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1. 发明申请

US20070110350A1 Sensor-integrated bearing for wheel 有权
标题翻译：传感器一体化轴承
公开(公告)号：US20070110350A1
公开(公告)日：2007-05-17
申请号：US10555733
申请日：2004-04-30
申请人： Hisashi Ohtsuki , Hideo Shinagawa , Kenichi Iwamoto , Koichi Okada
发明人： Hisashi Ohtsuki , Hideo Shinagawa , Kenichi Iwamoto , Koichi Okada
IPC分类号： F16C41/04
CPC分类号： B60B27/00 , F16C19/186 , F16C19/522 , F16C2326/02 , G01L5/0019 , G01L5/0023
摘要： A sensor-integrated wheel support bearing assembly includes an outer member (1) having a plurality of raceway surfaces (4), formed in an inner peripheral surface thereof, and also having a vehicle body fitting flange (1a) formed in an outer periphery thereof, and an inner member (2) having raceway surfaces (5) defined therein in alignment with the raceway surfaces (4) in the outer member (1). A plurality of rows of rolling elements (3) are arranged between the raceway surfaces (4) and (5) to enable a vehicle wheel (18) to be rotatably supported relative to a vehicle body structure. A load sensor (9) for detecting the load acting on the flange (1a) is disposed in a bolt insertion hole (21) provided in the vehicle body fitting flange (1a).
摘要翻译：传感器一体式车轮支撑轴承组件包括：外部构件（1），其具有形成在其内周表面中的多个滚道表面（4），并且还具有形成在外周中的车身安装凸缘（1a）以及内部构件（2），其具有与外部构件（1）中的轨道表面（4）对准的轨道表面（5）。在滚道表面（4）和（5）之间布置有多排滚动元件（3），以使得车轮（18）相对于车身结构可旋转地支撑。用于检测作用在凸缘（1a）上的负载的负载传感器（9）设置在设置在车身安装凸缘（1a）中的螺栓插入孔（21）中。

2. 发明授权

US07452133B2 Sensor-integrated wheel support bearing assembly 有权
标题翻译：传感器一体式车轮支撑轴承总成
公开(公告)号：US07452133B2
公开(公告)日：2008-11-18
申请号：US10555733
申请日：2004-04-30
申请人： Hisashi Ohtsuki , Hideo Shinagawa , Kenichi Iwamoto , Koichi Okada
发明人： Hisashi Ohtsuki , Hideo Shinagawa , Kenichi Iwamoto , Koichi Okada
IPC分类号： F16C41/04 , F16C32/04 , G01P3/42
CPC分类号： B60B27/00 , F16C19/186 , F16C19/522 , F16C2326/02 , G01L5/0019 , G01L5/0023
摘要： A sensor-integrated wheel support bearing assembly for rotatably supporting a vehicle wheel relative to a vehicle body structure has an outer member having an inner peripheral surface formed with a plurality of raceway surfaces, an inner member having an outer peripheral surface formed with raceway surfaces in alignment with the raceway surfaces in the outer member, a plurality of rows of rolling elements interposed between the raceway surfaces in the outer member and the raceway surfaces in the inner member, respectively, and a load sensor. The load sensor is disposed in one of the outer and inner members, which forms a stationary member. The outer member has an outer periphery formed with a vehicle body fitting flange. The load sensor for detecting a load acting on the vehicle wheel by detection of a load acting on the vehicle body fitting flange is disposed in the vehicle body fitting flange.
摘要翻译：一种用于相对于车体结构可转动地支撑车轮的传感器一体式车轮支撑轴承组件具有外部构件，该外部构件具有形成有多个滚道表面的内周表面，内部构件具有形成有滚道表面的外周表面与外部构件中的轨道表面对准，分别插入在外部构件中的轨道表面和内部构件的轨道表面之间的多排滚动元件和负载传感器。负载传感器设置在外部构件和内部构件中的一个中，其形成静止构件。外部构件具有形成有车体接合凸缘的外周。通过检测作用在车身安装凸缘上的载荷来检测作用在车轮上的载荷的载荷传感器设置在车身安装凸缘中。

