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1. 发明授权

US6092780A Low-bed type seismic isolator for display case 失效
标题翻译：用于展示柜的低床型隔震器
公开(公告)号：US6092780A
公开(公告)日：2000-07-25
申请号：US184477
申请日：1998-11-02
申请人： Hiroshi Kurabayashi , Nobuyuki Sone , Akira Matsuda , Daisuke Yaguchi , Toshio Omi , Hidesi Ito , Tomoya Ishida , Kazuhiko Maebayashi , Keiji Hasegawa , Haruhisa Inoue , Toshiyuki Imaki
发明人： Hiroshi Kurabayashi , Nobuyuki Sone , Akira Matsuda , Daisuke Yaguchi , Toshio Omi , Hidesi Ito , Tomoya Ishida , Kazuhiko Maebayashi , Keiji Hasegawa , Haruhisa Inoue , Toshiyuki Imaki
IPC分类号： E04H9/02 , F16M13/00
CPC分类号： E04H9/021
摘要： A low-bed type seismic isolator for a display case, which includes: at least two lines of arcuate X-rails (3) fixed to a lower plate (1) on a foundation and having lower central portions and higher end portions; at least two lines of arcuate Y-rails (4) fixed to a lower surface of an upper plate (2) above the X-rails (3) and having higher central portions and lower end portions in a direction perpendicularly to the X-rails; connection blocks (5) having lower portions clamping the X-rails, upper portions clamping the Y-rails, and a disk spring provided at the central portions thereof; absorbers (8) disposed on the ends of the X-rails and Y-rails and recesses which fixedly accommodates support legs (7) fixed to the lower surface of the upper plate and protruded downwardly from a seismic isolation object. The seismic isolator does not substantially change the height of a seismic isolation object, and can be applied, for instance, to a display case of a museum, so as to provide the effective seismic isolation as well as to facilitate an inspection to a displayed exhibit The additional provision of casters makes it possible to readily move the seismic isolator to any arbitrary place.
摘要翻译：一种用于展示柜的低床型地震隔离器，其包括：固定到基座上的下板（1）的至少两条弧形X形轨道（3），并具有下中央部分和较高端部; 至少两条弧形的Y形导轨（4）固定到X导轨（3）上方的上板（2）的下表面，并且在垂直于X导轨的方向上具有较高的中心部分和下端部 ; 连接块（5）具有夹紧X导轨的下部，夹紧Y形导轨的上部和设置在其中心部分的盘形弹簧; 设置在X导轨和Y导轨的端部上的吸收器（8）和固定地容纳固定到上板的下表面并从地震隔离物体向下突出的支撑腿（7）的凹槽。地震隔离器基本上不改变地震隔离物的高度，并且可以应用于例如博物馆的展示柜，以便提供有效的隔震，并且便于对所展示的展览进行检查脚轮的额外设置使得可以方便地将地震隔离器移动到任何地方。

2. 发明授权

US09097727B2 Method for diagnosing a protein misfolding disease using nerve cells derived from iPS cells 有权
标题翻译：使用源自iPS细胞的神经细胞诊断蛋白质错折叠疾病的方法
公开(公告)号：US09097727B2
公开(公告)日：2015-08-04
申请号：US13582403
申请日：2011-03-03
申请人： Haruhisa Inoue , Shiho Kitaoka , Naoki Yahata , Nobuhisa Iwata , Takaomi Saido
发明人： Haruhisa Inoue , Shiho Kitaoka , Naoki Yahata , Nobuhisa Iwata , Takaomi Saido
IPC分类号： G01N33/48 , G01N33/50 , G01N33/573 , G01N33/68 , C12N5/0793
CPC分类号： G01N33/6896 , C12N5/0619 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2501/155 , C12N2501/385 , C12N2501/41 , C12N2501/91 , C12N2503/02 , C12N2506/00 , C12N2506/45 , C12N2533/32 , G01N2333/4709 , G01N2333/96486 , G01N2800/2821
摘要： The present invention provides a method for detecting onset of, or the risk of development of, a protein misfolding disease, and a method for predicting the age of onset of a protein misfolding disease using nerve cells derived from iPS cells. The present invention also provides a kit to be used in these methods.
摘要翻译：本发明提供了一种用于检测蛋白质错折叠疾病的发病或发展的风险的方法，以及使用源自iPS细胞的神经细胞来预测蛋白质错折叠疾病发病年龄的方法。本发明还提供了用于这些方法的试剂盒。

