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    • 1. 发明专利
    • Metallic microparticle, manufacturing method therefor, and magnetic bead
    • 金属微粒,其制造方法和磁珠
    • JP2010156054A
    • 2010-07-15
    • JP2010020898
    • 2010-02-02
    • Hitachi Metals Ltd日立金属株式会社
    • KANEKO YASUSHIFUJII SHIGEOTOKORO HISATONAKABAYASHI TAKASHI
    • B22F1/02B22F1/00B22F9/20C22C38/00H01F1/06H01F1/09H01F1/20H01F1/33
    • PROBLEM TO BE SOLVED: To provide a metallic microparticle having a high insulating property, hardly degrading saturation magnetization and having excellent biological-substance-extracting ability, which is manufactured by a method suitable for industrial use and having high productivity. SOLUTION: This metallic microparticle comprises a metallic particle nucleus which is composed mainly of a magnetic metal and has an average particle diameter of 10 μm or smaller, and the metallic particle nucleus is covered with two or more inorganic materials which are different from each other in a multilayer form. The inorganic material of covering one part or all parts of the metallic particle nucleus while coming into contact with the metallic microparticle nucleus is composed of the oxide of at least one element selected from Si, V, Ti, Al, Nb, Zr and Cr, and to the outside of the inorganic material of covering one part or all parts of the metallic particle nucleus while coming into contact with the metallic microparticle nucleus, the coating layer of an amorphous silicon oxide is provided. COPYRIGHT: (C)2010,JPO&INPIT
    • 要解决的问题:提供一种具有高绝缘性的金属微粒,几乎不降低饱和磁化强度并且具有优异的生物物质提取能力,其通过适用于工业上使用并具有高生产率的方法制造。 解决方案:该金属微粒包括主要由磁性金属组成并具有10μm或更小的平均粒径的金属微粒核,并且金属颗粒核被两种或更多种不同于 彼此以多层形式。 在与金属微粒核接触的同时覆盖金属微粒核的一部分或全部的无机材料由选自Si,V,Ti,Al,Nb,Zr和Cr中的至少一种元素的氧化物构成, 并且在与金属微粒核接触的同时覆盖金属微粒核的一部分或全部的无机材料的外部,提供非晶氧化硅的被覆层。 版权所有(C)2010,JPO&INPIT
    • 3. 发明专利
    • Metallic microparticle, manufacturing method therefor, and magnetic bead
    • 金属微粒,其制造方法和磁珠
    • JP2006097123A
    • 2006-04-13
    • JP2005048818
    • 2005-02-24
    • Hitachi Metals Ltd日立金属株式会社
    • KANEKO YASUSHIFUJII SHIGEOTOKORO HISATONAKABAYASHI TAKASHI
    • B22F1/02C22C38/00G11B5/712G11B5/842H01F1/06
    • PROBLEM TO BE SOLVED: To provide a metallic microparticle having a high insulating property, hardly degrading saturation magnetization and having superior biological-substance-extracting ability, which is manufactured by a method suitable for industrial use and having high productivity. SOLUTION: This metallic microparticle comprises a metallic particle nucleus 1 which is mainly made from a magnetic metal and has an average particle diameter of 10 μm or smaller, and a multilayer which covers the nucleus and consists of two or more inorganic materials which are different from each other. Furthermore, the inorganic material of covering one part or all parts of the metallic particle nucleus while contacting with it forms a coating film 2 mainly composed of carbon or boron nitride, and the outside inorganic material of the above inorganic materials forms a coating film 3 mainly containing silicon. COPYRIGHT: (C)2006,JPO&NCIPI
    • 要解决的问题:提供一种具有高绝缘性的金属微粒,几乎不降低饱和磁化强度并且具有优异的生物物质提取能力,其通过适用于工业上使用并具有高生产率的方法制造。 解决方案:该金属微粒包括主要由磁性金属制成的平均粒径为10μm以下的金属微粒子核1和覆盖细胞核并由两种或更多种无机材料组成的多层, 是不同的。 此外,覆盖金属粒子核的一部分或全部的金属粒子与其形成主要由碳或氮化硼构成的涂膜2的无机材料,上述无机材料的外部无机材料主要形成涂膜3 含硅。 版权所有(C)2006,JPO&NCIPI
    • 5. 发明专利
    • Coated metal microparticle and production method therefor
    • 包覆金属微生物及其生产方法
    • JP2008075118A
    • 2008-04-03
    • JP2006254671
    • 2006-09-20
    • Hitachi Metals Ltd日立金属株式会社
    • TOKORO HISATONAKABAYASHI TAKASHIFUJII SHIGEO
    • B22F1/02B22F9/20G11B5/712G11B5/842H01F1/24H01F1/44
    • PROBLEM TO BE SOLVED: To provide coated metal microparticles which have superior corrosion resistance and large specific surface area, and to provide a method for producing such coated metal microparticles.
