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1. 发明申请

US20070027156A1 Crf antagonists and heterobicyclic compounds 审中-公开
标题翻译： Crf拮抗剂和杂双环化合物
公开(公告)号：US20070027156A1
公开(公告)日：2007-02-01
申请号：US10571271
申请日：2004-09-08
申请人： Hisao Nakai , Tetsuji Saito , Tetsuo Obitsu , Chiaki Minamoto , Mayuki Yoshida , Akihiro Kishi , Seishi Katsumata , Hideo Katayama
发明人： Hisao Nakai , Tetsuji Saito , Tetsuo Obitsu , Chiaki Minamoto , Mayuki Yoshida , Akihiro Kishi , Seishi Katsumata , Hideo Katayama
IPC分类号： A61K31/53 , A61K31/519 , C07D487/02
CPC分类号： C07D239/70 , C07D221/04 , C07D487/04 , C07D491/04
摘要： CRF antagonists comprising as an active ingredient, the compound of formula (I) wherein A ring is 5-6 membered mono-cyclic ring which may be substituted; B ring is 5-7 membered unsaturated mono-heterocyclic ring which may be contained another 1-2 of hetero atom(s) and substituted by another substituents; W1 and W2 is carbon atom or nitrogen atom; Z is NR3, oxygen atom, sulfur which may be oxidized or CR4R5; R1 is alkyl, alkenyl or alkynyl that may be substituted, amino which may be protected, hydroxyl which may be protected, S(O)nR6, COR7, or cyclic group which may be substituted; R2 is unsaturated cyclic group which may be substituted.
摘要翻译： CRF拮抗剂，其包含作为活性成分的式（I）化合物，其中A环是可被取代的5-6元单环; B环是5-7元不饱和单杂环，其可以含有另外1-2个杂原子并被另一个取代基取代; W 1和W 2是碳原子或氮原子; Z是NR 3，氧原子，可被氧化的硫或CR 4 R 5; R 1是可被取代的烷基，烯基或炔基，可被保护的氨基，可被保护的羟基，S（O）n R 6， COR 7或可以被取代的环状基团; R 2是可以被取代的不饱和环状基团。

2. 发明授权

US07947697B1 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d] pyrazolo[1,5-a]pyrimidine methanesulfonate as a CRF antagonist 有权
标题翻译： 8-（3-戊基氨基）-2-甲基-3-（2-氯-4-甲氧基苯基）-6,7-二氢-5H-环戊二烯并[d]吡唑并[1,5-a]嘧啶甲磺酸盐，为CRF拮抗剂
公开(公告)号：US07947697B1
公开(公告)日：2011-05-24
申请号：US10561214
申请日：2004-06-24
申请人： Tomoyuki Hasegawa , Toshiaki Matsui , Hiroshi Araki , Tetsuji Saito , Tetsuo Obitsu , Masaki Okamoto , Yuichi Gemba , Yutaka Mikami
发明人： Tomoyuki Hasegawa , Toshiaki Matsui , Hiroshi Araki , Tetsuji Saito , Tetsuo Obitsu , Masaki Okamoto , Yuichi Gemba , Yutaka Mikami
IPC分类号： C07D487/04 , A61K31/519 , A61P25/28 , A61P25/24 , A61P3/04 , A61P25/22
CPC分类号： C07D487/04
摘要： 8-(3-pentylamino)-2-methyl-3-(2-chloro-4-methoxyphenyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidine methanesulfonate of the structural formula (I) has Corticotropin Releasing Factor (CRF) antagonist activity and is useful in treating neuropsychiatric and digestive system diseases.
摘要翻译：具有结构式的8-（3-戊基氨基）-2-甲基-3-（2-氯-4-甲氧基苯基）-6,7-二氢-5H-环戊并[d]吡唑并[1,5-a]嘧啶甲磺酸盐（I）具有促肾上腺皮质激素释放因子（CRF）拮抗剂活性，可用于治疗神经精神和消化系统疾病。

