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1. 发明申请

US20120190888A1 TREPROSTINIL PRODUCTION 有权
标题翻译：曲妥珠单抗生产
公开(公告)号：US20120190888A1
公开(公告)日：2012-07-26
申请号：US13435708
申请日：2012-03-30
申请人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
发明人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
IPC分类号： C07C51/353
CPC分类号： C07C51/00 , C07B2200/07 , C07C29/143 , C07C29/42 , C07C45/00 , C07C45/29 , C07C45/61 , C07C45/64 , C07C51/09 , C07C51/367 , C07C59/72 , C07C67/343 , C07C253/30 , C07F7/1892 , Y02P20/55 , C07C69/736 , C07C255/13
摘要： The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
摘要翻译：本发明涉及一种制备曲前列素合成中间体的新方法。还描述了制备曲前列环素的方法，其包括利用本文所述的新型中间体以及可用于合成前列环素衍生物例如曲前列素的新型中间体。

2. 发明授权

US08940930B2 Treprostinil production 有权
标题翻译：曲前列环素生产
公开(公告)号：US08940930B2
公开(公告)日：2015-01-27
申请号：US13435708
申请日：2012-03-30
申请人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
发明人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
IPC分类号： C07C51/353 , C07C59/72 , C07C51/09 , C07C51/367 , C07C67/343 , C07C253/30 , C07F7/18
CPC分类号： C07C51/00 , C07B2200/07 , C07C29/143 , C07C29/42 , C07C45/00 , C07C45/29 , C07C45/61 , C07C45/64 , C07C51/09 , C07C51/367 , C07C59/72 , C07C67/343 , C07C253/30 , C07F7/1892 , Y02P20/55 , C07C69/736 , C07C255/13
摘要： The present invention is directed to a novel method for preparing a synthetic intermediates for treprostinil. Also described are methods of preparing treprostinil comprising utilizing novel intermediates described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
摘要翻译：本发明涉及一种制备曲前列素合成中间体的新方法。还描述了制备曲前列环素的方法，其包括利用本文所述的新型中间体以及可用于合成前列环素衍生物例如曲前列素的新型中间体。

3. 发明申请

US20110319641A1 TREPROSTINIL PRODUCTION 有权
标题翻译：曲妥珠单抗生产
公开(公告)号：US20110319641A1
公开(公告)日：2011-12-29
申请号：US13151465
申请日：2011-06-02
申请人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
发明人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
IPC分类号： C07D309/12 , C07C51/08 , C07C41/08 , C07C67/347 , C07C253/30 , C07F7/18 , C07C51/09
CPC分类号： C07C51/00 , C07B2200/07 , C07C29/143 , C07C29/42 , C07C45/00 , C07C45/29 , C07C45/61 , C07C45/64 , C07C51/09 , C07C51/367 , C07C59/72 , C07C67/343 , C07C253/30 , C07F7/1892 , Y02P20/55 , C07C69/736 , C07C255/13
摘要： The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
摘要翻译：本发明涉及通过立体选择性炔炔加成反应制备曲前列素的合成中间体的新方法。还描述了制备包含本文所述的炔炔加成反应的曲前列素的方法以及可用于合成前列环素衍生物例如曲前列素的新型中间体。

4. 发明授权

US08481782B2 Treprostinil production 有权
标题翻译：曲前列环素生产
公开(公告)号：US08481782B2
公开(公告)日：2013-07-09
申请号：US13151465
申请日：2011-06-02
申请人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
发明人： Hitesh Batra , Raju Penmasta , Vijay Sharma , Sudersan M. Tuladhar , David A. Walsh
IPC分类号： C07C51/36
CPC分类号： C07C51/00 , C07B2200/07 , C07C29/143 , C07C29/42 , C07C45/00 , C07C45/29 , C07C45/61 , C07C45/64 , C07C51/09 , C07C51/367 , C07C59/72 , C07C67/343 , C07C253/30 , C07F7/1892 , Y02P20/55 , C07C69/736 , C07C255/13
摘要： The present invention is directed to a novel method for preparing a synthetic intermediate for treprostinil via a stereoselective alkyne addition reaction. Also described are methods of preparing treprostinil comprising the alkyne addition reaction described herein as well as novel intermediates useful for synthesis prostacyclin derivatives, such as treprostinil.
摘要翻译：本发明涉及通过立体选择性炔炔加成反应制备曲前列素的合成中间体的新方法。还描述了制备包含本文所述的炔炔加成反应的曲前列素的方法以及可用于合成前列环素衍生物例如曲前列素的新型中间体。

