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    • 10. 发明申请
    • Biochemical measuring chip and measuring apparatus
    • 生化测量芯片和测量仪器
    • US20050250198A1
    • 2005-11-10
    • US11007366
    • 2004-12-09
    • Toru FujimuraYasushi Goto
    • Toru FujimuraYasushi Goto
    • G01N33/53G01N21/45G01N33/543G01N33/566C12M1/34
    • G01N33/54373G01N21/55
    • A simple and convenient sensor and measuring apparatus utilizing the optical interference effect of an optical thin film capable of measuring the binding between biochemical substances at a high throughput and having alkali resistance. An optical thin film of silicon nitride is disposed on the first surface and the rear surface of a silicon substrate, and the thickness of the silicon nitride film is modified in a direction parallel to the film. A portion of the thin film with increased thickness is used as a sensor upon which a probe is disposed, and over which a sample-containing solution is caused to flow. The binding between the probe and biochemical sample is detected based upon the change of the intensity of reflected light.
    • 一种简单方便的传感器和测量装置,利用光学薄膜的光学干涉效应,能够以高通量测量生化物质之间的结合并具有耐碱性。 氮化硅的光学薄膜设置在硅衬底的第一表面和后表面上,并且氮化硅膜的厚度在与膜平行的方向上被改变。 使用具有增加厚度的薄膜的一部分用作传感器,在其上设置探针,并使含有样品的溶液流过。 基于反射光强度的变化来检测探针和生化样品之间的结合。