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1. 发明授权

US08349840B2 Piperazine-substituted benzothiophenes for treatment of mental disorders 有权
公开(公告)号：US08349840B2
公开(公告)日：2013-01-08
申请号：US12970690
申请日：2010-12-16
申请人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： A61K31/496
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.

2. 发明授权

US08071600B2 Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders 有权
标题翻译：适用于治疗CNS疾病的4-哌嗪-1-基-4-苯并[b]噻吩的衍生物
公开(公告)号：US08071600B2
公开(公告)日：2011-12-06
申请号：US11991146
申请日：2006-08-31
申请人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , A61K31/55 , A61K31/551 , C07D333/54 , C07D409/12 , C07D409/14 , A61K31/536 , A61K31/5415 , C07D407/12 , C07D413/12 , C07D417/12
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。

3. 发明申请

US20090264404A1 Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene suitable for the treatment of cns disorders 有权
标题翻译：适用于治疗cns病症的4-哌嗪-1-基-4-苯并[b]噻吩的衍生物
公开(公告)号：US20090264404A1
公开(公告)日：2009-10-22
申请号：US11991146
申请日：2006-08-31
申请人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , C07D409/14 , C07D265/36 , C07D223/08 , C07D243/08 , C07D267/14 , A61K31/536 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/397 , A61P25/00
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。

4. 发明申请

US20120028920A1 DERIVATIVES OF 4-PIPERAZIN-1-YL-4-BENZO[B]THIOPHENE SUITABLE FOR THE TREATMENT OF CNS DISORDERS 失效
标题翻译：适用于治疗CNS病症的4-哌啶-1-基-4-苯并[b]噻吩的衍生物
公开(公告)号：US20120028920A1
公开(公告)日：2012-02-02
申请号：US13270544
申请日：2011-10-11
申请人： Hiroshi YAMASHITA , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
发明人： Hiroshi YAMASHITA , Hideaki Kuroda , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Haruka Takahashi , Tae Fukushima , Satoshi Shimizu , Kazumi Kondo , Yohji Sakurai , Takeshi Kuroda , Shinichi Taira , Motohiro Itotani , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , C07D409/10 , C07D417/14 , C07D413/14 , A61K31/538 , A61K31/517 , A61K31/506 , A61K31/55 , A61K31/5415 , A61K31/553 , C07F7/18 , A61K31/695 , A61P25/18 , A61P25/24 , A61P25/00 , C07D409/14
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。

5. 发明申请

US20110152286A1 PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS 有权
标题翻译：用于治疗精神疾病的哌嗪取代的苯二酚
公开(公告)号：US20110152286A1
公开(公告)日：2011-06-23
申请号：US12970690
申请日：2010-12-16
申请人： Hiroshi YAMASHITA , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi YAMASHITA , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： A61K31/497 , C07D401/14 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/28 , A61P25/14 , A61P25/16
CPC分类号： A61K31/496 , C07D405/12 , C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：本发明提供由通式（1）表示的杂环化合物：本发明化合物具有广泛的精神障碍治疗谱，包括中枢神经系统疾病，副作用高，安全性高。

6. 发明授权

US07888362B2 Piperazine-substituted benzothiophenes for treatment of mental disorders 有权
标题翻译：哌嗪取代的苯并噻吩用于治疗精神障碍
公开(公告)号：US07888362B2
公开(公告)日：2011-02-15
申请号：US11659005
申请日：2006-04-12
申请人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： A61K31/496 , C07D409/12
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：本发明提供由通式（1）表示的杂环化合物：本发明化合物具有广泛的精神障碍治疗谱，包括中枢神经系统疾病，副作用高，安全性高。

7. 发明申请

US20100179322A1 Piperazine-substituted benzothiophenes for treatment of mental disorders 有权
标题翻译：哌嗪取代的苯并噻吩用于治疗精神障碍
公开(公告)号：US20100179322A1
公开(公告)日：2010-07-15
申请号：US11659005
申请日：2006-04-12
申请人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
发明人： Hiroshi Yamashita , Nobuaki Ito , Shin Miyamura , Kunio Oshima , Jun Matsubara , Hideaki Kuroda , Haruka Takahashi , Satoshi Shimizu , Tatsuyoshi Tanaka
IPC分类号： C07D409/14
CPC分类号： C07D409/12 , C07D409/14
摘要： The present invention provides a heterocyclic compound represented by the general formula (1): The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：本发明提供由通式（1）表示的杂环化合物：本发明化合物具有广泛的精神障碍治疗谱，包括中枢神经系统疾病，副作用高，安全性高。