      SOLUTION: This production method comprises the steps of; mixing a powder containing Ti (except powder of Ti oxide) with an oxide powder of a metal (M) having such a standard free energy of formation of the oxide as to satisfy a relationship of ΔG
      M-O >ΔG
      TiO2 ; obtaining coated metal microparticles by reducing an oxide of the metal (M) by heat-treating the mixed powder obtained in the first step, at 650 to 900°C in a non-oxidative atmosphere; and coating the surface of the obtained microparticles of the metal (M) with Ti oxide which includes TiO
      2 as a main component; and immersing the coated metal microparticles in an artificial liquid of a living body.
      COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:提供具有优异的耐腐蚀性和大的比表面积的涂覆金属微粒,并提供这种涂覆的金属微粒的制造方法。 解决方案:该生产方法包括以下步骤: 将含有Ti(除了Ti氧化物粉末)的粉末与具有形成氧化物的标准自由能的金属(M)的氧化物粉末混合以满足ΔG MO >ΔG的关系 二氧化钛; 通过在非氧化性气氛中在650〜900℃下热处理第一工序中得到的混合粉末来还原金属(M)的氧化物而得到被覆金属微粒子; 并用包含TiO 2 SB SB2的主要成分的Ti氧化物涂覆得到的金属(M)微粒的表面; 将被覆金属微粒浸渍在生物体的人造液中。 版权所有(C)2008,JPO&INPIT
    • 6. 发明专利
    • Method for extracting nucleic acid, method for detecting cancer cell, and magnetic bead
    • 提取核酸的方法,检测癌细胞的方法和磁珠
    • JP2007089563A
    • 2007-04-12
    • JP2006133292
    • 2006-05-12
    • Hitachi Metals Ltd日立金属株式会社
    • NAKABAYASHI TAKASHIFUJII SHIGEO
    • C12N15/09C12Q1/02G01N33/574
    • PROBLEM TO BE SOLVED: To provide a method for rapidly extracting a nucleic acid from a subject, and to provide a magnetic bead capable of rapidly recovering a target cell. SOLUTION: This method for extracting the nucleic acid comprises adding the magnetic bead to the subject containing the cell, making the magnetic bead capture the cell, and separating the cell captured by the magnetic bead from the subject by using magnetic force, so that the nucleic acid of the cell is extracted with the magnetic bead. Further, the magnetic bead for recovering the cell comprises a magnetic bead in which a core of a metal particle consisting mainly of a magnetic metal is multilayeredly covered with two or more kinds of inorganic materials different from each other and has a probe having affinity for a desired cell on the surface of the magnetic bead. COPYRIGHT: (C)2007,JPO&INPIT
    • 要解决的问题:提供一种从受试者中快速提取核酸的方法,并提供能够快速回收靶细胞的磁珠。 解决方案:提取核酸的方法包括向含有细胞的受试者加入磁珠,使磁珠捕获细胞,并通过使用磁力将受磁珠捕获的细胞与受试者分离,因此 用磁珠提取细胞的核酸。 此外,用于回收电池的磁珠包括磁珠,其中主要由磁性金属组成的金属颗粒的芯多层覆盖有两种或更多种彼此不同的无机材料,并且具有对于 磁珠表面上的所需电池。 版权所有(C)2007,JPO&INPIT
    • 7. 发明专利
    • Magnetic bead for cell recovery
    • 用于细胞恢复的磁珠
    • JP2007252240A
    • 2007-10-04
    • JP2006078354
    • 2006-03-22
    • Hitachi Metals Ltd日立金属株式会社
    • NAKABAYASHI TAKASHIFUJII SHIGEOTOKORO HISATO
    • C12N1/02
    • PROBLEM TO BE SOLVED: To obtain magnetic beads controlling nonspecific adsorption and efficiently recovering cells.
