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1. 发明授权

US4578465A Phenyliperazine derivatives 失效
标题翻译：苯基哌嗪衍生物
公开(公告)号：US4578465A
公开(公告)日：1986-03-25
申请号：US604415
申请日：1984-04-30
申请人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
发明人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
IPC分类号： C07D403/06 , A61K31/505 , A61K31/517 , A61P9/00 , A61P9/12 , C07D239/96
CPC分类号： C07D239/96
摘要： Phenylpiperazine derivatives of the formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a straight- or branched-chain saturated or unsaturated alkyl group having 1 to 8 carbon atoms which may be substituted at any position by a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group or an oxo group; and R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or a sulfamoyl group, and a process for producing the same are disclosed. The derivatives of the formula have alpha blocking and serotonin antagonizing activities and are useful as a drug.
摘要翻译：具有下式的苯基哌嗪衍生物：其中R1是氢原子或可以在任何位置被羟基取代的具有1-8个碳原子的直链或支链饱和或不饱和烷基，羧基，低级烷氧基羰基或氧代基; R 2为氢原子，卤素原子，低级烷基或氨磺酰基及其制造方法。该衍生物具有α阻断和5-羟色胺拮抗活性，可用作药物。

2. 发明授权

US4560686A Method for treating circulatory diseases by using (2-lower alkoxyphenyl)piperazine derivatives 失效
标题翻译：通过使用（2-低级烷氧基苯基）哌嗪衍生物治疗循环系统疾病的方法
公开(公告)号：US4560686A
公开(公告)日：1985-12-24
申请号：US532271
申请日：1983-09-14
申请人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
发明人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Hiroyuki Nabata , Yasuhiro Ohba , Kazushige Sakai , Shun-ichi Hata , Yasumi Uchida
IPC分类号： C07D295/12 , A61K31/495 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , C07D295/13 , C07D317/68 , C07D241/04
CPC分类号： C07D295/13 , C07D317/68
摘要： Compounds of the formula ##STR1## (wherein R.sub.1 is a lower alkyl group, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a trifluoromethyl group or a lower alkoxycarbonyl group; two adjacent groups of R.sub.2, R.sub.3 and R.sub.4 may combine to form a methylenedioxy group; n is an integer of 2 to 6) or salts thereof, are disclosed.These compounds are useful as agents for treating circulatory diseases because they have hypotensive action and are capable of increasing the cerebral blood flow, decreasing the heart rate and suppressing ventricular arrhythmia due to myocardial ischemia.
摘要翻译：式（IMAGE）的化合物（其中R 1为低级烷基，R 2，R 3和R 4可相同或不同，表示氢原子，卤素原子，低级烷基，低级烷氧基，羟基，三氟甲基或低级烷氧基羰基; R 2，R 3和R 4的两个相邻基团可以结合形成亚甲二氧基; n是2至6的整数）或其盐。这些化合物可用作治疗循环系统疾病的药剂，因为它们具有降血压作用，并且能够增加脑血流量，降低心率并抑制心肌缺血引起的室性心律失常。

3. 发明授权

US4438115A Compositions and methods for treating diseases in circulatory organs 失效
标题翻译：用于治疗循环器官疾病的组合物和方法
公开(公告)号：US4438115A
公开(公告)日：1984-03-20
申请号：US272077
申请日：1981-06-10
申请人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Tamotsu Yamazaki , Hiroyuki Nabata , Kazushige Sakai , Shun-ichi Hata
发明人： Hiroyuki Nagano , Mitiro Takagi , Noboru Kubodera , Isao Matsunaga , Tamotsu Yamazaki , Hiroyuki Nabata , Kazushige Sakai , Shun-ichi Hata
IPC分类号： C07D295/02 , A61K31/495 , A61P9/00 , A61P9/10 , A61P9/12 , C07D295/14 , C07D295/15 , A01N43/48
CPC分类号： C07D295/15 , A61K31/495
摘要： An agent for treating diseases in circulatory organs which comprises a piperazine compound of the formula ##STR1## wherein R.sub.1, R.sub.2 and A are as defined hereunder, or a salt thereof and a pharmaceutically acceptable carrier.
摘要翻译：一种用于治疗循环器官疾病的药剂，其包含式IMA IMA的化合物，其中R 1，R 2和A如下文所定义，或其盐和药学上可接受的载体。

