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1. 发明申请

US20070082862A1 Novel antisense oligonucleotide and anti-hiv agent 审中-公开
标题翻译：新型反义寡核苷酸和抗-HIV剂
公开(公告)号：US20070082862A1
公开(公告)日：2007-04-12
申请号：US10549601
申请日：2004-03-19
申请人： Hiroshi Takaku , Naoko Kurosaki
发明人： Hiroshi Takaku , Naoko Kurosaki
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N15/1132
摘要： A novel antisense oligonucleotide that targets at DIS (Dimerization Initiation Site) region of HIV-1; and an anti-HIV agent (HIV curative and/or preventive agent) comprising the same. This anti-HIV agent realizes effective treatment and/or prevention for HIV infection.
摘要翻译：靶向HIV-1的DIS（二聚起始位点）区域的新型反义寡核苷酸; 和包含其的抗HIV剂（HIV治疗剂和/或预防剂）。这种抗HIV药物可以有效地治疗和/或预防艾滋病毒感染。

2. 发明申请

US20090035861A1 RNAi Medicine Having No Adverse Effects 审中-公开
标题翻译：没有不良反应的RNAi药物
公开(公告)号：US20090035861A1
公开(公告)日：2009-02-05
申请号：US11883227
申请日：2006-01-27
申请人： Hiroshi Takaku , Naoko Kurosaki , Kazuya Yamaguchi , Takuma Gondai
发明人： Hiroshi Takaku , Naoko Kurosaki , Kazuya Yamaguchi , Takuma Gondai
IPC分类号： C12N15/85 , C07H21/00 , C12N15/63
CPC分类号： C12N15/111 , C12N2310/14 , C12N2310/53 , C12N2320/50
摘要： An RNAi reagent and a medicine that have no adverse effects such as interferon and/or cytotoxicity induction are provided.An shRNA used for sequence-specific RNA interference without interferon and/or cytotoxicity induction and a medicine and a reagent containing the shRNA are provided, such shRNA comprising a sense strand comprising a sequence homologous to a target sequence of the target mRNA and an antisense strand comprising a sequence complementary to the sequence of the sense strand and having an overhang comprising one or a plurality of G(s) at the 5′ end of the sense strand.
摘要翻译：提供RNAi试剂和没有不利影响的药物，例如干扰素和/或细胞毒性诱导。提供了用于没有干扰素和/或细胞毒性诱导的序列特异性RNA干扰的shRNA和含有shRNA的药物和试剂，所述shRNA包含含有与靶mRNA的靶序列同源的序列的反义链和反义链包括与有义链的序列互补的序列，并且具有在有义链的5'末端具有一个或多个G（s）的突出端。

3. 发明授权

US06807023B2 Method and apparatus for dubbing a recording tape loaded with information 失效
标题翻译：用于复制装载有信息的记录带的方法和装置
公开(公告)号：US06807023B2
公开(公告)日：2004-10-19
申请号：US09976020
申请日：2001-10-15
申请人： Seiichi Satoh , Noriyuki Nakazawa , Hiroshi Takaku
发明人： Seiichi Satoh , Noriyuki Nakazawa , Hiroshi Takaku
IPC分类号： G11B586
CPC分类号： G11B5/0086 , G11B5/86 , G11B27/031 , G11B27/032 , G11B27/034 , G11B27/34 , G11B2220/90 , H04N5/765
摘要： Each of slave recorders includes a rotary drum, heads mounted on the rotary drum at positions spaced from a phase reference position on the rotary drum by different angular intervals respectively, and an arrangement for selecting at least one from the heads as an active head in accordance with a designated recording mode. Non-delayed stream data are delayed by a delay time interval to form delayed stream data. A distributor operates for distributing the delayed stream data to the slave recorders. Each of the slave recorders records the delayed stream data on a slave recording medium by the active head. The delay time interval corresponds to the angular interval between the phase reference position and the position of the active head.
摘要翻译：每个从动记录器包括旋转磁鼓，磁头安装在旋转磁鼓上，分别与旋转磁鼓上的相位基准位置分开不同的角度间隔，以及用于根据磁头从头部中选择至少一个作为主动头的装置具有指定的记录模式。非延迟流数据被延迟延迟时间间隔以形成延迟流数据。分配器用于将延迟的流数据分发给从属记录器。每个从动记录器通过主动头在从属记录介质上记录延迟流数据。延迟时间间隔对应于相位基准位置和有效头部位置之间的角度间隔。

