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1. 发明授权

US08920832B2 Composition for nucleic acid transfection 有权
标题翻译：用于核酸转染的组合物
公开(公告)号：US08920832B2
公开(公告)日：2014-12-30
申请号：US13249120
申请日：2011-09-29
申请人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号： A61K31/7088 , A61K48/00
CPC分类号： A61K31/7088 , A61K48/0025
摘要： The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译：本发明提供了一种显示低细胞毒性的核酸转染组合物，其有利于有效的核酸转染到细胞中，并且其改善细胞中核酸的表达。用于将核酸转染入细胞的组合物含有二（C 12-16烷基）二甲基卤化铵和磷脂。

2. 发明申请

US20130149369A1 COMPOSITION FOR NUCLEIC ACID TRANSFECTION 有权
标题翻译：用于核酸转运的组合物
公开(公告)号：US20130149369A1
公开(公告)日：2013-06-13
申请号：US13249120
申请日：2011-09-29
申请人： Hiroshi KIKUCHI , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人： Hiroshi KIKUCHI , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号： A61K31/7088
CPC分类号： A61K31/7088 , A61K48/0025
摘要： The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译：本发明提供了一种显示低细胞毒性的核酸转染组合物，其有利于有效的核酸转染到细胞中，并且其改善细胞中核酸的表达。用于将核酸转染入细胞的组合物含有二（C 12-16烷基）二甲基卤化铵和磷脂。

3. 发明申请

US20100055684A1 COMPOSITION FOR NUCLEIC ACID TRANSFECTION 审中-公开
标题翻译：用于核酸转运的组合物
公开(公告)号：US20100055684A1
公开(公告)日：2010-03-04
申请号：US12306993
申请日：2007-06-29
申请人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
发明人： Hiroshi Kikuchi , Hideo Kobayashi , Kouichi Hashimoto , Ayako Iijima , Daigo Asano , Junko Yasuda
IPC分类号： C12Q1/68 , C12N15/88
CPC分类号： A61K31/7088 , A61K48/0025
摘要： The invention provides a nucleic-acid-transfecting composition which exhibits low cytotoxicity, which facilitates an effective nucleic acid transfection into a cell, and which improves expression of the nucleic acid in the cell.The composition for transfecting a nucleic acid into a cell, contains a di(C12-16 alkyl)dimethylammonium halide and a phospholipid.
摘要翻译：本发明提供了一种显示低细胞毒性的核酸转染组合物，其有利于有效的核酸转染到细胞中，并且其改善细胞中核酸的表达。将核酸转染入细胞的组合物含有二（C 12-16烷基）二甲基卤化铵和磷脂。

4. 发明申请

US20070112176A1 Lipid membrane structure containing anti-mt-mmp monoclonal antibody 审中-公开
标题翻译：含有抗-mt-mmp单克隆抗体的脂质膜结构
公开(公告)号：US20070112176A1
公开(公告)日：2007-05-17
申请号：US10551780
申请日：2004-04-02
申请人： Motoharu Seiki , Ikuo Yana , Takanori Aoki , Junko Yasuda , Hiroshi Kikuchi , Emi Ishida
发明人： Motoharu Seiki , Ikuo Yana , Takanori Aoki , Junko Yasuda , Hiroshi Kikuchi , Emi Ishida
IPC分类号： A61K9/127 , C07K14/82
CPC分类号： A61K31/704 , A61K9/127 , A61K47/6871 , A61K47/6901 , A61K48/00
摘要： A lipid membrane structure containing an anti-membrane-type matrix metalloproteinase monoclonal antibody such as an anti-MT1-MMP monoclonal antibody as a component of the lipid membrane structure. Said structure can be utilized as a drug delivery system for efficiently delivering a medicinally active ingredient and/or a gene to tumor cells, neoplastic vessel and the like in which a membrane-type matrix metalloproteinase (MT-MMP) is expressed.
摘要翻译：含有抗 - 膜型基质金属蛋白酶单克隆抗体如抗MT1-MMP单克隆抗体作为脂质膜结构的组分的脂质膜结构。所述结构可用作药物递送系统，用于向其中表达膜型基质金属蛋白酶（MT-MMP）的肿瘤细胞，肿瘤血管等有效递送药物活性成分和/或基因。

