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1. 发明申请

US20080026976A1 Highly productive alpha-amylases 审中-公开
标题翻译：高生产力的α-淀粉酶
公开(公告)号：US20080026976A1
公开(公告)日：2008-01-31
申请号：US11590769
申请日：2006-11-01
申请人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
发明人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
IPC分类号： C11D3/386 , C07H21/00 , C12N1/00 , C12N15/63 , C12N9/26 , C12P21/00
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to mutant α-amylases that may be produced at high yield from recombinant microorganisms.
摘要翻译：本发明涉及可以从重组微生物以高产率产生的突变型α-淀粉酶。

2. 发明授权

US07297527B2 Highly productive α-amylases 失效
标题翻译：高生产力的α-淀粉酶
公开(公告)号：US07297527B2
公开(公告)日：2007-11-20
申请号：US10798278
申请日：2004-03-12
申请人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
发明人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
IPC分类号： C12N9/00 , C12N9/28 , C11D3/00 , C11D7/42
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to mutant α-amylases that may be produced at high yield from recombinant microorganisms.
摘要翻译：本发明涉及可以从重组微生物以高产率产生的突变型α-淀粉酶。

3. 发明授权

US06743616B2 Highly productive alpha-amylases 失效
标题翻译：高生产力的α-淀粉酶
公开(公告)号：US06743616B2
公开(公告)日：2004-06-01
申请号：US09971611
申请日：2001-10-09
申请人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
发明人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
IPC分类号： C12N900
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to mutant &agr;-amylases that may be produced at high yield from recombinant microorganisms.
摘要翻译：本发明涉及可以从重组微生物以高产率产生的突变型α-淀粉酶。

4. 发明申请

US20050181493A1 Mutant alpha-amylases 审中-公开
标题翻译：突变型α-淀粉酶
公开(公告)号：US20050181493A1
公开(公告)日：2005-08-18
申请号：US10988529
申请日：2004-11-16
申请人： Keiji Endo , Kazuaki Igarashi , Yasuhiro Hayashi , Hiroshi Hagihara , Katsuya Ozaki
发明人： Keiji Endo , Kazuaki Igarashi , Yasuhiro Hayashi , Hiroshi Hagihara , Katsuya Ozaki
IPC分类号： C11D3/386 , C12N1/21 , C12N9/28 , C12N15/56 , C11D7/42
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase. The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.
摘要翻译：本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶具有所述氨基酸序列的淀粉酶或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，用于产生突变型α-淀粉酶的方法，包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

5. 发明授权

US07078212B1 Mutant α-amylases 失效
标题翻译：突变型α-淀粉酶
公开(公告)号：US07078212B1
公开(公告)日：2006-07-18
申请号：US09590375
申请日：2000-06-09
申请人： Keiji Endo , Kazuaki Igarashi , Yasuhiro Hayashi , Hiroshi Hagihara , Katsuya Ozaki
发明人： Keiji Endo , Kazuaki Igarashi , Yasuhiro Hayashi , Hiroshi Hagihara , Katsuya Ozaki
IPC分类号： C12N9/26 , C12N9/28 , C07H21/04
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase.The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.
摘要翻译：本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶具有所述氨基酸序列的淀粉酶或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，用于产生突变型α-淀粉酶的方法，包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

