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1. 发明申请

US20070082908A1 Bicycle pyrazole derivative 审中-公开
标题翻译：自行车吡唑衍生物
公开(公告)号：US20070082908A1
公开(公告)日：2007-04-12
申请号：US10595125
申请日：2004-08-25
申请人： Hiroyuki Nakahira , Hitoshi Hochigai , Tatsuya Takeda , Tomonori Kobayashi , William Hume
发明人： Hiroyuki Nakahira , Hitoshi Hochigai , Tatsuya Takeda , Tomonori Kobayashi , William Hume
IPC分类号： A61K31/53 , A61K31/498 , C07D487/04
CPC分类号： C07D487/04
摘要： A compound represented by the following formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of either. These are compounds having high DPP-IV inhibitory activity and improved in safety, nontoxicity, etc. (I) [In the formula, R1 represents hydrogen, optionally substituted alkyl, etc.; the solid line and dotted line between A1 and A2 indicate a double bond (A1=A2), etc.; A1 represents a group represented by the formula C(R2), etc.; A2 represents a group represented by the formula C(R4), etc.; R2 represents hydrogen, optionally substituted alkyl, etc.; R4 represents hydrogen, optionally substituted alkyl, etc.; R6 represents hydrogen, optionally substituted aryl, etc.; and —Y represents, e.g.; a group represented by the formula (A): (A) (wherein m1 is 0, 1, 2, or 3; and R7 is absent, or one or two R7's are present and each independently represents optionally substituted alkyl, etc.).]
摘要翻译：由下式（I）表示的化合物，其前药或其药学上可接受的盐。这些是具有高DPP-IV抑制活性和安全性，无毒性等改善的化合物。（I）[式中，R 1表示氢，任选取代的烷基等; A 1和A 2之间的实线和虚线表示双键（A 1 SUP 1 = A 2））等 A ^{1表示由式C（R 2 O 2）表示的基团等; A <2>表示由式C（R 4）表示的基团等。 R 2表示氢，任选取代的烷基等; R 4表示氢，任选取代的烷基等; R 6表示氢，任选取代的芳基等; -Y表示例如由式（A）表示的基团：（A）（其中m1为0,1,2或3; R 7为不存在，或一个或两个R 7为氢， SUP'是存在的，各自独立地表示任选取代的烷基等）。}

2. 发明申请

US20070105890A1 Novel condensed imidazole derivative 审中-公开
标题翻译：新型稠合咪唑衍生物
公开(公告)号：US20070105890A1
公开(公告)日：2007-05-10
申请号：US10580321
申请日：2004-11-24
申请人： Hiroyuki Nakahira , Hidenori Kimura , Tomonori Kobayashi , Hitoshi Hochigai
发明人： Hiroyuki Nakahira , Hidenori Kimura , Tomonori Kobayashi , Hitoshi Hochigai
IPC分类号： A61K31/4745 , C07D471/02
CPC分类号： C07D471/14 , C07D471/04 , C07D491/14 , C07D495/14
摘要： Disclosed is a compound represented by the formula (1) below which has a high DPP-IV inhibitory activity and is improved in safety, toxicity and the like. Also disclosed is a prodrug of such a compound and pharmaceutically acceptable salts of them. (In the formula, R1 represents a hydrogen atom, an optionally substituted alkyl group or the like; R2 and R3 independently represent a hydrogen atom, an optionally substituted alkyl group or the like; R4 and R5 independently represent a hydrogen atom, an optionally substituted alkyl group or the like: R6 represents a hydrogen atom, an optionally substituted aryl group or the like; and —Y—NH2, represents a group represented by the following formula (A): (wherein m is 0, 1 or 2; and R7 may not exist or one or two R7 may exist and independently represent an optionally substituted alkyl group or the like) or the like.]
摘要翻译：公开了由下式（1）表示的化合物，其具有高的DPP-IV抑制活性，并且其安全性和毒性等得到改善。还公开了这种化合物的前药和它们的药学上可接受的盐。（式中，R 1表示氢原子，任选取代的烷基等; R 2和R 3独立地表示氢原子，氢原子，任选取代的烷基等; R 4和R 5独立地表示氢原子，任选取代的烷基等： 6表示氢原子，任选取代的芳基等; -Y-NH 2表示由下式（A）表示的基团：（其中m为0 ，1或2; R 7可以不存在或一个或两个R 7可以存在并且独立地表示任选取代的烷基等）。

