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    • 2. 发明申请
    • Gingerol analogues and use thereof
    • 姜醇类似物及其用途
    • US20050171211A1
    • 2005-08-04
    • US10515649
    • 2003-05-23
    • Hisatoyo KatoShuhei Yamaguchi
    • Hisatoyo KatoShuhei Yamaguchi
    • A61P17/00A61P31/12A61P39/06A61P43/00C07C43/23C07C45/71C07C49/255A61K31/12A61K31/075
    • C07C49/255C07C43/23C07C45/71
    • The invention provides novel compounds with a chemical structure similar to that of gingerol useful as a component for foods, pharmaceutical products, cosmetics and the like. After intensive investigations, the inventors found the gingerol analogues represented by the following general formulae (1) and (2). Additionally, the inventors found that these compounds had excellent properties as an inhibitor of tyrosinase activity and an antioxidant. By using the following compounds of the invention as a component for cosmetics, for example, cosmetics suppressing the generation of speckles and spots can be produced. By using the compounds as a component for foods, quality deterioration due to the oxidation of foods can be prevented. Gingerol analogues represented by the following general formula (1). (In the formula (1), R1 represents an alkyl group with one to 18 carbon atoms; R2 is hydrogen atom or methyl group; R3 is methyl group or ethyl group; and A represents an alkylene group with one to 4 carbon atoms.) Gingerol analogues represented by the following general formula (2). (In the formula (2), R1 represents an alkyl group with one to 18 carbon atoms; R2 is hydrogen atom or methyl group; R3 is methyl group or ethyl group; and A represents an alkylene group with one to 4 carbon atoms.)
    • 本发明提供具有类似于姜醇的化学结构的新型化合物,其用作食品,药品,化妆品等的组分。 经深入研究,本发明人发现由以下通式(1)和(2)表示的姜醇类似物。 此外,本发明人发现这些化合物具有作为酪氨酸酶活性抑制剂和抗氧化剂的优异性能。 通过使用本发明的以下化合物作为化妆品的成分,例如可以制造抑制斑点和斑点的产生的化妆品。 通过使用化合物作为食品的成分,可以防止食品氧化引起的品质恶化。 姜醇类似物由以下通式(1)表示。 (式(1)中,R 1表示具有1至18个碳原子的烷基; R 2是氢原子或甲基; R 3, / SUP>是甲基或乙基; A表示具有1至4个碳原子的亚烷基。)由以下通式(2)表示的姜醇类似物。 (式(2)中,R 1表示具有1至18个碳原子的烷基; R 2是氢原子或甲基; R 3, / SUP>是甲基或乙基; A表示碳原子数1〜4的亚烷基。
    • 4. 发明授权
    • Autoradiographic gene-screening method
    • 放射自显影基因筛选方法
    • US5270162A
    • 1993-12-14
    • US735675
    • 1991-07-29
    • Hisashi ShiraishiJunji MiyaharaHisatoyo Kato
    • Hisashi ShiraishiJunji MiyaharaHisatoyo Kato
    • C12Q1/68C12Q1/70G01N27/26G03C5/16
    • C12Q1/6825
    • An autoradiographic gene-screening method employing a hybridization process, which comprises:(1) a step of transferring at least a portion of nucleic acids, fragments thereof or derivatives thereof resolved on a medium onto a transfer support to fix them thereonto;(2) a step of hybridizing the nucleic acids, fragments thereof or derivatives thereof fixed onto said transfer support with radioactively labeled probes; and(3) a step of obtaining locational information on the radioactively labeled substances on said transfer support, which comprises placing said transfer support having been subjected to the hybridization and a stimulable phosphor sheet in layers for a given period of time to cause said sheet to absorb at least a portion of radiation energy emitted by the radioactively labeled substances on said transfer support, exciting said stimulable phosphor sheet with an electromagnetic wave to release the radiation energy stored in said sheet as stimulated emission, and detecting the stimulated emission.
    • 使用杂交方法的放射自显影基因筛选方法,其包括:(1)将至少一部分核酸,其片段或衍生物在培养基上转移到转移载体上以将其固定在其上的步骤; (2)使用放射性标记的探针将固定在所述转移载体上的核酸,其片段或其衍生物杂交的步骤; (3)获得所述转移支持体上的放射性标记物质的位置信息的步骤,其包括将经过杂交的所述转移支持体和可刺激的荧光体片层层叠一段给定的时间,以使所述片材 吸收由所述转印支撑体上的放射性标记物质发射的辐射能量的至少一部分,用电磁波激发所述可刺激的荧光粉片,以释放作为受激发射存储在所述片材中的辐射能量,以及检测受激发射。
    • 5. 发明授权
    • Autoradiographic gene-screening method
    • 放射自显影基因筛选方法
    • US4865967A
    • 1989-09-12
    • US127605
    • 1987-11-30
    • Hisashi ShiraishiJunji MiyaharaHisatoyo Kato
    • Hisashi ShiraishiJunji MiyaharaHisatoyo Kato
    • G01N33/50C12N15/09C12Q1/68G01N33/58G01N33/60G01T1/29
    • G01T1/2942C12Q1/6841
    • An autoradiographic gene-screening method employing a hybridization process, which comprises:(1) a step of transferring a portion of genetic clones cultured on a culture medium onto a filter to fix them thereonto;(2) a step of hybridizing the genes of said clones fixed onto said filter with radioactively labeled probes;(3) a step of obtaining two dimensional information on the location of the radioactively labeled substances on the filter which comprises placing said filter having been subjected to the hybridization and a stimulable phosphor sheet in layers for a given period of time to cause said stimulable phosphor sheet to absorb at least a portion of radiation energy emitted by the radioactively labeled substances on the filter, exciting said sheet with an electromagnetic wave to release the radiation energy stored in said sheet as stimulated emission, and detecting the stimulated emission to obtain a locational information on the radioactively labeled substances on the filter; and(4) a step recovering the clones on the culture medium according to the obtained locational information.