6. 发明授权

US06916645B2 Amylases 失效
标题翻译：淀粉酶
公开(公告)号：US06916645B2
公开(公告)日：2005-07-12
申请号：US10136272
申请日：2002-05-02
申请人： Hiroshi Hagihara , Kaori Kitayama , Yasuhiro Hayashi , Kazuaki Igarashi , Keiji Endo , Katsuya Ozaki
发明人： Hiroshi Hagihara , Kaori Kitayama , Yasuhiro Hayashi , Kazuaki Igarashi , Keiji Endo , Katsuya Ozaki
IPC分类号： C12N9/28 , C12N15/31 , C12N15/56 , C12N15/09 , C07H21/04 , C12N1/20 , C12N9/00
CPC分类号： C12N9/2417
摘要： Liquefying alkaline amylases, each having residual activity not less than 70% when treated at pH 10 and 45° C. for 30 minutes in the presence of 1 to 100 mM of EDTA or EGTA, are described. Also described are detergents comprising these amylases. In comparison with conventional amylases for detergents, the liquefying alkaline amylases of this invention have a high chelating-agent resisting performance.
摘要翻译：描述了在1至100mM EDTA或EGTA的存在下，在pH10和45℃下处理30分钟时，残留活性不低于70％的液体碱性淀粉酶。还描述了包含这些淀粉酶的洗涤剂。与用于洗涤剂的常规淀粉酶相比，本发明的液化碱性淀粉酶具有高螯合剂抵抗性能。

7. 发明授权

US06403355B1 Amylases 有权
标题翻译：淀粉酶
公开(公告)号：US06403355B1
公开(公告)日：2002-06-11
申请号：US09465519
申请日：1999-12-16
申请人： Hiroshi Hagihara , Kaori Kitayama , Yasuhiro Hayashi , Kazuaki Igarashi , Keiji Endo , Katsuya Ozaki
发明人： Hiroshi Hagihara , Kaori Kitayama , Yasuhiro Hayashi , Kazuaki Igarashi , Keiji Endo , Katsuya Ozaki
IPC分类号： C12N900
CPC分类号： C12N9/2417
摘要： Described are liquefying alkaline amylases each having residual activity not less than 70% when treated at pH 10 and 45° C. for 30 minutes in the presence of 1 to 100 mM of EDTA or EGTA; and a detergent comprising the same. Compared with the conventional amylases for a detergent, they have high chelating-agent resisting performance.
摘要翻译：描述了在1至100mM EDTA或EGTA的存在下，在pH 10和45℃下处理30分钟时液化碱性淀粉酶，其各自具有不小于70％的残留活性; 和含有该洗涤剂的洗涤剂。与用于洗涤剂的常规淀粉酶相比，它们具有高螯合剂抗性。

8. 发明申请

US20090226961A1 MUTANT ALPHA-AMYLASES 审中-公开
标题翻译：突变型ALPHA-AMYLASES
公开(公告)号：US20090226961A1
公开(公告)日：2009-09-10
申请号：US11864245
申请日：2007-09-28
申请人： Keiji Endo , Kazuaki Igarashi , Yasuhiro Hayashi , Hiroshi Hagihara , Katsuya Ozaki
发明人： Keiji Endo , Kazuaki Igarashi , Yasuhiro Hayashi , Hiroshi Hagihara , Katsuya Ozaki
IPC分类号： C12P21/00 , C07H21/00 , C12N15/63 , C12N1/00
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to a mutant α-amylase obtained by making replacement or deletion of at least one of amino acid residues such as the 167th Gln, 169th Tyr and 178th Ala in the amino acid sequence set forth in SEQ ID NO:1 in an α-amylase having said amino acid sequence, or an α-amylase having a homology of at least 70% to said amino acid sequence, a gene encoding the mutant α-amylase, a vector, transformed cells, a process for producing a mutant α-amylase, comprising culturing the transformed cells, and a detergent composition comprising the mutant α-amylase.The mutant α-amylase of the invention has excellent properties of high resistance to chelating agents, high specific activity in an alkaline region and excellent stability to heat, and is hence useful for detergents for automatic dish washer, laundry detergents and the like.
摘要翻译：本发明涉及通过使SEQ ID NO：1所示的氨基酸序列中的至少一个氨基酸残基例如第167位Gln，第169位和第178位氨基酸置换成α位点而获得的突变型α-淀粉酶具有所述氨基酸序列的淀粉酶，或与所述氨基酸序列具有至少70％同源性的α-淀粉酶，编码突变型α-淀粉酶的基因，载体，转化细胞，产生突变型α-淀粉酶的方法，包括培养转化细胞的淀粉酶和包含突变型α-淀粉酶的洗涤剂组合物。本发明的突变型α-淀粉酶具有优异的抗螯合剂抗性，在碱性区域中具有高比活性和优异的耐热稳定性，因此可用于自动洗碗机，衣物洗涤剂等的洗涤剂。