3. 发明申请

US20100137318A1 BICYCLIC HETEROCYCLIC COMPOUND 有权
标题翻译：双相杂环化合物
公开(公告)号：US20100137318A1
公开(公告)日：2010-06-03
申请号：US12597302
申请日：2008-04-25
申请人： Tetsuji Saito , Tetsuo Obitsu , Yoshifumi Kagamiishi
发明人： Tetsuji Saito , Tetsuo Obitsu , Yoshifumi Kagamiishi
IPC分类号： A61K31/53 , C07D487/04 , A61P25/22 , A61P25/18 , A61P1/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A compound of a formula (I): wherein R1 represents a C3-10 branched alkyl group which may be substituted; R2 represents a hydrogen atom or a C1-4 alkyl group which may be substituted; R3 represents a C1-4 alkyl group which may be substituted or a halogen atom; R4 represents a C1-4 alkyl group which may be substituted; and ring 1 represents a cyclic group which has planarity and may have a substituent group, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a medicinal component having CRF antagonistic activity for the prevention and/or treatment of a neuropsychiatric disease, a peripheral organ disease and the like.
摘要翻译：式（I）的化合物：其中R1表示可被取代的C3-10支链烷基; R2表示氢原子或可被取代的C1-4烷基; R 3表示可以被取代的C 1-4烷基或卤素原子; R 4表示可以被取代的C 1-4烷基; 环1表示具有平面性并且可以具有取代基的环状基团，其盐，其N-氧化物或其溶剂合物或其前药可用作具有CRF拮抗活性的药物成分，用于预防和/ /或治疗神经精神疾病，外周器官疾病等。

4. 发明授权

US08420810B2 Bicyclic heterocyclic compound 有权
标题翻译：双环杂环化合物
公开(公告)号：US08420810B2
公开(公告)日：2013-04-16
申请号：US12597302
申请日：2008-04-25
申请人： Tetsuji Saito , Tetsuo Obitsu , Yoshifumi Kagamiishi
发明人： Tetsuji Saito , Tetsuo Obitsu , Yoshifumi Kagamiishi
IPC分类号： C07D487/04 , A61K31/53 , A61P3/04 , A61P15/12 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/30 , A61P25/32
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： A compound of a formula (I): wherein R1 represents a C3-10 branched alkyl group which may be substituted; R2 represents a hydrogen atom or a C1-4 alkyl group which may be substituted; R3 represents a C1-4 alkyl group which may be substituted or a halogen atom; R4 represents a C1-4 alkyl group which may be substituted; and ring 1 represents a cyclic group which has planarity and may have a substituent group, a salt thereof, an N-oxide thereof or a solvate thereof, or a prodrug thereof, is useful as a medicinal component having CRF antagonistic activity for the prevention and/or treatment of a neuropsychiatric disease, a peripheral organ disease and the like.
摘要翻译：式（I）的化合物：其中R1表示可被取代的C3-10支链烷基; R2表示氢原子或可被取代的C1-4烷基; R 3表示可以被取代的C 1-4烷基或卤素原子; R 4表示可以被取代的C 1-4烷基; 环1表示具有平面性并且可以具有取代基的环状基团，其盐，其N-氧化物或其溶剂合物或其前药可用作具有CRF拮抗活性的药物成分，用于预防和/ /或治疗神经精神疾病，外周器官疾病等。

5. 发明申请

US20100184771A1 Bicyclic Heterocyclic Compound 审中-公开
标题翻译：双环杂环化合物
公开(公告)号：US20100184771A1
公开(公告)日：2010-07-22
申请号：US12097685
申请日：2006-12-14
申请人： Hisao Nakai , Tetsuji Saito , Yoshifumi Kagamiishi
发明人： Hisao Nakai , Tetsuji Saito , Yoshifumi Kagamiishi
IPC分类号： A61K31/5025 , C07D487/04 , A61P25/00 , A61P1/00 , A61P25/22 , A61P25/18 , A61P25/24
CPC分类号： C07D487/04 , A61K45/06
摘要： A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof: wherein X1 represents N and X2 represents C, or X1 represents C and X2 represents N; Y1 represents CR4 or N; Y2 represents CH or N; wherein both Y1 and Y2 do not represent N at the same time; R1 represents (1) C3-10 branched alkyl which may be substituted or (2) —(CH2)m—NR5R6; R2, R3, and R4 each independently represent H, C1-4 alkyl, a halo-substituted C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, or the like; R5 and R6 each independently represent C1-6 alkyl which may be substituted, or R5 represents H, and R6 represents C3-6 branched alkyl which may be substituted; and Ar represents an aromatic ring which may be substituted, is useful as a pharmacologically active ingredient having a CRF antagonistic activity in preventing and/or treating neuropsychiatric diseases, diseases of peripheral organs or the like.
摘要翻译：由式（I）表示的化合物，其盐，其N-氧化物，其溶剂合物或其前药：其中X1表示N，X2表示C，或X1表示C，X2表示N; Y1表示CR4或N; Y2表示CH或N; 其中Y1和Y2同时不表示N; R1表示（1）可被取代的C3-10支链烷基或（2） - （CH2）m-NR5R6; R2，R3和R4各自独立地表示H，C1-4烷基，卤素取代的C1-4烷基，C2-4烯基，C2-4炔基等; R5和R6各自独立地表示可以被取代的C1-6烷基，或R5表示H，R6表示可以被取代的C3-6支链烷基; Ar表示可以被取代的芳香环，可用作在预防和/或治疗神经精神疾病，外周器官等疾病中具有CRF拮抗作用的药理活性成分。

