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1. 发明授权

US07378423B2 Pyrimidine compound and medical use thereof 有权
标题翻译：嘧啶化合物及其医疗用途
公开(公告)号：US07378423B2
公开(公告)日：2008-05-27
申请号：US11150792
申请日：2005-06-10
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： A61K31/519 , C07D487/04 , C07D413/10 , C07D413/12 , A61P35/00 , A61P31/5355
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

2. 发明授权

US08835443B2 Pyrimidine compound and medical use thereof 有权
标题翻译：嘧啶化合物及其医疗用途
公开(公告)号：US08835443B2
公开(公告)日：2014-09-16
申请号：US12626443
申请日：2009-11-25
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： A61K31/519 , C07D239/545 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

3. 发明申请

US20080312228A1 PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF 审中-公开
标题翻译：吡嗪类化合物及其医疗用途
公开(公告)号：US20080312228A1
公开(公告)日：2008-12-18
申请号：US12053133
申请日：2008-03-21
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , A61K31/496 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

4. 发明申请

US20060014768A1 Pyrimidine compound and medical use thereof 有权
标题翻译：嘧啶化合物及其医疗用途
公开(公告)号：US20060014768A1
公开(公告)日：2006-01-19
申请号：US11150792
申请日：2005-06-10
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： A61K31/513 , C07D405/02
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

5. 发明申请

US20100240613A1 PYRIMIDINE COMPOUND AND MEDICAL USE THEREOF 有权
标题翻译：吡嗪类化合物及其医疗用途
公开(公告)号：US20100240613A1
公开(公告)日：2010-09-23
申请号：US12626443
申请日：2009-11-25
申请人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
发明人： Hisashi Kawasaki , Hiroyuki Abe , Kazuhide Hayakawa , Tetsuya Iida , Shinichi Kikuchi , Takayuki Yamaguchi , Toyomichi Nanayama , Hironori Kurachi , Masahiro Tamaru , Yoshikazu Hori , Mitsuru Takahashi , Takayuki Yoshida , Toshiyuki Sakai
IPC分类号： A61K31/675 , C07D471/04 , A61K31/519 , C07F9/53 , A61K31/5377 , C07D487/04 , C07C275/30 , C07C275/50 , C07D239/545 , A61P29/00 , A61P35/00
CPC分类号： C07D471/04 , A61K31/519 , C07C275/30 , C07C275/50 , C07C2601/16 , C07D239/545 , C07D239/553 , C07D239/62 , C07D471/16 , C07D487/04 , C07F9/53
摘要： The present invention relates to a pyrimidine compound or a pharmaceutically acceptable salt thereof represented by the following formula [I] wherein each symbol is as defined in the specification and a method of therapeutically or prophylactically treating an undesirable cell proliferation, comprising administering such a compound. The compound of the present invention has superior activity in suppressing undesirable cell proliferation, particularly, an antitumor activity, and is useful as an antitumor agent for the prophylaxis or treatment of cancer, rheumatism, and the like. In addition, the compound of the present invention can be a more effective antitumor agent when used in combination with other antitumor agents such as an alkylating agent or metabolism antagonist.
摘要翻译：本发明涉及由下式[I]表示的嘧啶化合物或其药学上可接受的盐，其中每个符号如说明书中所定义，以及治疗或预防性治疗不期望的细胞增殖的方法，包括施用这种化合物。本发明的化合物在抑制不期望的细胞增殖，特别是抗肿瘤活性方面具有优异的活性，可用作预防或治疗癌症，风湿病等的抗肿瘤剂。此外，当与其它抗肿瘤剂如烷化剂或代谢拮抗剂组合使用时，本发明的化合物可以是更有效的抗肿瘤剂。

6. 发明授权

US07645779B2 Linked biaryl compounds 失效
标题翻译：联结联芳基化合物
公开(公告)号：US07645779B2
公开(公告)日：2010-01-12
申请号：US10939918
申请日：2004-08-20
申请人： Hiroyuki Abe , Jonathan Houze , Hisashi Kawasaki , Frank Kayser , Rajiv Sharma , Samuel Sperry
发明人： Hiroyuki Abe , Jonathan Houze , Hisashi Kawasaki , Frank Kayser , Rajiv Sharma , Samuel Sperry
IPC分类号： A61K31/44 , A61K31/19 , C07D213/02
CPC分类号： C07C317/22 , C07C323/20 , C07C323/21 , C07C2602/10
摘要： Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in lipid metabolism, inflammation and cell proliferation. The subject compounds are linked biaryl compounds.
摘要翻译：本文提供了可用于治疗代谢紊乱，炎性疾病和癌症的化合物，组合物和方法。特别地，本发明提供调节参与脂质代谢，炎症和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物是联芳基化合物。

