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1. 发明申请

US20100247458A1 Emulsified External Skin Preparations 审中-公开
标题翻译：乳化外用皮肤制剂
公开(公告)号：US20100247458A1
公开(公告)日：2010-09-30
申请号：US11996752
申请日：2006-07-26
申请人： Hiroyuki Kakoki , Takashi Ohmori , Akio Nasu , Akira Ishikubo
发明人： Hiroyuki Kakoki , Takashi Ohmori , Akio Nasu , Akira Ishikubo
IPC分类号： A61K8/34 , A61Q17/04
CPC分类号： C07C43/135 , A61K8/062 , A61K8/39 , A61Q1/02 , A61Q17/04 , A61Q19/00 , A61Q19/02
摘要： The emulsified external skin preparation of the present invention is characterized by comprising a polyglycerol derivative represented by formula (1): wherein, m+2 represents the average polymerization degree of polyglycerol and 1≦m≦4; R1 is a hydrocarbon group having 1 to 4 carbon atoms or a hydrogen atom; AO is an oxyalkylene group having 3 to 4 carbon atoms; and n is the average addition mole number of the oxyalkylene group and 1≦m n≦200. In a water-in-oil type external skin preparation, and especially in that containing a polar oil or a silicone oil, emulsion stability is improved. In an oil-in-water type external skin preparation, feeling in use and emulsion stability are improved. Especially, in an oil-in-water type external skin preparation containing hydrophobized powder, powder dispersion stability is improved as well as feeling in use and emulsion stability.
摘要翻译：本发明的乳化外用皮肤制剂的特征在于，含有式（1）表示的聚甘油衍生物：其中，m +2表示聚甘油的平均聚合度，1＆nlE; m＆lt; 1l; 4; R1为碳原子数为1〜4的烃基或氢原子; AO是具有3〜4个碳原子的氧化烯基; 并且n是氧化烯基的平均加成摩尔数和1＆nlE; m n＆nlE; 200。在油包水型外用皮肤制剂中，特别是含有极性油或硅油的乳化稳定性提高。在水包油型外用皮肤制剂中，使用感和乳液稳定性得到改善。特别地，在含有疏水化粉末的水包油型外用皮肤制剂中，粉末分散稳定性以及使用感和乳液稳定性均得到改善。

2. 发明授权

US07625574B2 Skin treatment composition 有权
标题翻译：皮肤护理组成
公开(公告)号：US07625574B2
公开(公告)日：2009-12-01
申请号：US10134441
申请日：2002-04-30
申请人： Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
发明人： Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
IPC分类号： A61K8/02 , A61K8/72 , A61K9/14 , A61Q7/00
CPC分类号： A61K8/39 , A61K8/34 , A61K8/347 , A61K8/676 , A61K8/90 , A61K9/0014 , A61K47/08 , A61K47/10 , A61Q5/00 , A61Q15/00 , A61Q19/00 , Y10S514/946 , Y10S514/947
摘要： A skin treatment composition of the present invention is an external composition for skin comprising an alkylene oxide derivative expressed by Formula (I): R1O—[(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group of C3 or C4; EO is an oxyethylene group; m and n are 1≦m≦70 and 1≦n≦70 respectively, wherein EO is 20˜80% by weight with respect to a total of AO and EO; each of R1 and R2 is a hydrogen or a hydrocarbon group having C1-4. The alkylene oxide derivative (I) has a moisturizing effect, a rough skin improving effect, a stickiness improving effect, and a transdermal absorption promoting effect. When a refreshing agent is used together therewith in the composition of the present invention, the refreshing effect lasts for a long time and it is excellent in feeling of use without skin stimulation.
摘要翻译：本发明的皮肤治疗组合物是皮肤外用组合物，其含有式（I）表示的烯化氧衍生物：R1O - [（AO）m（EO）n] -R2（Ⅰ）其中，AO为氧化烯基 C3或C4; EO是氧乙烯基; m和n分别为1≤m≤70和1≤n≤70，其中EO相对于AO和EO的总和为20〜80重量％ R 1和R 2各自为氢或具有C 1-4的烃基。氧化烯衍生物（I）具有保湿效果，粗糙的皮肤改善效果，粘着性改善效果和透皮吸收促进效果。当与本发明的组合物一起使用清新剂时，清爽效果持续很长时间，并且在没有皮肤刺激的情况下使用感觉优异。