6. 发明申请

US20090281120A1 BICYCLIC HETEROCYCLIC COMPOUND 审中-公开
标题翻译：双相杂环化合物
公开(公告)号：US20090281120A1
公开(公告)日：2009-11-12
申请号：US12097024
申请日：2006-12-11
申请人： Hisao Nakai , Tetsuji Saito , Yoshifumi Kagamiishi
发明人： Hisao Nakai , Tetsuji Saito , Yoshifumi Kagamiishi
IPC分类号： A61K31/519 , A61K31/437 , A61K31/415 , C07D487/04 , C07D471/04 , C07D235/02
CPC分类号： C07D471/04 , A61K45/06
摘要： A compound represented by the formula (I), a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof: wherein X, Y, and W each independently represent a carbon atom or a nitrogen atom;Z represents CH or a nitrogen atom;R1 represents (1) C3-10 branched alkyl which may be substituted or (2) —(CH2)m—NR4R5; R2 and R3 each independently represent (1) a hydrogen atom, (2) C1-4 alkyl which may be substituted with a halogen atom, hydroxy which may be protected, amino which may be protected, or carboxyl which may be protected, (3) C2-4 alkenyl, (4) C2-4 alkynyl, (5) nitrile, (6) COOR6, (7) CONR7R8, (8) COR101, (9) S(O)nR102, or (10) a halogen atom, in which R6 represents a hydrogen atom or C1-4 alkyl, R7 and R8 each independently represent a hydrogen atom or C1-4 alkyl, R101 represents a hydrogen atom or C1-4 alkyl, R102 represents C1-4 alkyl, n represents 1 or 2; andAr represents an aromatic ring which may be substituted, is useful as a pharmacologically active ingredient having a CRF antagonist action in preventing and/or treating neuropsychiatric diseases, diseases of peripheral organs or the like.
摘要翻译：由式（I）表示的化合物，其盐，其N-氧化物，其溶剂化物或其前药：其中X，Y和W各自独立地表示碳原子或氮原子; Z表示CH或氮原子; R1表示（1）可以被取代的C3-10支链烷基或（2） - （CH2）m-NR4R5; R2和R3各自独立地表示（1）氢原子，（2）可以被卤素原子取代的C1-4烷基，可被保护的羟基，可被保护的氨基或可被保护的羧基，（3 ）C2-4烯基，（4）C2-4炔基，（5）腈，（6）COOR6，（7）CONR7R8，（8）COR101，（9）S（O）nR102或（10）卤素原子其中R 6表示氢原子或C 1-4烷基，R 7和R 8各自独立地表示氢原子或C 1-4烷基，R 101表示氢原子或C 1-4烷基，R 102表示C 1-4烷基，n表示1 或2; Ar表示可被取代的芳环，可用作具有CRF拮抗作用的药理活性成分，用于预防和/或治疗神经精神疾病，外周器官等疾病。

7. 发明授权

US07629369B2 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 失效
标题翻译： N-苯基芳基磺酰胺化合物，包含该化合物作为活性成分的药物组合物，该化合物的合成中间体及其制备方法
公开(公告)号：US07629369B2
公开(公告)日：2009-12-08
申请号：US11239406
申请日：2005-09-30
申请人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
发明人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
IPC分类号： C07D285/08 , C07D271/06 , C07D257/04 , A61K31/41
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译：式（I）的N-苯基芳基磺酰胺化合物（R1是COOH等; R2是氢，甲基等; R3和R4是甲基和甲基的组合等; R5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基，各自任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。式（I）化合物结合前列腺素E2受体，特别是EP1亚型受体，并拮抗它。蛋白质结合的影响较小，因此具有令人满意的体内活性。因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