5. 发明授权

US08779170B2 Method of producing beraprost 有权
标题翻译：贝拉前列素的生产方法
公开(公告)号：US08779170B2
公开(公告)日：2014-07-15
申请号：US13524568
申请日：2012-06-15
申请人： Vijay Sharma , Hitesh Batra , Sudersan Tuladhar
发明人： Vijay Sharma , Hitesh Batra , Sudersan Tuladhar
IPC分类号： C07D307/93
CPC分类号： C07D307/93 , C07C259/06 , C07F7/1804 , C07F7/1892 , C07F9/28 , C07F9/4006 , Y02P20/55
摘要： An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
摘要翻译：描述了一种用于制备合成的苯并孕烯环素类似物化合物的单一异构体的改进方法，特别是贝前列素的药理学活性的314-d异构体。与现有技术相反，该方法是立体选择性的，并且比制备这些化合物的已知方法需要更少的步骤。

6. 发明申请

US20120323025A1 METHOD OF PRODUCING BERAPROST 有权
标题翻译：生产BERAPROST的方法
公开(公告)号：US20120323025A1
公开(公告)日：2012-12-20
申请号：US13524568
申请日：2012-06-15
申请人： Vijay Sharma , Hitesh Batra , Sudersan Tuladhar
发明人： Vijay Sharma , Hitesh Batra , Sudersan Tuladhar
IPC分类号： C07D307/93
CPC分类号： C07D307/93 , C07C259/06 , C07F7/1804 , C07F7/1892 , C07F9/28 , C07F9/4006 , Y02P20/55
摘要： An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
摘要翻译：描述了一种用于制备合成的苯并孕烯环素类似物化合物的单一异构体的改进方法，特别是贝前列素的药理学活性的314-d异构体。与现有技术相反，该方法是立体选择性的，并且比制备这些化合物的已知方法需要更少的步骤。

7. 发明申请

US20140343260A1 PET/SPECT AGENTS FOR APPLICATIONS IN BIOMEDICAL IMAGING 有权
标题翻译： PET / SPECT药剂在生物医学成像中的应用
公开(公告)号：US20140343260A1
公开(公告)日：2014-11-20
申请号：US13984723
申请日：2012-02-10
申请人： Vijay Sharma , Jothilingam Sivapackiam , David Piwnica-Worms
发明人： Vijay Sharma , Jothilingam Sivapackiam , David Piwnica-Worms
IPC分类号： A61K51/04 , C07B59/00
CPC分类号： A61K51/0478 , C05D9/02 , C07B59/001 , C07B59/002 , C07C251/24 , C07F5/003
摘要： Tracers that can be used for PET or SPECT imaging of the distribution of Pgp are disclosed. The tracers are metalloprobes that can comprise a radioactive metal ion such as 67Ga or 68Ga. Methods of synthesizing the tracers, and methods of imaging heart and other tissues are also disclosed. The tracers can be used to obtain high signal-to-background ratios for imaging tissues in vivo such as heart or tumor tissue. In various embodiments, disclosed tracers can exhibit, a) enhanced first pass extraction into heart tissue compared to presently available probes, b) linearity with true blood flow, c) enhanced detection of myocardial viability compared to presently available probes, d) reduced liver retention compared to presently available probes, and e) more efficient clearance from non-cardiac and adjoining tissues compared to presently available probes.
摘要翻译：公开了可用于Pgp分布的PET或SPECT成像的示踪剂。示踪剂是可以包含诸如67Ga或68Ga的放射性金属离子的金属杂酚。还公开了合成示踪剂的方法，以及心脏和其他组织成像方法。示踪剂可用于获得体内成像组织（例如心脏或肿瘤组织）的高信噪比。在各种实施方案中，所公开的示踪剂可以表现出：a）与目前可用的探针相比，增强的第一次通过提取到心脏组织中，b）具有真实血流的线性，c）与目前可用的探针相比增强了心肌存活力的检测，d）与目前可用的探针相比，和e）与目前可用的探针相比，非心脏和邻近组织的更有效的清除。