3. 发明申请

US20080153929A1 One-Phase Microemulsion Compositions, O/W Ultrafine Emulsion External Formulations And Method For Producing The Same 有权
标题翻译：单相微乳液组合物，O / W超细乳液外用制剂及其制备方法
公开(公告)号：US20080153929A1
公开(公告)日：2008-06-26
申请号：US10585262
申请日：2005-01-06
申请人： Reiji Miyahara , Hiroyuki Kakoki , Nozomi Oguchi , Takashi Ohmori , Toshihiko Nakane
发明人： Reiji Miyahara , Hiroyuki Kakoki , Nozomi Oguchi , Takashi Ohmori , Toshihiko Nakane
IPC分类号： B01F3/08
CPC分类号： A61K8/86 , A61K8/068 , A61K8/894 , A61Q1/14 , A61Q19/00
摘要： A one-phase microemulsion composition, which can be easily prepared without the use of special equipment, has high safety, and stays stable for a long period in an ultrafine emulsion state when the composition is added to an aqueous formulation, is provided by appropriately adjusting the ratio of (A) a hydrophilic nonionic surfactant, (B) a lipophilic nonionic surfactant, (C) an oil component, (D) a water-miscible solvent that does not interdissolve with the oil component, and the critical micelle concentration (CMC) of the hydrophilic nonionic surfactant in the water-miscible solvent is higher than that of the hydrophilic nonionic surfactant in water, and (E) water.
摘要翻译：可以在不使用特殊设备的情况下容易地制备的单相微乳液组合物具有高安全性，并且当将组合物加入到水性制剂中时，在超细乳液状态下长时间保持稳定，通过适当调节（A）亲水性非离子表面活性剂，（B）亲油性非离子表面活性剂，（C）油组分，（D）与油组分不溶解的水混溶性溶剂和临界胶束浓度（CMC ）在水溶性溶剂中的亲水性非离子表面活性剂高于水中的亲水性非离子表面活性剂，（E）水。

4. 发明申请

US20050079188A1 Base for external preparations for the skin and cosmetic containing the same 审中-公开
标题翻译：用于皮肤和化妆品的外用制剂的基础含有相同的
公开(公告)号：US20050079188A1
公开(公告)日：2005-04-14
申请号：US10490960
申请日：2002-09-27
申请人： Takashi Ohmori , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Kei-chi Maruyama , Takeshi Sakoda , Tohru Yasukohchi , Yoji Tezuka
发明人： Takashi Ohmori , Hiroyuki Kakoki , Reiji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Kei-chi Maruyama , Takeshi Sakoda , Tohru Yasukohchi , Yoji Tezuka
IPC分类号： A61K8/72 , A61K8/39 , A61K8/86 , A61K8/90 , A61Q19/00 , A61K7/075 , A61K7/08
CPC分类号： A61Q19/00 , A61K8/39 , A61K8/86 , A61K8/90
摘要： A base for a skin external composition comprises, as a main ingredient, an alkylene oxide derivative represented by the following formula (I): R1O—[(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group having a carbon number of 3 to 4; EO is an oxyethylene group; and R1 and R2 may be the same or different, and are a hydrocarbon group having a carbon number of 1 to 4, or a hydrogen atom. The base is a water-soluble base that can exert both of the smooth feeling and the moist feeling.
摘要翻译：皮肤外用组合物的基质包含作为主要成分的由下式（I）表示的环氧烷衍生物：R 1 O - [（AO）m（EO）n] -R 2（I ）其中AO是碳数为3〜4的氧化烯基; EO是氧化乙烯基; R 1和R 2可以相同或不同，为碳数为1〜4的烃基或氢原子。该基质是可以发挥光滑感和潮湿感的水溶性基质。

