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    • 1. 发明专利
    • Probe for nmr apparatus using magnesium diboride
    • 使用二氧化钛的NMR装置的探针
    • JP2008083065A
    • 2008-04-10
    • JP2007312971
    • 2007-12-04
    • Hitachi Ltd株式会社日立製作所
    • MORITA YUTAKAOKADA MICHIYAAIHARA KATSUZO
    • G01R33/34G01R33/32H01F6/06
    • PROBLEM TO BE SOLVED: To provide a probe coil for NMR apparatus which can send and receive high-frequency radio waves and improves Q value and S/N ratio. SOLUTION: For one means, the probe coil for NMR apparatus is designed as a solenoid type composed of a magnesium diboride superconductor. For another means, the probe coil for NMR apparatus comprises two or more coils which are composed of a magnesium diboride superconductor and are connected in series. For another means, a metal mixed magnesium diboride superconductor is used. For the other means, the probe coil for NMR apparatus is composed of a single metal or an alloy of two or more metals chosen from gold, silver, copper, aluminum, iron, platinum, palladium, nickel, stainless steel, chrome, magnesium, tantalum, niobium, titanium, tin, beryllium, tungsten, and cobalt. COPYRIGHT: (C)2008,JPO&INPIT
    • 要解决的问题:提供可以发送和接收高频无线电波并提高Q值和S / N比的用于NMR装置的探针线圈。 解决方案:用于NMR装置的探针线圈被设计为由二硼化镁超导体组成的螺线管型。 另一方面,用于NMR装置的探针线圈包括由二硼化镁超导体组成并且串联连接的两个或更多个线圈。 另一方面,使用金属混合的二硼化镁超导体。 另一方面,用于NMR装置的探针线圈由选自金,银,铜,铝,铁,铂,钯,镍,不锈钢,铬,镁,镁等的两种或更多种金属的单一金属或合金构成。 钽,铌,钛,锡,铍,钨和钴。 版权所有(C)2008,JPO&INPIT
    • 2. 发明专利
    • Nuclear magnetic resonance analyzer for solution
    • 用于解决方案的核磁共振分析仪
    • JP2007114209A
    • 2007-05-10
    • JP2006330102
    • 2006-12-07
    • Hitachi Ltd株式会社日立製作所
    • OKADA MICHIYAWAKUTA TAKESHIKADOKAWA SHIGERUMORITA YUTAKAAIHARA KATSUZO
    • G01R33/465G01R33/30G01R33/32G01R33/34G01R33/3815H01F5/00H01F6/00H01F7/20
    • PROBLEM TO BE SOLVED: To provide a new detection method which is independent of the magnetic field strength, for improving the detection sensitivity, by increasing the central magnetic field of NMR, since the improvement in the sensitivity of conventional methods has reached a limit, and according to the development of a protein research in recent years, increasing the need for the structure analysis of a complicated compound, having a large molecular weight, thus, enhancing the need for NMR performance each year. SOLUTION: The shape of a detecting coil is modified from a conventional bird cage type 27 to a solenoid type 4, having higher sensitivity. A superconducting magnet is constituted of a split magnet using the superconducting magnets 1, 2 and 3 and is divided into left and right sections having the magnetic field 11T horizontally, preferably, 14.1T or higher, instead of the superconducting magnet, comprising the conventional multilayered solenoids 28, 29 and 30, and it is required that the magnetic field homogeneity be 0.001 ppm or smaller, and time stability be 0.001 ppm or smaller. COPYRIGHT: (C)2007,JPO&INPIT
    • 要解决的问题:为了提供独立于磁场强度的新的检测方法,通过增加NMR的中心磁场来提高检测灵敏度,因为传统方法的灵敏度的提高已达到 限制,并且根据近年来蛋白质研究的发展,增加了对具有大分子量的复杂化合物的结构分析的需要,从而增加了每年对NMR性能的需要。 解决方案:检测线圈的形状从传统的鸟笼型27改为具有较高灵敏度的螺线管型4。 超导磁体由使用超导磁体1,2和3的分割磁体构成,并且被划分为具有磁场11T的左右部分,优选地为14.1T或更高,而不是超导磁体,包括常规的多层磁体 螺线管28,29和30,要求磁场均匀性为0.001ppm以下,时间稳定性为0.001ppm以下。 版权所有(C)2007,JPO&INPIT
    • 3. 发明专利
    • Supersensitive nuclear magnetic resonance imaging apparatus
    • 超声核磁共振成像装置
    • JP2007090089A
    • 2007-04-12
    • JP2006330101
    • 2006-12-07
    • Hitachi Ltd株式会社日立製作所
    • OKADA MICHIYAWAKUTA TAKESHIKADOKAWA SHIGERUMORITA YUTAKAAIHARA KATSUZO
    • A61B5/055G01R33/28G01R33/34G01R33/3815
    • PROBLEM TO BE SOLVED: To enable to grasp the behavior of a protein in a cell by achieving a nuclear magnetic resonance imaging method having spatial resolutions on the scale of a cell, and to provide an industrial means for developing a high-quality protein utilizing this technology.
