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1. 发明授权

US07790725B2 Thiazolidine derivatives and medicinal use thereof 有权
标题翻译：噻唑烷衍生物及其医药用途
公开(公告)号：US07790725B2
公开(公告)日：2010-09-07
申请号：US11774941
申请日：2007-07-09
申请人： Hiroshi Sakashita , Tomohiro Yoshida , Hiroshi Kitajima , Masahiro Takeuchi , Yoshihito Tanaka , Takuya Yoshimura , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Sakashita , Tomohiro Yoshida , Hiroshi Kitajima , Masahiro Takeuchi , Yoshihito Tanaka , Takuya Yoshimura , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61K31/435 , A61K31/496 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
CPC分类号： C07D277/04
摘要： A thiazolidine derivative represented by the formula (I) wherein each symbol is as defined in the specification, and a pharmaceutically acceptable salt thereof exhibit a potent DPP-IV inhibitory activity, and can be provided as an agent for the prophylaxis or treatment of diabetes, an agent for the prophylaxis or treatment of obesity and the like.
摘要翻译：由式（I）表示的噻唑烷衍生物，其中每个符号如说明书中所定义，及其药学上可接受的盐显示出有效的DPP-IV抑制活性，并且可以作为预防或治疗糖尿病，用于预防或治疗肥胖症等的药剂。

2. 发明申请

US20060173056A1 Proline derivatives and use thereof as drugs 审中-公开
公开(公告)号：US20060173056A1
公开(公告)日：2006-08-03
申请号：US11351118
申请日：2006-02-10
申请人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61K31/427 , A61K31/4025 , C07D417/02 , C07D403/02
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04
摘要： The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.

3. 发明申请

US20050245538A1 Proline derivatives and use thereof as drugs 有权
标题翻译：脯氨酸衍生物和作为药物的用途
公开(公告)号：US20050245538A1
公开(公告)日：2005-11-03
申请号：US11142523
申请日：2005-06-02
申请人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61P1/02 , A61P3/04 , A61P3/10 , A61P13/08 , A61P17/00 , A61P31/18 , A61P35/04 , A61P37/06 , A61P43/00 , C07D207/16 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04 , C07D498/04 , A61K31/496 , A61K31/427 , A61K31/454 , C07D417/02
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04
摘要： The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products. The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
摘要翻译：本发明旨在提供由于DPP-IV抑制作用而具有治疗作用的化合物，并且作为药物产品令人满意。本发明人发现具有引入式（I）表示的脯氨酸的γ-位置的取代基的衍生物，其中每个符号如说明书中所定义，具有有效的DPP-IV抑制活性，并通过增加稳定性。

4. 发明授权

US07074794B2 Proline derivatives and the use thereof as drugs 有权
标题翻译：脯氨酸衍生物及其作为药物的用途
公开(公告)号：US07074794B2
公开(公告)日：2006-07-11
申请号：US10344255
申请日：2001-08-10
申请人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61K31/495 , C07D403/04
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04
摘要： The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products.The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
摘要翻译：本发明旨在提供由于DPP-IV抑制作用而具有治疗作用的化合物，并且作为药物产品令人满意。本发明人发现具有引入式（I）表示的脯氨酸的γ-位置的取代基的衍生物，其中每个符号如说明书中所定义，具有有效的DPP-IV抑制活性，并通过增加稳定性。

5. 发明授权

US07060722B2 Proline derivatives and use thereof as drugs 有权
标题翻译：脯氨酸衍生物和作为药物的用途
公开(公告)号：US07060722B2
公开(公告)日：2006-06-13
申请号：US11142523
申请日：2005-06-02
申请人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Hiroshi Kitajima , Hiroshi Sakashita , Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61K31/4025 , A61K31/427
CPC分类号： C07D401/14 , C07D207/16 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/10 , C07D487/04
摘要： The present invention aims at providing compounds having therapeutic effects due to a DPP-IV inhibitory action, and satisfactory as pharmaceutical products.The present inventors have found that derivatives having a substituent introduced into the γ-position of proline represented by the formula (I) wherein each symbol is as defined in the specification, have a potent DPP-IV inhibitory activity, and completed the present invention by increasing the stability.
摘要翻译：本发明旨在提供由于DPP-IV抑制作用而具有治疗作用的化合物，并且作为药物产品令人满意。本发明人发现具有引入式（I）表示的脯氨酸的γ-位置的取代基的衍生物，其中每个符号如说明书中所定义，具有有效的DPP-IV抑制活性，并通过增加稳定性。