5. 发明授权

US06607736B2 Skin preparations for external use 有权
标题翻译：外用皮肤准备
公开(公告)号：US06607736B2
公开(公告)日：2003-08-19
申请号：US09890285
申请日：2001-08-13
申请人： Takashi Ohmori , Reiji Miyahara , Hiroyuki Kakoki , Tomiyuki Namba
发明人： Takashi Ohmori , Reiji Miyahara , Hiroyuki Kakoki , Tomiyuki Namba
IPC分类号： A61K600
CPC分类号： A61K8/39 , A61Q1/02 , A61Q19/00 , A61Q19/02 , Y10S514/844
摘要： An endermic liniment comprising a polyoxyethylene dicarboxylate represented by the following chemical formula (1). (In this formula, R1 and R2 are hydrogen or alkyl or branched alkyl groups having 1-4 carbon atoms, and m, n, X, and Y are integers 0-5 which are not all zero at the same time. R3 is a branched or linear chain alkylene group having 0-10 carbon atoms.) The endermic liniment of the present invention achieves superior tactile sensation during use, smoothness in particular, without a sticky sensation, while maintaining a lasting moisture retaining effect by means of blending in a humectant and a polyoxyethylene dicarboxylate.
摘要翻译：含有下述化学式（1）表示的聚氧乙烯二羧酸酯的皮肤外用剂（在该式中，R 1和R 2为氢或具有1-4个碳原子的烷基或支链烷基，m，n，X和Y为整数0-5并不全部为零，R3为具有0-10个碳原子的支链或直链的链亚烷基）本发明的皮肤外用剂在使用过程中具有优异的触感，特别是平滑度，无特别的同时通过在保湿剂和聚氧乙烯二羧酸酯中共混而保持持久的保湿效果。

6. 发明授权

US08461214B2 One-phase microemulsion compositions, O/W ultrafine emulsion external formulations and method for producing the same 有权
标题翻译：单相微乳液组合物，O / W超细乳液外用制剂及其制备方法
公开(公告)号：US08461214B2
公开(公告)日：2013-06-11
申请号：US10585262
申请日：2005-01-06
申请人： Reiji Miyahara , Hiroyuki Kakoki , Nozomi Oguchi , Takashi Ohmori , Toshihiko Nakane
发明人： Reiji Miyahara , Hiroyuki Kakoki , Nozomi Oguchi , Takashi Ohmori , Toshihiko Nakane
IPC分类号： B01J13/00 , C08L83/04 , A61K8/06 , B01F3/08 , B01F17/42
CPC分类号： A61K8/86 , A61K8/068 , A61K8/894 , A61Q1/14 , A61Q19/00
摘要： A one-phase microemulsion composition, which can be easily prepared without the use of special equipment, has high safety, and stays stable for a long period in an ultrafine emulsion state when the composition is added to an aqueous formulation, is provided by appropriately adjusting the ratio of (A) a hydrophilic nonionic surfactant, (B) a lipophilic nonionic surfactant, (C) an oil component, (D) a water-miscible solvent that does not interdissolve with the oil component, and the critical micelle concentration (CMC) of the hydrophilic nonionic surfactant in the water-miscible solvent is higher than that of the hydrophilic nonionic surfactant in water, and (E) water.
摘要翻译：可以在不使用特殊设备的情况下容易地制备的单相微乳液组合物具有高安全性，并且当将组合物加入到水性制剂中时，在超细乳液状态下长时间保持稳定，通过适当调节（A）亲水性非离子表面活性剂，（B）亲油性非离子表面活性剂，（C）油组分，（D）与油组分不溶解的水混溶性溶剂和临界胶束浓度（CMC ）在水溶性溶剂中的亲水性非离子表面活性剂高于水中的亲水性非离子表面活性剂，（E）水。

