发明人： Toshinari Sugasawa , Takashi Nakajima , Hitoshi Fujita , Toshio Kanai
IPC分类号： A61K31/56 , A61P11/00 , A61K31/5377
CPC分类号： A61K31/56 , A61K9/10 , A61K31/5377 , C07D277/42
摘要： Disclosed is a method for the prevention and/or treatment of a chronic obstructive pulmonary disease by administrating a 5-membered cyclic compound represented by the formula below: or a pharmaceutically acceptable salt of the compound or a prodrug of the compound or salt: wherein X represents an oxygen or sulfur atom; R1 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; R2 represents a hydrogen atom, a substituted or unsubstituted alkyl or the like; Y1 represents single bond, a substituted or unsubstituted alkylene or the like; the wavy line means an (E) or (Z) coordination; R3 represents a hydrogen atom, a substituted or unsubstituted aryl or the like; Y2 represents a substituted or unsubstituted alkylene or an alkenylene; R4 represents a hydrogen atom, a substituted or unsubstituted alkanoyl or the like; and R5 represents a hydrogen atom or a substituted or unsubstituted alkyl.
摘要翻译：本发明公开了一种预防和/或治疗慢性阻塞性肺疾病的方法，该方法是通过给予由下式表示的5元环状化合物：或化合物的药学上可接受的盐或其化合物或盐的前体药物：其中X 表示氧或硫原子; R1表示氢原子，取代或未取代的烷基等; R 2表示氢原子，取代或未取代的烷基等; Y1表示单键，取代或未取代的亚烷基等; 波浪线表示（E）或（Z）配位; R3表示氢原子，取代或未取代的芳基等; Y2表示取代或未取代的亚烷基或亚烯基; R4表示氢原子，取代或未取代的烷酰基等; 并且R 5表示氢原子或取代或未取代的烷基。

5. 发明授权

US06587294B1 Method and apparatus for error correction of stored data 失效
标题翻译：存储数据纠错方法和装置
公开(公告)号：US06587294B1
公开(公告)日：2003-07-01
申请号：US09413011
申请日：1999-10-05
申请人： Teruhiko Ushio , Toshio Kanai
发明人： Teruhiko Ushio , Toshio Kanai
IPC分类号： G11B509
CPC分类号： G11B20/1866
摘要： Method and apparatus to correct an error of read-out data from a data storage medium, particularly a bit shift error, is described. The correction apparatus includes a gray bit detection circuit which flags bits with a phase shift exceeding a threshold and determines whether the previous or next bit cell has a smaller phase error. An RLL error detection circuit and a table containing valid bit combinations may be used in combination with the gray bit detector to correct errors on-the-fly without degrading performance. An advantage of the invention is that it allows correction of errors without regard to conventional ECC and its maximum number of errors.
摘要翻译：描述了从数据存储介质校正读出数据的错误，特别是位移错误的方法和装置。校正装置包括灰阶检测电路，其以相移超过阈值的位进行标识，并确定前一位或下一位单元是否具有较小的相位误差。 RLL错误检测电路和包含有效位组合的表可以与灰度位检测器组合使用，以便在不降低性能的情况下即时校正错误。本发明的优点在于它允许校正错误，而不考虑常规ECC及其最大错误数量。

