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1. 发明授权

US4245099A 2-Acyl-6-aminomethylphenol derivatives 失效
标题翻译： 2-酰基-6-氨基甲基苯酚衍生物
公开(公告)号：US4245099A
公开(公告)日：1981-01-13
申请号：US60113
申请日：1979-07-24
申请人： Hiroyuki Itoh , Mitoshi Konno , Takao Tokuhiro , Sadahiko Iguchi , Masaki Hayashi
发明人： Hiroyuki Itoh , Mitoshi Konno , Takao Tokuhiro , Sadahiko Iguchi , Masaki Hayashi
IPC分类号： A61K31/135 , A61K31/16 , A61K31/165 , A61P29/00 , C07C43/205 , C07C45/00 , C07C45/46 , C07C45/54 , C07C45/67 , C07C49/825 , C07C49/84 , C07C67/00 , C07C213/00 , C07C225/16 , C07C225/18 , C07C233/31 , C07C313/00 , C07C317/00 , C07C323/29 , C07C323/32 , C07C323/41 , C07D213/50
CPC分类号： C07D213/50 , C07C323/00 , C07C43/205 , C07C45/004 , C07C45/46 , C07C45/54 , C07C45/673 , C07C49/825 , C07C49/84 , Y10S514/87
摘要： A 2-acyl-6-aminomethylphenol derivative having the formula (I): ##STR1## wherein R.sup.1 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms unsubstituted or substituted with 1 to 3 halogen atoms; a hydrogen atom or a group having the formula (II):--C.sub.n H.sub.2n --R.sup.7 (II)wherein n represents 0 or an integer of 1 to 6; R.sup.7 represents a cycloalkyl group of 3 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a halogen atom, a lower alkoxy group or a lower alkylthio group; a lower alkoxy group; a lower alkylthio group; a lower alkylsulfinyl group; a lower alkylsulfonyl group; an N-lower alkylamino group; an N,N-di-lower alkylamino group; or a pyridyl, furyl or thienyl group; R.sup.2 represents a straight chain or branched chain alkyl group of 1 to 6 carbon atoms; a cycloalkyl group of 4 to 8 carbon atoms unsubstituted or substituted with at least one lower alkyl group; a phenyl group unsubstituted or substituted with at least one lower alkyl group, a lower alkoxy group, a lower alkylthio group or a halogen atom; or a lower alkylthio group; R.sup.3 and R.sup.4 each represents a hydrogen atom or R.sup.2 and R.sup.3 or R.sup.2 and R.sup.4 when taken together represent an alkylene group of 2 to 5 carbon atoms unsubstituted or substituted with 1 or 2 lower alkyl groups; R.sup.5 represents a hydrogen atom or a lower alkyl group; and R.sup.6 represents a hydrogen atom, a lower alkyl group or an acyl group, and the pharmaceutically acceptable acid addition salt thereof having anti-inflammatory, analgesic, antipyretic, diuretic and hypotensive effects that can be used for preventing and curing diseases caused by inflammation, edema, hypertension, etc. are disclosed. Also disclosed is a process for preparing such derivative or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：具有式（I）的2-酰基-6-氨基甲基苯酚衍生物：其中R 1表示未被取代或被1至3个卤素原子取代的1至6个碳原子的直链或支链烷基; 氢原子或具有式（II）的基团：-C n H 2n-R 7（II）其中n表示0或1至6的整数; R7表示未被取代或被至少一个低级烷基取代的3-8个碳原子的环烷基; 未取代或被至少一个低级烷基，卤素原子，低级烷氧基或低级烷硫基取代的苯基; 低级烷氧基; 低级烷硫基; 低级烷基亚磺酰基; 低级烷基磺酰基; N-低级烷基氨基; N，N-二低级烷基氨基; 或吡啶基，呋喃基或噻吩基; R2表示1〜6个碳原子的直链或支链烷基; 未取代或被至少一个低级烷基取代的4-8个碳原子的环烷基; 未取代或被至少一个低级烷基，低级烷氧基，低级烷硫基或卤素原子取代的苯基; 或低级烷硫基; R 3和R 4各自表示氢原子或R 2，R 3或R 2和R 4一起表示未取代或被1或2个低级烷基取代的2至5个碳原子的亚烷基; R5表示氢原子或低级烷基; R6表示氢原子，低级烷基或酰基，及其药学上可接受的酸加成盐，其具有抗炎，镇痛，解热，利尿和降血压作用，可用于预防和治疗由炎症引起的疾病，水肿，高血压等。还公开了制备此类衍生物或其药学上可接受的酸加成盐的方法。

