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1. 发明授权

US5432192A Tricyclic compounds and method for treating allergic diseases 失效
标题翻译：三环化合物和治疗过敏性疾病的方法
公开(公告)号：US5432192A
公开(公告)日：1995-07-11
申请号：US122603
申请日：1993-10-01
申请人： Hiroyuki Sawanishi , Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Kouji Morikawa
发明人： Hiroyuki Sawanishi , Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Kouji Morikawa
IPC分类号： A61K31/195 , A61K31/335 , A61K31/35 , A61K31/352 , A61P37/08 , A61P43/00 , C07C229/14 , C07D311/80 , C07D311/82 , C07D313/12 , C07D313/14
CPC分类号： C07D313/14 , C07C229/14 , C07D311/82 , C07D313/12 , C07C2103/32
摘要： Tricyclic compounds represented by the following formula: ##STR1## wherein X represents --CH.dbd.CH--, --CH.sub.2 O--, or --O--;R.sup.1 represents a lower alkyl group,R.sup.2 represents a hydrogen atom or a lower alkyl group; andn represents an integer of from 1 to 5, pharmacologically acceptable salts thereof, and a method for preparing the same. The present compounds have anti-allergic and anti-histaminic activities and reduced side effects, and are useful as anti-allergic agents and anti-histaminic agents.
摘要翻译： PCT No.PCT / JP92 / 00365 Sec。 371日期：1993年10月1日 102（e）日期1993年10月1日PCT 1991年3月26日PCT公布。第WO92 / 17440号公报日期：10月15日，1992.由下式表示的三环化合物：其中X表示-CH = CH-，-CH 2 O-或-O-; R1表示低级烷基，R2表示氢原子或低级烷基; 和n表示1〜5的整数，其药理学上可接受的盐及其制备方法。本发明化合物具有抗过敏和抗组胺活性并减少副作用，并且可用作抗过敏剂和抗组胺剂。

2. 发明授权

US5344828A Piperazinealkanoic acid and a pharmaceutical composition comprising the same 失效
标题翻译：哌嗪烷酸和包含其的药物组合物
公开(公告)号：US5344828A
公开(公告)日：1994-09-06
申请号：US663154
申请日：1991-03-01
申请人： Hiroyuki Sawanishi , Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Kouji Morikawa
发明人： Hiroyuki Sawanishi , Yasuo Ito , Hideo Kato , Eiichi Koshinaka , Nobuo Ogawa , Kouji Morikawa
IPC分类号： A61K31/55 , A61K31/00 , A61K31/554 , A61P1/00 , A61P1/08 , A61P9/06 , A61P9/12 , A61P25/00 , A61P25/04 , A61P37/08 , A61P43/00 , C07D223/20 , C07D267/20 , C07D281/16 , C07D487/04 , C07D403/04 , C07D413/04 , C07D417/04
CPC分类号： C07D487/04 , C07D223/20 , C07D267/20 , C07D281/16
摘要： Novel polycyclic compounds represented by the following formula: A--(CH.sub.2).sub.n --COOR.sup.1, wherein R.sup.1 represents a hydrogen atom or a lower alkyl group; n represents an integer of from 0 to 5; and A is a group represented by the following formula: ##STR1## wherein X represents a hydrogen atom or a halogen atom; and Y represents a methylene group, an oxygen atom, or a sulfur atom, or A is a group represented by the following formula: ##STR2## and pharmacologically acceptable salts thereof are disclosed. Also disclosed are a method for preparing the same, a pharmaceutical composition comprising the same, an antiallergic agent and an agent for bronchial asthma comprising the same, and a method for treatment of an allergic disease or bronchial asthma comprising the step of administering the same.
摘要翻译：由下式表示的新型多环化合物：A-（CH 2）n -COOR 1，其中R 1表示氢原子或低级烷基; n表示0〜5的整数， A是由下式表示的基团：其中X表示氢原子或卤素原子; Y表示亚甲基，氧原子或硫原子，或A为下式表示的基团：其中，可以列举出其药理学上可接受的盐。还公开了其制备方法，包含其的药物组合物，抗过敏剂和包含其的支气管哮喘剂，以及治疗过敏性疾病或支气管哮喘的方法，包括施用该过敏性疾病或支气管哮喘的步骤。

3. 发明授权

US4912116A Propiophenone derivatives for treatment of pollakiuria (frequency urination) 失效
标题翻译：用于治疗尿频的苯丙酮衍生物（排尿）
公开(公告)号：US4912116A
公开(公告)日：1990-03-27
申请号：US136912
申请日：1987-12-22
申请人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Kouji Morikawa , Toshie Yamauchi
发明人： Yasuo Itoh , Hideo Kato , Eiichi Koshinaka , Kouji Morikawa , Toshie Yamauchi
IPC分类号： C07D295/10 , A61K31/40 , A61K31/4025 , A61K31/443 , A61K31/445 , A61K31/535 , A61K31/54 , A61K31/55 , A61P13/02 , A61P15/00 , C07D307/79 , C07D317/58 , C07D405/06
CPC分类号： A61K31/535 , A61K31/40 , A61K31/445 , A61K31/55 , Y10S514/906
摘要： A method for the treatment of pollakiurea in a subject in need thereof, comprising the step of administering to said subject an effective antipollakiurea amount of a propiophenone of the formula (I) ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 each independently represents hydrogen, halogen, lower alkyl- or halogeno-lower-alkyl, lower-alkoxy, or cycloalkyl having 3-8 carbon atoms, two of which R.sub.1, R.sub.2, and R.sub.3 groups may combine to form methylenedioxy or ethyleneoxy, R.sub.4 represents hydrogen or a lower-alkyl, and A represents pyrrolidinyl-, piperidinyl-, morpholinyl-, or azepinyl or a pharmaceutically-acceptable acid addition salt thereof, is disclosed.

