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1. 发明授权

US09274123B2 Method for analysis of compounds with amino group and analytical reagent therefor 有权
公开(公告)号：US09274123B2
公开(公告)日：2016-03-01
申请号：US11514130
申请日：2006-09-01
申请人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
发明人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
IPC分类号： G01N30/72 , G01N33/68
CPC分类号： G01N33/58 , C07D207/46 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2458/15 , G01N2560/00 , Y10T436/13 , Y10T436/14 , Y10T436/145555 , Y10T436/24
摘要： The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.

2. 发明申请

US20060286673A1 Method for analysis of compounds with amino group and analytical reagent therefor 审中-公开
标题翻译：氨基化合物分析方法及分析试剂
公开(公告)号：US20060286673A1
公开(公告)日：2006-12-21
申请号：US11514130
申请日：2006-09-01
申请人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
发明人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
IPC分类号： G01N33/00 , C07D207/48 , C07D403/02
CPC分类号： G01N33/58 , C07D207/46 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2458/15 , G01N2560/00 , Y10T436/13 , Y10T436/14 , Y10T436/145555 , Y10T436/24
摘要： The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.
摘要翻译：本发明提供了用于分析样品中所含的氨基（例如氨基酸或肽）的化合物的方法，并且以高灵敏度方便地进行分析。含有氨基化合物的样品中具有氨基的化合物用特定的氨基甲酸酯化合物如对三甲基铵苯乙烯基-N-羟基琥珀酰亚胺基氨基甲酸酯碘化物进行标记以提高选择性和灵敏度。本发明优选与诸如MS / MS方法的质谱结合使用以促进定量分析。本发明还提供用于质谱的标记试剂。

3. 发明申请

US20050079624A1 Method for analysis of compounds with amino group and analytical reagent therefor 有权
标题翻译：氨基化合物分析方法及分析试剂
公开(公告)号：US20050079624A1
公开(公告)日：2005-04-14
申请号：US10918380
申请日：2004-08-16
申请人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
发明人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
IPC分类号： G01N33/68 , G01N33/00 , C07D215/38 , C07K14/47 , C07D41/02 , C07D43/02
CPC分类号： G01N33/58 , C07D207/46 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2458/15 , G01N2560/00 , Y10T436/13 , Y10T436/14 , Y10T436/145555 , Y10T436/24
摘要： The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.
摘要翻译：本发明提供了用于分析样品中所含的氨基（例如氨基酸或肽）的化合物的方法，并且以高灵敏度方便地进行分析。含有氨基化合物的样品中具有氨基的化合物用特定的氨基甲酸酯化合物如对三甲基铵苯乙烯基-N-羟基琥珀酰亚胺基氨基甲酸酯碘化物进行标记以提高选择性和灵敏度。本发明优选与诸如MS / MS方法的质谱结合使用以促进定量分析。本发明还提供用于质谱的标记试剂。

4. 发明授权

US07148069B2 Method for analysis of compounds with amino group and analytical reagent therefor 有权
公开(公告)号：US07148069B2
公开(公告)日：2006-12-12
申请号：US10918380
申请日：2004-08-16
申请人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
发明人： Hiroshi Miyano , Akihisa Yahashi , Kazutaka Shimbo , Masakazu Nakazawa , Kazuo Hirayama
IPC分类号： G01N33/00 , G01N24/00 , C07D215/38
CPC分类号： G01N33/58 , C07D207/46 , G01N33/6803 , G01N33/6806 , G01N33/6848 , G01N2458/15 , G01N2560/00 , Y10T436/13 , Y10T436/14 , Y10T436/145555 , Y10T436/24
摘要： The present invention provides a method for the analysis of a compound with amino group (e.g., an amino acid or peptide) contained in a sample and convenient manner with a high sensitivity. The compound with amino group in a sample containing the compound with amino group is labeled with a specific carbamate compound such as p-trimethylammonium anilyl-N-hydroxysuccinimidyl carbamate iodide to enhance the selectivity and sensitivity. The present invention is preferably used in conjunction with mass spectrometry such as MS/MS method to facilitate quantitative analysis. The present invention further provides labeling reagents for mass spectrometry.