3. 发明授权

US07267486B2 Protective cap for wheel support bearing assembly 有权
标题翻译：车轮支承轴承总成保护盖
公开(公告)号：US07267486B2
公开(公告)日：2007-09-11
申请号：US10721359
申请日：2003-11-26
申请人： Hisashi Ohtsuki , Hideo Shinagawa , Takayuki Norimatsu
发明人： Hisashi Ohtsuki , Hideo Shinagawa , Takayuki Norimatsu
IPC分类号： F16C33/78
CPC分类号： F16C41/04 , B60T8/329 , F16C19/184 , F16C33/7879 , F16C33/805 , F16C41/007 , F16C2326/02 , G01P3/443
摘要： To avoid an adherence of metallic particles from a knuckle to a magnetic encoder during coupling of a wheel support bearing assembly to the knuckle and/or transportation of the wheel support bearing assembly, a protective cap (18) is provided. The wheel support bearing assembly with which the protective cap (18) can be used is of a type including a magnetic encoder (10) provided in a sealing unit (5). This protective cap (18) includes an annular cover-up portion (18a) for enclosing an annular surface of the magnetic encoder (10) that is exposed bare to the outside, and an engagement wall (18b). The engagement wall (18b) is integral with the annular cover-up portion (18a) and of a cylindrical shape capable of being removably engaged in the wheel support bearing assembly.
摘要翻译：为了避免在将车轮支撑轴承组件联接到转向节期间和/或运送车轮支撑轴承组件时将金属颗粒从转向节粘附到磁性编码器，提供了保护帽（18）。可以使用保护盖（18）的轮支撑轴承组件是包括设置在密封单元（5）中的磁编码器（10）的类型。该保护帽（18）包括用于封闭暴露于外部的磁性编码器（10）的环形表面的环形覆盖部分（18a）和接合壁（18b）。接合壁（18b）与环形覆盖部分（18a）和能够可拆卸地接合在车轮支撑轴承组件中的圆柱形形状是一体的。

4. 发明授权

US6020171A Method of preparing plasmid having both expressing ability of retroviral gene and processing ability after translation, and resultant plasmid and expression products thereof 失效
标题翻译：制备具有逆转录病毒基因的表达能力和翻译后的加工能力的质粒的方法，以及所得质粒及其表达产物
公开(公告)号：US6020171A
公开(公告)日：2000-02-01
申请号：US684187
申请日：1996-07-19
申请人： Atsushi Saito , Hideo Shinagawa , Atsuo Nakata
发明人： Atsushi Saito , Hideo Shinagawa , Atsuo Nakata
IPC分类号： C12N15/09 , A61K38/00 , C07K14/16 , C12N1/21 , C12N9/12 , C12N9/50 , C12N15/00 , C12N15/33 , C12N15/48 , C12N15/49 , C12N15/55 , C12N15/70 , C12R1/92 , C12N15/64 , C12N15/63
CPC分类号： C07K14/005 , C12N15/00 , C12N15/70 , C12N9/1276 , C12N9/506 , A61K38/00 , C12N2740/16022 , C12N2740/16222 , C12N2740/16322
摘要： The present invention provides a method of preparing a plasmid having both the ability of expressing retroviral genes and the ability of effecting the after-translational processing of the encoded products, and the resultant plasmid and the expression products thereof. The method of the present invention is to prepare a plasmid by insertion-linking a cDNA fragment containing at least the protease gene from among retroviral genes with a highly expressing gene or a gene direct expressing vector, thereby causing expression of the retroviral genes, and at the same time, to process said expression product itself with the protease in that expression product, thereby mass-producing three kinds of core protein encoded by vaq gene, and three kinds of enzymes encoded by pol gene, in the form of individual single mature or active proteins. Alternatively, the method of the present invention is to prepare a plasmid in which a cDNA fragment containing HIV nef gene region is inserted into a highly expressing gene and a gene direct expression vector, thereby mass-producing Nef protein which is the expression product of nef gene.
摘要翻译：本发明提供了制备具有表达逆转录病毒基因的能力和进行编码产物的翻译后加工的能力的质粒的方法，以及所得质粒及其表达产物。本发明的方法是通过将含有至少来自逆转录病毒基因的蛋白酶基因的cDNA片段与高表达基因或直接表达载体的基因插入连接而形成质粒，从而引起逆转录病毒基因的表达，同时用该表达产物中的蛋白酶处理所述表达产物本身，从而大量生产由vaq基因编码的三种核心蛋白，以及由pol基因编码的三种酶，其形式为个体单一成熟或活性蛋白。或者，本发明的方法是制备将含有HIV nef基因区域的cDNA片段插入高表达基因和基因直接表达载体的质粒，从而大量产生作为nef表达产物的Nef蛋白质基因。

