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1. 发明授权

US08475638B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08475638B2
公开(公告)日：2013-07-02
申请号：US12823676
申请日：2010-06-25
申请人： Hiroyuki Tokunaga , Shoji Miyazaki , Eriko Yamanishi
发明人： Hiroyuki Tokunaga , Shoji Miyazaki , Eriko Yamanishi
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , G01N27/3272
摘要： In a biosensor that detects introduction of a sample liquid into a specimen supply path using a detecting electrode, a means of improving accuracy of detection is provided. The biosensor has: an electrode system including measuring electrode, counter electrode, and detecting electrode on first electrically insulating support; specimen supply path for introducing the sample liquid; and reagent layer used for quantifying a substrate contained in the sample liquid. The means is characterized in that detecting electrode is spaced from measuring electrode by a distance sufficient for the sample liquid to sufficiently cover measuring electrode before the sample liquid reaches detecting electrode.
摘要翻译：在使用检测电极检测样本液体进入样本供给路径的生物传感器中，提供提高检测精度的手段。生物传感器具有：电极系统，其包括第一电绝缘支撑件上的测量电极，对电极和检测电极; 用于引入样品液的样品供应路径; 以及用于定量样品液体中所含的基板的试剂层。该装置的特征在于，检测电极与测量电极隔开足够的距离，使得样品液体在样品液体到达检测电极之前足以覆盖测量电极。

2. 发明申请

US20110117269A1 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
公开(公告)号：US20110117269A1
公开(公告)日：2011-05-19
申请号：US12930919
申请日：2011-01-20
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
IPC分类号： B05D5/12
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.

3. 发明申请

US20100243443A1 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
标题翻译：生物传感器，薄膜电极形成方法，定量装置和定量方法
公开(公告)号：US20100243443A1
公开(公告)日：2010-09-30
申请号：US12802573
申请日：2010-06-09
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
IPC分类号： G01N33/50
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.
摘要翻译：根据本发明的生物传感器包括支撑体1，由诸如金，钯等的诸如贵金属的导电材料构成的导电层2和碳，平行于载体侧的狭缝3a和3b 如图1所示，与支撑体1侧垂直的狭缝4a，4b，工作电极5，对电极6，检测电极7，覆盖工作电极5的间隔件8，对置电极6和检测电极7 支撑体1，形成试样供给路径的矩形切口部9，试料供给路径的入口9a，通过将包含酶等的试剂涂布在工作电极5上而形成的试剂层12，对电极6和从间隔件8的切口部9暴露的检测电极7和覆盖间隔件8的盖13，如图1所示。如此构造的生物传感器可以通过简单的方法形成，并且测量精度优异的生物传感器以及试剂层均匀地放置在电极上而不考虑试剂液体组成的生物传感器，并且其中具有统一的性能可以实现。

4. 发明申请

US20050247562A1 Determination method for automatically identifying analyte liquid and standard solution for biosensor 有权
标题翻译：用于自动识别分析液体和生物传感器的标准溶液的测定方法
公开(公告)号：US20050247562A1
公开(公告)日：2005-11-10
申请号：US10523076
申请日：2003-10-31
申请人： Hiroyuki Tokunaga , Motonori Uchiyama , Eriko Yamanishi , Shoji Miyazaki
发明人： Hiroyuki Tokunaga , Motonori Uchiyama , Eriko Yamanishi , Shoji Miyazaki
IPC分类号： C12Q1/00 , C07K1/26
CPC分类号： C12Q1/006 , C12Q1/001 , G01N33/96 , G01N2496/80
摘要： According to the standard solution and the determination method of the present invention, in a case where a voltage is applied by a drive voltage of a measurement apparatus to an electrode portion of a biosensor comprising an electrode portion including a counter electrode and a measuring electrode formed on an insulating substrate, and a reagent layer which reacts with a sample solution supplied to the electrode portion, and a current value which flows at the application is measured, thereby determining a substrate contained in the sample solution, a reducing substance is contained in the standard solution used for controlling a precision of measurement of the measurement apparatus. Therefore, when the standard solution is measured, a large change occurs in a current waveform between time t0 and t1 shown in FIG. 6 due to the reducing substance, thereby discriminating whether the analyte liquid being measured is the standard solution or the sample solution and easily identifying the kind of analyte liquid.
摘要翻译：根据本发明的标准方案和确定方法，在通过测量装置的驱动电压将电压施加到生物传感器的电极部分的情况下，该生物传感器包括形成有对电极和测量电极的电极部分在与绝缘基板一起使用的试剂层和与供给到电极部的试样溶液进行反应的试剂层，测定在施加时流动的电流值，由此测定包含在试样溶液中的基板，还原物质被包含在用于控制测量装置的测量精度的标准溶液。因此，当测量标准溶液时，在图1所示的时间t 0和t 1之间的电流波形中发生大的变化。 6由于还原物质，从而区分被测分析物是否是标准溶液或样品溶液，并且容易地识别分析物液体的种类。

5. 发明授权

US08673127B2 Biosensor 有权
标题翻译：生物传感器
公开(公告)号：US08673127B2
公开(公告)日：2014-03-18
申请号：US12928841
申请日：2010-12-21
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Takahiro Nakaminami , Junko Nakayama , Eriko Yamanishi
IPC分类号： G01N27/327
CPC分类号： C12Q1/003
摘要： In a biosensor for measuring a specific substance in a liquid sample, one or a combination of sugar alcohol, metallic salt, organic acid or organic acid salt which has at least one carboxyl group in a molecule, and organic acid or organic acid salt which has at least one carboxyl group and one amino group in a molecule, is included in a reagent layer provided on electrodes, thereby providing a highly-accurate biosensor which is excellent in stability and has high response (sensitivity, linearity) of the sensor to the substrate concentration.
摘要翻译：在用于测量液体样品中的特定物质的生物传感器中，分子中具有至少一个羧基的糖醇，金属盐，有机酸或有机酸盐的一种或组合，以及有机酸或有机酸盐，其具有分子中的至少一个羧基和一个氨基被包含在设置在电极上的试剂层中，从而提供稳定性优异并且具有高传感器对基板的响应（灵敏度，线性）的高精度生物传感器浓度。

6. 发明授权

US08480878B2 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
公开(公告)号：US08480878B2
公开(公告)日：2013-07-09
申请号：US12930627
申请日：2011-01-11
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.