4. 发明授权

US4545347A Intake system for an automotive engine 失效
标题翻译：汽车发动机进气系统
公开(公告)号：US4545347A
公开(公告)日：1985-10-08
申请号：US609090
申请日：1984-05-11
申请人： Kouji Morikawa
发明人： Kouji Morikawa
IPC分类号： F02B31/00 , F02B29/02 , F02B31/08 , F02M35/10 , F02M35/108
CPC分类号： F02M35/10183 , F02B29/02 , F02B31/08 , F02M35/10072 , F02M35/10229 , F02M35/10255 , F02M35/108 , F02B2031/003 , F02M35/1038 , Y02T10/146
摘要： An intake system for an automotive engine having cylinders, primary intake ports communicated with the cylinders, and secondary intake ports communicated with the cylinders. Each of the primary and secondary intake ports is communicated with a corresponding cylinder at a common intake valve. A primary intake manifold communicated with the primary intake ports and a secondary intake manifold communicated with the secondary intake ports are provided. A control valve is provided in each branch of the secondary intake manifold for controlling a counter flow of induced mixture. A vacuum operated actuator opens the control valve in dependency on an increase of engine speed and load on the engine.
摘要翻译：一种用于汽车发动机的进气系统，其具有气缸，与气缸连通的主进气口和与汽缸连通的二级进气口。主进气口和次进气口中的每一个在公共进气门与相应的气缸连通。提供与主进气口连通的主进气歧管和与次进气口连通的次进气歧管。在第二进气歧管的每个分支中设置控制阀，以控制诱导混合物的逆流。真空操作的执行器依赖于发动机转速和发动机负载的增加而打开控制阀。

5. 发明授权

US4494493A Intake system for an automotive engine 失效
标题翻译：汽车发动机进气系统
公开(公告)号：US4494493A
公开(公告)日：1985-01-22
申请号：US609168
申请日：1984-05-11
申请人： Kouji Morikawa , Hitoshi Suzuki
发明人： Kouji Morikawa , Hitoshi Suzuki
IPC分类号： F02B31/00 , F02B29/02 , F02B31/08 , F02M35/10 , F02M35/108
CPC分类号： F02M35/10308 , F02B29/02 , F02B31/08 , F02M35/10072 , F02M35/10183 , F02M35/10255 , F02M35/108 , F02B2031/003 , F02M35/10229 , F02M35/10275 , Y02T10/146
摘要： An intake system for an automotive engine having cylinders, primary intake ports communicated with the cylinders, secondary intake ports communicated with the cylinders. Each of the primary and secondary intake ports is communicated with a corresponding cylinder at a common intake valve. A primary intake manifold communicated with the primary intake ports and a secondary intake manifold communicated with the secondary intake ports are provided.A first valve is provided in each branch of the secondary intake manifold for preventing a counter flow of inducted mixture. A bypass is provided at a position downstream of the first valve for communicating the primary intake manifold with the adjacent secondary intake manifold, and a second valve is provided to be operated to open the bypass when load on the engine exceeds a predetermined partial load.
摘要翻译：一种用于具有气缸的汽车发动机的进气系统，与气缸连通的主进气口，与气缸连通的二级进气口。主进气口和次进气口中的每一个在公共进气门与相应的气缸连通。提供与主进气口连通的主进气歧管和与次进气口连通的次进气歧管。在第二进气歧管的每个分支中设置第一阀，以防止引入混合物的逆流。在第一阀下游的位置设置旁路，用于使主进气歧管与相邻的次级进气歧管连通，并且当发动机上的负载超过预定的部分负荷时，设置第二阀以操作以打开旁路。

6. 发明授权

US4488528A System for controlling the ignition timing of a combustion engine 失效
标题翻译：用于控制内燃机的点火正时的系统
公开(公告)号：US4488528A
公开(公告)日：1984-12-18
申请号：US587739
申请日：1984-03-08
申请人： Kouji Morikawa
发明人： Kouji Morikawa
IPC分类号： F02P5/152 , F02P5/153 , G01L23/22 , G01M15/00 , F02P5/04
CPC分类号： G01L23/221 , G01L23/225
摘要： A system for controlling the ignition timing of an engine has a probe provided on the wall of a cylinder of the engine opposite the piston in the cylinder. A capacitance-to-voltage converting circuit is provided for measuring the crank angle of the engine by the capacitance between the probe and the top of the piston and for producing an output dependent on the crank angle, and a second circuit is provided for measuring the velocity of flame propagation in the cylinder by detecting the ionization current flowing between the probe and the cylinder and for producing an output when the velocity is very high. An ignition timing control circuit is responsive to output of the converting circuit and second circuit for retarding the ignition timing so as to prevent the knocking of the engine.
摘要翻译：用于控制发动机的点火正时的系统具有设置在发动机气缸的壁上的探针，其与气缸中的活塞相对。提供了一种电容电压转换电路，用于通过探头与活塞的顶部之间的电容来测量发动机的曲柄角，并且用于产生取决于曲柄角的输出，并且提供第二电路用于测量通过检测在探针和气缸之间流动的电离电流并且当速度非常高时产生输出，在气缸中的火焰传播速度。点火正时控制电路响应于转换电路和第二电路的输出以延迟点火正时，以防止发动机的爆震。

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