5. 发明授权

US4703005A Expression vector carrying a gene coding for a phosphate-binding protein, a method for preparing the same and a method for preparing the same and a method for producing a polypeptide using the same 失效
标题翻译：携带编码磷酸结合蛋白的基因的表达载体，其制备方法及其制备方法以及使用其制备多肽的方法
公开(公告)号：US4703005A
公开(公告)日：1987-10-27
申请号：US501559
申请日：1983-06-06
申请人： Atsuo Nakata , Hideo Shinagawa
发明人： Atsuo Nakata , Hideo Shinagawa
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C07K14/24 , C12N9/38 , C12N15/00 , C12R1/19 , C12P21/00 , C12N1/00 , C12P19/34
CPC分类号： C07K14/24 , C12N9/2471 , C12Y302/01023 , C07K2319/00 , C07K2319/034 , C07K2319/61 , Y10S435/849
摘要： An expression vector carrying a gene coding for a phosphate-binding protein has been found to have a strong gene expression. The expression vector can be produced by transforming a bacterium belonging to Enterobacteriaceae with a recombinant vector carrying a DNA fragment containing a gene coding for a phosphate-binding protein to form transformants, selecting the transformants containing the desired recombinant vector from said transformants, and isolating the desired recombinant vector from the selected transformants. The expression vector is useful for producing polypeptides.
摘要翻译：已经发现携带编码磷酸结合蛋白的基因的表达载体具有强的基因表达。表达载体可以通过用携带含有编码磷酸结合蛋白的基因的DNA片段的重组载体转化属于肠杆菌科的细菌来形成转化体，从所述转化体中选择含有所需重组载体的转化体，来自所选转化体的所需重组载体。表达载体可用于产生多肽。

