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1. 发明授权

US5859244A 1,4-dihydropyridine derivatives and methods of producing the same 失效
标题翻译： 1,4-二氢吡啶衍生物及其制备方法
公开(公告)号：US5859244A
公开(公告)日：1999-01-12
申请号：US855500
申请日：1997-05-13
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
IPC分类号： A61K31/435 , A61K31/4422 , A61K31/4427 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/12 , A61P11/08 , A61P25/28 , A61P29/00 , A61P37/08 , C07D211/90 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D473/08 , C07F7/10 , C07D213/12 , C07D401/04 , C07D403/04
CPC分类号： C07D401/06 , C07D211/90 , C07D213/82 , C07D401/12
摘要： 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.
摘要翻译：公开了具有下式的1,4-二氢吡啶衍生物和光学活性的1,4-二氢吡啶衍生物，其具有基于钙拮抗作用的血管舒张活性和PAF抗体，其制备方法：其中（*）表示在光学活性的1,4-二氢吡啶衍生物的情况下手性中心。

2. 发明授权

US5763614A 1,4-dihydropyridine derivatives and methods of producing the same 失效
标题翻译： 1,4-二氢吡啶衍生物及其制备方法
公开(公告)号：US5763614A
公开(公告)日：1998-06-09
申请号：US258487
申请日：1994-06-10
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
IPC分类号： A61K31/435 , A61K31/4422 , A61K31/4427 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/12 , A61P11/08 , A61P25/28 , A61P29/00 , A61P37/08 , C07D211/90 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D473/08 , C07F7/10 , C07D213/09 , C07D213/12 , C07D213/56 , C07D213/84
CPC分类号： C07D401/06 , C07D211/90 , C07D213/82 , C07D401/12
摘要： 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antagonism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.
摘要翻译：公开了具有下式的1,4-二氢吡啶衍生物和具有基于钙拮抗作用的血管舒张活性和PAF拮抗作用的光学活性1,4-二氢吡啶衍生物及其制备方法：其中（*）表示在光学活性的1,4-二氢吡啶衍生物的情况下手性中心。

3. 发明授权

US5644059A 1,4-dihydropyridine derivatives and methods of producing the same 失效
标题翻译： 1,4-二氢吡啶衍生物及其制备方法
公开(公告)号：US5644059A
公开(公告)日：1997-07-01
申请号：US460764
申请日：1995-06-02
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
IPC分类号： C07D211/90 , C07D213/82 , C07D401/06 , C07D401/12 , C07D213/56 , C07D213/57 , C07D403/06
CPC分类号： C07D401/06 , C07D211/90 , C07D213/82 , C07D401/12
摘要： 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.
摘要翻译：公开了具有下式的1,4-二氢吡啶衍生物和光学活性的1,4-二氢吡啶衍生物，其具有基于钙拮抗作用的血管舒张活性和PAF抗体，其制备方法：其中（*）表示在光学活性的1,4-二氢吡啶衍生物的情况下手性中心。

4. 发明授权

US5696268A 1, 4-Dihydropyridine derivatives and methods of producing the same 失效
标题翻译： 1,4-二氢吡啶衍生物及其制备方法
公开(公告)号：US5696268A
公开(公告)日：1997-12-09
申请号：US460273
申请日：1995-06-02
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
IPC分类号： C07D211/90 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/04 , C07D211/84 , C07D213/56
CPC分类号： C07D401/06 , C07D211/90 , C07D213/82 , C07D401/12
摘要： 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.
摘要翻译：公开了具有下式的1,4-二氢吡啶衍生物和光学活性的1,4-二氢吡啶衍生物，其具有基于钙拮抗作用的血管舒张活性和PAF抗体，其制备方法：其中（*）表示在光学活性的1,4-二氢吡啶衍生物的情况下手性中心。

5. 发明授权

US5367081A 1,4-dihydropyridine derivatives 失效
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：US5367081A
公开(公告)日：1994-11-22
申请号：US800249
申请日：1991-11-29
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuko Konagai , Tetsuaki Yamaura , Noriko Kase
IPC分类号： A61K31/435 , A61K31/4422 , A61K31/4427 , A61K31/495 , A61P7/02 , A61P9/08 , A61P9/12 , A61P11/08 , A61P25/28 , A61P29/00 , A61P37/08 , C07D211/90 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12 , C07D473/08 , C07F7/10 , C07D213/51
CPC分类号： C07D401/06 , C07D211/90 , C07D213/82 , C07D401/12
摘要： 1,4-dihydropyridine derivatives and optically active 1,4-dihydropyridine derivatives with the following formula, having vasodilating activity based on calcium antagonism, and PAF antaognism, and methods of producing the same are disclosed: ##STR1## wherein (*) indicates a chiral center in the case of the optically active 1,4-dihydropyridine derivatives.
摘要翻译：公开了具有下式的1,4-二氢吡啶衍生物和具有基于钙拮抗作用的血管舒张活性和PAF拮抗作用的光学活性1,4-二氢吡啶衍生物及其制备方法：其中（*）表示在光学活性的1,4-二氢吡啶衍生物的情况下手性中心。