4. 发明授权

US4022768A Process for preparation of 1.alpha.,25-dihydroxycholecalciferol 失效
标题翻译：制备1 {60,25-二羟基胆钙化甾醇的方法
公开(公告)号：US4022768A
公开(公告)日：1977-05-10
申请号：US657375
申请日：1976-02-12
申请人： Isao Matsunaga , Kiyoshige Ochi , Hiroyuki Nagano , Minoru Shindo , Masayuki Ishikawa , Chikara Kaneko , Hector F. DeLuca
发明人： Isao Matsunaga , Kiyoshige Ochi , Hiroyuki Nagano , Minoru Shindo , Masayuki Ishikawa , Chikara Kaneko , Hector F. DeLuca
IPC分类号： C07J9/00 , C07J71/00
CPC分类号： C07J71/0042 , C07J9/00
摘要： 1.alpha.,25-dihydroxycholecalciferol is prepared by reacting 1,5,7-trien-3.beta.,25-diol with a 1,2,4-triazoline-dione derivative represented by the formula: ##STR1## wherein R represents an alkyl group or an aryl or substituted-aryl group; reacting the resulting 1,4-cyclic adduct represented by the general formula ##STR2## wherein R is as defined above, with a peroxide to form a 1.alpha.,2.alpha.-epoxide compound represented by the general formula ##STR3## wherein R is as defined above, reducing the so formed compound with a metal hydride to form cholesta-5,7-diene-1.alpha.,3.beta.,25-triol, irradiating the so formed compound with ultraviolet rays to form 1.alpha.,25-dihydroxyprevitamin D.sub.3, isomerizing the so formed previtamin D.sub.3, and recovering 1.alpha.,25-dihydroxycholecalciferol.
摘要翻译： 1α，25-二羟基胆钙化醇通过使1,5,7-三烯-3β，25-二醇与下式表示的1,2,4-三唑啉二酮衍生物反应制备：其中R表示烷基或芳基或取代的芳基; 使得到的由通式“IMAGE”表示的所得1,4-环加成物与上述定义相同，与过氧化物反应，形成由通式“IMAGE”表示的1α，2α-环氧化合物，其中R为用金属氢化物还原形成的化合物以形成胆甾烯-5,7-二烯-1α，3β，25-三醇，用紫外线照射所形成的化合物以形成1α，25-二羟维生素D3，异构化所形成的维生素D3，并回收1α，25-二羟基胆钙化甾醇。

5. 发明授权

US4200640A Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use 失效
标题翻译： N-（2-羟乙基）烟酰胺的硝酸酯和药物用途
公开(公告)号：US4200640A
公开(公告)日：1980-04-29
申请号：US940194
申请日：1978-09-07
申请人： Hiroyuki Nagano , Takashi Mori , Sakae Takaku , Isao Matsunaga , Tatsuo Kujirai , Toshichika Ogasawara , Shigeru Sugano , Minoru Shindo
发明人： Hiroyuki Nagano , Takashi Mori , Sakae Takaku , Isao Matsunaga , Tatsuo Kujirai , Toshichika Ogasawara , Shigeru Sugano , Minoru Shindo
IPC分类号： C07D213/81 , A61K31/455 , C07D213/82
CPC分类号： C07D213/81
摘要： A compound of the formula ##STR1## is useful for treating circulatory diseases.
摘要翻译：式的化合物可用于治疗循环系统疾病。

6. 发明授权

US07211324B2 Method of forming film having a heat shielding function, laminate film formed by the method, and article coated with the laminate film 失效
标题翻译：形成具有隔热功能的膜的方法，通过该方法形成的层压膜和涂覆有层压膜的制品
公开(公告)号：US07211324B2
公开(公告)日：2007-05-01
申请号：US10379565
申请日：2003-03-06
申请人： Isao Kamimori , Yutaka Masuda , Takaaki Kato , Hiroyuki Nagano
发明人： Isao Kamimori , Yutaka Masuda , Takaaki Kato , Hiroyuki Nagano
IPC分类号： B32B27/20 , B32B19/02 , B32B33/00
CPC分类号： B05D7/572 , B05D7/16 , C09D5/00 , Y10T428/25 , Y10T428/256 , Y10T428/26 , Y10T428/263 , Y10T428/265 , Y10T428/269
摘要： A laminate film having heat shielding property and jet blackness with clearness can be obtained by the steps of: applying a heat shielding coating (I) containing a compound which does not absorb infrared radiation and having a heat shielding function to form the corresponding heat cured or uncured film; applying thereto a black base coating (A) containing a perylene black pigment, and/or an azomethine pigment, and/or an azo dye to form the corresponding film; applying a color clear coating (B) containing a black dye onto the heat cured or uncured film of the black base coating (A) to form the corresponding film; applying thereto a clear coating (C) to form the corresponding film; and heat curing a laminate film having the films of the heat shielding coating (I), the black base coating (A), the color clear coating (B) and the clear coating (C) stacked one after another.
摘要翻译：通过以下步骤可以获得具有隔热性和清亮度的喷射黑色的层压膜：施加含有不吸收红外辐射并具有隔热功能的化合物的隔热涂层（I），以形成相应的热固化或未胶片向其施涂含有苝黑颜料的黑底涂层（A）和/或偶氮甲碱颜料和/或偶氮染料以形成相应的膜; 将含有黑色染料的着色透明涂层（B）施加到黑底涂层（A）的热固化或未固化膜上以形成相应的膜; 向其施加透明涂层（C）以形成相应的膜; 并且将具有隔热层（I），黑色底涂层（A），透明涂层（B）和透明涂层（C））的膜的层叠膜热固化。