7. 发明授权

US08142629B2 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
标题翻译：生物传感器，薄膜电极形成方法，定量装置和定量方法
公开(公告)号：US08142629B2
公开(公告)日：2012-03-27
申请号：US12802573
申请日：2010-06-09
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.
摘要翻译：根据本发明的生物传感器包括支撑体1，由诸如金，钯等的诸如贵金属的导电材料构成的导电层2和碳，平行于载体侧的狭缝3a和3b 如图1所示，与支撑体1侧垂直的狭缝4a，4b，工作电极5，对电极6，检测电极7，覆盖工作电极5的间隔件8，对置电极6和检测电极7 支撑体1，形成试样供给路径的矩形切口部9，试料供给路径的入口9a，通过将包含酶等的试剂涂布在工作电极5上而形成的试剂层12，对电极6和从间隔件8的切口部9暴露的检测电极7和覆盖间隔件8的盖13，如图1所示。如此构造的生物传感器可以通过简单的方法形成，并且测量精度优异的生物传感器以及试剂层均匀地放置在电极上而不考虑试剂液体组成的生物传感器，并且其中具有统一的性能可以实现。

8. 发明申请

US20110272296A1 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
公开(公告)号：US20110272296A1
公开(公告)日：2011-11-10
申请号：US13135816
申请日：2011-07-15
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
IPC分类号： G01N27/26 , G01N33/50
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.

9. 发明申请

US20110147234A1 Biosensor, thin film electrode forming method, quantification apparatus, and quantification method 有权
公开(公告)号：US20110147234A1
公开(公告)日：2011-06-23
申请号：US12930957
申请日：2011-01-20
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
IPC分类号： G01N27/416
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor according to the present invention comprises a support 1, a conductive layer 2 composed of an electrical conductive material such as noble metal, for example gold, palladium or the like, and carbon, slits 3a and 3b parallel to the side of the support 1, slits 4a and 4b vertical to the side of the support 1, a working electrode 5, a counter electrode 6, a detecting electrode 7, a spacer 8 which covers the working electrode 5, the counter electrode 6 and the detecting electrode 7 on the support 1, a rectangular cutout part 9 forming a specimen supply path, an inlet 9a of the specimen supply path, a reagent layer 12 formed by applying a reagent including an enzyme or the like to the working electrode 5, the counter electrode 6 and the detecting electrode 7, which is exposed from the cutout part 9 of the spacer 8, and a cover 13 which covers the spacer 8, as shown in FIG. 1. The so-constructed biosensor can be formed by a simple method, and a biosensor which is excellent in a measuring accuracy as well as a biosensor in which a reagent layer is placed uniformly on the electrodes regardless of a reagent liquid composition, and which has a uniform performance can be realized.

10. 发明申请

US20120251708A1 BIOSENSOR, THIN FILM ELECTRODE FORMING METHOD, QUANTIFICATION APPARATUS, AND QUANTIFICATION METHOD 有权
标题翻译：生物传感器，薄膜电极形成方法，量化装置和定量方法
公开(公告)号：US20120251708A1
公开(公告)日：2012-10-04
申请号：US13490553
申请日：2012-06-07
申请人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
发明人： Shoji Miyazaki , Hiroyuki Tokunaga , Masaki Fujiwara , Eriko Yamanishi , Yoshinobu Tokuno
IPC分类号： H05K13/04 , B05D5/12 , B23K26/38 , C23C14/34
CPC分类号： G01N27/3272 , C12Q1/001 , G01N33/48771 , Y10T29/49002
摘要： A biosensor is disclosed comprising a support; a conductive layer composed of an electrical conductive material such as a noble metal, for example gold or palladium, and carbon; slits parallel to and perpendicular to the side of the support; working, counter, and detecting electrodes; a spacer which covers the working, counter, and detecting electrodes on the support; a rectangular cutout in the spacer forming a specimen supply path; an inlet to the specimen supply path; a reagent layer formed by applying a reagent containing an enzyme to the working, counter, and detecting electrodes, which are exposed through the cutout in the spacer; and a cover over the spacer. The biosensor can be formed by a simple method, and provides a uniform reagent layer on the electrodes regardless of the reagent composition.
摘要翻译：公开了一种生物传感器，其包括支撑件; 由诸如金或钯等贵金属的导电材料和碳组成的导电层; 平行于和垂直于支撑体侧面的狭缝; 工作，计数器和检测电极; 覆盖支架上的工作电极，反电极和检测电极的间隔件; 在间隔件中形成矩形切口，形成试样供应路径; 样品供应路径的入口; 通过将含有酶的试剂施加到通过所述间隔件中的切口暴露的所述工作，反向和检测电极而形成的试剂层; 和间隔物上的盖子。可以通过简单的方法形成生物传感器，并且不管试剂组成如何，在电极上提供均匀的试剂层。

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