6. 发明授权

US07504423B2 α-amino acid derivatives and use thereof as medicines 失效
标题翻译： α-氨基酸衍生物及其作为药物的用途
公开(公告)号：US07504423B2
公开(公告)日：2009-03-17
申请号：US10582602
申请日：2004-12-10
申请人： Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A01N43/78 , A61K31/425 , C07D277/04 , C07D277/08
CPC分类号： C07D417/14
摘要： Compounds represented by the α-amino acid derivative or a pharmaceutically acceptable salt thereof of the present invention have a therapeutic effect due to a DPP-IV inhibitory action and useful as pharmaceutical agents for the treatment and/or prophylaxis of diseases relating to a DPP-IV inhibitor.
摘要翻译：由本发明的α-氨基酸衍生物或其药学上可接受的盐表示的化合物由于DPP-IV抑制作用而具有治疗作用，并且可用作用于治疗和/或预防与DPP- IV抑制剂。

7. 发明申请

US20070049619A1 Alpha-amino acid derivatives and use thereof as medicines 失效
标题翻译： α-氨基酸衍生物及其作为药物的用途
公开(公告)号：US20070049619A1
公开(公告)日：2007-03-01
申请号：US10582602
申请日：2004-12-10
申请人： Fumihiko Akahoshi , Yoshiharu Hayashi
发明人： Fumihiko Akahoshi , Yoshiharu Hayashi
IPC分类号： A61K31/454 , A61K31/401 , A61K31/4025 , C07D403/02
CPC分类号： C07D417/14
摘要： Compounds represented by the α-amino acid derivative or a pharmaceutically acceptable salt thereof of the present invention have a therapeutic effect due to a DPP-IV inhibitory action and useful as pharmaceutical agents for the treatment and/or prophylaxis of diseases relating to a DPP-IV inhibitor.
摘要翻译：由本发明的α-氨基酸衍生物或其药学上可接受的盐表示的化合物由于DPP-IV抑制作用而具有治疗作用，并且可用作用于治疗和/或预防与DPP- IV抑制剂。

8. 发明申请

US20090088442A1 PROPHYLACTIC/THERAPEUTIC AGENT FOR ABNORMALITIES OF SUGAR/LIPID METABOLISM 审中-公开
标题翻译：糖/脂肪代谢异常的预防/治疗药物
公开(公告)号：US20090088442A1
公开(公告)日：2009-04-02
申请号：US11912717
申请日：2006-04-26
申请人： Yuji Abe , Aki Kusunoki , Yoshiharu Hayashi , Fumihiko Akahoshi
发明人： Yuji Abe , Aki Kusunoki , Yoshiharu Hayashi , Fumihiko Akahoshi
IPC分类号： A61K31/496 , C07D413/14 , A61P3/08 , A61P3/06
CPC分类号： A61K31/496 , C07D417/14
摘要： The present invention provides a pharmaceutical agent for the treatment and/or prophylaxis of abnormal blood glucose and lipid metabolism associated with eating, for which a sufficient treatment method or a therapeutic drug has not been found.
摘要翻译：本发明提供了用于治疗和/或预防与进食相关的异常血糖和脂质代谢的药剂，其中尚未发现足够的治疗方法或治疗药物。