7. 发明授权

US06691619B2 Apparatus for automating switching operations of a web offset printing press 失效
标题翻译：用于使卷筒纸胶版印刷机的切换操作自动化的装置
公开(公告)号：US06691619B2
公开(公告)日：2004-02-17
申请号：US09852687
申请日：2001-05-11
申请人： Kazunori Saito , Hiroyuki Nagano
发明人： Kazunori Saito , Hiroyuki Nagano
IPC分类号： B41F146
CPC分类号： B41F33/16
摘要： A web offset printing press has a single switch for automatically changing a previous printing to next printing in order to actuate web continuous supplement means 100, printing plate changing means 207, 208, folding device status switching means, and an ink supplement means 800 along predetermined steps in accordance with a signal from said switch when switching from a previous job to a next job.
摘要翻译：卷筒纸胶版印刷机具有单个开关，用于自动地将先前的打印改变为下一次打印，以便沿预定的方向致动纸幅连续补充装置100，印版更换装置207,208，折叠装置状态切换装置和墨补充装置800 根据来自所述开关的信号从先前作业切换到下一作业时的步骤。

8. 外观设计

USD466160S1 Game machine 失效
公开(公告)号：USD466160S1
公开(公告)日：2002-11-26
申请号：US29154098
申请日：2002-01-18
申请人： Jun Hirato , Hiroyuki Nagano , Yu Suzuki , Kouichi Iimura
设计人： Jun Hirato , Hiroyuki Nagano , Yu Suzuki , Kouichi Iimura

9. 发明授权

US06383073B1 Gaming machine 有权
标题翻译：游戏机
公开(公告)号：US06383073B1
公开(公告)日：2002-05-07
申请号：US09411203
申请日：1999-10-04
申请人： Hiroyuki Nagano
发明人： Hiroyuki Nagano
IPC分类号： A63F924
CPC分类号： G07F17/3227 , G07F17/32
摘要： A gaming machine displays a plurality of rows of symbols in moving and stopped states at an image display section formed in a front panel. If big winning symbols to be displayed in a stopped state are not attained as the result of determination (S4), then random number sampling for deciding whether or not to execute an image action is carried out (S6). According to the result of this sampling, whether or not to execute the image action is determined (S7). If it is determined to execute the image action, then an operation for randomly blinking tricolor-emitting LEDs is carried out at step 8 (S8). The LED display when executing the image action may be at a low luminance, as long as a player can guess, by seeing the blinking of tricolor-emitting LEDs, that a certain phenomenon relating to big winning might be occurring. The blinking pattern of the tricolor-emitting LEDs is constituted by randomly repeating their color changes. Thus performed is an attraction from which the player continuing a game while waiting for a specific winning arrangement can guess a relation to the winning arrangement, thereby multiplying interest in the game and enhancing the amusement.
摘要翻译：游戏机在形成在前面板上的图像显示部分上以移动和停止状态显示多行符号。如果作为确定结果（S4）不能获得要停止状态显示的大胜利符号（S4），则执行用于决定是否执行图像动作的随机数抽样（S6）。根据该采样的结果，确定是否执行图像动作（S7）。如果确定执行图像动作，则在步骤8执行用于随机闪烁三色发光LED的操作（S8）。执行图像动作时的LED显示可以是低亮度，只要玩家可以通过观察三色发光LED的闪烁来猜测可能发生与大胜利有关的某种现象。三色发光LED的闪烁图案通过随机重复其颜色变化而构成。这样执行的是玩家在等待特定的获胜安排的同时持续游戏的吸引力，可以猜测与获胜装置的关系，从而增加游戏的兴趣并提高娱乐性。

10. 发明授权

US06299165B1 Dividedly paying game machine 有权
标题翻译：分钱付费游戏机
公开(公告)号：US06299165B1
公开(公告)日：2001-10-09
申请号：US09533730
申请日：2000-03-23
申请人： Hiroyuki Nagano
发明人： Hiroyuki Nagano
IPC分类号： G07F1734
CPC分类号： G07F17/3248 , G07F17/32 , G07F17/34
摘要： In a game machine, when a result of hit determination is a hit of double odds, a motor drive circuit 36 is controlled, any one of stepping motor 37 through 39 of reels 3 through 5 including a symbol “wild” is driven to rotate and any one of the reels 3 through 5 including the symbol “wild” is rotated by one rotation (step 109). Next, a hopper 49 is driven by a hopper drive circuit 48 and coins having a number of sheets of a normal hit in accordance with an allotment display table are paid to a coin tray 20 (step 110). Next, any one of the reels 3 through 5 including the symbol “wild” is again rotated by one rotation (step 111). Thereafter, coins of the normal hit in accordance with the allotment display table are again paid (step 112).
摘要翻译：在游戏机中，当命中确定的结果是双重赔率的结果时，控制马达驱动电路36，驱动包括符号“野”的卷轴3至5的步进马达37至39中的任何一个旋转，包括符号“野”的卷轴3至5中的任何一个旋转一圈（步骤109）。接下来，料斗49由料斗驱动电路48驱动，并且具有根据分配显示台的正常打击数量的纸币被支付到硬币托盘20（步骤110）。接下来，包括符号“野”的卷轴3至5中的任何一个再次旋转一圈（步骤111）。此后，再次支付根据分配显示表的正常命中的硬币（步骤112）。

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