3. 发明申请

US20130115622A1 PHARMACEUTICAL COMPOSITION FOR PREVENTION AND TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS 审中-公开
标题翻译：用于预防和治疗左心室狭窄的药物组合物
公开(公告)号：US20130115622A1
公开(公告)日：2013-05-09
申请号：US13515897
申请日：2010-12-14
申请人： Haruhisa Inoue , Norio Nakatsuji , Shiho Kitaoka , Kayoko Tsukita , Ryosuke Takahashi , Gaku Murakami , Yuji Amagai , Kazuhiro Aiba
发明人： Haruhisa Inoue , Norio Nakatsuji , Shiho Kitaoka , Kayoko Tsukita , Ryosuke Takahashi , Gaku Murakami , Yuji Amagai , Kazuhiro Aiba
IPC分类号： G01N33/50
CPC分类号： G01N33/5073 , A61K31/40 , A61K45/06 , C12N5/0622 , C12N5/0696 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/235 , C12N2501/60 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/91 , C12N2506/45 , C12N2533/32 , C12N2533/90 , G01N33/5058 , G01N33/6896 , G01N2333/90283 , G01N2500/10 , G01N2800/28 , G01N2800/2835 , A61K2300/00
摘要： Provided are a prophylactic and therapeutic agent for amyotrophic lateral sclerosis containing an HMG-CoA reductase inhibitor and a method of screening for a prophylactic and therapeutic drug for amyotrophic lateral sclerosis using an induced pluripotent stem cell derived from a patient with amyotrophic lateral sclerosis.
摘要翻译：提供含有HMG-CoA还原酶抑制剂的肌萎缩性侧索硬化症的预防和治疗剂以及使用来自患有肌萎缩性侧索硬化症的患者的诱导性多能干细胞筛选用于肌萎缩性侧索硬化的预防和治疗药物的方法。

4. 发明授权

US08945576B2 Vaccine for treatment of tautopathy 有权
标题翻译：用于治疗tautopathy的疫苗
公开(公告)号：US08945576B2
公开(公告)日：2015-02-03
申请号：US13520968
申请日：2011-01-11
申请人： Haruhisa Inoue , Hiroki Takeuchi , Ryosuke Takahashi , Makoto Higuchi , Bin Ji , Tetsuya Suhara
发明人： Haruhisa Inoue , Hiroki Takeuchi , Ryosuke Takahashi , Makoto Higuchi , Bin Ji , Tetsuya Suhara
IPC分类号： A61K39/00 , A61K38/00 , A61K38/16 , C07K14/47
CPC分类号： C07K14/4711 , A61K39/0005 , A61K39/0007 , A61K2039/5256 , A61K2039/53 , C07K2319/02 , C12N2799/021
摘要： This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要翻译：本发明涉及用于预防或治疗tau蛋白病的疫苗，其包含作为活性成分的载体，其包含编码与分泌信号序列连接的突变型tau蛋白的核酸，其中所述疫苗能够诱导针对（任选地与直接施用突变型tau蛋白的情况相比，以更持续的方式在受试者中磷酸化tau蛋白。