6. 发明授权

US5610067A Method of preparing plasmid having both expressing ability of retroviral gene and processing ability after translation, and resultant plasmid and expression products 失效
标题翻译：制备具有逆转录病毒基因的表达能力和翻译后的加工能力的质粒的方法，以及所得的质粒和表达产物
公开(公告)号：US5610067A
公开(公告)日：1997-03-11
申请号：US202684
申请日：1994-02-25
申请人： Atsusi Saito , Hideo Shinagawa , Atsuo Nakata
发明人： Atsusi Saito , Hideo Shinagawa , Atsuo Nakata
IPC分类号： C12N15/09 , A61K38/00 , C07K14/16 , C12N1/21 , C12N9/12 , C12N9/50 , C12N15/00 , C12N15/33 , C12N15/48 , C12N15/49 , C12N15/55 , C12N15/70 , C12R1/92 , C12P21/00 , C07H21/04
CPC分类号： C07K14/005 , C12N15/00 , C12N15/70 , C12N9/1276 , C12N9/506 , A61K38/00 , C12N2740/16022 , C12N2740/16222 , C12N2740/16322
摘要： The present invention provides a method of preparing a plasmid having both the ability of expressing retroviral genes and the ability of effecting the after-translational processing of the encoded products, and the resultant plasmid and the expression products thereof. The method of the present invention is to prepare a plasmid by insertion-linking a cDNA fragment containing at least the protease gene from among-retroviral genes with a highly expressing gene or a gene direct expressing vector, thereby causing expression of the retroviral genes, and at the same time, to process said expression product itself with the protease in that expression product, thereby mass-producing three kinds of core protein encoded by gag gene, and three kinds of enzymes encoded by pol gene, in the form of individual single mature or active proteins. Alternatively, the method of the present invention is to prepare a plasmid in which a cDNA fragment containing HIV nef gene region is inserted into a highly expressing gene and a gene direct expression vector, thereby mass-producing Nef protein which is the expression product of nef gene.
摘要翻译：本发明提供了制备具有表达逆转录病毒基因的能力和进行编码产物的翻译后加工的能力的质粒的方法，以及所得质粒及其表达产物。本发明的方法是通过将含有至少含有来自逆转录病毒基因的蛋白酶基因的cDNA片段与高表达基因或基因直接表达载体插入连接而引起逆转录病毒基因的表达，同时用该表达产物中的蛋白酶处理所述表达产物本身，从而大量生产由gag基因编码的三种核心蛋白和由pol基因编码的三种以个体单一成熟形式的酶或活性蛋白。或者，本发明的方法是制备将含有HIV nef基因区域的cDNA片段插入高表达基因和基因直接表达载体的质粒，从而大量产生作为nef表达产物的Nef蛋白质基因。

7. 发明授权

US5500355A Protease, reverse transcriptase and endonuclease of HIV-1 and RSV method for producing these enzymes 失效
标题翻译：蛋白酶，逆转录酶和HIV-1的内切核酸酶以及用于生产这些酶的RSV方法
公开(公告)号：US5500355A
公开(公告)日：1996-03-19
申请号：US82505
申请日：1993-06-25
申请人： Atsushi Saito , Hideo Shinagawa , Atsuo Nakata
发明人： Atsushi Saito , Hideo Shinagawa , Atsuo Nakata
IPC分类号： C12N9/12 , A61K39/00 , C07K14/15 , C07K14/16 , C12N9/22 , C12N9/50 , C12N15/09 , C12N15/57 , C12P21/02 , C12N15/48 , C12N15/49 , C12N15/70
CPC分类号： C07K14/005 , C12N9/1276 , C12N9/22 , C12N9/506 , A61K39/00 , C12N2740/11022 , C12N2740/15022 , C12N2740/16122 , Y10S435/849 , Y10S930/221
摘要： Disclosed is a method for producing retroviral proteins which are protease,everse transcriptase and endonuclease. The method is characterized by the consecutive expression and processing of retroviral genes by the stepwise cultivation of hosts transformed with a vector constructed to carry retroviral gene fragments comprising at least a protease gene and one or more of the other genes coding for retroviral proteins. The retroviral proteins of this invention are used as specific reagents for the diagnosis of retroviral disease, e.g., AIDS, malignant tumors and so forth, also may be used as the basis for research and development of antiviral agents and a vaccine against the above infectious diseases, and for genetic engineering.
摘要翻译：公开了生产蛋白酶，逆转录酶和内切核酸酶的逆转录病毒蛋白的方法。该方法的特征在于逆转录病毒基因的连续表达和处理，其通过逐步培养用构建成携带包含至少包含蛋白酶基因和编码逆转录病毒蛋白的其它一个或多个基因的逆转录病毒基因片段的载体转化的宿主。本发明的逆转录病毒蛋白质用作诊断逆转录病毒疾病（如艾滋病，恶性肿瘤等）的特异性试剂，也可用作研究和开发抗病毒药物和针对上述传染病的疫苗的基础，以及遗传工程。

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