2. 发明授权

US4254056A 2-Aminomethyl phenol derivative and process for preparing thereof 失效
标题翻译： 2-氨基甲基苯酚衍生物及其制备方法
公开(公告)号：US4254056A
公开(公告)日：1981-03-03
申请号：US974179
申请日：1978-12-28
申请人： Mitoshi Konno , Hiroyuki Itoh , Takao Tokuhiro , Katsumi Ohta , Masaki Hayashi
发明人： Mitoshi Konno , Hiroyuki Itoh , Takao Tokuhiro , Katsumi Ohta , Masaki Hayashi
IPC分类号： A61K31/57 , A61K31/135 , A61P29/00 , C07C37/62 , C07C67/00 , C07C213/00 , C07C215/64 , C07C87/20 , A61K27/00 , C07C91/30
CPC分类号： C07C37/62 , C07C2102/08 , C07C2102/10
摘要： A 2-aminomethyl phenol derivative of the formula (I): ##STR1## wherein X is a halogen atom; R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which may be the same or different are each a hydrogen atom or a straight or branched chain alkyl group having 1 to 4 carbon atoms; n is 2, 3, 4 or 5 and a pharmaceutically acceptable acid addition salt thereof are disclosed. Also disclosed is a process for preparing such derivative or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：式（I）的2-氨基甲基苯酚衍生物：其中X是卤素原子; 可以相同或不同的R 1，R 2，R 3和R 4各自为氢原子或具有1至4个碳原子的直链或支链烷基; n为2,3,4或5及其药学上可接受的酸加成盐。还公开了制备此类衍生物或其药学上可接受的酸加成盐的方法。

3. 发明授权

US4180675A 15-Cycloalkyl-prostaglandin derivatives 失效
标题翻译： 15-环烷基 - 前列腺素衍生物
公开(公告)号：US4180675A
公开(公告)日：1979-12-25
申请号：US857341
申请日：1977-12-05
申请人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
发明人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
IPC分类号： C07C405/00 , C07D309/12 , C07F9/40 , C08B37/00 , C07C177/00
CPC分类号： C08B37/0015 , C07C405/00 , C07D309/12 , C07F9/4006
摘要： The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## wherein A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5 and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
摘要翻译：本发明涉及下式的15-环烷基 - 前列腺素：其中A表示下式的基团：W表示亚乙基或反式亚乙烯基，X表示亚乙基或顺式亚乙烯基，Y表示亚乙基或反式亚乙烯基 - 亚乙烯基，R表示氢原子或含有1至12个碳原子的直链或支链烷基，R1表示氢原子或甲基或乙基，R2表示直链或支链烷基， 2至8个碳原子的苯基或未被取代或被含有1至3个碳原子的烷基取代的苯基，R 3表示氢原子或含有1至3个碳原子的直链或支链烷基，n 代表这些酸和酯的4或5和环糊精包合物，当R代表氢原子时，其无毒性盐。这些新化合物表现出特征性的前列腺素样活性。

4. 发明授权

US4087620A 15-Cycloalkyl-prostaglandin derivatives 失效
标题翻译： 15-环烷基 - 前列腺素衍生物
公开(公告)号：US4087620A
公开(公告)日：1978-05-02
申请号：US703158
申请日：1976-07-07
申请人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
发明人： Masaki Hayashi , Seiji Kori , Isao Ohyama , Sadahiko Iguchi , Takanori Okada
IPC分类号： A61K31/557 , A61K31/19 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D309/12 , C07F9/40 , C08B37/00 , C07C177/00
CPC分类号： C07F9/4018 , C07C405/00 , C07D309/12 , C08B37/0015
摘要： The present invention relates to 15-cycloalkyl-prostaglandins of the formula: ##STR1## WHEREIN A represents a grouping of the formula: ##STR2## W represents ethylene or trans-vinylene, X represents ethylene or cis-vinylene, Y represents ethylene or trans-vinylene, R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 12 carbon atoms, R.sup.1 represents a hydrogen atom or a methyl or ethyl group, R.sup.2 represents a straight- or branched-chain alkyl group containing from 2 to 8 carbon atoms or a phenyl group unsubstituted or substituted by an alkyl group containing from 1 to 3 carbon atoms, R.sup.3 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 3 carbon atoms, and n represents 4 or 5) and cyclodextrin clathrates of such acids and esters and, when R represents a hydrogen atom, non-toxic salts thereof.These new compounds exhibit characteristic prostaglandin-like activities.
摘要翻译：本发明涉及下式的15-环烷基 - 前列腺素：其中A表示下式的基团：W表示亚乙基或反 - 亚乙烯基，X表示亚乙基或顺式 - 亚乙烯基，Y表示亚乙基或反式 - 亚乙烯基，R表示氢原子或含有1至12个碳原子的直链或支链烷基，R1表示氢原子或甲基或乙基，R2表示直链或支链烷基， 2至8个碳原子的苯基或未被取代或被含有1至3个碳原子的烷基取代的苯基，R 3表示氢原子或含有1至3个碳原子的直链或支链烷基，n 代表4或5）和这些酸和酯的环糊精包合物，当R代表氢原子时，其无毒性盐。