5. 发明申请

US20100242126A1 Regulator of ephrin-Eph receptor signaling and mouse having abnormal ephrin-Eph receptor signaling mechanisms 失效
标题翻译： ephrin-Eph受体信号传导调节因子和ephrin-Eph受体信号转导机制异常
公开(公告)号：US20100242126A1
公开(公告)日：2010-09-23
申请号：US12230016
申请日：2008-08-21
申请人： Takuji Iwasato , Shigeyoshi Itohara , Ryosuke Takahashi , Haruhisa Inoue
发明人： Takuji Iwasato , Shigeyoshi Itohara , Ryosuke Takahashi , Haruhisa Inoue
IPC分类号： C12Q1/02 , C07H21/04 , C07K16/18 , A01K67/027
CPC分类号： C07K14/4705 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , G01N33/6863 , G01N2333/52
摘要： It is intended to provide an agent for regulating axon extension during neuranagenesis by regulating ephrin-Eph receptor signaling mechanisms and to provide a mouse having abnormal ephrin-Eph receptor signaling mechanisms. The present invention relates to a regulator of axon extension, comprising an agent for promoting or suppressing the function of α-chimerin, and to a miffy (mfy) mouse derived from a B6 strain, which displays autosomal recessive inheritance of an abnormal walking trait exhibiting a hopping gait with left-right synchronized movement of limbs and has mutation in an α-chimerin gene.
摘要翻译：旨在提供通过调节ephrin-Eph受体信号传导机制来调节神经元生成过程中轴突延伸的药剂，并提供具有异常ephrin-Eph受体信号传导机制的小鼠。本发明涉及一种轴突延伸调节剂，其包含用于促进或抑制α-嵌合蛋白的功能的药剂，以及衍生自B6株的miffy（mfy）小鼠，其显示出异常行走特征的常染色体隐性遗传具有左右同步运动的跳跃步态并且在α-嵌合体基因中具有突变。

6. 发明申请

US20060051835A1 Pael receptor, cells and animal expressing pael receptor and method of screning remedy for parkinson's disease 审中-公开
标题翻译： Pael受体，表达pael受体的细胞和动物，以及帕金森氏病的治疗方法
公开(公告)号：US20060051835A1
公开(公告)日：2006-03-09
申请号：US10482028
申请日：2002-06-28
申请人： Ryosuke Takahashi , Yuzuru Imai , Nobutaka Hattori , Yoshikuni Mizuno , Mariko Soda , Haruhisa Inoue
发明人： Ryosuke Takahashi , Yuzuru Imai , Nobutaka Hattori , Yoshikuni Mizuno , Mariko Soda , Haruhisa Inoue
IPC分类号： A01K67/027 , C07H21/04 , C12P21/06 , C07K14/705 , C12N5/06
CPC分类号： G01N33/5011 , A01K2217/05 , C07K14/705 , C07K14/72 , C07K16/28 , G01N33/5008 , G01N33/566 , G01N33/6896 , G01N33/74 , G01N2500/00 , G01N2500/20 , G01N2800/2835
摘要： An object of the present invention is to provide a substrate of Parkin, a system for elucidating the cause of Parkinson's disease using the substrate and a method of screening for a remedy for Parkinson's disease. An animal cell having a DNA encoding a human Pael receptor or a DNA having a variant of the DNA incorporated therein; a non-human mammal having a DNA carrying the aforementioned DNA incorporated therein; a probe comprising the whole or a part of DNA encoding the human Pael receptor; and an antibody specifically recognizing Pael receptor.
摘要翻译：本发明的一个目的是提供一种Parkin的底物，一种使用该底物来阐明帕金森氏病的原因的系统和一种筛选帕金森氏病的药物的方法。具有编码人Pael受体的DNA或其中掺入DNA的变体的DNA的动物细胞; 具有携带上述DNA的DNA的非人哺乳动物; 包含编码人Pael受体的全部或部分DNA的探针; 和特异性识别Pael受体的抗体。