      SOLUTION: In order to achieve spatial resolutions in the order of one-tenth of the size of a cell, a highly sensitive measurement is achieved by the combination of a solenoid detector coil and a high magnetic field NMR of not less than 14 Tesla, which has not been used so far. It is combined with the magnetic field uniformity of 0.001 ppm, so that the super-sensitive NMR imaging of 0.5 μm, which has been impossible heretofore, is achieved. The physico-chemical behavior of protein molecules can be easily clarified thereby, and thus, the bio-infomatic network or the process of metabolism of the cell can be made clear.
      COPYRIGHT: (C)2007,JPO&INPIT
    • 要解决的问题:通过实现在细胞规模上具有空间分辨率的核磁共振成像方法,能够掌握细胞中的蛋白质的行为,并提供用于开发高质量的工业手段 蛋白质利用这种技术。

      解决方案:为了实现电池尺寸十分之一的空间分辨率,通过螺线管检测器线圈和不小于14的高磁场NMR的组合来实现高灵敏度测量 特斯拉,迄今尚未使用。 它与0.001ppm的磁场均匀性相结合,使得实现了迄今为止不可能的0.5μm的超灵敏NMR成像。 因此蛋白质分子的物理化学性质可以很容易地澄清,从而可以清楚生物信息网络或细胞代谢过程。 版权所有(C)2007,JPO&INPIT

    • 5. 发明专利
    • Ultrahighsensitivity nuclear magnetic resonance imaging apparatus
    • 超声波敏感度核磁共振成像装置
    • JP2003329756A
    • 2003-11-19
    • JP2002132253
    • 2002-05-08
    • Hitachi Ltd株式会社日立製作所
    • OKADA MICHIYAWAKUTA TAKESHIKADOKAWA SHIGERUMORITA YUTAKAAIHARA KATSUZO
    • G01R33/465G01R33/30G01R33/34G01R33/3815G01R33/48G01R33/56G01V3/00
    • G01R33/3815G01R33/465G01R33/5604
    • PROBLEM TO BE SOLVED: To grasp the behavior of protein in a cell by achieving a nuclear magnetic resonance imaging method having the space resolution of a cell scale, and to provide an industrial means for raising a high-grade protein by utilizing the technique. SOLUTION: A solenoid detection coil that has not been used conventionally is combined with an NMR having a high magnetic field of at least 14 teslas for realizing high sensitivity measurement to achieve a space resolution of approximately 1/10 the size of a cell. After that, 0.5 μm ultrahighsensitivity NMR imaging that has been impossible conventionally is achieved by combining a magnetic field uniformity degree of 0.001 ppm. As a result, the physiochemical behavior of protein molecules can be clarified easily, thus clarifying bio information networks and the metabolism process of the cells. COPYRIGHT: (C)2004,JPO
    • 要解决的问题:通过实现具有细胞规模的空间分辨率的核磁共振成像方法来掌握细胞中的蛋白质的行为,并提供通过利用细胞量表提高高级蛋白质的工业手段 技术。

      解决方案:传统上未使用的电磁线圈检测线圈与具有至少14特斯拉的高磁场的NMR组合,以实现高灵敏度测量,以实现大小为单元大小的1/10的空间分辨率 。 之后,通过组合0.001ppm的磁场均匀度来实现传统上不可能的0.5μm超高灵敏度NMR成像。 结果,蛋白质分子的物理化学行为可以很容易地澄清,从而澄清生物信息网络和细胞的代谢过程。 版权所有(C)2004,JPO

    • 6. 发明专利
    • Nmr analyzer
    • NMR分析仪
    • JP2003329755A
    • 2003-11-19
    • JP2002132254
    • 2002-05-08
    • Hitachi Ltd株式会社日立製作所
    • AIHARA KATSUZOOKADA MICHIYAKADOKAWA SHIGERUMORITA YUTAKAWAKUTA TAKESHI
    • G01R33/32G01R33/345G01R33/3815G01R33/3875
    • G01R33/34046G01R33/34053G01R33/3806G01R33/3815G01R33/44G01R33/4808
    • PROBLEM TO BE SOLVED: To provide an NMR analyzer of good operability and installability which provides an ultrahigh sensitivity at or above 500 MHz of resonance frequency of proton as well as a new function.