5. 发明授权

US07494815B2 Method and apparatus for analyzing compounds with amino group 有权
标题翻译：用氨基分析化合物的方法和装置
公开(公告)号：US07494815B2
公开(公告)日：2009-02-24
申请号：US11563324
申请日：2006-11-27
申请人： Kazutaka Shimbo , Takashi Ohnuki , Hiroshi Miyano
发明人： Kazutaka Shimbo , Takashi Ohnuki , Hiroshi Miyano
IPC分类号： G01N27/62 , G01N30/72
CPC分类号： G01N33/6809 , G01N30/88 , G01N2030/8813 , G01N2030/8818 , Y10T436/145555 , Y10T436/24
摘要： The present invention provides a method and apparatus for analyzing compounds with amino group(s) contained in biological organisms. In this method, a compound with amino group(s) is derivatized and then the derivative of the compound with amino group(s) is eluted by liquid chromatography using a stepwise elution means on a concentration gradient. Subsequently, the derivative of the compound with amino group(s) eluted from the liquid chromatography is detected by mass spectrometry.
摘要翻译：本发明提供了一种用于分析生物有机体中含有氨基的化合物的方法和装置。在该方法中，将具有氨基的化合物衍生化，然后通过液相色谱法使用逐步洗脱方法在浓度梯度上洗脱具有氨基的化合物的衍生物。随后，通过质谱检测从液相色谱法洗脱出的具有氨基的化合物的衍生物。

6. 发明申请

US20150064792A1 STANDARD SOLUTION FOR USE IN ANALYSIS OF AMINO ACID IN PLASMA 有权
标题翻译：在等离子体中氨基酸分析中使用的标准溶液
公开(公告)号：US20150064792A1
公开(公告)日：2015-03-05
申请号：US14232073
申请日：2012-07-19
申请人： Masako Hayakawa , Kazutaka Shimbo , Hiroo Yoshida
发明人： Masako Hayakawa , Kazutaka Shimbo , Hiroo Yoshida
IPC分类号： G01N33/96 , G01N33/68
CPC分类号： G01N33/96 , G01N33/6806 , G01N33/6848 , G01N2030/042 , G01N2496/80 , Y10T436/105831 , Y10T436/106664
摘要： An external standard solution for use in the analysis of amino acid in plasma, containing, (1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A, [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.
摘要翻译：用于血浆中氨基酸分析的外标溶液，其含有（1）选自以下组分A中的至少一种氨基酸，浓度为0.0007M至0.49M，和（2）（i）选自以下组分B中的至少一种氨基酸，选自组分A的氨基酸中浓度为最低浓度氨基酸的0.2至0.9倍，（ii）至少一种选自以下组分C，浓度为选自组分A的氨基酸中的最低浓度氨基酸的0.1至0.4倍，或（iii）至少一种选自以下组分D的氨基酸，浓度为0.05至0.2倍选自组分A，[组分A]缬氨酸，甘氨酸，丙氨酸和谷氨酰胺的氨基酸中的最低浓度氨基酸[组分B]丝氨酸，脯氨酸，苏氨酸，牛磺酸，亮氨酸，异亮氨酸，赖氨酸，组氨酸，苯丙氨酸和酪氨酸[组分 C] 天冬酰胺，鸟氨酸，精氨酸和色氨酸[组分D]谷氨酸，甲硫氨酸，瓜氨酸和胱氨酸。

7. 发明授权

US09638706B2 Standard solution for use in analysis of amino acid in plasma 有权
公开(公告)号：US09638706B2
公开(公告)日：2017-05-02
申请号：US14232073
申请日：2012-07-19
申请人： Masako Hayakawa , Kazutaka Shimbo , Hiroo Yoshida
发明人： Masako Hayakawa , Kazutaka Shimbo , Hiroo Yoshida
IPC分类号： G01N33/68 , G01N33/96 , G01N30/04
CPC分类号： G01N33/96 , G01N33/6806 , G01N33/6848 , G01N2030/042 , G01N2496/80 , Y10T436/105831 , Y10T436/106664
摘要： An external standard solution for use in the analysis of amino acid in plasma, containing,(1) at least one amino acid selected from the following components A, at a concentration of 0.0007 M to 0.49 M, and (2) (i) at least one amino acid selected from the following components B, at a concentration of 0.2 to 0.9 times of the lowest-concentration amino acid among the amino acids selected from components A, (ii) at least one amino acid selected from the following components C, at a concentration of 0.1 to 0.4 times of the lowest-concentration amino acid among amino acids selected from the components A, or (iii) at least one amino acid selected from the following components D, at a concentration of 0.05 to 0.2 times of the lowest-concentration amino acid among amino acids selected from the components A; [Components A] valine, glycine, alanine and glutamine [Components B] serine, proline, threonine, taurine, leucine, isoleucine, lysine, histidine, phenylalanine and tyrosine [Components C] asparagine, ornithine, arginine and tryptophan [Components D] glutamic acid, methionine, citrulline and cystine.

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