3. 发明申请

US20080318922A1 Bicyclic Pyrrole Derivatives 审中-公开
标题翻译：双环吡咯衍生物
公开(公告)号：US20080318922A1
公开(公告)日：2008-12-25
申请号：US11722037
申请日：2005-12-21
申请人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
发明人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
IPC分类号： A61K31/519 , C07D487/04 , A61K31/5377 , C07D401/04 , A61P3/10
CPC分类号： C07D487/04
摘要： Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkyl group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.]
摘要翻译：提供由通式（I）表示的化合物，其前体药物或两者的药学上可接受的盐作为具有高DPP-IV抑制活性并且具有改善的安全性，毒性等的化合物：（I）其中实线和 A1和A2之间的虚线表示双键（A1 = A2）等; A1是C（R4）等; A2是氮原子等; R1是氢原子，任选取代的烷基等; R2是氢原子，任选取代的烷基等; R3是氢原子，卤素原子等; R4是氢原子，羟基，卤素原子等; Y为由通式（A）等表示的基团。（A）[其中m1为0,1,2或3; 并且基团（A）可以被R6除去，或被一个或两个各自独立地为卤素原子的R6取代。

4. 发明授权

US07601728B2 Bicyclic pyrrole derivatives 失效
标题翻译：双环吡咯衍生物
公开(公告)号：US07601728B2
公开(公告)日：2009-10-13
申请号：US12127858
申请日：2008-05-28
申请人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
发明人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
IPC分类号： A61K31/519
CPC分类号： C07D487/04
摘要： Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1═A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.]
摘要翻译：提供由通式（I）表示的化合物，其前体药物或两者的药学上可接受的盐作为具有高DPP-IV抑制活性并且具有改善的安全性，毒性等的化合物：（I）其中实线和 A1和A2之间的虚线表示双键（A1-A2）等; A1是C（R4）等; A2是氮原子等; R1是氢原子，任意取代的烷基等; R2是氢原子，任选取代的烷基等; R3是氢原子，卤素原子等; R4是氢原子，羟基，卤素原子等; Y为由通式（A）等表示的基团。（A）[其中m1为0,1,2或3; 并且基团（A）可以被R6除去，或被一个或两个各自独立地为卤素原子的R6取代。

5. 发明申请

US20090149483A1 BICYCLIC PYRROLE DERIVATIVES 失效
标题翻译：双相PYROROLE DORIVATIVES
公开(公告)号：US20090149483A1
公开(公告)日：2009-06-11
申请号：US12127858
申请日：2008-05-28
申请人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
发明人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
IPC分类号： A61K31/519 , C07D487/04 , A61P3/10
CPC分类号： C07D487/04
摘要： Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.]
摘要翻译：提供由通式（I）表示的化合物，其前体药物或两者的药学上可接受的盐作为具有高DPP-IV抑制活性并且具有改善的安全性，毒性等的化合物：（I）其中实线和 A1和A2之间的虚线表示双键（A1 = A2）等; A1是C（R4）等; A2是氮原子等; R1是氢原子，任意取代的烷基等; R2是氢原子，任选取代的烷基等; R3是氢原子，卤素原子等; R4是氢原子，羟基，卤素原子等; Y为由通式（A）等表示的基团。（A）[其中m1为0,1,2或3; 并且基团（A）可以被R6除去，或被一个或两个各自独立地为卤素原子的R6取代。

