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    • 10. 发明授权
    • Antibodies to human leukemia virus-related peptides and a process for
production of the antibodies
    • 人类白血病病毒相关肽的抗体和抗体的制备方法
    • US4804746A
    • 1989-02-14
    • US713659
    • 1985-03-19
    • Mitsuaki YoshidaHaruo SuganoFumio ShimizuKenichi Imagawa
    • Mitsuaki YoshidaHaruo SuganoFumio ShimizuKenichi Imagawa
    • C07K14/15C07K16/10C07K15/14A61K39/395
    • C07K14/005C07K16/1036C12N2740/14022Y10S530/806Y10S930/221
    • An antibody of a human leukemia virus-related peptide obtained by collecting an antibody produced in a mammal body by administering to the mammal an antigen prepared by reacting a human leukemia virus-related peptide selected from the group consisting of:(a) a peptide represented by formula (1):H-Tyr-Val-Glu-Pro-Thr-Ala-Pro-Gln-Val-Leu-H (1)(b) a peptide represented by formula (2): psR-Ile-Pro-His-Pro-Lys-Asn-Ser-Ile-Gly-Gly-Glu-Val-OH (2)wherein R is the same as defined above;(c) a peptide represented by formula (3):R-Thr-Trp-Thr-Pro-Lys-Asp-Lys-Thr-Lys-Val-Leu-OH (3)wherein R is the same as defined above;(d) a peptide represented by formula (4):H-Val-Val-Gln-Pro-Lys-Lys-Pro-Pro-Pro-Tyr-OH (4)(e) a peptide represented by formula (5):R-Met-Gly-Gln-Ile-Phe-Ser-Arg-Ser-Ala-Ser-Pro-OH (5)wherein R is the same as defined above; and(f) a peptide represented by formula (6):H-Tyr-Pro-Glu-Gly-Thr-Pro-Lys-Asp-Pro-Ile-Leu-Arg-Ser-Leu-OH (6)as a hapten, with a carrier in the presence of a haptencarrier binding agent.
    • 通过对哺乳动物体内产生的抗体进行收集而获得的人类白血病病毒相关肽的抗体,其通过向哺乳动物施用通过使人白血病病毒相关肽反应而制备的抗原,所述人白血病病毒相关肽选自:(a) 式(1)表示的肽:H-Tyr-Val-Glu-Pro-Thr-Ala-Pro-Gln-Val-Leu-H(1)(b)由式(2)表示的肽:ps R-Ile-Pro -His-Pro-Lys-Asn-Ser-Ile-Gly-Gly-Glu-Val-OH(2)其中R与上述定义相同; (c)由式(3)表示的肽:R-Thr-Trp-Thr-Pro-Lys-Asp-Lys-Thr-Lys-Val-Leu-OH(3)其中R与上述定义相同; (d)由式(4)表示的肽:H-Val-Val-Gln-Pro-Lys-Lys-Pro-Pro-Pro-Tyr-OH(4)(e)由式(5)表示的肽: R-Met-Gly-Gln-Ile-Phe-Ser-Arg-Ser-Ala-Ser-Pro-OH(5)其中R与上述定义相同; 和(f)由式(6)表示的肽:作为半抗原的H-Tyr-Pro-Glu-Gly-Thr-Pro-Lys-Asp-Pro-Ile-Leu-Arg-Ser-Leu-OH 在载体中存在半载体结合剂。