6. 发明授权

US06429704B1 Power consumption reduction method, power consumption reduction circuit, control circuit, and hard disk drive apparatus 失效
标题翻译：功耗降低方法，功耗降低电路，控制电路和硬盘驱动装置
公开(公告)号：US06429704B1
公开(公告)日：2002-08-06
申请号：US09675547
申请日：2000-09-28
申请人： Toshio Kanai , Masayuki Murakami , Yasuhiro Takase
发明人： Toshio Kanai , Masayuki Murakami , Yasuhiro Takase
IPC分类号： H03B1900
CPC分类号： G11B19/00
摘要： A power consumption reduction circuit includes a clock frequency downconverting circuit. The clock frequency downconverting circuit downconverts a frequency of a CK signal, which is inputted, when a POR signal inputted is asserted, and outputs the CK signal to an IC selection circuit. In addition, if the POR signal inputted is negated, the clock frequency downconverting circuit outputs the CK signal inputted as it is to the IC selection circuit. A signal outputted from the clock frequency downconverting circuit is supplied to a plurality of ICs through the IC selection circuit.
摘要翻译：功耗降低电路包括时钟频率下变频电路。当输入的POR信号被置位时，时钟频率下变频电路降频输入的CK信号的频率，并将CK信号输出到IC选择电路。此外，如果输入的POR信号被否定，则时钟频率下变频电路将输入的CK信号原样输出到IC选择电路。从时钟下变频电路输出的信号通过IC选择电路提供给多个IC。

7. 发明授权

US06295259B1 Method and apparatus for digitizing a signal read from a data storage medium into a binary value 失效
标题翻译：将从数据存储介质读取的信号数字化为二进制值的方法和装置
公开(公告)号：US06295259B1
公开(公告)日：2001-09-25
申请号：US09315898
申请日：1999-05-20
申请人： Toshio Kanai
发明人： Toshio Kanai
IPC分类号： G11B509
CPC分类号： G11B20/1025 , G11B20/10009 , G11B20/1403
摘要： To more precisely digitize a signal read from a data storage medium into a binary value to reduce the rate of occurrence of bit error in reproduction. A phase difference of the intersecttion between a signal read from a data storage medium and a slice signal is evaluated to select a probable time cell in which the intersection should be contained for more precisely digitizing the read signal into a binary value.
摘要翻译：为了更精确地将从数据存储介质读取的信号数字化为二进制值，以减少再现中位错误的发生率。评估从数据存储介质读取的信号与切片信号之间的相交的相位差，以选择其中应包含交点的可能时间单元，以将读取信号更精确地数字化为二进制值。

8. 发明授权

US4368060A Gas sparging method 失效
标题翻译：气体喷射法
公开(公告)号：US4368060A
公开(公告)日：1983-01-11
申请号：US287114
申请日：1981-07-27
申请人： Hiroshi Yanagiako , Toshio Kanai , Yoshio Kogawa , Michihiro Yoshida , Zenji Mashino , Shin-ichi Shimizu , Teruo Sugiya , Masaki Onozaki
发明人： Hiroshi Yanagiako , Toshio Kanai , Yoshio Kogawa , Michihiro Yoshida , Zenji Mashino , Shin-ichi Shimizu , Teruo Sugiya , Masaki Onozaki
IPC分类号： B01D53/34 , B01D53/52 , B01D53/58 , B01D53/60 , B01D53/68 , B01F3/04
CPC分类号： B01D53/52 , B01D53/34 , B01D53/58 , B01D53/60 , B01D53/68 , B01F3/04262 , B01F3/04836 , B01F2003/0429 , B01F2003/04319 , B01F2003/04361 , B01F2003/04368
摘要： This invention is directed to a sparging method wherein efficient gas-liquid contact is obtained without causing sloshing by introducing and dispensing gas into the liquid only through openings in the side wall of a specially designed sparger which has a single row of openings in its side wall around the periphery thereof and an open end, the gas being introduced at a rate such that the distance l between the openings in the side wall and the liquid level on the gas introduction side is within a range represented by the formula:10 mm
摘要翻译：本发明涉及一种喷射方法，其中通过仅通过在其侧壁中具有单排开口的特殊设计的喷射器的侧壁中的开口将气体引入和分配到液体中而不会引起晃动而获得有效的气 - 液接触围绕其周边和开口端，气体以使得侧壁中的开口和气体导入侧的液面之间的距离l在由下式表示的范围内被引入：10mm <（L-10）mm其中L表示在分布器的侧壁中的开口和开口底部之间的距离至少为50mm。