7. 发明授权

US5499144A Magnetic recording/playback apparatus which shifts the head scan by a 1/2 t r 失效
标题翻译：磁记录/重放装置，其在高速重放期间将头部扫描偏移1/2道间距
公开(公告)号：US5499144A
公开(公告)日：1996-03-12
申请号：US106722
申请日：1993-08-16
申请人： Sadayuki Inoue , Junko Ishimoto , Haruhisa Inoue , Ken Onishi
发明人： Sadayuki Inoue , Junko Ishimoto , Haruhisa Inoue , Ken Onishi
IPC分类号： G11B5/008 , G11B5/09 , G11B15/12 , G11B15/18 , G11B15/467 , G11B20/12 , G11B27/00 , H04N5/7826 , H04N5/783 , H04N5/945 , H04N9/797 , H04N9/804 , G11B5/584
CPC分类号： G11B15/4672 , G11B15/1875 , G11B15/4678 , G11B20/1207 , G11B27/005 , G11B5/0086 , G11B5/09 , H04N9/8047 , G11B15/125 , G11B15/4671 , G11B2220/90 , H04N5/78266 , H04N5/783 , H04N5/945 , H04N9/7973
摘要： In a magnetic recording/playback apparatus for recording and playing back a digital video signal on a helical track of a magnetic tape using two or more rotary heads, the playback image at the time of high-speed playback is improved by setting the tape travel speed at the time of high-speed playback at an even multiple of a normal playback speed. Further a tracking phase is offset by one half the track pitch with respect to the tracking during normal speed playback. Alternatively, essential information of the information having been high-efficiency coded is recorded in the central part, and near the ends of the tracks, while high-precision information is recorded in intermediate parts intermediate between the central part and the parts near the ends. Still alternatively, the video data of one of the consecutive fields is recorded in the central part of the tracks and the video data of the other of the consecutive fields is recorded near the ends of the tracks.
摘要翻译：在用于使用两个或多个旋转磁头在磁带的螺旋磁道上记录和重放数字视频信号的磁记录/重放装置中，通过设置磁带行进速度来改善高速重放时的重放图像在正常播放速度的偶数倍的高速播放时。此外，在正常速度重放期间，跟踪相位相对于跟踪偏移了一半的轨道间距。或者，高精度编码的信息的基本信息被记录在中央部分和轨道的端部附近，而高精度信息被记录在中心部分和靠近端部的部分之间的中间部分。或者，连续场中的一个的视频数据被记录在轨道的中心部分，并且另外一个连续场的视频数据被记录在轨迹的末端附近。

8. 发明申请

US20130189289A1 VACCINE FOR TREATMENT OF TAUTOPATHY 有权
标题翻译：用于治疗胃肠病的疫苗
公开(公告)号：US20130189289A1
公开(公告)日：2013-07-25
申请号：US13520968
申请日：2011-01-11
申请人： Haruhisa Inoue , Hiroki Takeuchi , Ryosuke Takahashi , Makoto Higuchi , Bin Ji , Tetsuya Suhara
发明人： Haruhisa Inoue , Hiroki Takeuchi , Ryosuke Takahashi , Makoto Higuchi , Bin Ji , Tetsuya Suhara
IPC分类号： C07K14/47
CPC分类号： C07K14/4711 , A61K39/0005 , A61K39/0007 , A61K2039/5256 , A61K2039/53 , C07K2319/02 , C12N2799/021
摘要： This invention relates to a vaccine for preventing or treating tautopathy, comprising a vector, as an active ingredient, comprising a nucleic acid encoding a mutant tau protein linked to a secretion signal sequence, wherein the vaccine is capable of inducing an antibody against an (optionally phosphorylated) tau protein in a subject in a more sustained manner compared with a case where the mutant tau protein is administered directly.
摘要翻译：本发明涉及用于预防或治疗tau蛋白病的疫苗，其包含作为活性成分的载体，其包含编码与分泌信号序列连接的突变型tau蛋白的核酸，其中所述疫苗能够诱导针对（任选地与直接施用突变型tau蛋白的情况相比，以更持续的方式在受试者中磷酸化tau蛋白。