      SOLUTION: A first room-temperature space is formed by penetrating a cryostat at a center axis of a split type multilayer cylindrical superconducting coil system, which is horizontally placed so that the center axis of a coil is horizontal with a ratio between a maximum experience magnetic field and a central magnetic field being 1.3 or less. The first room-temperature space is provided with a room-temperature shim coil system for improving evenness of the magnetic field. A second room-temperature space passing the center of a split gap is vertically formed by penetrating the cryostat. An NMR probe comprising a solenoid type probe coil as well as a sample is inserted in the second room-temperature space. The NMR analyzer provides a new function by comprising an electromagnetic wave irradiation system and electromagnetic wave detection system of wavelength 0.1 mm or less.
      COPYRIGHT: (C)2004,JPO
    • 要解决的问题:提供具有良好可操作性和可安装性的NMR分析仪,其在500MHz以上提供超高灵敏度,质子谐振频率以及新功能。 解决方案:通过在分离式多层圆柱形超导线圈系统的中心轴处穿过低温恒温器形成第一室温空间,水平放置,使得线圈的中心轴线是水平的, 最大经验磁场和中心磁场为1.3以下。 第一室温空间设置有用于改善磁场均匀性的室温垫片线圈系统。 通过分裂间隙的中心的第二室温空间通过穿透低温恒温器而垂直形成。 包括螺线管型探针线圈和样品的NMR探针插入第二室温空间。 NMR分析仪通过包括波长为0.1mm以下的电磁波照射系统和电磁波检测系统提供了新的功能。 版权所有(C)2004,JPO
    • 7. 发明专利
    • Nmr device probe using magnesium diboride
    • 使用二氧化钛的NMR装置探针
    • JP2003324012A
    • 2003-11-14
    • JP2002131071
    • 2002-05-07
    • Hitachi Ltd株式会社日立製作所
    • MORITA YUTAKAOKADA MICHIYAAIHARA KATSUZO
    • H01F6/00G01R33/34G01V3/00H01F6/06
    • G01R33/34053G01R33/34023G01R33/34069G01R33/34092H01F6/06
    • PROBLEM TO BE SOLVED: To provide a probe coil for an NMR device, which is capable of transmitting and receiving high-frequency radio waves and has a Q factor and an S/N ratio which are both improved. SOLUTION: As one of means for solving the problem, the NMR device probe coil is formed into a solenoid composed of a magnesium diboride superconductor. Or, as the other means, the NMR device probe coil is composed of a plurality of magnesium diboride super conductor coils which are connected together in series. Or, as the other means, the NMR device probe coil is composed of the magnesium diboride superconductor in which metal is mixed. Furthermore, as the other means, the NMR device probe coil is composed of a single metal or an alloy of a plurality of metals selected from gold, silver, palladium, nickel, niobium, titanium, tin, beryllium, tungsten, and cobalt. COPYRIGHT: (C)2004,JPO
    • 要解决的问题:提供能够发送和接收高频无线电波并且具有改善的Q因子和S / N比的用于NMR装置的探针线圈。 解决方案:作为解决问题的手段之一,NMR器件探针线圈形成为由二硼化镁超导体组成的螺线管。 或者,作为其他方式,NMR器件探针线圈由多个串联连接在一起的二硼化镁超导体线圈组成。 或者,作为其他方式,NMR装置探针线圈由其中混合有金属的二硼化镁超导体组成。 此外,作为其他手段,NMR装置探针线圈由选自金,银,钯,镍,铌,钛,锡,铍,钨和钴的多种金属的单一金属或合金构成。 版权所有(C)2004,JPO
    • 10. 发明专利
    • DE69314522D1
    • 1997-11-20
    • DE69314522
    • 1993-03-10
    • HITACHI LTD
    • AIHARA KATSUZOMATSUDA SHINPEIKAMO TOMOICHI
    • G01R33/3815H01L39/20
    • A magnetic field generator has a superconductive coil (1) immersed in a coolant material (6). When power is supplied to the superconductive coil (1) from a suitable power source (5), the superconductive coil (1) is energised to generate the magnetic field. The ends of the superconductive coil (1) may then be shorted through a persistent current switch (2), to maintain the magnetic field without the need for further power. The persistent current switch (2) has a superconductive connection (12) connected across the ends of the superconductive coil (1) and a heater (13). These components are enclosed in a casing (15) with a gap (14) between these components and the casing (15). Apertures (16) in the casing (15) permit coolant material (6) to enter the gap (14). When the heater (13) is energised, it heats the coolant material (6) in the gap (14) until it vaporises. There is then a significant decrease in the thermal conductivity through the gap (14) hence the superconductive connection (12) is heated rapidly to its critical temperature. Only low power is needed. When the heater (13) stops being energised, liquid coolant material (6) fills the gap (14) thereby rapidly cooling the superconductive connection (12) to below its critical temperature.