9. 发明授权

US06421309B1 Apparatus and method for detecting maximum mark lengths 有权
标题翻译：用于检测最大标记长度的装置和方法
公开(公告)号：US06421309B1
公开(公告)日：2002-07-16
申请号：US09388751
申请日：1999-09-02
申请人： Toshio Kanai , Teruhiko Ushio
发明人： Toshio Kanai , Teruhiko Ushio
IPC分类号： G11B700
CPC分类号： G11B27/36 , G11B20/14 , G11B20/1426 , G11B27/3027 , G11B27/34 , G11B2220/2545 , G11B2220/2562
摘要： A maximum mark length detector comprising a total value register for storing a total value Lsum of measured mark lengths; a measured value register for storing a measured value of a mark length; an arithmetic unit for computing the sum Lp of a current measured value Lk and a previously measured value PLk stored in the measured value register and subtracting a maximum value Lmax from the total value Lsum when the total value Lsum reaches the measured maximum value Lmax; a counter to count the number of times the subtraction is performed; and a comparator for completing the detection when a count value C of the counter reaches a predetermined value.
摘要翻译：最大标记长度检测器，包括用于存储测量标记长度的总值Lsum的总值寄存器; 用于存储标记长度的测量值的测量值寄存器; 用于计算当前测量值Lk的和Lp和存储在测量值寄存器中的先前测量值PLk的算术单元，并且当总值Lsum达到测量的最大值Lmax时从总值Lsum中减去最大值Lmax; 计数执行减法次数的计数器; 以及当计数器的计数值C达到预定值时完成检测的比较器。

10. 发明授权

US06292626B1 Reproducing apparatus, recording apparatus and recording/reproducing apparatus 有权
标题翻译：再现装置，记录装置和记录/再现装置
公开(公告)号：US06292626B1
公开(公告)日：2001-09-18
申请号：US09265700
申请日：1999-03-10
申请人： Hidefumi Ino , Tokuo Nakatani , Toshio Kanai
发明人： Hidefumi Ino , Tokuo Nakatani , Toshio Kanai
IPC分类号： H04N5781
CPC分类号： G11B27/11 , G11B20/10 , G11B27/002 , G11B27/034 , G11B27/329 , G11B2020/10768 , G11B2220/216 , G11B2220/2562 , G11B2220/2575 , G11B2220/65
摘要： A reproducing apparatus according to the present invention includes: a first storage including a changer for housing a plurality of storage media and a drive for reading out data from first and second target storage media selected from the storage media in that order; a second storage; a data processing unit for presenting the data stored on the first and second target storage media; and a controller for controlling the changer, the drive, the data processing unit and the second storage. Before the data processing unit starts to present the data stored on the first and second target storage media, the controller controls the first storage to read out at least part of the data stored on one of the first and second target storage media as bridging data and controls the second storage to store the read bridging data. When the data processing unit starts to present the data stored on the first and second target storage media, the controller controls the second storage to supply the bridging data to the data processing unit during a period in which reading the data stored on the first and second target storage media is discontinuous because of exchange of the first target storage medium for the second target storage medium, so as to present the data stored on the first and second target storage media continuously.
摘要翻译：根据本发明的再现装置包括：第一存储器，包括用于容纳多个存储介质的更换器和用于从依次从存储介质选择的第一和第二目标存储介质读出数据的驱动器; 第二个存储; 数据处理单元，用于呈现存储在第一和第二目标存储介质上的数据; 以及用于控制更换器，驱动器，数据处理单元和第二存储器的控制器。在数据处理单元开始呈现存储在第一和第二目标存储介质上的数据之前，控制器控制第一存储器读出存储在第一和第二目标存储介质中的一个上的数据的至少一部分作为桥接数据，控制第二个存储以存储读桥接数据。当数据处理单元开始呈现存储在第一和第二目标存储介质上的数据时，控制器控制第二存储器，以在其中读取存储在第一和第二目录上的数据的时段期间将桥接数据提供给数据处理单元目标存储介质由于交换第二目标存储介质的第一目标存储介质而不连续，以便连续地呈现存储在第一和第二目标存储介质上的数据。

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