5. 发明授权

US4367237A Prostacyclin analogues 失效
公开(公告)号：US4367237A
公开(公告)日：1983-01-04
申请号：US097675
申请日：1979-11-27
申请人： Hirohisa Wakatsuka , Katsuichi Shimoji , Sadahiko Iguchi , Yoshitaka Konishi , Hisashi Suga , Yasuyuki Miyata , Yoichi Iguchi , Hajimu Miyake , Masaki Hayashi
发明人： Hirohisa Wakatsuka , Katsuichi Shimoji , Sadahiko Iguchi , Yoshitaka Konishi , Hisashi Suga , Yasuyuki Miyata , Yoichi Iguchi , Hajimu Miyake , Masaki Hayashi
IPC分类号： C07C405/00 , C07D333/78 , C07D335/04 , A61K31/38
CPC分类号： C07C405/0033 , C07C405/00 , C07D333/78 , C07D335/04
摘要： Prostaglandin analogues of the general formula: ##STR1## [wherein the ring A represents: ##STR2## the ring B represents: ##STR3## (wherein R.sup.6 represents hydrogen, methyl or ethyl, and r is zero, one or two), Y represents ethylene, cis- or trans-vinylene or ethynylene, Z represents a grouping of the formula: --(CH.sub.2).sub.m --, --(CH.sub.2).sub.3 --CHR.sup.7 --, --(CH.sub.2).sub.2 --CHR.sup.7 --CH.sub.2 --, --CH.sub.2 --CHR.sup.7 --(CH.sub.2).sub.2 --, --CHR.sup.7 --(CH.sub.2).sub.3 --, or trans--(CH.sub.2).sub.2 --CH.dbd.CH-- (wherein m is 3, 4 or 5, and R.sup.7 represents methyl or ethyl), R.sup.1 represents a grouping of the formula: --COOR.sup.8, ##STR4## or --CH.sub.2 OR.sup.11 (wherein R.sup.8 represents hydrogen, alkyl, aralkyl, cycloalkyl which is unsubstituted or substituted by at least one alkyl group, or R.sup.8 represents phenyl which is unsubstituted or substituted by halogen, trifluoromethyl, alkyl, alkoxy, alkylthio or phenyl, or represents naphthyl, 2,3- or 1,3-dihydroxypropyl, 2,3- or 1,3-bisalkanoyloxypropyl, a grouping of the formula: -D.sub.1 --COOR.sup.12, ##STR5## -D.sub.2 -R.sup.15 or -D.sub.3 -R.sup.16, wherein D.sub.1 represents alkylene, D.sub.2 represents alkylene, D.sub.3 represents a single bond or alkylene, R.sup.12, R.sup.13 and R.sup.14, each represent alkyl, R.sup.15 represents hydroxy, alkoxy or alkylthio and R.sup.16 represents a heterocyclic ring, or R.sup.8 represents a grouping of the formula: ##STR6## R.sup.9 and R.sup.10, each represent hydrogen, alkyl, alkylsulphonyl, alkanoyl or ##STR7## represents a heterocyclic ring, and R.sup.11 represents hydrogen or alkanoyl, R.sup.2 represents hydrogen, methyl or ethyl, R.sup.3 represents a single bond or alkylene, R.sup.4 represents hydrogen, alkyl, alkoxy, cycloalkyl or cycloalkyloxy unsubstituted or substituted by alkyl, or represents phenyl or phenoxy unsubstituted or substituted by halogen, trifluoromethyl or alkyl with the proviso that, when R.sup.3 represents a single bond, R.sup.4 does not represent alkoxy, cycloalkyloxy or phenoxy, R.sup.5 represents hydrogen, methyl or ethyl and with the proviso that, when one of the groups R.sup.5, R.sup.6 and R.sup.7 represents methyl or ethyl the other two groups are hydrogen atoms] and cyclodextrin clathrates, non-toxic salts and non-toxic acid addition salts thereof, possess selective strong stimulatory activity on uterine contraction in female mammals.