7. 发明授权

US06869975B2 Linked biaryl compounds 失效
标题翻译：联结联芳基化合物
公开(公告)号：US06869975B2
公开(公告)日：2005-03-22
申请号：US10244063
申请日：2002-09-13
申请人： Hiroyuki Abe , Jonathan Houze , Hisashi Kawasaki , Frank Kayser , Rajiv Sharma , Samuel Sperry
发明人： Hiroyuki Abe , Jonathan Houze , Hisashi Kawasaki , Frank Kayser , Rajiv Sharma , Samuel Sperry
IPC分类号： C07D215/20 , A61K31/192 , A61K31/216 , A61K31/4184 , A61K31/421 , A61K31/426 , A61K31/4406 , A61K31/47 , A61P1/00 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/08 , A61P13/12 , A61P15/00 , A61P19/02 , A61P25/00 , A61P25/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/00 , C07C317/22 , C07C321/30 , C07C323/20 , C07C323/21 , C07D213/65 , C07D215/22 , C07D235/26 , C07D263/40 , C07D277/20 , C07D277/34 , A01N37/10
CPC分类号： C07C317/22 , C07C323/20 , C07C323/21 , C07C2602/10
摘要： Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in lipid metabolism, inflammation and cell proliferation. The subject compounds are linked biaryl compounds.
摘要翻译：本文提供了可用于治疗代谢紊乱，炎性疾病和癌症的化合物，组合物和方法。特别地，本发明提供调节参与脂质代谢，炎症和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物是联芳基化合物。

8. 发明申请

US20080161351A1 Linked biaryl compounds 失效
标题翻译：联结联芳基化合物
公开(公告)号：US20080161351A1
公开(公告)日：2008-07-03
申请号：US10939918
申请日：2004-08-20
申请人： Hiroyuki Abe , Jonathan Houze , Hisashi Kawasaki , Frank Kayser , Rajiv Sharma , Samuel Sperry
发明人： Hiroyuki Abe , Jonathan Houze , Hisashi Kawasaki , Frank Kayser , Rajiv Sharma , Samuel Sperry
IPC分类号： A61K31/216 , C07C69/612 , C07C317/14 , C07D215/233 , C07D213/65 , A61K31/44 , A61K31/421 , A61P35/00 , A61P3/00 , A61P29/00 , A61K31/4164 , A61K31/426 , A61K31/47 , C07D277/22 , C07D263/32 , C07D233/56
CPC分类号： C07C317/22 , C07C323/20 , C07C323/21 , C07C2602/10
摘要： Compounds, compositions and methods that are useful for the treatment of metabolic disorders, inflammatory diseases and cancer are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in lipid metabolism, inflammation and cell proliferation. The subject compounds are linked biaryl compounds.
摘要翻译：本文提供了可用于治疗代谢紊乱，炎性疾病和癌症的化合物，组合物和方法。特别地，本发明提供调节参与脂质代谢，炎症和细胞增殖的蛋白质的表达和/或功能的化合物。主题化合物是联芳基化合物。

9. 发明授权

US09670461B2 Method for undifferentiated growth of mesenchymal stem cell and method for concentration of mesenchymal stem cell 有权
公开(公告)号：US09670461B2
公开(公告)日：2017-06-06
申请号：US14342975
申请日：2013-08-08
申请人： Hiroyuki Abe , Hiroaki Kawasaki
发明人： Hiroyuki Abe , Hiroaki Kawasaki
IPC分类号： C12N5/0775
CPC分类号： C12N5/0665 , C12N2501/113 , C12N2501/115 , C12N2501/125 , C12N2501/2303 , C12N2501/2306 , C12N2501/26 , C12N2501/41
摘要： A method in accordance with the present invention includes the steps of: concentrating cord blood-derived mesenchymal stem cells; and causing the mesenchymal stem cells thus concentrated to grow with use of a particular factor while maintaining undifferentiated state of the mesenchymal stem cells.

10. 发明授权

US09348330B2 Method of adjusting the position of origin of a machine and a machine having a function for adjusting the position of origin 有权
标题翻译：调整机器原点位置和调整原点位置功能的机器的方法
公开(公告)号：US09348330B2
公开(公告)日：2016-05-24
申请号：US13585946
申请日：2012-08-15
申请人： Hiroyuki Abe
发明人： Hiroyuki Abe
IPC分类号： G05B19/404
CPC分类号： G05B19/404 , G05B2219/37153 , G05B2219/50025
摘要： A machine having a function for adjusting the position of mechanical origin of a moving part (10) that is driven by a servo motor equipped with a position detector, comprising a reference counter (16) for counting the value detected by the position detector, a storage unit (17) for storing the capacity of the reference counter of when the moving part is moved in a predetermined direction and is positioned at the position of mechanical origin, a reference counter reading unit (18) for reading the value of the reference counter of when the moving part is positioned, a counter capacity reading unit (19) for reading the counter capacity of the reference counter, and an adjustment amount calculation unit (20) for calculating the amount of adjusting the position of mechanical origin based on the value of the reference counter and on the capacity of the reference counter.
摘要翻译：一种具有调整由配备有位置检测器的伺服电机驱动的移动部件（10）的机械原点的位置的功能的机器，包括用于对由位置检测器检测的值进行计数的基准计数器（16）存储单元（17），用于存储当移动部件沿预定方向移动并且位于机械原点位置时参考计数器的容量;参考计数器读取单元（18），用于读取参考计数器的值当所述移动部件被定位时，用于读取所述参考计数器的计数器容量的计数器容量读取单元（19）和用于基于所述值来计算机械原点的位置的调整量的调整量计算单元（20）的参考计数器和参考计数器的容量。

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