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1. 发明申请

US20090081787A1 AGENT FOR PROMOTING HEPATIC CELL REPLICATION AND AGENT FOR IMPROVING INSULIN RESISTANCE 审中-公开
标题翻译：促进细胞再生的代理和改善胰岛素抵抗的药剂
公开(公告)号：US20090081787A1
公开(公告)日：2009-03-26
申请号：US11912424
申请日：2006-04-24
申请人： Hiroyuki Yoneyama , Takafumi Ichida , Shosaku Narumi
发明人： Hiroyuki Yoneyama , Takafumi Ichida , Shosaku Narumi
IPC分类号： C12N5/06 , C07K16/28
CPC分类号： C07K16/24 , A61K2039/505
摘要： The present invention aims at providing a medicament and a method for promoting replication of hepatocytes and a medicament and a method for ameliorating insulin resistance. An effective amount of a neutralizing agent for CXCL10 belonging to a subfamily of chemokines which are heparin-binding proteins is administered to the hepatocytes to promote the replication of the hepatocytes. As the neutralizing agent for CXCL10, a factor which is specifically bound to CXCL10 and inhibits an activity of CXCL10 or a factor which inhibits CXCL10 expression is suitably used. By administering the neutralizing agent to impaired hepatic tissue, it is possible to restore and regenerate the hepatic tissue. Meanwhile, by administering an effective amount of the neutralizing agent for CXCL10 to the hepatocytes, the insulin resistance in type II diabetes and metabolic syndrome is ameliorated.
摘要翻译：本发明的目的在于提供促进肝细胞复制的药物和方法，以及用于改善胰岛素抵抗的药物和方法。向肝细胞施用有效量的属于肝素结合蛋白的趋化因子亚类的CXCL10的中和剂，以促进肝细胞的复制。作为CXCL10的中和剂，适当使用与CXCL10特异性结合并抑制CXCL10活性或抑制CXCL10表达的因子的因子。通过将中和剂施用于肝组织损伤，可以恢复和再生肝组织。同时，通过向肝细胞施用有效量的CXCL10中和剂，可以改善II型糖尿病和代谢综合征中的胰岛素抵抗。

2. 发明授权

US08705174B2 Antiglare film, polarizing plate, and image display device 有权
标题翻译：防伪胶片，偏光板和图像显示装置
公开(公告)号：US08705174B2
公开(公告)日：2014-04-22
申请号：US12512608
申请日：2009-07-30
申请人： Shuntaro Ibuki , Kenichi Fukuda , Hiroyuki Yoneyama , Tokuju Oikawa
发明人： Shuntaro Ibuki , Kenichi Fukuda , Hiroyuki Yoneyama , Tokuju Oikawa
IPC分类号： G02B5/30 , G02B5/02 , G02B1/11 , G02F1/1335
CPC分类号： G02B5/0294 , G02B1/105 , G02B1/14 , G02B5/0226 , Y10T428/25 , Y10T428/252 , Y10T428/254 , Y10T428/26
摘要： An antiglare film is provided, the antiglare film including a transparent plastic film substrate; an antiglare layer having fine recesses and projections on the surface thereof; and an abrasion resistant layer provided at an uppermost surface of the antiglare film, the abrasion resistant layer having an average film thickness of from 0.03 to 0.4 μm, wherein the abrasion resistant layer is formed from a curable composition containing at least following components (A), (B), and (C): (A) an inorganic fine particle containing silicon oxide as a main component and having an average particle size of from 1 to 300 nm; (B) an ionizing radiation-curable resin; and (C) a polymer thickener.
摘要翻译：提供防眩膜，防眩膜包括透明塑料膜基材; 防眩层，其表面上具有细小的凹凸; 以及设置在所述防眩膜的最上表面的耐磨层，所述耐磨层的平均膜厚度为0.03〜0.4μm，其中，所述耐磨层由至少含有以下成分（A）的固化性组合物形成，，（B）和（C）：（A）以氧化硅为主要成分，平均粒径为1〜300nm的无机细粒; （B）电离辐射固化树脂; 和（C）聚合物增稠剂。