6. 发明授权

US4294849A Prostaglandin analogues 失效
标题翻译：前列腺素类似物
公开(公告)号：US4294849A
公开(公告)日：1981-10-13
申请号：US114804
申请日：1980-01-24
申请人： Masaki Hayashi , Sadahiko Iguchi , Takanori Okada , Akiyoshi Kawasaki
发明人： Masaki Hayashi , Sadahiko Iguchi , Takanori Okada , Akiyoshi Kawasaki
IPC分类号： A61K31/557 , A61K31/5575 , A61P43/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07F9/40 , C07C177/00
CPC分类号： C07C405/00 , C07F9/4006
摘要： Prostaglandin analogues of the formula:- ##STR1## (wherein R represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 4 carbon atoms, the wavy line indicates attachment in .alpha.- or .beta.-configuration or a mixture thereof, and the double bonds between C.sub.2 -C.sub.3 and C.sub.13 -C.sub.14 are trans), and cyclodextrin clathrates of such acids and esters, and when R represents a hydrogen atom, non-toxic salts of such acids, possess hypotensive activity, inhibitory activity on blood platelet aggregation and vasodilator activity, and weak diarrhoea-producing activity.
摘要翻译：具有下式的前列腺素类似物： - （其中R表示氢原子或含有1至4个碳原子的直链或支链烷基，波浪线表示以α-或β-构型或混合物的连接其中C2-C3和C13-C14之间的双键是反式的）和这些酸和酯的环糊精包合物，当R代表氢原子时，这种酸的无毒盐具有低血压活性，抑制活性血小板聚集和血管扩张剂活性，以及腹泻产生活性低。

7. 发明授权

US08900710B2 Light-emitting device, method for manufacturing same, and molded part 有权
标题翻译：发光装置及其制造方法和成型部件
公开(公告)号：US08900710B2
公开(公告)日：2014-12-02
申请号：US12026469
申请日：2008-02-05
申请人： Masaki Hayashi , Hiroto Tamaki , Masafumi Kuramoto , Tomohide Miki , Takayuki Sano , Tomohisa Kishimoto
发明人： Masaki Hayashi , Hiroto Tamaki , Masafumi Kuramoto , Tomohide Miki , Takayuki Sano , Tomohisa Kishimoto
IPC分类号： B32B27/38 , B29C45/02 , B29C45/28 , B29K63/00
CPC分类号： B29C45/02 , B29C45/2806 , B29D11/0074 , B29K2063/00 , H01L2224/48247 , H01L2224/48257 , H01L2224/73265 , H01L2924/181 , Y10T428/31511 , H01L2924/00012
摘要： A light-emitting device includes a light-emitting element on a molded part. The molded part is formed by molding and curing a thermosetting epoxy resin composition comprising (A) the reaction product of a triazine derived epoxy resin with an acid anhydride, (B) an internal parting agent having m.p. 50-90° C., (C) a reflective agent, (D) an inorganic filler, and (E) a curing catalyst.
摘要翻译：发光装置在模制部件上包括发光元件。模制部件通过模制和固化热固性环氧树脂组合物而形成，该热固性环氧树脂组合物包含（A）三嗪衍生的环氧树脂与酸酐的反应产物，（B）具有m.p。的内分离剂。 50-90℃，（C）反射剂，（D）无机填料和（E）固化催化剂。