7. 发明授权

US08404258B2 External preparation for the skin 有权
标题翻译：外用皮肤准备
公开(公告)号：US08404258B2
公开(公告)日：2013-03-26
申请号：US12074394
申请日：2008-03-04
申请人： Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takashi Ohmori
发明人： Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takashi Ohmori
IPC分类号： A61K8/02 , A01N37/02
CPC分类号： A61Q19/00 , A61K8/39 , A61Q1/02 , A61Q1/06 , A61Q1/12 , A61Q1/14 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/10
摘要： A skin treatment composition that characteristically contains alkylene polyglycol dineopentanoate having a specific structure.The object is to provide a skin treatment composition that gives a refreshing sensation at the time of application and contains an oil component that is highly safe with low skin irritation.The skin treatment composition specifically contains diethyleneglycol dineopentanoate, triethyleneglycol dineopentanoate, tetraethyleneglycol dineopentanoate, dipropyleneglycol dineopentanoate, tripropyleneglycol dineopentanoate, etc.Dipropyleneglycol dineopentanoate and tripropyleneglycol dineopentanoate are particularly preferable in terms of the sensation at the time of application; they provide a skin treatment composition that is particularly superior in absorption into the skin and a sensation of permeation and highly safe.
摘要翻译：特征在于含有具有特定结构的亚烷基二醇二新戊酸酯的皮肤处理组合物。本发明的目的是提供一种皮肤处理组合物，其在使用时具有清爽感，并且含有高度安全且低皮肤刺激性的油性成分。皮肤治疗组合物具体包含二甘醇二全新戊酸酯，三甘醇二全新戊酸酯，四甘醇二全新戊酸酯，二丙二醇二全新戊酸酯，三丙二醇二全新戊酸酯等。二丙二醇二全新戊酸酯和三丙二醇二全新戊酸酯在使用时的感觉方面是特别优选的; 它们提供了对皮肤吸收特别优异的渗透感和高度安全性的皮肤处理组合物。

8. 发明授权

US08153142B2 Skin treatment composition 有权
标题翻译：皮肤护理组成
公开(公告)号：US08153142B2
公开(公告)日：2012-04-10
申请号：US12461426
申请日：2009-08-11
申请人： Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
发明人： Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
IPC分类号： A61K9/00 , A61K8/02 , A01N5/00 , A61Q7/00
CPC分类号： A61K8/39 , A61K8/34 , A61K8/347 , A61K8/676 , A61K8/90 , A61K9/0014 , A61K47/08 , A61K47/10 , A61Q5/00 , A61Q15/00 , A61Q19/00 , Y10S514/946 , Y10S514/947
摘要： A skin treatment composition of the present invention is an external composition for skin comprising an alkylene oxide derivative expressed by Formula (I): R1O-[(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group of C3 or C4; EO is an oxyethylene group; m and n are 1≦m≦70 and 1≦n≦70 respectively, wherein EO is 20˜80% by weight with respect to a total of AO and EO; each of R1 and R2 is a hydrogen or a hydrocarbon group having C1-4. The alkylene oxide derivative (I) has a moisturizing effect, a rough skin improving effect, a stickiness improving effect, and a transdermal absorption promoting effect. When a refreshing agent is used together therewith in the composition of the present invention, the refreshing effect lasts for a long time and it is excellent in feeling of use without skin stimulation.
摘要翻译：本发明的皮肤治疗组合物是皮肤外用组合物，其含有式（I）表示的烯化氧衍生物：R1O - [（AO）m（EO）n] -R2（Ⅰ）其中，AO为氧化烯基 C3或C4; EO是氧化乙烯基; m和n分别为1和nlE; m和nlE; 70和1＆nlE; n＆nlE; 70，其中EO相对于AO和EO的总和为20〜80重量％ R 1和R 2各自为氢或具有C 1-4的烃基。氧化烯衍生物（I）具有保湿效果，粗糙的皮肤改善效果，粘着性改善效果和透皮吸收促进效果。当与本发明的组合物一起使用清新剂时，清爽效果持续很长时间，并且在没有皮肤刺激的情况下使用感觉优异。