4. 发明申请

US20060051804A1 Oligonucleotides labeled with stable isotopes and a method for detecting the same 审中-公开
标题翻译：用稳定同位素标记的寡核苷酸及其检测方法
公开(公告)号：US20060051804A1
公开(公告)日：2006-03-09
申请号：US11248852
申请日：2005-10-11
申请人： Gota Kawai , Akira Wada , Hiroshi Takaku
发明人： Gota Kawai , Akira Wada , Hiroshi Takaku
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , C12N2310/3125 , C12N2310/315 , C12N2310/3181 , C12N2310/3517 , C12Q1/68 , Y10T436/24 , C12Q2565/633 , C12Q2563/101
摘要： Antisense oligonucleotide sequences which enable the measurement of the distribution and structure of antisense oligonucleotide drugs in the body, with lapse of time, and a method of detecting these sequences are provided. The antisense chains have a natural or non-natural nucleotide or peptide nucleic acid as a structural unit in which carbon atoms and nitrogen atoms are substituted by 13C and 15N, respectively, and the antisense chains can be detected by nuclear magnetic resonance spectroscopy (NMR) such as 15N—1H or 13C—1H hereto nuclear multiple quantum coherence spectroscopy.
摘要翻译：提供能够测量体内反义寡核苷酸药物在时间上的分布和结构的反义寡核苷酸序列，以及检测这些序列的方法。反义链具有天然或非天然核苷酸或肽核酸作为结构单元，其中碳原子和氮原子分别被13个和15个N取代，并且可以通过核磁共振光谱（NMR）检测反义链，例如<！ - SIPO - > <！ - SIPO < > 1 H在核多量子相干光谱学。

5. 发明授权

US4552955A Process for the synthesis of 4',5'-unsaturated nucleosides 失效
标题翻译：合成4'，5'-不饱和核苷的方法
公开(公告)号：US4552955A
公开(公告)日：1985-11-12
申请号：US393254
申请日：1982-06-29
申请人： Hiroshi Takaku , Takeshi Noda
发明人： Hiroshi Takaku , Takeshi Noda
IPC分类号： C07H19/06 , C07H19/16 , C07H17/00
CPC分类号： C07H19/06 , C07H19/16
摘要： Process for the production of 4',5'-unsaturated nucleosides via a novel compound, 5'-Se-(2- or 4-nitrophenyl)-selenonucleoside, is disclosed, said selenonucleoside being represented by the formula ##STR1## wherein R is a hydrogen atom or a hydroxyl group, A is 2- or 4-nitrophenyl group and B is a base.
摘要翻译：公开了通过新型化合物5'-Se-（2-或4-硝基苯基） - 硒核苷生产4'，5'-不饱和核苷的方法，所述硒核苷由下式表示：其中R为氢原子或羟基，A是2-或4-硝基苯基，B是碱。

6. 发明授权

US07038036B2 Oligonucleotides labeled with stable isotopes and a method for detecting the same 有权
标题翻译：用稳定同位素标记的寡核苷酸及其检测方法
公开(公告)号：US07038036B2
公开(公告)日：2006-05-02
申请号：US10214503
申请日：2002-08-07
申请人： Gota Kawai , Akira Wada , Hiroshi Takaku
发明人： Gota Kawai , Akira Wada , Hiroshi Takaku
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , C12N2310/3125 , C12N2310/315 , C12N2310/3181 , C12N2310/3517 , C12Q1/68 , Y10T436/24 , C12Q2565/633 , C12Q2563/101
摘要： Antisense oligonucleotide sequences which enable the measurement of the distribution and structure of antisense oligonucleotide drugs in the body, with lapse of time, and a method of detecting these sequences are provided. The antisense chains have a natural or non-natural nucleotide or peptide nucleic acid as a structural unit in which carbon atoms and nitrogen atoms are substituted by 13C and 15N, respectively, and the antisense chains can be detected by nuclear magnetic resonance spectroscopy (NMR) such as 15N—1H or 13C—1H hetero nuclear multiple quantum coherence spectroscopy.
摘要翻译：提供能够测量体内反义寡核苷酸药物在时间上的分布和结构的反义寡核苷酸序列，以及检测这些序列的方法。反义链具有天然或非天然核苷酸或肽核酸作为结构单元，其中碳原子和氮原子分别被13个和15个N取代，并且可以通过核磁共振光谱（NMR）检测反义链，例如<！ - SIPO - > <！ - SIPO < 1异质核多重量子相干光谱。

7. 发明授权

US5134228A Nucleoside-3'-phosphites for synthesis of oligonucleotides 失效
标题翻译：用于合成寡核苷酸的核苷-3'-磷酸酶
公开(公告)号：US5134228A
公开(公告)日：1992-07-28
申请号：US412990
申请日：1989-09-26
申请人： Hiroshi Takaku
发明人： Hiroshi Takaku
IPC分类号： C07F9/141 , C07H19/10 , C07H19/20
CPC分类号： C07H19/10 , C07F9/1411 , C07H19/20 , Y02P20/55
摘要： The invention provides novel phosphites represented by the general formula (I) and nucleoside-3'-phosphite derivatives represented by the general formula (III).(RO).sub.3 P (I)wherein R is, for example, a fluoroalkyl group or a substituted phenyl group. ##STR1## wherein R is the same as in (I), R" is a protecting group such as dimethoxytrityl group, and B represents a base, e.g. thymine.A phosphite (I) is prepared by reacting an alcohol ROH with PCl.sub.3 in the presence of a tertiary amine, and a nucleoside-3'-phosphite (III) is prepared by reacting a phosphite (I) with a nucleoside in a solvent in the presence of a tertiary amine. Phosphites (I) are very stable. Using a nucleoside-3'-phosphite (III) an oligonucleotide can be synthesized on a solid support by a simplified process.
摘要翻译：本发明提供由通式（I）表示的新型亚磷酸酯和由通式（III）表示的核苷-3'-亚磷酸酯衍生物。（RO）3P（I）其中R是例如氟代烷基或取代的苯基。（III）其中R与（I）中的相同，R“是保护基，例如二甲氧基三苯甲基，B表示碱。胸腺嘧啶通过在叔胺存在下使醇ROH与PCl 3反应制备亚磷酸酯（I），通过使亚磷酸酯（I）与核苷在溶剂中反应制备核苷-3'-亚磷酸酯（III）存在叔胺。亚磷酸酯（I）非常稳定。使用核苷-3'-亚磷酸酯（III），可以通过简化的方法在固体支持物上合成寡核苷酸。