8. 发明授权

US08871981B2 Method for oxidizing alcohols 有权
标题翻译：氧化醇的方法
公开(公告)号：US08871981B2
公开(公告)日：2014-10-28
申请号：US13809753
申请日：2011-05-30
申请人： Yoshiharu Iwabuchi , Masaki Hayashi
发明人： Yoshiharu Iwabuchi , Masaki Hayashi
IPC分类号： C07C45/29 , C07D493/20 , C07D213/50 , C07H19/16 , C07C269/06 , C07C45/39 , C07C201/12 , C07H9/04 , C07C45/30 , C07B53/00 , C07H19/167
CPC分类号： C07H19/16 , B01J31/0235 , B01J2231/70 , C07B53/00 , C07B2200/07 , C07C45/29 , C07C45/30 , C07C45/39 , C07C201/12 , C07C269/06 , C07C2601/14 , C07C2603/74 , C07D213/50 , C07D493/20 , C07H9/04 , C07H19/167 , C07C271/24 , C07C205/44 , C07C47/228 , C07C49/213 , C07C49/407 , C07C49/437 , C07C49/76 , C07C49/04 , C07C49/657 , C07C49/453 , C07C47/235 , C07C47/575 , C07C49/784
摘要： A method for oxidizing an alcohol, wherein oxidation is performed in the presence of a compound represented by the following formula (I) and a bulk oxidant, which enables efficient oxidation of secondary alcohols as well as primary alcohols, and can attain high reaction efficiency even when air is used as a bulk oxidant.
摘要翻译：一种氧化醇的方法，其中在由下式（I）表示的化合物和本体氧化剂的存在下进行氧化，其能够有效地氧化仲醇以及伯醇，并且甚至可以获得高的反应效率，甚至当空气用作体积氧化剂时。

9. 发明授权

US08616556B2 Combined oil ring 有权
标题翻译：组合油环
公开(公告)号：US08616556B2
公开(公告)日：2013-12-31
申请号：US12427228
申请日：2009-04-21
申请人： Masaki Hayashi
发明人： Masaki Hayashi
IPC分类号： F16J9/06 , F16J9/00 , F16J9/12 , B60T11/236 , F02F5/00
CPC分类号： F16J9/062 , F16J9/064
摘要： A combined oil ring includes an oil ring having upper and lower rails formed integrally at an outer circumferential side of the oil ring to slide on a cylinder wall; a coil expander installed at an inner circumferential side of the oil ring to force the oil ring radially outwards; and a side rail installed at an upper side of the oil ring and having no torsion along an axial direction of the oil ring.
摘要翻译：组合油环包括油环，其具有一体地形成在油环的外周侧上并在气缸壁上滑动的上轨道和下轨道; 一个安装在油环的内周侧的线圈膨胀器，以使油环径向向外; 以及安装在油环的上侧并且沿着油环的轴向没有扭转的侧轨。

10. 发明授权

US08532539B2 Image forming apparatus 失效
标题翻译：图像形成装置
公开(公告)号：US08532539B2
公开(公告)日：2013-09-10
申请号：US12729747
申请日：2010-03-23
申请人： Hideya Muramoto , Hirohisa Endou , Eiji Nimura , Ikuo Makie , Masaki Hayashi , Yoshihiro Yamagishi
发明人： Hideya Muramoto , Hirohisa Endou , Eiji Nimura , Ikuo Makie , Masaki Hayashi , Yoshihiro Yamagishi
IPC分类号： G03G15/08
CPC分类号： G03G15/0822 , G03G15/50 , G03G2215/1647 , G03G2221/0005
摘要： An image forming apparatus includes: an image carrier that carries an electrostatic latent image; a development device that includes a toner carrier which is disposed opposite to the image carrier, carries and supplies toner to the image carrier, and develops the electrostatic latent image formed on a surface of the image carrier; and a control means that performs a refresh process in which toner is ejected from the toner carrier to the image carrier in a time an image is not formed, and a toner ejection pattern which is formed by ejecting a line image a plurality of times that has an acute angle to a main scan direction at predetermined intervals in a circumferential direction of the image carrier over a total width of a development region.
摘要翻译：图像形成装置包括：承载静电潜像的图像载体; 一种显影装置，其包括与图像载体相对设置的调色剂载体，将调色剂携带并供应到图像载体，并且使形成在图像载体的表面上的静电潜像显影; 以及控制装置，其执行刷新处理，其中调色剂在没有形成图像的时间内从调色剂载体喷射到图像载体，以及调色剂排出图案，其通过多次排出线图像而形成，在显影区域的总宽度上在图像载体的圆周方向上以预定间隔与主扫描方向成锐角。

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