6. 发明授权

US5276150A 1,4-dihydropyridine derivatives 失效
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：US5276150A
公开(公告)日：1994-01-04
申请号：US850201
申请日：1992-03-12
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Nobuo Kobayashi , Yasuko Konagai , Yasuo Sekine
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Nobuo Kobayashi , Yasuko Konagai , Yasuo Sekine
IPC分类号： C07D211/90 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D473/04 , C07D473/08 , C07D521/00 , C07D217/18 , C07D417/04 , C07D419/04
CPC分类号： C07D231/12 , C07D211/90 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D473/04 , C07D473/08
摘要： 1,4-dihydropyridine derivatives of formula (I): ##STR1## wherein Ar.sup.1 and Ar.sup.2 each represent an unsubstituted or substituted aromatic hydrocarbon or aromatic heterocyclic group; and R.sup.1 represents --CO.sub.2 R.sup.2, --SO.sub.2 R.sup.3, --COR.sup.4, --CON(R.sup.5).sub.2, --CH--or --NO.sub.2 in which R.sup.2 is hydrogen, a straight chain, branched chain or cyclic saturated hydrocarbon group, which may have a substituent or a straight chain, branched chain or cyclic unsaturated hydrocarbon group having 2 to 10 carbon atoms, which may have a substituent, R.sup.3 is an alkyl group having 1 to 4 carbon atoms, R.sup.4 is an alkyl group having 1 to 4 carbon atoms or a phenyl group; and R.sup.5 is an alkyl group having 1 to 4 carbon atoms.
摘要翻译：式（I）的1,4-二氢吡啶衍生物：其中Ar 1和Ar 2各自表示未取代或取代的芳族烃或芳族杂环基; 和R 1表示可以具有取代基的直链，支链或环状饱和烃基的-CO 2 R 2，-SO 2 R 3，-COR 4，-CON（R 5）2，-CH或-NO 2，可以具有取代基的碳原子数为2〜10的直链，支链或支链或环状不饱和烃基，R3为碳原子数1〜4的烷基，R4为碳原子数1〜4的烷基或苯基 ; R5为碳原子数为1〜4的烷基。

7. 发明授权

US5286869A 1,4-dihydropyridine derivatives 失效
标题翻译： 1,4-二氢吡啶衍生物
公开(公告)号：US5286869A
公开(公告)日：1994-02-15
申请号：US492951
申请日：1990-03-12
申请人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuo Sekine
发明人： Hiroshi Ikawa , Akiyoshi Kadoiri , Yasuo Sekine
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： 1,4-Dihydropyridine derivatives of formula: ##STR1## wherein Ar.sup.1 represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R.sup.1 represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of --R--O--N.dbd.CH--, --R--N.dbd.N--, --R--CH.dbd.N-- and --R--N.dbd.CH--, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar.sup.2 represents an aromatic hydrocarbon group or a heterocyclic group; Ar.sup.3 represents a heterocyclic group which may have one or more substituents; and n is 0 or 1, and the corresponding optical active 1,4-dihydropyridine derivatives, having an optically active cite as indicated by *, have both superior vasodilative and platelet aggregation inhibiting activities.
摘要翻译：其中Ar 1表示芳族烃基或含有选自氧，硫和氮的1至3个原子的芳族杂单环或杂双环基; R1表示可具有一个或多个取代基的烃基; A表示（i）直链或支链不饱和烃基，（ii）环状不饱和烃基，或（iii）选自-RON = CH-，-RN = N-，-R -CH = N-和-RN = CH-，其中R是具有1至6个碳原子的亚烷基; B表示可以具有取代基的碳原子数1〜3的亚烷基或亚烯基; Ar 2表示芳香族烃基或杂环基; Ar 3表示可以具有一个以上取代基的杂环基; 并且n为0或1，并且具有如*所示的光学活性引物的相应的光学活性1,4-二氢吡啶衍生物具有优异的血管扩张和血小板聚集抑制活性。

8. 发明授权

US5965538A Azapeptide derivative 失效
标题翻译： Azapeptide衍生物
公开(公告)号：US5965538A
公开(公告)日：1999-10-12
申请号：US138656
申请日：1998-08-24
申请人： Yoshiharu Nakashima , Michiyo Hizuka , Yasushi Higashide , Tetsuaki Yamaura , Hiroshi Ikawa
发明人： Yoshiharu Nakashima , Michiyo Hizuka , Yasushi Higashide , Tetsuaki Yamaura , Hiroshi Ikawa
IPC分类号： A61K38/00 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/093 , A61K38/07 , C07K5/04
CPC分类号： C07K5/0819 , C07K5/0606 , C07K5/06086 , C07K5/06104 , C07K5/06113 , A61K38/00 , Y02P20/55
摘要： Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group,and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.
摘要翻译：公开了由式（I）表示的氮杂肽衍生物：其中A表示直接键，α-氨基酸或二肽的残基; R1表示氢原子或末端氨基的保护基; R2表示苯基或被一个或两个取代基取代的苯基，所述取代基选自低级烷基，卤素原子，可被保护的羟基，硝基，可被保护的氨基和全卤代低级烷基 ; R3表示羟基或末端羧基的保护基及其盐，和包含式（I）所示的氮杂多肽衍生物或其盐的呼吸器官，哮喘和支气管痉挛的神经炎症的治疗剂作为活性成分。