8. 发明申请

US20120189663A1 METHOD OF PRODUCING A MEDICAL COMPOSITION 审中-公开
标题翻译：生产医药组合物的方法
公开(公告)号：US20120189663A1
公开(公告)日：2012-07-26
申请号：US13261211
申请日：2010-09-10
申请人： Hiroshi Takaku , Tomoyuki Suzuki , Myint Oo Chang , Norio Yamamoto , Kazuo Wakabayashi
发明人： Hiroshi Takaku , Tomoyuki Suzuki , Myint Oo Chang , Norio Yamamoto , Kazuo Wakabayashi
IPC分类号： A61K39/00 , A61P37/04 , G01N33/569 , A61P35/00 , C12N5/078 , C12Q1/70
CPC分类号： A61K35/12 , A61K2035/124 , C12N5/0639 , C12N2500/70
摘要： The present invention aims to produce a safe and reliable medical composition, which efficiently boosts nonspecific immunity of antigen-presenting cells and thereby promotes an antitumor activity. To produce the medical composition, antigen-presenting cells such as dendritic cells are exposed to an activating reagent containing baculoviruses. Then, the antigen-presenting cells are separated from the activating reagent. The antigen-presenting cells are optionally cultured after the separation. Furthermore, an absence of the baculoviruses in the composition are optionally checked. The medical composition produced by the present invention is expected to have an outstanding therapeutic effect.
摘要翻译：本发明旨在产生一种安全可靠的医药组合物，其有效地提高抗原呈递细胞的非特异性免疫，从而促进抗肿瘤活性。为了产生医疗组合物，将抗原呈递细胞如树突状细胞暴露于含有杆状病毒的活化试剂。然后，将抗原呈递细胞与活化试剂分离。分离后任选地培养抗原呈递细胞。此外，任选地检查组合物中不存在杆状病毒。预期本发明生产的医药组合物具有突出的治疗效果。

9. 发明授权

US06495675B1 Pharmaceutical composition for treating or preventing influenza, and novel capped oligonucleotide 失效
标题翻译：用于治疗或预防流感的药物组合物和新型封端寡核苷酸
公开(公告)号：US06495675B1
公开(公告)日：2002-12-17
申请号：US09603378
申请日：2000-06-26
申请人： Hiroshi Takaku , Kin-ichiro Miura , Toshifumi Hatta , Kazuyuki Takai , Masahide Ishikawa
发明人： Hiroshi Takaku , Kin-ichiro Miura , Toshifumi Hatta , Kazuyuki Takai , Masahide Ishikawa
IPC分类号： C07H2104
CPC分类号： A61K31/7105 , A61K38/00 , C07H21/00 , C12N15/1131 , C12N2310/317 , C12N2310/321 , C12N2310/3521
摘要： A pharmaceutical composition comprising a capped oligonucleotide capable of binding to a PB2 protein of an influenza virus RNA polymerase, and a pharmaceutically acceptable carrier or dilute, said capped oligonucleotide having a structure of the formula (I): m7GpppXpY (I) wherein ppp is a triphosphate bridge, p is a monophosphate bridge, m7G is 7-methylguanosine group binding at 5′ end thereof to said ppp, X is a 2′-O-methyl guanosine group or guanosine group, said 2′-O-methyl guanosine group or guanosine group binds at a 5′ end thereof to said ppp, and at a 3′ end thereof to said p, and Y is an oligoribonucleotide moiety binding at 5′ end thereof to said p, and having 5 to 11 bases is disclosed. The pharmaceutical composition can inhibit a protein expression of an influenza virus.
摘要翻译：一种药物组合物，其包含能够结合流感病毒RNA聚合酶的PB2蛋白的封端寡核苷酸和药学上可接受的载体或稀释的具有式（I）结构的所述封端寡核苷酸：其中ppp是三磷酸桥，p 是单磷酸桥，m7G是在5'末端与所述ppp结合的7-甲基鸟苷类，X是2'-O-甲基鸟苷或鸟苷酸，所述2'-O-甲基鸟苷或鸟苷基结合于其5'端至所述ppp，并且在其3'末端与所述p结合，Y是在其5'末端与所述p结合并且具有5至11个碱基的寡核糖核苷酸部分。药物组合物可以抑制流感病毒的蛋白质表达。

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