5. 发明授权

US6147114A Highly water-soluble metalloproteinase inhibitors 失效
标题翻译：高度水溶性金属蛋白酶抑制剂
公开(公告)号：US6147114A
公开(公告)日：2000-11-14
申请号：US945356
申请日：1997-10-24
申请人： Tetsunori Fujisawa , Shinjiro Odake , Yasuo Morita , Tomoko Hongo , Hajime Ito , Junko Yasuda , Eiko Suda , Katsuhiro Igeta , Tadanori Morikawa
发明人： Tetsunori Fujisawa , Shinjiro Odake , Yasuo Morita , Tomoko Hongo , Hajime Ito , Junko Yasuda , Eiko Suda , Katsuhiro Igeta , Tadanori Morikawa
IPC分类号： A61K31/165 , C07C239/06 , C07C259/06 , C07C279/14 , C07C279/16 , C07C305/24 , C07C309/61 , C07C323/60 , C07F9/12 , A01N37/28 , C07C239/14
CPC分类号： C07C323/60 , A61K31/165 , C07C239/06 , C07C259/06 , C07C279/14 , C07C279/16 , C07C305/24 , C07C309/61 , C07F9/12
摘要： New compounds of the general formula (I) ##STR1## (wherein R.sup.1 is a hydrogen atom, or a hydroxyl, aryl (C.sub.1 -C.sub.6)alkylene or --A--SOn--B group (A is a (C.sub.1 -C.sub.6) alkylene group; B is a (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) acyl, aryl or heterocyclyl group; n is 0, 1 or 2), R.sup.2 is a hydrogen atom, or a (C.sub.1 -C.sub.6) alkyl, (C.sub.1 -C.sub.6) alkyloxy 10 or (C.sub.1 -C.sub.6) alkylthio group, R.sup.3 and R.sup.4 are identical or different, representing a hydrogen atom, or a (C.sub.1 -C.sub.6) alkyl, aryl or aryl(C.sub.1 -C.sub.6)alkylene group, R.sup.5 is a --Y--C or C group (Y is a (C.sub.1 -C.sub.6) alkylene group, an oxygen atom, an imino group or a (C.sub.1 -C.sub.6) alkyleneimino group, C is a sulfonic acid, phosphonic acid, amidino, (C.sub.1 -C.sub.6) acyl, acylimidoyl, diphosphonomethine or dicarboxymethine group), and R.sup.6 is a hydrogen atom, or a nonsubstituted or substituted benzyl, trialkylsilyl, tert-butyldiphenylsilyl, tetrahydropyranyl or tert-butyl group) or stereoisomers thereof, and pharmaceutically acceptable salts thereof and solvates thereof, and the process for the preparation thereof, and metalloproteinase inhibitors which comprise one or more compounds selected from those compounds as effective ingredients and inhibit matrix metalloproteinases (MMPs) and/or TNF-.alpha. converting enzyme. Furthermore, the preparation intermediates to obtain the compounds of the formula (I) and the process for the preparation.
摘要翻译： PCT No.PCT / JP96 / 01135 Sec。 371 1997年10月24日第 102（e）1997年10月24日PCT PCT 1996年4月25日PCT公布。 WO96 / 33968 PCT公开号日期：1996年10月31日新化合物通式（Ⅰ）（其中R1是氢原子，或羟基，芳基（C1-C6）亚烷基或-A-SOn-B基团（A是（C1-C6）亚烷基; B是（C1-C6）烷基，（C1-C6）酰基，芳基或杂环基; n是0,1或2），R2是氢原子或（C1-C6）烷基， C1-C6）烷氧基10或（C1-C6）烷硫基，R3和R4相同或不同，代表氢原子或（C1-C6）烷基，芳基或芳基（C1-C6）亚烷基，R5是 -YC或C基（Y是（C1-C6）亚烷基，氧原子，亚氨基或（C1-C6）亚烷基亚氨基），C是磺酸，膦酸，脒基，（C1-C6 ）酰基，酰亚氨基，二亚膦酰基或二羧基甲基），R6为氢原子，或未取代或取代的苄基，三烷基甲硅烷基，叔丁基二苯基甲硅烷基，四氢吡喃基或叔丁基）或其立体异构体及其药学上可接受的盐及其溶剂合物，以及其准备过程 f和金属蛋白酶抑制剂，其包含一种或多种选自那些化合物的化合物作为有效成分并抑制基质金属蛋白酶（MMP）和/或TNF-α转化酶。此外，制备中间体以获得式（I）化合物及其制备方法。

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