8. 发明申请

US20090244306A1 IMAGE RECORDING AND REPRODUCING APPARATUS 有权
标题翻译：图像记录和再现设备
公开(公告)号：US20090244306A1
公开(公告)日：2009-10-01
申请号：US12415894
申请日：2009-03-31
申请人： Tetsuji Saito
发明人： Tetsuji Saito
IPC分类号： H04N5/225
CPC分类号： H04N1/2166 , H04N1/212 , H04N1/2129 , H04N1/2137 , H04N1/215 , H04N2101/00 , H04N2201/214 , H04N2201/3277
摘要： An image recording and reproducing apparatus that records and reproduces image data shot at a frame rate higher than a normal reproduction rate employed during reproduction of a moving image can generate a still image by attaching still image recording information to at least one frame image included in the recorded image data and combining a plurality of frame images of the recorded image data in accordance with the still image recording information.
摘要翻译：记录和再现以比运动图像再现期间采用的正常再现速率更高的帧速率拍摄的图像数据的图像记录和再现装置可以通过将静止图像记录信息附加到包含在运动图像中的至少一个帧图像来生成静止图像记录图像数据，并根据静止图像记录信息组合记录图像数据的多个帧图像。

9. 发明申请

US20080205306A1 COMMUNICATION APPARATUS AND CONTROL METHOD THEREOF 失效
标题翻译：通信装置及其控制方法
公开(公告)号：US20080205306A1
公开(公告)日：2008-08-28
申请号：US12038713
申请日：2008-02-27
申请人： Tetsuji Saito
发明人： Tetsuji Saito
IPC分类号： H04L5/16
CPC分类号： H04L5/16 , G09G5/006 , G09G2370/047 , G09G2370/12 , H04N5/765 , H04N21/43632
摘要： There is provided a communication apparatus that includes: a data communication unit which performs half-duplex communication of video frame data with an external device on a video frame-by-video frame basis, a switching unit which switches a transmission direction in which the data communication unit transmits the video frame data, a first control unit which controls the data communication unit to include a start command in the video frame data and send the video frame data, as well as controls the switching unit to switch the transmission direction in response to completion of the sending of the video frame data that includes the start command, and a second control unit which controls the switching unit to switch the transmission direction in response to completion of the reception of the video frame data that includes the start command.
摘要翻译：提供了一种通信装置，其包括：数据通信单元，其以视频帧为基础，与外部设备进行视频帧数据的半双工通信;切换单元，切换传输方向，其中数据通信单元发送视频帧数据，控制数据通信单元以在视频帧数据中包括开始命令并发送视频帧数据的第一控制单元，并且控制切换单元响应于完成包括开始命令的视频帧数据的发送;以及第二控制单元，其响应于包括开始命令的视频帧数据的接收完成而控制切换单元切换发送方向。

10. 发明申请

US20050124672A1 N-phenylarylsulfonamide compound drug containing the compound as active ingredient intermediate for the compound and processes for producing the same 有权
标题翻译：含有化合物作为化合物的活性成分中间体的N-苯基芳基磺酰胺化合物药物及其制备方法
公开(公告)号：US20050124672A1
公开(公告)日：2005-06-09
申请号：US10471673
申请日：2002-03-11
申请人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
发明人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
IPC分类号： C07D307/64 , A61K31/34 , A61K31/341 , A61K31/41 , A61K31/4245 , A61K31/426 , A61K31/427 , A61K31/4402 , A61K31/4406 , A61K31/4439 , A61P1/04 , A61P13/00 , A61P13/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D213/70 , C07D213/71 , C07D277/20 , C07D277/36 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译：式（I）的N-苯基芳基磺酰胺化合物（R 1）是COOH等; R 2是氢，甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。式（I）化合物与前列腺素E 2受体结合，特别是EP 1亚型受体，并拮抗它。蛋白质结合的影响较小，因此具有令人满意的体内活性。因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

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