3. 发明授权

US08330895B2 Method of making antiglare film, antiglare film, polarizing plate, image display device, and transmissive/semi-transmissive liquid crystal display 有权
标题翻译：制造防眩膜，防眩膜，偏振片，图像显示装置和透射/半透射液晶显示器的方法
公开(公告)号：US08330895B2
公开(公告)日：2012-12-11
申请号：US12749916
申请日：2010-03-30
申请人： Jun Watanabe , Hiroyuki Yoneyama , Takato Suzuki
发明人： Jun Watanabe , Hiroyuki Yoneyama , Takato Suzuki
IPC分类号： G02F1/1335 , G02B5/02 , G02B1/08 , G02B27/00 , B05D5/06 , B05D3/02
CPC分类号： G02B5/02 , G02F1/133502
摘要： In a method for making an antiglare film including the casting, the releasing, the drying, the applying and the curing as defined herein, the transparent particles have an average primary particle size of greater than 2.5 μm and not greater than 12 μm, the transparent base has on at least one side thereof flat portions substantially parallel to a film-forming plane and rounded protrusions arising from the transparent particles, the protrusions having a maximum height Rt from the flat portions of from 1 to 15 μm, and the cured layer has an average thickness of from 1 to 15.0 μm and a surface profile with an arithmetic average roughness Ra, a mean spacing between peaks Sm, and an average slope θa, all as measured in accordance with JIS B0601, satisfying the relationships (1) to (3) as defined herein.
摘要翻译：在制造包括如本文所定义的浇铸，脱模，干燥，施加和固化的防眩膜的方法中，透明颗粒的平均一次粒径大于2.5μm且不大于12μm，透明基底的至少一侧的平坦部分基本上平行于成膜平面和由透明颗粒产生的圆形突起，突起具有从1至15μm的平坦部分的最大高度Rt，并且固化层具有平均厚度为1至15.0μm，具有算术平均粗糙度Ra，平均间距Sm和平均斜率等的表面轮廓; a，根据JIS B0601测量的全部满足关系式（1）至（3）。

4. 发明授权

US08208197B2 Optical film, and polarizing plate and liquid crystal display device using the optical film 有权
标题翻译：光学膜，偏光板和使用该光学膜的液晶显示装置
公开(公告)号：US08208197B2
公开(公告)日：2012-06-26
申请号：US12032389
申请日：2008-02-15
申请人： Tetsuya Asakura , Hiroyuki Yoneyama , Naohiro Matsunaga
发明人： Tetsuya Asakura , Hiroyuki Yoneyama , Naohiro Matsunaga
IPC分类号： G02B5/20 , F21V9/06
CPC分类号： G02B5/208 , G02B1/111 , G02B5/3025 , G02F1/133528
摘要： An optical film includes a filmy support that includes a polymer having all alicyclic structure; an ultraviolet absorbing layer; and a hardcoat layer, wherein the ultraviolet absorbing layer has a beam transmittance of 5% or less in a wavelength region of 200 to 340 nm and includes at least one ultraviolet absorbent selected from the group consisting of a metal oxide fine particle and a polymer particle.
摘要翻译：光学膜包括膜状载体，其包括具有所有脂环结构的聚合物; 紫外线吸收层; 以及硬涂层，其中所述紫外线吸收层的波长范围为200〜340nm的波长透射率为5％以下，并且包括选自金属氧化物微粒和聚合物粒子中的至少一种紫外线吸收剂。

5. 发明申请

US20120117671A1 STEATOHEPATITIS-LIVER CANCER MODEL ANIMAL 审中-公开
标题翻译： STEATOHEPATITIS-LIVER CANCER模型动物
公开(公告)号：US20120117671A1
公开(公告)日：2012-05-10
申请号：US13319851
申请日：2009-07-31
申请人： Hiroyuki Yoneyama , Masato Fujii
发明人： Hiroyuki Yoneyama , Masato Fujii
IPC分类号： A01K67/027 , G01N33/566 , C12Q1/02 , A61K49/00 , A61K31/7008
CPC分类号： A01K67/027 , A01K2207/20 , A01K2207/25 , A01K2227/10 , A01K2267/0331
摘要： Fatty liver was induced by administering agents for inducing organ inflammation to experimental animals to evoke insulin resistance and by rearing them with high-fat diets. As a result, steatohepatitis was successfully induced in the animals. The animals show pathological findings similar to those of humans. By using these model animals, substances for treating or preventing diseases can be efficiently screened and the efficacy of medicinal substances can be effectively evaluated.
摘要翻译：通过给实验动物诱导器官炎症的给药剂引起脂肪肝，以诱发胰岛素抵抗，并通过用高脂饮食饲养它们。结果，在动物中成功诱导了脂肪性肝炎。动物显示类似于人类的病理学发现。通过使用这些模型动物，可以有效地筛选用于治疗或预防疾病的物质，并且可以有效地评价药物的功效。