6. 发明申请

US20090192129A1 BICYCLIC PYRROLE DERIVATIVES 审中-公开
公开(公告)号：US20090192129A1
公开(公告)日：2009-07-30
申请号：US12144430
申请日：2008-06-23
申请人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
发明人： Hiroyuki Nakahira , Hidenori Kimura , Hitoshi Hochigai
IPC分类号： A61K31/519 , C07D487/04 , A61K31/551 , A61P9/00 , A61K31/5377 , A61P37/00 , A61K31/565 , A61K31/568 , A61P29/00 , A61P3/00
CPC分类号： C07D487/04
摘要： Compounds represented by the general formula (I), prodrugs thereof, or pharmaceutically acceptable salts of both are provided as compounds which have high DPP-IV inhibiting activity and are improved in safety, toxicity and so on: (I) wherein the solid line and dotted line between A1 and A2 represents a double bond (A1=A2) or the like; A1 is C(R4) or the like; A2 is nitrogen atom or the like; R1 is hydrogen atom, optionally substituted alkly group, or the like; R2 is hydrogen atom, optionally substituted alkyl group, or the like; R3 is hydrogen atom, halogen atom, or the like; R4 is hydrogen atom, hydroxyl, halogen atom, or the like; and Y is a group represented by the general formula (A) or the like; (A) [wherein m1 is 0, 1, 2 or 3; and the group (A) may be freed from R6 or substituted with one or two R6's which are each independently halogen atom or the like.]

7. 发明申请

US20100056497A1 AMIDE DERIVATIVE 审中-公开
公开(公告)号：US20100056497A1
公开(公告)日：2010-03-04
申请号：US12524921
申请日：2008-01-30
申请人： Hiroyuki Nakahira , Yohei Ikuma , Nobuhisa Fukuda , Tomonori Kobayashi , Shinya Tosaki
发明人： Hiroyuki Nakahira , Yohei Ikuma , Nobuhisa Fukuda , Tomonori Kobayashi , Shinya Tosaki
IPC分类号： A61K31/4462 , C07D211/56 , C07D207/14 , C07D223/12 , C07D401/12 , C07D413/12 , A61P9/12 , A61K31/40 , A61K31/55 , A61K31/4545 , A61K31/5377
CPC分类号： C07D207/14 , C07D211/56 , C07D221/22 , C07D223/12
摘要： The present invention relates to a compound of the formula (I) being useful as a renin inhibitor, or a pharmaceutically acceptable salt thereof. wherein R1a is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R1b is an optionally substituted C1-6 alkoxy, etc.; R1c is a hydrogen atom, an optionally substituted C1-6 alkoxy, etc.; R2 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; R3a, R3b, R3c and R3d are independently the same or different, and each is a group of the formula: -A-B (in which A is a single bond, —(CH2)sO—, —(CH2)sN(R4)CO—, etc., B is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.), etc.; R4 is a hydrogen atom, an optionally substituted C1-6 alkyl, etc.; s is 0, etc.; and n is 1, etc.
摘要翻译：本发明涉及可用作肾素抑制剂的式（I）化合物或其药学上可接受的盐。其中R 1a是氢原子，任选取代的C 1-6烷基等; R1b是任选取代的C 1-6烷氧基等; R1c是氢原子，任选被取代的C 1-6烷氧基等; R2是氢原子，任选取代的C 1-6烷基等; R3a，R3b，R3c和R3d独立地相同或不同，并且各自为下式基团：其中A为单键， - （CH2）sO-， - （CH2）sN（R4）CO - 等等，B是氢原子，任选取代的C 1-6烷基等）等; R4是氢原子，任意取代的C 1-6烷基等; s为0等 n为1等

8. 发明申请

US20050270677A1 Write compensation circuit and signal interpolation circuit of recording device 有权
公开(公告)号：US20050270677A1
公开(公告)日：2005-12-08
申请号：US11198950
申请日：2005-08-08
申请人： Hirokuni Fujivama , Shiro Dosho , Hiroyuki Nakahira , Akira Yamamoto , Hiroki Mouri
发明人： Hirokuni Fujivama , Shiro Dosho , Hiroyuki Nakahira , Akira Yamamoto , Hiroki Mouri
IPC分类号： G11B5/00 , G11B5/09 , G11B20/10 , H03K5/08 , H03K5/13
CPC分类号： G11B20/10 , G11B5/09 , G11B20/10194 , G11B20/10212 , G11B2005/0005 , H03K5/082 , H03K5/13 , H03K5/133
摘要： A write compensation circuit of a recording device includes a first delay portion driven by a first driving voltage, for receiving a clock signal, delaying the clock signal by a first delay time, and outputting the delayed clock signal, and a voltage supplying portion for supplying the first driving voltage to the first delay portion in such a manner that the first delay time is substantially equal to a clock period of the clock signal.