    • 使用杂交方法的放射自显影基因筛选方法,其包括:(1)将在培养基上培养的一部分遗传克隆转移到过滤器上以将其固定在其上的步骤; (2)将固定在所述过滤器上的所述克隆的基因与放射性标记的探针杂交的步骤; (3)获得关于过滤器上的放射性标记物质的位置的二维信息的步骤,该步骤包括将已经进行了杂交的所述过滤器和可刺激的磷光体片层压一段给定的时间以引起所述可刺激的荧光体 以吸收由过滤器上的放射性标记的物质发射的辐射能量的至少一部分,用电磁波激发所述片材,以释放作为受激发射存储在所述片材中的辐射能量,并且检测受激发射以获得位置信息 在过滤器上的放射性标记物质上; 和(4)根据获得的位置信息恢复培养基上的克隆的步骤。
    • 6. 发明授权
    • Gradation processing method for a radiation image recording system
    • 辐射图像记录系统的分级处理方法
    • US4346406A
    • 1982-08-24
    • US168799
    • 1980-07-11
    • Hisatoyo KatoMasamitsu Ishida
    • Hisatoyo KatoMasamitsu Ishida
    • A61B6/00G01N23/04G01T1/29G03B42/02G06T1/00G06T5/00H04N5/30
    • G01N23/04G01T1/2014
    • In a radiation image recording system using a stimulable phosphor in which a radiation image is once recorded and then read out by use of stimulating rays impinging thereupon, the gradation of the image is processed by setting the read out level of the read out system and by setting the gain of the read out system. Among the image signal read out from the stimulable phosphor, the maximum Smax, the minimum Smin and the average S are determined. When logSmax-logSmin is less than a predetermined value, Smin is made a standard input signal. When it is more than the predetermined value, S or (logSmax+logSmin)/2 is made a standard input signal. The standard input signal is read out as a predetermined level of a standard output signal. Further, the gain of amplification in the image read out system is controlled to be .DELTA.s/(logSmax-logSmin) in the former case, and is fixed in the latter case, where .DELTA.s is a reproduced signal region.
    • 在使用其中放射线图像被一次记录然后通过使用照射在其上的刺激光线读出的可刺激磷光体的放射线图像记录系统中,通过设置读出系统的读出电平并且通过 设置读出系统的增益。 在从可激发荧光体读出的图像信号中,确定最大Smax,最小Smin和平均值S. 当logSmax-logSmin小于预定值时,将Smin作为标准输入信号。 当超过预定值时,将S或(logSmax + logSmin)/ 2作为标准输入信号。 标准输入信号被读出作为标准输出信号的预定电平。 此外,图像读出系统中的放大增益在前一种情况下被控制为DELTA s /(logSmax-logSmin),并且在后一种情况下被固定,其中DELTA是再现信号区域。
    • 10. 发明授权
    • Radiation image read-out and reproducing apparatus
    • 辐射图像读出和再现装置
    • US4864135A
    • 1989-09-05
    • US254639
    • 1988-10-07
    • Hisatoyo KatoToshitaka Agano
    • Hisatoyo KatoToshitaka Agano
    • G01T1/29G03B42/02H04N1/04
    • G01T1/2014G01T1/2012G03B42/02
    • A radiation image read-out and reproducing apparatus comprises a section for feeding a stimulable phosphor sheet carrying a radiation image stored thereon, a section for feeding a developed film carrying a radiation image recorded thereon, a section for feeding a recording sheet, a light beam scanning section, and conveyance systems for conveying the stimulable phosphor sheet, the film and the recording sheet respectively to the light beam scanning section and then out of the light beam scanning section. The light beam scanning section detects the radiation image by scanning the stimulable phosphor sheet or the film, and reproduces the detected radiation image as a visible image on the recording sheet.
    • 一种放射线图像读出和重放装置包括一个用于馈送载有其上存储的放射线图像的可刺激的磷光体片的部分,用于馈送载有记录在其上的放射线图像的显影胶片的部分,用于馈送记录片材的部分, 扫描部分和用于将可刺激的磷光体片,胶片和记录片材分别输送到光束扫描部分,然后从光束扫描部分输送的输送系统。 光束扫描部通过扫描可刺激的荧光体片或膜来检测放射线图像,并将检测到的放射线图像作为可见图像再现在记录片材上。