8. 发明授权

US08741658B2 Rapid method to measure cyanide in biological samples 有权
标题翻译：快速测定生物样品中氰化物的方法
公开(公告)号：US08741658B2
公开(公告)日：2014-06-03
申请号：US13634703
申请日：2011-03-15
申请人： Gerry Boss , Vijay Sharma , Matthew Brenner , Purnendu K. Dasgupta , William Curt Blackledge
发明人： Gerry Boss , Vijay Sharma , Matthew Brenner , Purnendu K. Dasgupta , William Curt Blackledge
IPC分类号： G01N21/78 , G01N21/77 , G01N33/52 , G01N33/48
CPC分类号： G01N21/78 , G01N31/22 , G01N33/523 , G01N33/84 , G01N2201/0221
摘要： A method and devices analyze for the presence of cyanide in samples using colorimetric analysis of samples after contacting with cobinamide or monocyanocohinapmide.
摘要翻译：一种方法和装置用样品中的氰化物或单异氰尿酸药物接触后，使用比色分析来分析样品中氰化物的存在。

9. 发明申请

US20110250145A1 BIOLUMINESCENCE IMAGING OF MYELOPEROXIDASE ACTIVITY IN VIVO, METHODS, COMPOSITIONS AND APPARATUSES THEREFOR 有权
标题翻译：血液中的多酚氧化酶活性的生物荧光成像，方法，组合物及其装置
公开(公告)号：US20110250145A1
公开(公告)日：2011-10-13
申请号：US13127448
申请日：2009-11-03
申请人： Vijay Sharma , Seth Gammon , David Piwnica-Worms , Shimon Gross
发明人： Vijay Sharma , Seth Gammon , David Piwnica-Worms , Shimon Gross
IPC分类号： A61K49/00 , C07D413/14 , C07D405/12 , C07D403/14 , C07D237/32 , C07D491/22
CPC分类号： C12Q1/28 , A61K49/0013
摘要： Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.
摘要翻译：公开了在受试者中成像骨髓过氧化物酶活性分布的方法。这些方法包括使用生物发光底物，包括鲁米诺和鲁米诺的波长偏移类似物。显示出比鲁米诺更长波长发光的生物发光髓过氧化物酶底物可用于体内髓过氧化物酶活性成像。所公开的方法可用于与体内MPO活性异常水平相关的炎症和其他病理状况的成像部位。还公开了鲁米诺类似物的合成方法。

10. 发明申请

US20110201804A1 PROCESS FOR THE PREPARATION OF 1- ( 3-HYDROXYMETHYLPYRID-2 -YL ) -2 -PHENYL-4-METHYLPIPERAZINE AND MIRTAZAPINE 审中-公开
标题翻译：制备1-（3-羟基甲基吡啶-2-基）-2-苯基-4-甲基哌啶和咪唑啉的方法
公开(公告)号：US20110201804A1
公开(公告)日：2011-08-18
申请号：US13063085
申请日：2009-10-20
申请人： Manjunath Narayan Bhanu , Samir Naik , Prashant Joshi , Vijay Sharma
发明人： Manjunath Narayan Bhanu , Samir Naik , Prashant Joshi , Vijay Sharma
IPC分类号： C07D487/14 , C07D401/04
CPC分类号： C07D471/14 , C07D401/04
摘要： Disclosed herein is a process for the manufacture of mirtazapine and intermediates useful in preparing mirtazapine which includes the reduction of 1-(3-carboxypyridyl-2)-4-methyl-2-phenylpiperazine with an organoaluminum hydride.
摘要翻译：本文公开了一种制备米氮平和可用于制备米氮平的中间体的方法，其包括用有机铝氢化物还原1-（3-羧基吡啶-2）-4-甲基-2-苯基哌嗪。

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