8. 发明授权

US08598162B2 Derivatives of 4-piperazin-1-yl-4-benzo[B]thiophene suitable for the treatment of CNS disorders 失效
标题翻译：适用于治疗CNS疾病的4-哌嗪-1-基-4-苯并[b]噻吩的衍生物
公开(公告)号：US08598162B2
公开(公告)日：2013-12-03
申请号：US13270544
申请日：2011-10-11
申请人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Jun Matsubara , Yohji Sakurai
发明人： Hiroshi Yamashita , Hideaki Kuroda , Nobuaki Ito , Jun Matsubara , Yohji Sakurai
IPC分类号： A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K31/541 , C07D409/12 , C07D409/14 , C07D417/14
CPC分类号： C07D409/12 , C07D333/54 , C07D407/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D487/08 , C07D491/113
摘要： A heterocyclic compound or a salt thereof represented by the formula (1): where R2 represents a hydrogen atom or a lower alkyl group; A represents a lower alkylene group or lower alkenylene group; and R1 represents an aromatic group or a heterocyclic group. The compound of the present invention has a wide treatment spectrum for mental disorders including central nervous system disorders, no side effects and high safety.
摘要翻译：由式（1）表示的杂环化合物或其盐：其中R 2表示氢原子或低级烷基; A表示低级亚烷基或低级亚烯基; R1表示芳基或杂环基。本发明的化合物具有广泛的精神障碍治疗范围，包括中枢神经系统疾病，无副作用和高安全性。

9. 发明授权

US5148295A Information processing apparatus 失效
标题翻译：信息处理装置
公开(公告)号：US5148295A
公开(公告)日：1992-09-15
申请号：US733964
申请日：1991-07-22
申请人： Jun Matsubara
发明人： Jun Matsubara
IPC分类号： H04N1/00 , H04N1/04
CPC分类号： H04N1/00405 , H04N1/00384 , H04N1/00411 , H04N1/00413 , H04N1/0049 , H04N1/0402 , H04N1/0405 , H04N1/0417
摘要： An information processing apparatus including an image scanner, on which original documents with any vertical or horizontal format are placed, for optically scanning the images of the original documents to generate output image information and format setting keys for designating the format of the original documents and generating information concerning the format of the original documents. The apparatus further includes a first memory for storing the information concerning the format of the original documents generated by the format setting keys and for outputting the information concerning the format; an enlargement/reduction unit for changing the size of the image information of a whole vertical original document and a whole horizontal original document output from the image scanner with the same magnification and for outputting the changed image information; a second memory for storing the image information output from the enlargement/reduction unit in accordance with the information concerning the format of the original documents output from the first memory and for outputting the image information; and a display unit having a square screen for displaying the image information from the second memory on the square screen.
摘要翻译：一种信息处理设备，包括：图像扫描器，其上放置有任何垂直或水平格式的原始文档，用于光学扫描原始文档的图像，以产生输出图像信息和格式设置键，用于指定原始文档的格式并产生有关原始文件格式的信息。该装置还包括第一存储器，用于存储关于由格式设置键生成的原始文档的格式的信息，并且用于输出关于格式的信息; 放大/缩小单元，用于改变整个垂直原稿的图像信息的尺寸和以相同的倍率从图像扫描仪输出的整个水平原稿，并输出改变的图像信息; 第二存储器，用于根据关于从第一存储器输出的原始文档的格式的信息存储从放大/缩小单元输出的图像信息，并输出图像信息; 以及显示单元，具有用于在平方屏幕上显示来自第二存储器的图像信息的方形屏幕。

10. 发明授权

US5806493A Distributor type fuel injection pump 失效
标题翻译：分配器型燃油喷射泵
公开(公告)号：US5806493A
公开(公告)日：1998-09-15
申请号：US977239
申请日：1997-11-24
申请人： Kenichi Kubo , Mitsunori Urano , Toru Yokota , Jun Matsubara
发明人： Kenichi Kubo , Mitsunori Urano , Toru Yokota , Jun Matsubara
IPC分类号： F02D1/04 , F02M41/14 , F02M37/04
CPC分类号： F02M41/1405
摘要： In an inner-cam system fuel injection pump, two balance ports that are offset symmetrically relative to a distribution port in a circumferential direction to form a Y-shape are formed at a rotor. The opening ends of the balance ports and the opening end of the distribution port are positioned on the same plane that is perpendicular to the axis of the rotor. The offset angle .theta. by which the balance ports are offset in the circumferential direction relative to the axis of the distribution port, the opening area S.sub.1 of the distribution port and the opening area S.sub.2 of each of the balance ports are set to satisfy a relationship expressed as S.sub.1 =.vertline.2.multidot.S.sub.2 .multidot.cos .theta..vertline.. The phase intervals of the fuel delivery passages and the phase interval of the two balance ports are set equal to each other. Seizure at the area where the rotor slides in contact with its supporting member is prevented effectively and stable injection characteristics are achieved by equalizing the residual pressures in the individual fuel delivery passages.
摘要翻译：在内凸轮系的燃料喷射泵中，在转子上形成有两个平衡端口，其相对于分配口在圆周方向上对称地偏移以形成Y形。平衡口的开口端和分配口的开口端位于垂直于转子轴线的同一平面上。平衡端口相对于分配口的轴线在圆周方向上偏移的偏移角度θ，分配口的开口面积S1和每个平衡端口的开口面积S2被设定为满足表达的关系如S1 = | 2xS2xcos theta |。燃料输送通道的相位间隔和两个平衡端口的相位间隔彼此相等。有效地防止了转子滑动与其支撑构件接触的区域的缉获，并且通过均衡各个燃料输送通道中的残余压力来实现稳定的喷射特性。

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