9. 发明授权

US08554706B2 Power plant control device which uses a model, a learning signal, a correction signal, and a manipulation signal 有权
标题翻译：使用模型，学习信号，校正信号和操作信号的发电厂控制装置
公开(公告)号：US08554706B2
公开(公告)日：2013-10-08
申请号：US13415876
申请日：2012-03-09
申请人： Yoshiharu Hayashi , Akihiro Yamada , Takaaki Sekiai , Satoru Shimizu , Masayuki Fukai
发明人： Yoshiharu Hayashi , Akihiro Yamada , Takaaki Sekiai , Satoru Shimizu , Masayuki Fukai
IPC分类号： G06E1/00 , G05B13/02
CPC分类号： G05B13/027
摘要： A gas concentration estimation device of a coal-burning boiler adapted to estimate the concentration of the gas component included in an exhaust gas emitted from a coal-burning boiler using a neural network, including: a process database section adapted to store process data of a coal-burning boiler; a filtering processing section adapted to perform filtering processing for extracting data suitable for learning of a neural network from the process data stored in the process database section; a neural-network learning processing section adapted to perform learning processing of the neural network based on the data extracted by the filtering processing section and suitable for learning of the neural network; and a neural-network estimation processing section adapted to perform estimation processing of the CO concentration or the NOx concentration in the exhaust gas emitted from the coal-burning boiler based on the learning processing of the neural-network learning processing section.
摘要翻译：一种燃煤锅炉的气体浓度估计装置，其适用于使用神经网络来估计从燃煤锅炉排出的排气中所含的气体成分的浓度，所述气体成分估算装置包括：处理数据库部，其适于存储燃煤锅炉; 滤波处理部，其适于进行从存储在所述处理数据库部中的处理数据中提取适于神经网络的学习的数据的滤波处理; 神经网络学习处理部分，适于基于由所述滤波处理部分提取并适合于所述神经网络的学习来执行所述神经网络的学习处理; 以及神经网络估计处理部，其基于神经网络学习处理部的学习处理，对从燃煤锅炉排出的排气中的CO浓度或NOx浓度进行估计处理。

10. 发明授权

US08413596B2 Oxyfuel boiler and a method of controlling the same 有权
标题翻译：氧气锅炉及其控制方法
公开(公告)号：US08413596B2
公开(公告)日：2013-04-09
申请号：US12581724
申请日：2009-10-19
申请人： Yoshiharu Hayashi , Akihiro Yamada , Tsuyoshi Shibata
发明人： Yoshiharu Hayashi , Akihiro Yamada , Tsuyoshi Shibata
IPC分类号： F23N5/02
CPC分类号： F23C9/003 , F01K13/02 , F22B35/002 , F22B35/18 , F23C2202/30 , F23L7/007 , F23L2900/07001 , F23N1/042 , F23N5/006 , F23N2021/12 , F23N2037/20 , F23N2037/28 , Y02E20/322 , Y02E20/344
摘要： An oxyfuel boiler 1 is equipped with an oxygen separation apparatus 23 to produce oxygen by separating oxygen from the air, a recirculation fan 26 to supply a portion of combustion flue gas branched from the combustion flue gas discharged from the boiler to the oxyfuel boiler 1, a temperature sensor 14a to detect gas temperature at a boiler outlet 1d in the oxyfuel boiler 1, and a control apparatus 150 to calculate gas temperature at a furnace outlet 1c in the boiler from the gas temperature at the boiler outlet 1d detected by the temperature sensor 14a and control the operating condition of the recirculation fan 26 so that the calculated gas temperature at the furnace outlet 1c becomes a desired preset gas temperature.
摘要翻译：氧燃料锅炉1配备有通过从空气中分离氧而产生氧的氧分离装置23，再循环风扇26，以将从锅炉排出的燃烧烟道气分支的一部分燃烧烟道气供应到氧燃料锅炉1，用于检测氧燃料锅炉1中的锅炉出口1d处的气体温度的温度传感器14a以及从由温度传感器检测到的锅炉出口1d处的气体温度来计算锅炉中炉出口1c处的气体温度的控制装置150 并且控制再循环风扇26的操作状态，使得炉出口1c处的计算出的气体温度成为期望的预设气体温度。

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