6. 发明授权

US07968181B2 Antireflection film and polarizing plate and image display device using same 有权
标题翻译：防反射膜和偏振板以及使用其的图像显示装置
公开(公告)号：US07968181B2
公开(公告)日：2011-06-28
申请号：US12801441
申请日：2010-06-09
申请人： Hiroyuki Yoneyama , Yasuhiro Okamoto
发明人： Hiroyuki Yoneyama , Yasuhiro Okamoto
IPC分类号： B32B27/20
CPC分类号： G02B1/111 , B32B17/10018 , B32B17/10174 , G02B5/3033 , Y10T428/249953 , Y10T428/249971 , Y10T428/249986 , Y10T428/249991 , Y10T428/249992 , Y10T428/249993 , Y10T428/25
摘要： An antireflection film comprises: at least one layer containing fine pores; and an antistatic layer, wherein the antistatic layer and one of said at least one layer containing fine pores are the same or different; and wherein, when a surface of the antireflection film is brought into contact with water for 15 minutes, a wiped portion of the surface shows a chromaticity change, ΔE, of 0.45 or less in the CIE 1976 L*a*b* color space measured under a standard illuminant D65.
摘要翻译：防反射膜包括：至少一层含有细孔的层; 和抗静电层，其中所述抗静电层和所述至少一层含有细孔的层之一相同或不同; 并且其中，当防反射膜的表面与水接触15分钟时，表面的擦拭部分在CIE 1976 L * a * b *颜色中显示色度变化，Dgr; E为0.45以下在标准光源D65下测量的空间。

7. 发明申请

US20110026121A1 Laminate, antireflective film, polarizing plate and image display device 审中-公开
标题翻译：层压板，防反射膜，偏振板和图像显示装置
公开(公告)号：US20110026121A1
公开(公告)日：2011-02-03
申请号：US12805442
申请日：2010-07-30
申请人： Masaaki Suzuki , Hiroyuki Yoneyama , Katsuyuki Takada
发明人： Masaaki Suzuki , Hiroyuki Yoneyama , Katsuyuki Takada
IPC分类号： G02B1/11 , B32B27/06 , B32B5/00 , G02B1/04
CPC分类号： G02B1/111 , G02B1/04 , G02B2207/121 , G02F1/133502 , G02F1/133528 , G02F2201/50 , G02F2202/22 , G02F2202/28 , H01J2211/444 , H01J2229/8913 , H01J2329/892 , Y10T428/269 , Y10T428/31971 , C08L27/12 , C08L101/12
摘要： A laminate includes a support and a layer formed from a composition containing at least (A) an organic conductive compound and (B) a fluorine-containing curable compound, a common logarithm value (log SR) of surface resistivity SR (Ω/sq) of a surface of the laminate on the layer side is 13.0 or less, and a lower part uneven distribution ratio of the organic conductive compound (A) in the layer defined by the formula as defined herein is from 55 to 100 percent.
摘要翻译：层压体包括载体和由至少包含（A）有机导电化合物和（B）含氟可固化化合物的组合物形成的层，表面电阻率SR（＆amp; OHgr / sq）的通常对数值（log SR）层叠层的表面的面积为13.0以下，由本发明定义的层中的有机导电性化合物（A）的下部不均匀分布比例为55〜100％。