9. 发明申请

US20100209370A1 Skin treatment composition 有权
标题翻译：皮肤护理组成
公开(公告)号：US20100209370A1
公开(公告)日：2010-08-19
申请号：US12461426
申请日：2009-08-11
申请人： Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
发明人： Takashi Ohmori , Tohru Okamoto , Hiroyuki Kakoki , Reji Miyahara , Tomiyuki Nanba , Toshihiko Nakane , Yohei Hamano , Eriko Takeoka
IPC分类号： A61K8/84 , A61K8/90 , A61Q19/00 , A61Q15/00 , A61Q1/06 , A61Q5/00 , A61Q19/02
CPC分类号： A61K8/39 , A61K8/34 , A61K8/347 , A61K8/676 , A61K8/90 , A61K9/0014 , A61K47/08 , A61K47/10 , A61Q5/00 , A61Q15/00 , A61Q19/00 , Y10S514/946 , Y10S514/947
摘要： A skin treatment composition of the present invention is an external composition for skin comprising an alkylene oxide derivative expressed by Formula (I): R1O-[(AO)m(EO)n]—R2 (I) wherein AO is an oxyalkylene group of C3 or C4; EO is an oxyethylene group; m and n are 1≦m≦70 and 1≦n≦70 respectively, wherein EO is 20-80% by weight with respect to a total of AO and EU; each of R1 and R2 is a hydrogen or a hydrocarbon group having C1-4. The alkylene oxide derivative (I) has a moisturizing effect, a rough skin improving effect, a stickiness improving effect, and a transdermal absorption promoting effect. When a refreshing agent is used together therewith in the composition of the present invention, the refreshing effect lasts for a long time and it is excellent in feeling of use without skin stimulation.
摘要翻译：本发明的皮肤治疗组合物是皮肤外用组合物，其含有式（I）表示的烯化氧衍生物：R1O - [（AO）m（EO）n] -R2（Ⅰ）其中，AO为氧化烯基 C3或C4; EO是氧乙烯基; m和n分别为1和nlE; m＆nlE; 70和1＆nlE; n＆nlE; 70，其中EO相对于AO和EU的总量为20-80重量％ R 1和R 2各自为氢或具有C 1-4的烃基。氧化烯衍生物（I）具有保湿效果，粗糙的皮肤改善效果，粘着性改善效果和透皮吸收促进效果。当与本发明的组合物一起使用清新剂时，清爽效果持续很长时间，并且在没有皮肤刺激的情况下使用感觉优异。

10. 发明申请

US20080293811A1 External preparation for the the skin 有权
标题翻译：外用皮肤准备
公开(公告)号：US20080293811A1
公开(公告)日：2008-11-27
申请号：US12074394
申请日：2008-03-04
申请人： Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takashi Ohmori
发明人： Nozomi Oguchi , Reiji Miyahara , Hiroyuki Kakoki , Takashi Ohmori
IPC分类号： A61K31/225 , A61P17/00
CPC分类号： A61Q19/00 , A61K8/39 , A61Q1/02 , A61Q1/06 , A61Q1/12 , A61Q1/14 , A61Q5/00 , A61Q5/02 , A61Q17/04 , A61Q19/10
摘要： A skin treatment composition that characteristically contains alkylene polyglycol dineopentanoate having a specific structure.The object is to provide a skin treatment composition that gives a refreshing sensation at the time of application and contains an oil component that is highly safe with low skin irritation.The skin treatment composition specifically contains diethyleneglycol dineopentanoate, triethyleneglycol dineopentanoate, tetraethyleneglycol dineopentanoate, dipropyleneglycol dineopentanoate, tripropyleneglycol dineopentanoate, etc.Dipropyleneglycol dineopentanoate and tripropyleneglycol dineopentanoate are particularly preferable in terms of the sensation at the time of application; they provide a skin treatment composition that is particularly superior in absorption into the skin and a sensation of permeation and highly safe.
摘要翻译：特征在于含有具有特定结构的亚烷基二醇二新戊酸酯的皮肤处理组合物。本发明的目的是提供一种皮肤处理组合物，其在使用时具有清爽感，并且含有高度安全且低皮肤刺激性的油性成分。皮肤治疗组合物具体包含二甘醇二全新戊酸酯，三甘醇二全新戊酸酯，四甘醇二全新戊酸酯，二丙二醇二全新戊酸酯，三丙二醇二全新戊酸酯等。二丙二醇二全新戊酸酯和三丙二醇二全新戊酸酯在使用时的感觉方面是特别优选的; 它们提供了对皮肤吸收特别优异的渗透感和高度安全性的皮肤处理组合物。

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