9. 发明授权

US07829322B2 Recombinant microorganism comprising inactivation of the AprX gene 有权
标题翻译：包含AprX基因失活的重组微生物
公开(公告)号：US07829322B2
公开(公告)日：2010-11-09
申请号：US11722162
申请日：2005-12-20
申请人： Takeko Kodama , Keiji Endo , Katsuya Ozaki , Junichi Sekiguchi
发明人： Takeko Kodama , Keiji Endo , Katsuya Ozaki , Junichi Sekiguchi
IPC分类号： C12N1/21 , C12N15/00 , C12N15/57 , C12N15/75
CPC分类号： C12P21/02 , C07K14/32 , C12N9/54 , C12N15/75
摘要： A host microorganism capable of increasing productivity of a protein or polypeptide, a recombinant microorganism obtained by introducing a gene encoding a protein or polypeptide into the host microorganism, and a method for producing a protein or polypeptide using the recombinant microorganism are provided.Also provided is a recombinant microorganism obtained by introducing into a host microorganism a gene encoding a heterologous protein or polypeptide, wherein in said host microorganism the Bacillus subtilis aprX gene or a gene corresponding to the aprX gene has been deleted or knocked out, and a method for producing a protein or polypeptide using the recombinant microorganism.
摘要翻译：提供能够提高蛋白质或多肽的生产力的宿主微生物，通过将编码蛋白质或多肽的基因导入宿主微生物而获得的重组微生物，以及使用该重组微生物产生蛋白质或多肽的方法。还提供了通过向宿主微生物中导入编码异源蛋白质或多肽的基因而获得的重组微生物，其中在所述宿主微生物中，枯草芽孢杆菌aprX基因或与aprX基因相对应的基因已被缺失或敲除，用于使用重组微生物产生蛋白质或多肽。

10. 发明申请

US20090170154A1 Mutant bacterium belonging to the genus bacillus 有权
标题翻译：属于杆菌属的突变细菌
公开(公告)号：US20090170154A1
公开(公告)日：2009-07-02
申请号：US10590275
申请日：2005-03-04
申请人： Keiji Endo , Katsuya Ozaki
发明人： Keiji Endo , Katsuya Ozaki
IPC分类号： C12P21/00 , C12N1/21 , C12N15/87
CPC分类号： C12N9/2417 , C12N9/2437 , C12N9/54 , C12Y302/01004
摘要： The present invention provides a mutant Bacillus bacterium capable of enhancing productivity of proteins or polypeptides, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutant Bacillus bacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism.A mutant Bacillus bacterium which has, on the genome or plasmid thereof, DNA having a promoter sequence which is recognized and transcribed specifically during the sporulation stage and which is ligated to an upstream end of a sigA gene or a gene equivalent thereto, a recombinant microorganism produced by introducing genes encoding heterologous proteins or polypeptides into the mutant Bacillus bacterium, and a method for producing proteins or polypeptides by use of the recombinant microorganism.
摘要翻译：本发明提供能够提高蛋白质或多肽生产力的突变芽孢杆菌属细菌，通过将编码异源蛋白质或多肽的基因导入突变芽孢杆菌属细菌产生的重组微生物，以及通过使用重组微生物产生蛋白质或多肽的方法。一种突变芽孢杆菌属细菌，其在基因组或质粒上具有在孢子形成阶段中特异性识别并转录并与sigA基因或其等同基因相连的基因的上游端的启动子序列的DNA，重组微生物通过将编码异源蛋白质或多肽的基因导入突变芽孢杆菌属细菌而产生，以及通过使用重组微生物产生蛋白质或多肽的方法。

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