8. 发明申请

US20100172913A1 FIBROSIS INHIBITOR 审中-公开
标题翻译：纤维蛋白酶抑制剂
公开(公告)号：US20100172913A1
公开(公告)日：2010-07-08
申请号：US12663420
申请日：2008-06-06
申请人： Hiroyuki Yoneyama
发明人： Hiroyuki Yoneyama
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , G01N2800/00 , G01N2800/042 , G01N2800/062 , G01N2800/085 , G01N2800/12 , G01N2800/2835 , G01N2800/325
摘要： An objective of the present invention is to provide methods for treating or preventing fibrotic diseases, which are based on the novel finding that fibrosis is suppressed by administering ER-TR7 to a subject.
摘要翻译：本发明的目的是提供治疗或预防纤维化疾病的方法，其基于通过向受试者施用ER-TR7来抑制纤维化的新发现。

9. 发明申请

US20100021442A1 METHOD FOR PROMOTING IMMUNOTHERAPY USING AN AGENT FOR ELEVATING DENDRITIC CELL PRECURSOR LEVEL IN BLOOD 审中-公开
标题翻译：促进免疫功能的方法，用于增加血液中的细胞前体水平
公开(公告)号：US20100021442A1
公开(公告)日：2010-01-28
申请号：US12554676
申请日：2009-09-04
申请人： Kouji MATSUSHIMA , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
发明人： Kouji MATSUSHIMA , Hiroyuki Yoneyama , Yuang Zhang , Shiro Kanegasaki , Teruo Akuta
IPC分类号： A61K35/12 , A61P37/00
CPC分类号： A61K38/195
摘要： Although the fields of therapeutic applications of dendritic cells are now expanding, dendritic cell precursors exist only in a small amount in the peripheral blood and, therefore, it is still difficult to obtain them in a therapeutically useful amount even though they are proliferated in vitro. Therefore, it is a key point in performing a therapy with the use of dendritic cells in practice to elevate dendritic cell precursor level in the peripheral blood of a patient. The present invention provides an agent for elevating dendritic cell precursor level in the blood which comprises an agonist to a receptor expressed in immature dendritic cells or a functional derivative thereof as the active ingredient.
摘要翻译：尽管树突状细胞的治疗应用领域现在正在扩大，但是树突状细胞前体在外周血中仅存在少量，因此即使体外增殖，仍然难以以治疗有用的量获得它们。因此，在实践中使用树突状细胞进行治疗是关键点，以提高患者外周血中的树突状细胞前体水平。本发明提供了一种用于提高血液中树突状细胞前体水平的试剂，其包含对未成熟树突状细胞中表达的受体的激动剂或其功能性衍生物作为活性成分。

10. 发明申请

US20090136738A1 HARDCOAT LAMINATE 审中-公开
标题翻译： HARDCOAT层压板
公开(公告)号：US20090136738A1
公开(公告)日：2009-05-28
申请号：US12274183
申请日：2008-11-19
申请人： Shunichi KONDO , Hiroyuki Yoneyama
发明人： Shunichi KONDO , Hiroyuki Yoneyama
IPC分类号： B32B5/16
CPC分类号： C09D133/06 , Y10T428/25
摘要： A hardcoat laminate including: a support formed from a thermoplastic resin composition; and a hardcoat layer formed from a hardcoat layer forming coating composition, wherein the thermoplastic resin composition contains a polymer having a lactone ring unit or a glutaric anhydride unit, and the hardcoat layer forming coating composition contains at least a component (a), a component (b), a component (c) and a component (d): (a) an ethylenically unsaturated compound having two or more polymerizable groups within one molecule, (b) a polymerization initiator, (c) a fine particle having an average primary particle diameter of 0.01 to 10 μm, and (d) an organic solvent.
摘要翻译：一种硬涂层叠体，其包含：由热塑性树脂组合物形成的载体; 以及由硬涂层形成用涂料组合物形成的硬涂层，其中，所述热塑性树脂组合物含有具有内酯环单元或戊二酸酐单元的聚合物，所述硬涂层形成用涂料组合物至少含有成分（a），成分（b）成分（c）和成分（d）：（a）在1分子内具有两个以上聚合性基团的烯键式不饱和化合物，（b）聚合引发剂，（c）粒径为0.01〜10μm，（d）有机溶剂。

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