9. 发明申请

US20050219985A1 Reproduced signal processor and reproduced signal processing method 审中-公开
标题翻译：再现信号处理器和再生信号处理方法
公开(公告)号：US20050219985A1
公开(公告)日：2005-10-06
申请号：US10513367
申请日：2003-09-02
申请人： Hiroyuki Nakahira
发明人： Hiroyuki Nakahira
IPC分类号： G11B20/10 , H03H17/02 , H03H17/06 , H03H21/00 , G11B5/09
CPC分类号： G11B20/10009 , G11B20/10046 , G11B20/10481 , H03H17/06
摘要： As shown in FIG. 1, in the reproduced signal processing apparatus (100) of the present invention, the pattern predictor (103) predicts a predicted value which is a data sequence of a reproduced signal X and judges whether the predicted value matches a previously set specific pattern or not, and the adaptive equalizer (110) performs adaptive equalization on the reproduced signal X with timely updating the coefficients W of the digital filter according to the judgement result from the pattern predictor (103), and the selection circuit (104) outputs one of the output from the adaptive equalizer (110) and the predicted value as a waveform-equalized output Y on the basis of the judgement result. The reproduced signal processing apparatus (100) so constructed can realize optimal waveform equalization for coping with the non-linear distortion included in the reproduced signal.
摘要翻译：如图所示。如图1所示，在本发明的再现信号处理装置（100）中，模式预测器（103）预测作为再现信号X的数据序列的预测值，并且判断预测值是否与预先设定的特定模式匹配，并且自适应均衡器（110）根据来自模式预测器（103）的判断结果及时更新数字滤波器的系数W，对再现信号X执行自适应均衡，并且选择电路（104）输出根据判断结果，将自适应均衡器（110）的输出和预测值作为波形均衡输出Y输出。这样构成的再现信号处理装置（100）可以实现最佳的波形均衡，以应对包含在再生信号中的非线性失真。

10. 发明授权

US5550544A Signal converter, noise shaper, AD converter and DA converter 失效
标题翻译：信号转换器，噪声整形器，AD转换器和DA转换器
公开(公告)号：US5550544A
公开(公告)日：1996-08-27
申请号：US200493
申请日：1994-02-23
申请人： Shiro Sakiyama , Shiro Dosho , Masakatsu Maruyama , Hiroyuki Nakahira , Toshiyuki Shono , Akira Matsuzawa
发明人： Shiro Sakiyama , Shiro Dosho , Masakatsu Maruyama , Hiroyuki Nakahira , Toshiyuki Shono , Akira Matsuzawa
IPC分类号： H03M3/00 , H03M1/00
CPC分类号： H03M3/424 , H03M3/456
摘要： The present invention provides a first-order delta-sigma AD converter adapted to conduct noise shaping and having a quantizer arranged such that, when the amplitude of an input signal entered into the quantizer is small, the amplitude of a difference signal between the input signal entered into the quantizer and an output signal therefrom, is small. It is therefore possible to achieve an efficient AD- or DA-converter reduced in power consumption, which satisfies the transmission characteristics of the specifications of CCITT G.714 based on a method of PCM-encoding an audio frequency band signal stipulated in the specifications of CCITT G.711.
摘要翻译：本发明提供了一种适用于进行噪声整形并具有量化器的一级Δ-ΣAD转换器，其被布置为使得当输入到量化器的输入信号的幅度较小时，输入信号之间的差信号的幅度进入量化器并且其输出信号很小。因此，可以实现功率消耗降低的有效的AD转换器或DA转换器，该功率消耗满足CCITT G.714的规格的传输特性，该方法基于对编码 CCITT G.711。

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