      SOLUTION: Magnetic beads useful for recovering cells have a metal particle nucleus comprising a magnetic metal as a main component and an inorganic material that covers the metal particle nucleus and is mainly composed of at least one kind of element of V, Ti, Al, Nb, Zr and Cr. The beads have an average particle diameter of preferably ≤3 μm and are covered with a material exhibiting adsorptivity to at least one kind of cells except cells to be recovered, nucleic acid and protein lower than that of silicon oxide.
      COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:获得控制非特异性吸附和有效回收细胞的磁珠。 解决方案:用于回收细胞的磁珠具有包含磁性金属作为主要成分的金属颗粒核和覆盖金属颗粒核的无机材料,主要由至少一种V,Ti, Al,Nb,Zr和Cr。 珠粒的平均粒径优选为≤3μm,并且被除了除了待回收的细胞,核酸和蛋白质比氧化硅低的细胞中的至少一种细胞表现出吸附性的材料覆盖。 版权所有(C)2008,JPO&INPIT
    • 8. 发明专利
    • リチウムイオン二次電池用正極活物質及びリチウムイオン二次電池用正極活物質の製造方法
    • 用于锂离子二次电池的正极电极活性材料及其制造用于锂离子二次电池的正极电极活性材料的方法
    • JP2015002092A
    • 2015-01-05
    • JP2013126283
    • 2013-06-17
    • 日立金属株式会社Hitachi Metals Ltd
    • YUASA TOYOTAKAKITAGAWA HIROSHINAKABAYASHI TAKASHITAKANO SHUICHITOYAMA TATSUYATOKORO HISATO
    • H01M4/58
    • Y02P20/133
    • 【課題】放電容量の低下を抑制し、且つ放電レート特性を向上させることができるリチウムイオン二次電池用正極活物質及びリチウムイオン二次電池を提供する。【解決手段】本発明は、LixMnyFe1-y-zMz(PO4)p(式中、Mは、Ti、Mg、Mo及びVからなる群より選択される1種類以上の金属元素であり、xは、0.8≦̸x≦̸1.1の範囲から選択され、yは、0.7≦̸y≦̸0.9の範囲から選択され、zは、0.01≦̸z≦̸0.05の範囲から選択され、pは、0.8≦̸p≦̸1.1の範囲から選択される。)で表される、オリビン構造を有するリチウム複合リン酸化物を含み、一次粒子から造粒された二次粒子の形態を有し、該二次粒子の表面から二次粒子の平均粒子径の1/10の深さまでの領域における式中のzの値は、該二次粒子全体におけるzの値の1.1以上となるように前記置換金属元素を含有する、リチウムイオン二次電池用正極活物質に関する。【選択図】なし
    • 要解决的问题:提供一种能够抑制放电容量的降低和放电特性的提高的锂离子二次电池用正极活性物质和锂离子二次电池。解决方案:一种正极活性物质,用于 锂离子二次电池包括具有由LiMnFeM(PO)表示的橄榄石结构的锂复合氧化磷(其中M表示选自由Ti,Mg,Mo和V组成的组中的至少一种金属元素; x选自给定的范围 0.8≤x≤1.1; y选自0.7≤y≤0.9给出的范围; z选自0.01≤z≤0.05给出的范围; p选自0.8≤p≤1.1给出的范围) ,并具有从初级粒子造粒的二次粒子的形式。 正极活性物质包括可取代金属元素,使得在从二次粒子的表面到表示二次粒子的平均粒径的1/10的深度的区域中的z的值等于或大于1.1 乘以整个二次粒子的z值。