9. 发明授权

US08337812B2 Regulator of ephrin-Eph receptor signaling and mouse having abnormal ephrin-Eph receptor signaling mechanisms 失效
标题翻译： ephrin-Eph受体信号传导调节因子和ephrin-Eph受体信号转导机制异常
公开(公告)号：US08337812B2
公开(公告)日：2012-12-25
申请号：US12230016
申请日：2008-08-21
申请人： Takuji Iwasato , Shigeyoshi Itohara , Ryosuke Takahashi , Haruhisa Inoue
发明人： Takuji Iwasato , Shigeyoshi Itohara , Ryosuke Takahashi , Haruhisa Inoue
IPC分类号： A61K49/00 , C12Q1/00 , G01N33/53
CPC分类号： C07K14/4705 , A01K67/0275 , A01K67/0276 , A01K2217/052 , A01K2217/075 , A01K2217/15 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , G01N33/6863 , G01N2333/52
摘要： It is intended to provide an agent for regulating axon extension during neuranagenesis by regulating ephrin-Eph receptor signaling mechanisms and to provide a mouse having abnormal ephrin-Eph receptor signaling mechanisms. The present invention relates to a regulator of axon extension, comprising an agent for promoting or suppressing the function of α-chimerin, and to a miffy (mfy) mouse derived from a B6 strain, which displays autosomal recessive inheritance of an abnormal walking trait exhibiting a hopping gait with left-right synchronized movement of limbs and has mutation in an α-chimerin gene.
摘要翻译：旨在提供通过调节ephrin-Eph受体信号传导机制来调节神经元生成过程中轴突延伸的药剂，并提供具有异常ephrin-Eph受体信号传导机制的小鼠。本发明涉及一种轴突延伸调节剂，其包含用于促进或抑制α-嵌合蛋白的功能的药剂，以及衍生自B6株的miffy（mfy）小鼠，其显示出异常行走特征的常染色体隐性遗传具有左右同步运动的跳跃步态并且在α-嵌合体基因中具有突变。

10. 发明授权

US5739968A Recording/playback apparatus for dividing encoded digital video data into essential information and high-precision information and for recording both the high-precision information onto a magnetic tape 失效
标题翻译：用于将编码的数字视频数据划分为基本信息和高精度信息并将高精度信息记录在磁带上的记录/重放装置
公开(公告)号：US5739968A
公开(公告)日：1998-04-14
申请号：US575035
申请日：1995-12-19
申请人： Sadayuki Inoue , Junko Ishimoto , Haruhisa Inoue , Ken Onishi
发明人： Sadayuki Inoue , Junko Ishimoto , Haruhisa Inoue , Ken Onishi
IPC分类号： G11B5/008 , G11B5/09 , G11B15/12 , G11B15/18 , G11B15/467 , G11B20/12 , G11B27/00 , H04N5/7826 , H04N5/783 , H04N5/945 , H04N9/797 , H04N9/804 , G11B5/584
CPC分类号： G11B15/4672 , G11B15/1875 , G11B15/4678 , G11B20/1207 , G11B27/005 , G11B5/0086 , G11B5/09 , H04N9/8047 , G11B15/125 , G11B15/4671 , G11B2220/90 , H04N5/78266 , H04N5/783 , H04N5/945 , H04N9/7973
摘要： In a magnetic recording/playback apparatus for recording and playing back a digital video signal on a helical track of a magnetic tape using two or more rotary heads, the playback image at the time of high-speed playback is improved by setting the tape travel speed at the time of high-speed playback at an even multiple of a normal playback speed. Further, a tracking phase is offset by one half the track pitch with respect to the tracking during normal speed playback. Alternatively, essential information of the information having been high-efficiency coded is recorded in the central part, and near the ends of the tracks, while high-precision information is recorded in intermediate parts intermediate between the central part and the parts near the ends. Still alternatively, the video data of one of the consecutive fields is recorded in the central part of the tracks and the video data of the other of the consecutive fields is recorded near the ends of the tracks.
摘要翻译：在用于使用两个或多个旋转磁头在磁带的螺旋磁道上记录和重放数字视频信号的磁记录/重放装置中，通过设置磁带行进速度来改善高速重放时的重放图像在正常播放速度的偶数倍的高速播放时。此外，在正常速度重放期间，跟踪相位相对于跟踪偏移了轨道间距的一半。或者，高精度编码的信息的基本信息被记录在中央部分和轨道的端部附近，而高精度信息被记录在中心部分和靠近端部的部分之间的中间部分。或者，连续场中的一个的视频数据被记录在轨道的中心部分，并且另外一个连续场的视频数据被记录在轨迹的末端附近。

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