9. 发明授权

US5393780A 4-fluorobiphenyl derivatives 失效
标题翻译： 4-氟联苯衍生物
公开(公告)号：US5393780A
公开(公告)日：1995-02-28
申请号：US217566
申请日：1994-03-25
申请人： Masakatsu Matsumoto , Nobuko Watanabe , Eiko Mori , Miwa Ishihara , Tetsuaki Yamaura , Misao Aoyama , Hiroshi Ikawa , Hisako Kobayashi
发明人： Masakatsu Matsumoto , Nobuko Watanabe , Eiko Mori , Miwa Ishihara , Tetsuaki Yamaura , Misao Aoyama , Hiroshi Ikawa , Hisako Kobayashi
IPC分类号： C07C45/44 , C07C47/277 , C07C59/64 , C07C69/734 , C07D213/30 , C07D309/12 , C07D309/30 , A01N37/10
CPC分类号： C07D213/30 , C07C45/44 , C07C47/277 , C07C59/64 , C07C69/734 , C07D309/12 , C07D309/30
摘要： A 4-fluorobiphenyl derivative of formula (I): ##STR1## wherein A is a .omega.-oxycarbonyldihydroxybutyl group of formula (II): ##STR2## wherein R.sup.2 is a hydrogen atom, an alkyl group, an alkaline metal or an alkaline earth metal; a tetrahydropyranyl group of formula (III): ##STR3## or a .omega.-oxycarbonyl-3-oxobutyl group of formula (IV): ##STR4## wherein R.sup.3 is an alkyl group; R.sup.1 is an alkyl group. This 4-fluorobiphenyl derivative is useful as an effective component for a cholesterol or lipid lowering agent.
摘要翻译：式（I）的4-氟联苯衍生物：其中A是式（II）的ω-氧羰基二羟基丁基：其中R 2是氢原子，烷基，碱金属或碱土金属; 式（Ⅳ）的四氢吡喃基：式（Ⅳ）的化合物：其中R 3为烷基; R1是烷基。该4-氟联苯衍生物可用作胆固醇或降脂剂的有效成分。

10. 发明授权

US5837687A Azapeptide derivative 失效
标题翻译： Azapeptide衍生物
公开(公告)号：US5837687A
公开(公告)日：1998-11-17
申请号：US406053
申请日：1995-03-17
申请人： Yoshiharu Nakashima , Michiyo Hizuka , Yasushi Higashide , Tetsuaki Yamaura , Hiroshi Ikawa
发明人： Yoshiharu Nakashima , Michiyo Hizuka , Yasushi Higashide , Tetsuaki Yamaura , Hiroshi Ikawa
IPC分类号： A61K38/00 , C07K5/06 , C07K5/068 , C07K5/072 , C07K5/093 , A61K38/07 , C07K5/04
CPC分类号： C07K5/0819 , C07K5/0606 , C07K5/06086 , C07K5/06104 , C07K5/06113 , A61K38/00 , Y02P20/55
摘要： Disclosed is an azapeptide derivative represented by the formula (I): ##STR1## wherein A represents a direct bond, an .alpha.-amino acid or a residue of a dipeptide; R.sup.1 represents a hydrogen atom or a protective group for a terminal amino group; R.sup.2 represents a phenyl group or a phenyl group substituted by one or two substituents selected from the group consisting of a lower alkyl group, halogen atom, hydroxyl group which may be protected, nitro group, amino group which may be protected and perhalo lower alkyl group; and R.sup.3 represents a hydroxyl group or a protective group for a terminal carboxyl group, and a salt thereof, and an agent for curing nervous inflammation of respiratory apparatus, asthma and bronchospasm comprising the azapeptide derivative represented by the formula (I) or a salt thereof as an active ingredient.
摘要翻译：公开了由式（I）表示的氮杂肽衍生物：其中A表示直接键，α-氨基酸或二肽的残基; R1表示氢原子或末端氨基的保护基; R2表示苯基或被一个或两个取代基取代的苯基，所述取代基选自低级烷基，卤素原子，可被保护的羟基，硝基，可被保护的氨基和全卤代低级烷基 ; R3表示羟基或末端羧基的保护基及其盐，和包含式（I）所示的氮杂多肽衍生物或其盐的呼吸器官，哮喘和支气管痉挛的神经炎症的治疗剂作为活性成分。

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